{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:22:31Z","timestamp":1794356551734,"version":"4.9.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973081"],"award-info":[{"award-number":["81973081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504373"],"award-info":[{"award-number":["82504373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.neuro.2026.103573","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:58:45Z","timestamp":1789052325000},"page":"103573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Exploring nonylphenol as a potential environmental contributor to Alzheimer\u2019s disease: A hypothesis-generating study integrating computational analyses and experimental evidence"],"prefix":"10.1016","volume":"117","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianqi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingcheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.neuro.2026.103573_bib1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1523\/JNEUROSCI.23-06-02333.2003","article-title":"Estrogen stimulates postsynaptic density-95 rapid protein synthesis via the Akt\/protein kinase B pathway","volume":"23","author":"Akama","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2026.103573_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2105-4-2","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"BMC Bioinforma."},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"jvenn: an interactive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinforma."},{"issue":"11","key":"10.1016\/j.neuro.2026.103573_bib4","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1001\/archneur.59.11.1764","article-title":"Survival following a diagnosis of Alzheimer disease","volume":"59","author":"Brookmeyer","year":"2002","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.neuro.2026.103573_bib5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1289\/ehp.7534","article-title":"Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population","volume":"113","author":"Calafat","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"4(4","key":"10.1016\/j.neuro.2026.103573_bib6","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.neuro.2026.103573_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1238639","article-title":"EGFR is a potential dual molecular target for cancer and Alzheimer's disease","volume":"14","author":"Choi","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"6559","key":"10.1016\/j.neuro.2026.103573_bib8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neuro.2026.103573_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109709","article-title":"Toxicity of nonylphenol and nonylphenol ethoxylate on Caenorhabditis elegans","volume":"187","author":"De la Parra-Guerra","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.neuro.2026.103573_bib10","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/etc.5633","article-title":"Studies of Endocrine Disruptors: Nonylphenol and Isomers in Biological Models","volume":"42","author":"De la Parra-Guerra","year":"2023","journal-title":"Environ. Toxicol. Chem."},{"issue":"49","key":"10.1016\/j.neuro.2026.103573_bib11","doi-asserted-by":"crossref","first-page":"32377","DOI":"10.1074\/jbc.273.49.32377","article-title":"CREB is a regulatory target for the protein kinase Akt\/PKB","volume":"273","author":"Du","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2026.103573_bib12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tox.2016.01.004","article-title":"4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK\/AKT-mTOR and JNK pathways","volume":"341-343","author":"Duan","year":"2016","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1210\/mend.16.1.0758","article-title":"Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis","volume":"16","author":"Filardo","year":"2002","journal-title":"Mol. Endocrinol."},{"issue":"17","key":"10.1016\/j.neuro.2026.103573_bib14","doi-asserted-by":"crossref","first-page":"10032","DOI":"10.1073\/pnas.1630428100","article-title":"Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease","volume":"100","author":"Gamblin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib15","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s13287-025-04580-3","article-title":"Small molecule-mediated rapid generation of functional human astrocytes: unveiling AKT1-STAT1\/3 signaling in astrocyte development","volume":"16","author":"Garg","year":"2025","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.neuro.2026.103573_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fnmol.2020.00116","article-title":"Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System","volume":"13","author":"Hannan","year":"2020","journal-title":"Front. Mol. Neurosci."},{"issue":"5580","key":"10.1016\/j.neuro.2026.103573_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.neuro.2026.103573_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041338","article-title":"Phytotoxicity, Bioaccumulation, and Degradation of Nonylphenol in Different Microalgal Species without Bacterial Influences","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.neuro.2026.103573_bib19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"3-4","key":"10.1016\/j.neuro.2026.103573_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/09727531211070532","article-title":"Role of JAK\/STAT in the Neuroinflammation and its Association with Neurological Disorders","volume":"28","author":"Jain","year":"2021","journal-title":"Ann. Neurosci."},{"issue":"10","key":"10.1016\/j.neuro.2026.103573_bib21","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1007\/s00204-022-03328-9","article-title":"Human risk assessment of 4-n-nonylphenol (4-n-NP) using physiologically based pharmacokinetic (PBPK) modeling: analysis of gender exposure differences and application to exposure analysis related to large exposure variability in population","volume":"96","author":"Jeong","year":"2022","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.neuro.2026.103573_bib22","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1021\/es403781z","article-title":"Ecological risk of nonylphenol in China surface waters based on reproductive fitness","volume":"48","author":"Jin","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.neuro.2026.103573_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000536643","article-title":"Potentially Modifiable Risk Factors for Dementia and Mild Cognitive Impairment: An Umbrella Review and Meta-Analysis","volume":"53","author":"Jones","year":"2024","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neuro.2026.103573_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121007","article-title":"Environmental risk factors for all-cause dementia, Alzheimer's disease dementia, vascular dementia, and mild cognitive impairment: An umbrella review and meta-analysis","volume":"270","author":"Jones","year":"2025","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12877-016-0342-y","article-title":"Environmental risk factors for dementia: a systematic review","volume":"16","author":"Killin","year":"2016","journal-title":"BMC Geriatr."