{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:22:38Z","timestamp":1794356558938,"version":"4.9.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021ZD0201101"],"award-info":[{"award-number":["2021ZD0201101"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971174"],"award-info":[{"award-number":["81971174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020230","name":"Health Commission of Jilin Province","doi-asserted-by":"publisher","award":["2024A005"],"award-info":[{"award-number":["2024A005"]}],"id":[{"id":"10.13039\/501100020230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["2026B34"],"award-info":[{"award-number":["2026B34"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.neuro.2026.103588","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:52:46Z","timestamp":1791820366000},"page":"103588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Microplastics detection in freshly harvested human brain tissues of northeast Chinese postmortem donors and their correlation with Alzheimer\u2019s disease-related pathological proteins"],"prefix":"10.1016","volume":"117","author":[{"given":"Qi","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aipeng","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.neuro.2026.103588_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s40263-025-01251-y","article-title":"Hippocampal atrophy on magnetic resonance imaging as a surrogate marker for clinical benefit and neurodegeneration in early symptomatic Alzheimer's disease: synthesis of evidence from observational and interventional trials","volume":"40","author":"Abushakra","year":"2026","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuro.2026.103588_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6564585","article-title":"Blood-brain barrier overview: structural and functional correlation","volume":"2021","author":"Alahmari","year":"2021","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuro.2026.103588_bib3","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.20829","article-title":"Dental microplastics as emerging neurotoxicants: a systematic review on human data","volume":"14","author":"Alkhamees","year":"2026","journal-title":"PeerJ"},{"key":"10.1016\/j.neuro.2026.103588_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126124","article-title":"Presence of airborne microplastics in human lung tissue","volume":"416","author":"Amato-Lourenco","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.neuro.2026.103588_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.120618","article-title":"Microplastics and nanoplastics: Source, behavior, remediation, and multi-level environmental impact","volume":"356","author":"Arif","year":"2024","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.neuro.2026.103588_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.178359","article-title":"Polyethylene packaging and alternative materials in the United States: A life cycle assessment","volume":"961","author":"Avery","year":"2025","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.neuro.2026.103588_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.178276","article-title":"Polyvinyl chloride (PVC), its additives, microplastic and human health: Unresolved and emerging issues","volume":"960","author":"Campisi","year":"2025","journal-title":"Sci. Total. Environ."},{"issue":"1","key":"10.1016\/j.neuro.2026.103588_bib8","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1038\/s41467-022-32510-x","article-title":"Catalytic oxidation of polystyrene to aromatic oxygenates over a graphitic carbon nitride catalyst","volume":"13","author":"Cao","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.neuro.2026.103588_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-023-02853-3","article-title":"Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation","volume":"20","author":"Chen","year":"2023","journal-title":"J. Neuroinflamm."},{"issue":"2","key":"10.1016\/j.neuro.2026.103588_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14477","article-title":"The etiology and prevention of early-stage tau pathology in higher cortical circuits: Insights from aging rhesus macaques","volume":"21","author":"Datta","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.neuro.2026.103588_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/cells15010059","article-title":"Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease","volume":"15","author":"Erginousakis","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.neuro.2026.103588_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2025.111553","article-title":"Adult hippocampal neurogenesis and temporal lobe epilepsy: A potential key to understanding cognitive deficit","volume":"143","author":"Fernandes","year":"2025","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.neuro.2026.103588_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.neuro.2026.103588_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131422","article-title":"Unpacking the complexity of the polyethylene food contact articles value chain: A chemicals perspective","volume":"454","author":"Gerassimidou","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.neuro.2026.103588_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133518","article-title":"Impact of nanoplastics on Alzheimer 's disease: Enhanced amyloid-\u03b2 peptide aggregation and augmented neurotoxicity","volume":"465","author":"Gou","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.neuro.2026.103588_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135266","article-title":"Discovery and analysis of microplastics in human bone marrow","volume":"477","author":"Guo","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.neuro.2026.103588_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104147","article-title":"Microplastics detected in cirrhotic liver tissue","volume":"82","author":"Horvatits","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neuro.2026.103588_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.127284","article-title":"Laser Direct Infrared Spectroscopy: A cutting-edge approach to microplastic detection in environmental samples","volume":"284","author":"Isaac Chandran","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.neuro.2026.103588_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154907","article-title":"Detection of microplastics in human lung tissue using muFTIR spectroscopy","volume":"831","author":"Jenner","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.neuro.2026.103588_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.120278","article-title":"Micro- and nanoplastics in the central nervous system: Transport pathways, neurotoxicity, and implications for brain disorders","volume":"319","author":"Jing","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.neuro.2026.103588_bib21","doi-asserted-by":"crossref","first-page":"15295","DOI":"10.1007\/s12035-025-05174-z","article-title":"Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation","volume":"62","author":"Kumari","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"Pt 2","key":"10.1016\/j.neuro.2026.103588_bib22","article-title":"Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo","volume":"807","author":"Kwon","year":"2022","journal-title":"Sci. Total. Environ."