{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:22:22Z","timestamp":1762100542373},"reference-count":47,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.neurobiolaging.2006.05.035","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T13:34:59Z","timestamp":1152711299000},"page":"1195-1205","source":"Crossref","is-referenced-by-count":42,"title":["Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet"],"prefix":"10.1016","volume":"28","author":[{"given":"Alexandra","family":"Bernardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"McCord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron M.","family":"Troen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-4347(87)80438-3","article-title":"Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection","volume":"422","author":"Araki","year":"1987","journal-title":"J Chromatogr"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib2","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1523\/JNEUROSCI.22-21-09166.2002","article-title":"Correlations between visual recognition memory and neocortical and hippocampal glucose metabolism after bilateral rhinal cortex lesions in the baboon: implications for Alzheimer's disease","volume":"22","author":"Blaizot","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/00005072-199704000-00010","article-title":"Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease","volume":"56","author":"Bobinski","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/6374","article-title":"Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice","volume":"2","author":"Chapman","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition","volume":"10","author":"Chen","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib6","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nn1372","article-title":"Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function","volume":"8","author":"Cleary","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.0022-3042.2001.00676.x","article-title":"Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease","volume":"80","author":"Duan","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/373523a0","article-title":"Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein","volume":"373","author":"Games","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0166-4328(01)00296-0","article-title":"Behavioral tests of hippocampal function: simple paradigms complex problems","volume":"125","author":"Gerlai","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1001\/archneur.58.3.487","article-title":"Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease","volume":"58","author":"Ho","year":"2001","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib12","series-title":"Comparative cytoarchitectonic atlas of the C57BL6 and 129Sv mouse brains","author":"Hof","year":"2000"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib13","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1093\/clinchem\/34.11.2357","article-title":"Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates","volume":"34","author":"Home","year":"1988","journal-title":"Clin Chem"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib15","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1212\/01.wnl.0000183063.99107.5c","article-title":"Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease","volume":"65","author":"Irizarry","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/ajcn\/73.3.613","article-title":"Determinants of plasma total homocysteine concentration in the Framingham offspring cohort","volume":"73","author":"Jacques","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib17","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1037\/0735-7044.97.6.873","article-title":"Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks","volume":"97","author":"Jarrard","year":"1983","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib18","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1523\/JNEUROSCI.22-05-01752.2002","article-title":"Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease","volume":"22","author":"Kruman","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib19","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/00001756-200507130-00005","article-title":"Folate deficiency inhibits proliferation of adult hippocampal progenitors","volume":"16","author":"Kruman","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib20","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0092-8674(00)80354-2","article-title":"Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1","volume":"90","author":"Lijam","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1037\/0735-7044.110.5.1025","article-title":"Galanin receptor antagonist M40 blocks galanin-induced choice accuracy deficits on a delayed-nonmatching-to-position task","volume":"110","author":"McDonald","year":"1996","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0163-1047(05)80059-7","article-title":"Effects of an exogenous beta-amyloid peptide on retention for spatial learning","volume":"62","author":"McDonald","year":"1994","journal-title":"Behav Neural Biol"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0149-7634(97)00024-9","article-title":"Present imperfect: a critical review of animal models of the mnemonic impairments in Alzheimer's disease","volume":"22","author":"McDonald","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/nlme.1996.0004","article-title":"Reversal of beta-amyloid-induced retention deficit after exposure to training and state cues","volume":"65","author":"McDonald","year":"1996","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib25","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1037\/0735-7044.111.3.552","article-title":"Analysis of galanin and the galanin antagonist M40 on delayed non-matching-to-position performance in rats lesioned with the cholinergic immunotoxin 192 IgG-saporin","volume":"111","author":"McDonald","year":"1997","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib26","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1523\/JNEUROSCI.18-13-05078.1998","article-title":"Coadministration of galanin antagonist M40 with a muscarinic M1 agonist improves delayed nonmatching to position choice accuracy in rats with cholinergic lesions","volume":"18","author":"McDonald","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0163-1047(05)80009-3","article-title":"Parallel information processing in the water maze: evidence for independent memory systems involving dorsal striatum and hippocampus","volume":"61","author":"McDonald","year":"1994","journal-title":"Behav Neural Biol"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib28","first-page":"126","article-title":"Homocysteine and Alzheimer's disease","volume":"57","author":"Miller","year":"1999","journal-title":"Nutr Rev"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib29","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/hipo.1092","article-title":"Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components","volume":"11","author":"Miyakawa","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib30","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1074\/jbc.274.10.6483","article-title":"Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain","volume":"274","author":"Moechars","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1601-183X.2006.00221.x","article-title":"Impaired spatial learning in the APPSwe+PSEN1\u0394E9 bigenic mouse model of Alzheimer's disease.","volume":"6","author":"Reiserer","year":"2007","journal-title":"Genes, Brain Behav"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib32","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/nn766","article-title":"Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression","volume":"4","author":"Roozendaal","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib33","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/archneur.1992.00530340059019","article-title":"Matching-to-sample deficits in patients with senile dementias of the Alzheimer and Lewy body types","volume":"49","author":"Sahgal","year":"1992","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib34","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer's disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib35","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1073\/pnas.042700999","article-title":"Impaired retention of spatial memory after transection of longitudinally oriented axons of hippocampal CA3 pyramidal cells","volume":"99","author":"Steffenach","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0006-8993(95)01589-2","article-title":"Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats","volume":"716","author":"Stubley-Weatherly","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1006\/nbdi.1997.0164","article-title":"Transneuronal degeneration in the spread of Alzheimer's disease pathology: immunohistochemical evidence for the transmission of tau hyperphosphorylation","volume":"4","author":"Su","year":"1997","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/nlme.1997.3770","article-title":"Intrahippocampal injections of exogenous beta-amyloid induce postdelay errors in an eight-arm radial maze","volume":"68","author":"Sweeney","year":"1997","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-2005-872406","article-title":"Homocysteine and cognitive function","volume":"5","author":"Troen","year":"2005","journal-title":"Semin Vase Med"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib40","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.pnpbp.2005.06.025","article-title":"The central nervous system in animal models of hyperhomocysteinemia","volume":"29","author":"Troen","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib41","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1073\/pnas.2436385100","article-title":"The atherogenic effect of excess methionine intake","volume":"100","author":"Troen","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/hipo.10002","article-title":"Long-term monitoring of hippocampus-dependent behavior in naturalistic settings: mutant mice lacking neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility","volume":"12","author":"Vyssotski","year":"2002","journal-title":"Hippocampus"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib43","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/hmg\/ddi224","article-title":"Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model","volume":"14","author":"Wang","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib44","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1073\/pnas.92.5.1585","article-title":"Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia","volume":"92","author":"Watanabe","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib45","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0306-4522(00)00388-2","article-title":"Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain","volume":"101","author":"Wengenack","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib46","first-page":"118","article-title":"Spatial memory and learning in transgenic mice: fact or artifact?","volume":"13","author":"Wolfer","year":"1998","journal-title":"News Physiol Sci"},{"key":"10.1016\/j.neurobiolaging.2006.05.035_bib47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.2218531","article-title":"Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides","volume":"250","author":"Yankner","year":"1990","journal-title":"Science"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458006001904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458006001904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T15:05:00Z","timestamp":1587049500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458006001904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0197458006001904"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2006.05.035","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}