},{"issue":"4","key":"10.1016\/j.neuro.2026.103573_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12040938","article-title":"BCL-2 Proteins in Pathogenesis and Therapy of B-Cell Non-Hodgkin Lymphomas","volume":"12","author":"Klanova","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.neuro.2026.103573_bib27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neulet.2007.11.058","article-title":"p-Nonylphenol induces endoplasmic reticulum stress-mediated apoptosis in neuronally differentiated PC12 cells","volume":"431","author":"Kusunoki","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuro.2026.103573_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117903","article-title":"Assessment of nonylphenol exposure based on global urinary concentration data and its risk analysis","volume":"244","author":"Li","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.neuro.2026.103573_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuint.2018.11.009","article-title":"Autophagy activation alleviates nonylphenol-induced apoptosis in cultured cortical neurons","volume":"122","author":"Li","year":"2019","journal-title":"Neurochem. Int."},{"issue":"6","key":"10.1016\/j.neuro.2026.103573_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00739","article-title":"Targeted ErbB4 receptor activation ameliorates neuronal deficits via DOCK3 signaling in a transgenic mouse AD model","volume":"22","author":"Liu","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"12","key":"10.1016\/j.neuro.2026.103573_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108417","article-title":"Lipid metabolism analysis providing insights into nonylphenol multi-toxicity mechanism","volume":"26","author":"Liu","year":"2023","journal-title":"iScience"},{"issue":"W1","key":"10.1016\/j.neuro.2026.103573_bib32","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"10248","key":"10.1016\/j.neuro.2026.103573_bib33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.neuro.2026.103573_bib34","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3389\/fnins.2019.01444","article-title":"Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer's Disease","volume":"13","author":"Llanos-Gonz\u00e1lez","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuro.2026.103573_bib35","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.11384","article-title":"Hospital-based case control study and animal study on the relationship between nonylphenol exposure and depression","volume":"9","author":"Luo","year":"2021","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/ijms12010114","article-title":"Behavioral impairment and oxidative damage induced by chronic application of nonylphenol","volume":"12","author":"Mao","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuro.2026.103573_bib37","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.chemosphere.2014.12.037","article-title":"Sorption behaviour of nonylphenol and nonylphenol monoethoxylate in soils","volume":"138","author":"Milinovic","year":"2015","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.neuro.2026.103573_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/074823370001600201","article-title":"Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin","volume":"16","author":"Monteiro-Riviere","year":"2000","journal-title":"Toxicol. Ind. Health"},{"issue":"Pt B","key":"10.1016\/j.neuro.2026.103573_bib39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cbi.2016.04.009","article-title":"AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease","volume":"259","author":"Nalivaeva","year":"2016","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.neuro.2026.103573_bib40","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/09593330.2020.1786166","article-title":"UVA\/persulfate-driven nonylphenol polyethoxylate degradation: effect of process conditions","volume":"43","author":"Nunes","year":"2022","journal-title":"Environ. Technol."},{"issue":"1-2","key":"10.1016\/j.neuro.2026.103573_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0169-328X(02)00488-6","article-title":"Up-regulation of mitogen-activated protein kinases ERK1\/2 and MEK1\/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease","volume":"109","author":"Pei","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"8","key":"10.1016\/j.neuro.2026.103573_bib42","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1111\/bph.12549","article-title":"Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress","volume":"171","author":"Pfeiffer","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib43","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.1038\/s41598-023-34183-y","article-title":"Transcriptomic analysis of glutamate-induced HT22 neurotoxicity as a model for screening anti-Alzheimer's drugs","volume":"13","author":"Prasansuklab","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib44","doi-asserted-by":"crossref","DOI":"10.1136\/gpsych-2022-100751","article-title":"The China Alzheimer Report 2022","volume":"35","author":"Ren","year":"2022","journal-title":"Gen. Psychiatr."},{"key":"10.1016\/j.neuro.2026.103573_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5059043","article-title":"Protective Effect of Tempol on Buthionine Sulfoximine-Induced Mitochondrial Impairment in Hippocampal Derived HT22 Cells","volume":"2016","author":"Salvi","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"18","key":"10.1016\/j.neuro.2026.103573_bib46","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/01.wnl.0000260698.46517.8f","article-title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment","volume":"68","author":"Scheff","year":"2007","journal-title":"Neurology"},{"issue":"10284","key":"10.1016\/j.neuro.2026.103573_bib47","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.neuro.2026.103573_bib48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/molehr\/gaaa039","article-title":"A prominent environmental endocrine disruptor, 4-nonylphenol, promotes endometriosis development via plasmacytoid dendritic cells","volume":"26","author":"Sharma","year":"2020","journal-title":"Mol. Hum. Reprod."