},{"issue":"1","key":"10.1016\/j.neuro.2026.103588_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5334\/aogh.4056","article-title":"The Minderoo-Monaco Commission on Plastics and Human Health","volume":"89","author":"Landrigan","year":"2023","journal-title":"Ann. Glob. Health"},{"key":"10.1016\/j.neuro.2026.103588_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.neuro.2026.103588_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2025.118270","article-title":"Advances and challenges in the determination of micro- and nano-plastics by pyrolysis-gas chromatography-mass spectrometry","volume":"189","author":"Li","year":"2025","journal-title":"Trac. -Trends Anal. Chem."},{"key":"10.1016\/j.neuro.2026.103588_bib26","article-title":"Microplastics and nanoplastics in brain tumours and the healthy human brain","author":"Li","year":"2026","journal-title":"Nat. Health"},{"key":"10.1016\/j.neuro.2026.103588_bib27","article-title":"Underestimated activity-based microplastic intake under scenario-specific exposures","volume":"18","author":"Liu","year":"2024","journal-title":"Environ. Sci. Ecotechnol"},{"key":"10.1016\/j.neuro.2026.103588_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscia.2023.100031","article-title":"The effect of particle size on drug bioavailability in various parts of the body","volume":"2","author":"Mok","year":"2024","journal-title":"Pharm. Sci. Adv."},{"issue":"4","key":"10.1016\/j.neuro.2026.103588_bib29","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/s41591-024-03453-1","article-title":"Bioaccumulation of microplastics in decedent human brains","volume":"31","author":"Nihart","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuro.2026.103588_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124799","article-title":"Effects of nanoparticle size, shape, and zeta potential on drug delivery","volume":"666","author":"Ozturk","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.neuro.2026.103588_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2026.154424","article-title":"Micro-nanoplastics in the central nervous system: Evidence, mechanisms and perspectives","volume":"522","author":"Pei","year":"2026","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.neuro.2026.103588_bib32","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2300582121","article-title":"Rapid single-particle chemical imaging of nanoplastics by SRS microscopy","volume":"121","author":"Qian","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.neuro.2026.103588_bib33","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s12264-018-0306-7","article-title":"Standardized Operational Protocol for Human Brain Banking in China","volume":"35","author":"Qiu","year":"2019","journal-title":"Neurosci. Bull."},{"issue":"13","key":"10.1016\/j.neuro.2026.103588_bib34","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.3390\/polym14132700","article-title":"Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk","volume":"14","author":"Ragusa","year":"2022","journal-title":"Polym. (Basel)"},{"key":"10.1016\/j.neuro.2026.103588_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: First evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"issue":"50","key":"10.1016\/j.neuro.2026.103588_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd1211","article-title":"Environmental exposure enhances the internalization of microplastic particles into cells","volume":"6","author":"Ramsperger","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.neuro.2026.103588_bib37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/NPM-200597","article-title":"Epidemiology and pathogenesis of stroke in preterm infants: A systematic review","volume":"15","author":"Roy","year":"2022","journal-title":"J. Neonatal Perinat. Med."},{"issue":"2","key":"10.1016\/j.neuro.2026.103588_bib38","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s11010-025-05428-3","article-title":"Do microplastics play a role in the pathogenesis of neurodegenerative diseases? Shared pathophysiological pathways for Alzheimer's and Parkinson's disease","volume":"481","author":"Siu","year":"2026","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.neuro.2026.103588_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109421","article-title":"Microplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats","volume":"198","author":"Suljevic","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.neuro.2026.103588_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.154030","article-title":"Microplastics\/nanoplastics and neurological health: An overview of neurological defects and mechanisms","volume":"511","author":"Sun","year":"2025","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.neuro.2026.103588_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096801","article-title":"IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples","volume":"9","author":"Varghese","year":"2014","journal-title":"PLoS. One"},{"issue":"Pt 1","key":"10.1016\/j.neuro.2026.103588_bib42","article-title":"Intrinsic challenges and strategic approaches for enhancing the potential of natural rubber and its derivatives: A review","volume":"276","author":"Whba","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.neuro.2026.103588_bib43","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.neuro.2026.103588_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2026.117642","article-title":"Analytical advances in microplastic detection: A comprehensive review of physical, chemical, and biosensing techniques","volume":"224","author":"Zhang","year":"2026","journal-title":"Microchem. J."},{"issue":"4","key":"10.1016\/j.neuro.2026.103588_bib45","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.4103\/NRR.NRR-D-24-01343","article-title":"Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications","volume":"21","author":"Zhao","year":"2026","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuro.2026.103588_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114818","article-title":"Transport of microplastics in the body and interaction with biological barriers, and controlling of microplastics pollution","volume":"255","author":"Zhu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26002093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26002093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:39:33Z","timestamp":1794353973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X26002093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"alternative-id":["S0161813X26002093"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103588","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microplastics detection in freshly harvested human brain tissues of northeast Chinese postmortem donors and their correlation with Alzheimer\u2019s disease-related pathological proteins","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103588"}}