{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:00:40Z","timestamp":1791025240198,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.neurobiolaging.2004.12.003","type":"journal-article","created":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T12:16:49Z","timestamp":1107433009000},"page":"10-15","source":"Crossref","is-referenced-by-count":59,"title":["Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt\u2013Jakob disease"],"prefix":"10.1016","volume":"27","author":[{"given":"Katharina","family":"Buerger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan J.","family":"Teipel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Zinkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"DeBernardis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kerkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sch\u00f6nknecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Cepek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Kretzschmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Hampel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.neurobiolaging.2004.12.003_bib1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1474-4422(03)00530-1","article-title":"CSF markers for incipient Alzheimer's disease","volume":"2","author":"Blennow","year":"2003","journal-title":"Rev Lancet Neurol"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2004.12.003_bib2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1212\/WNL.59.4.627","article-title":"CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects","volume":"59","author":"Buerger","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2004.12.003_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1176\/appi.ajp.160.2.376","article-title":"Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231","volume":"160","author":"Buerger","year":"2003","journal-title":"Am J Psychiatry"},{"issue":"8","key":"10.1016\/j.neurobiolaging.2004.12.003_bib4","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1001\/archneur.59.8.1267","article-title":"Differential diagnosis of Alzheimer's disease with CSF tau protein phosphorylated at threonine 231","volume":"59","author":"Buerger","year":"2002","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2004.12.003_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0197-4580(03)00002-2","article-title":"Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease","volume":"24","author":"Frank","year":"2003","journal-title":"Rev Neurobiol Aging"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2004.12.003_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s004010050870","article-title":"Coexistence of Alzheimer-type neuropathology in Creutzfeldt\u2013Jakob disease","volume":"96","author":"Hainfellner","year":"1998","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2004.12.003_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archpsyc.61.1.95","article-title":"Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study","volume":"61","author":"Hampel","year":"2004","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2004.12.003_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0361-9230(03)00087-X","article-title":"Advances in the development of biomarkers for Alzheimer's disease: from CSF total tau and Abeta (1-42) proteins to phosphorylated tau protein","volume":"61","author":"Hampel","year":"2003","journal-title":"Rev Brain Res Bull"},{"key":"10.1016\/j.neurobiolaging.2004.12.003_bib9","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiology.148.3.6878708","article-title":"A method of comparing the areas under receiver operating characteristics curves derived from the same cases","volume":"148","author":"Hanley","year":"1983","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2004.12.003_bib10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ana.1054","article-title":"Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease","volume":"50","author":"Itoh","year":"2001","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2004.12.003_bib11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/jnnp.71.3.401","article-title":"Highly increased CSF tau protein and decreased beta-amyloid (1-42) in sporadic CJD: a discrimination from Alzheimer's disease?","volume":"71","author":"Kapaki","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2004.12.003_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3940(00)01178-2","article-title":"Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer's disease patients","volume":"287","author":"Kohnken","year":"2000","journal-title":"Neurosci Lett"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2004.12.003_bib13","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/archneur.1996.00550090125018","article-title":"Diagnostic criteria for Creutzfeldt\u2013Jakob disease","volume":"53","author":"Kretzschmar","year":"1996","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2004.12.003_bib14","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2004.12.003_bib15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1212\/WNL.58.2.192","article-title":"Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt\u2013Jakob disease","volume":"58","author":"Otto","year":"2002","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2004.12.003_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.mp.4001220","article-title":"Phospho-tau\/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt\u2013Jakob disease from other dementias","volume":"8","author":"Riemenschneider","year":"2003","journal-title":"Mol Psychiatry"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2004.12.003_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ana.410300310","article-title":"Frequency and distribution of Alzheimer's disease in Europe: a collaborative study of 1990 prevalence findings. The EURODEM-Prevalence Research Group","volume":"30","author":"Rocca","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurobiolaging.2004.12.003_bib18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0304-3940(02)01481-7","article-title":"Levels of total tau and tau protein phosphorylated at threonine 181 in patients with incipient and manifest Alzheimer's disease","volume":"339","author":"Schoenknecht","year":"2003","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2004.12.003_bib19","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s004010051136","article-title":"Retrospective study of Creutzfeldt\u2013Jakob disease in Belgium: neuropathological findings","volume":"99","author":"Van Everbroeck","year":"2000","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2004.12.003_bib20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/jnnp.73.1.79","article-title":"Phosphorylated tau in cerebrospinal fluid as a marker for Creutzfeldt\u2013Jakob disease","volume":"73","author":"Van Everbroeck","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"10.1016\/j.neurobiolaging.2004.12.003_bib21","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/jnnp.74.9.1210","article-title":"A prospective study of CSF markers in 250 patients with possible Creutzfeldt\u2013Jakob disease","volume":"74","author":"Van Everbroeck","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2004.12.003_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0304-3940(00)01036-3","article-title":"Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization","volume":"285","author":"Vanmechelen","year":"2000","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.neurobiolaging.2004.12.003_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0197-4580(98)00071-2","article-title":"Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease","volume":"19","author":"Vincent","year":"1998","journal-title":"Neurobiol Aging"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458005000059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458005000059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T23:50:55Z","timestamp":1548805855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458005000059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0197458005000059"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2004.12.003","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}