},{"issue":"4","key":"10.1016\/j.neuro.2026.103573_bib49","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1073\/pnas.95.4.1455","article-title":"Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux","volume":"95","author":"Shimizu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.neuro.2026.103573_bib50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/etc.5778","article-title":"Contamination of Bisphenol A, Nonylphenol, Octylphenol, and Estrone in Major Rivers of Mega Manila, Philippines","volume":"43","author":"Sta Ana","year":"2024","journal-title":"Environ. Toxicol. Chem."},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2105\/AJPH.2023.307461","article-title":"Characterizing the Burden of Occupational Chemical Exposures by Sociodemographic Groups in the United States, 2021","volume":"114","author":"Stephan-Recaido","year":"2024","journal-title":"Am. J. Public. Health"},{"issue":"3","key":"10.1016\/j.neuro.2026.103573_bib52","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/jcp.26097","article-title":"The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands","volume":"233","author":"Urriola-Mu\u00f1oz","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.neuro.2026.103573_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12895","article-title":"Soluble amyloid-\u03b2 dimers are resistant to amyloid-\u03b2 prion conversion in vivo suggesting antiprion properties","volume":"49","author":"van Gerresheim","year":"2023","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neuro.2026.103573_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2024.106868","article-title":"Neurotoxicant effects of bisphenol A, nonylphenol, and tert\u2011butyl phenol in the Nile tilapia (Oreochromis niloticus)","volume":"268","author":"Vega-L\u00f3pez","year":"2024","journal-title":"Aquat. Toxicol."},{"issue":"7","key":"10.1016\/j.neuro.2026.103573_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112779","article-title":"Relationship between endocrine disruptors and neurodegenerative diseases: Systematic review and meta-analysis","volume":"28","author":"Wang","year":"2025","journal-title":"iScience"},{"issue":"9","key":"10.1016\/j.neuro.2026.103573_bib56","doi-asserted-by":"crossref","first-page":"96001","DOI":"10.1289\/EHP8716","article-title":"Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature","volume":"129","author":"Weuve","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neuro.2026.103573_bib57","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jad.2019.12.012","article-title":"Depressive behavior induced by nonylphenol and its effect on the expression of ER-\u03b1 and ER-\u03b2 in nerve cells of rats","volume":"263","author":"Xu","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"11","key":"10.1016\/j.neuro.2026.103573_bib58","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1002\/alz.14254","article-title":"Temporal trend and attributable risk factors of Alzheimer's disease and other dementias burden in China: Findings from the Global Burden of Disease Study 2021","volume":"20","author":"Yang","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"3","key":"10.1016\/j.neuro.2026.103573_bib59","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac087","article-title":"FitDock: protein-ligand docking by template fitting","volume":"23","author":"Yang","year":"2022","journal-title":"Brief. Bioinform"},{"issue":"34","key":"10.1016\/j.neuro.2026.103573_bib60","doi-asserted-by":"crossref","first-page":"8690","DOI":"10.1016\/j.biomaterials.2013.07.100","article-title":"Epidermal growth factor receptor targeting in cancer: a review of trends and strategies","volume":"34","author":"Yewale","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuro.2026.103573_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108228","article-title":"Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats","volume":"180","author":"You","year":"2023","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.neuro.2026.103573_bib62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.neuro.2026.103573_bib63","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/bioinformatics\/btu684","article-title":"DOSE: an R\/Bioconductor package for disease ontology semantic and enrichment analysis","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"issue":"9","key":"10.1016\/j.neuro.2026.103573_bib64","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/ijc.24540","article-title":"EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer","volume":"125","author":"Zhang","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.neuro.2026.103573_bib65","article-title":"Environmental factors and risks of cognitive impairment and dementia: A systematic review and meta-analysis","volume":"72","author":"Zhao","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.neuro.2026.103573_bib66","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101625R","article-title":"ChK1 activation induces reactive astrogliosis through CIP2A\/PP2A\/STAT3 pathway in Alzheimer's disease","volume":"36","author":"Zhou","year":"2022","journal-title":"Faseb J."},{"issue":"2","key":"10.1016\/j.neuro.2026.103573_bib67","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1471-4159.2001.00046.x","article-title":"Activation and redistribution of c-jun N-terminal kinase\/stress activated protein kinase in degenerating neurons in Alzheimer's disease","volume":"76","author":"Zhu","year":"2001","journal-title":"J. Neurochem."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26001944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26001944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:37:22Z","timestamp":1794353842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X26001944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":67,"alternative-id":["S0161813X26001944"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103573","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring nonylphenol as a potential environmental contributor to Alzheimer\u2019s disease: A hypothesis-generating study integrating computational analyses and experimental evidence","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103573"}}