{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:39:48Z","timestamp":1792485588553,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.neurobiolaging.2008.09.001","type":"journal-article","created":{"date-parts":[[2008,10,16]],"date-time":"2008-10-16T09:06:20Z","timestamp":1224147980000},"page":"1629-1636","source":"Crossref","is-referenced-by-count":112,"title":["Impact of MRI markers in subcortical vascular dementia: A multi-modal analysis in CADASIL"],"prefix":"10.1016","volume":"31","author":[{"given":"Anand","family":"Viswanathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ophelia","family":"Godin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jouvent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Gschwendtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Duering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Guichard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Holtmannsp\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Dufouil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chahin","family":"Pachai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Germaine","family":"Bousser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dichgans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Chabriat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/jnnp.2005.068726","article-title":"Cognitive profile in CADASIL","volume":"77","author":"Buffon","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib2","first-page":"147","article-title":"CADASIL. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"92","author":"Chabriat","year":"2003","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1212\/WNL.51.2.452","article-title":"Patterns of MRI lesions in CADASIL","volume":"51","author":"Chabriat","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib4","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1161\/01.STR.31.8.1904","article-title":"Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking","volume":"31","author":"Chabriat","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib5","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1161\/01.STR.30.12.2637","article-title":"Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI","volume":"30","author":"Chabriat","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0140-6736(95)91557-5","article-title":"Clinical spectrum of CADASIL: a study of 7 families, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"346","author":"Chabriat","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/1531-8249(200002)47:2<145::AID-ANA3>3.0.CO;2-P","article-title":"Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study","volume":"47","author":"de Groot","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.STR.0000150668.58689.f2","article-title":"Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden","volume":"36","author":"DeCarli","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1001\/archneur.64.1.108","article-title":"Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia","volume":"64","author":"DeCarli","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/hs0102.100885","article-title":"Cerebral microbleeds in CADASIL: a gradient-echo magnetic resonance imaging and autopsy study","volume":"33","author":"Dichgans","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1161\/01.STR.0000103141.82869.77","article-title":"Framingham stroke risk profile and lowered cognitive performance","volume":"35","author":"Elias","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib12","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1212\/WNL.55.11.1626","article-title":"Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease","volume":"55","author":"Fein","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib13","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1161\/01.STR.0000189696.70989.a4","article-title":"Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study","volume":"36","author":"Holtmannspotter","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib14","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1001\/archneur.60.12.1707","article-title":"Stroke and the risk of Alzheimer disease","volume":"60","author":"Honig","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib15","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1161\/01.STR.0000127810.92616.78","article-title":"Dementia after stroke: the Framingham Study","volume":"35","author":"Ivan","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1136\/jnnp.2004.055657","article-title":"White matter hyperintensities as a predictor of neuropsychological deficits post-stroke","volume":"76","author":"Jokinen","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/383707a0","article-title":"Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia","volume":"383","author":"Joutel","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib18","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1161\/STROKEAHA.106.478263","article-title":"Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL","volume":"38","author":"Jouvent","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib19","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1212\/01.WNL.0000160115.55756.DE","article-title":"Determinants of vascular dementia in the Cardiovascular Health Cognition Study","volume":"64","author":"Kuller","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib20","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1212\/WNL.57.6.1066","article-title":"Cerebral microbleeds in CADASIL","volume":"57","author":"Lesnik Oberstein","year":"2001","journal-title":"Neurology"},{"issue":"Suppl. 3","key":"10.1016\/j.neurobiolaging.2008.09.001_bib21","first-page":"S38","article-title":"Vascular dementia: the role of cerebral infarcts","volume":"13","author":"Leys","year":"1999","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib22","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.STR.27.8.1274","article-title":"Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study","volume":"27","author":"Longstreth","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib23","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1161\/hs0901.094255","article-title":"Diffusion tensor imaging study of subcortical gray matter in CADASIL","volume":"32","author":"Molko","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib24","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1161\/01.STR.0000041681.25514.22","article-title":"Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: a study with whole brain histogram analysis","volume":"33","author":"Molko","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1212\/01.wnl.0000172913.88973.0d","article-title":"Longitudinal volumetric MRI change and rate of cognitive decline","volume":"65","author":"Mungas","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib26","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1212\/WNL.57.12.2229","article-title":"MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer\u2019s disease","volume":"57","author":"Mungas","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib27","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/01.JGP.0000214558.63358.94","article-title":"White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study","volume":"14","author":"O\u2019Brien","year":"2006","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jnnp.2003.014910","article-title":"Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis","volume":"75","author":"O\u2019Sullivan","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib29","first-page":"1348","article-title":"Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"24","author":"O\u2019Sullivan","year":"2003","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib30","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1161\/01.STR.0000131546.71733.f1","article-title":"A two-year clinical follow-up study in 80 CADASIL subjects: progression patterns and implications for clinical trials","volume":"35","author":"Peters","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib31","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1212\/01.wnl.0000216271.96364.50","article-title":"Brain volume changes in CADASIL: a serial MRI study in pure subcortical ischemic vascular disease","volume":"66","author":"Peters","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib32","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1176\/appi.ajp.162.11.2078","article-title":"The pattern of cognitive performance in CADASIL: a monogenic condition leading to subcortical ischemic vascular dementia","volume":"162","author":"Peters","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib33","doi-asserted-by":"crossref","first-page":"S296","DOI":"10.1046\/j.1532-5415.5155.x","article-title":"Vascular dementia: distinguishing characteristics, treatment, and prevention","volume":"51","author":"Roman","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib34","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/BF00571504","article-title":"Systemic vascular smooth muscle cell impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"89","author":"Ruchoux","year":"1995","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib35","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1212\/01.WNL.0000142968.22691.70","article-title":"Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study","volume":"63","author":"Seshadri","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib36","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1212\/01.WNL.0000142966.22886.20","article-title":"White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage","volume":"63","author":"Smith","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ng0393-256","article-title":"Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12","volume":"3","author":"Tournier-Lasserve","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib38","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa022066","article-title":"Silent brain infarcts and the risk of dementia and cognitive decline","volume":"348","author":"Vermeer","year":"2003","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib39","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/01.STR.0000245091.28429.6a","article-title":"Cortical neuronal apoptosis in CADASIL","volume":"37","author":"Viswanathan","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib40","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1212\/01.wnl.0000265221.05610.70","article-title":"Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL","volume":"69","author":"Viswanathan","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib41","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/brain\/awl177","article-title":"Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort study","volume":"129","author":"Viswanathan","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib42","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/brain\/awh253","article-title":"Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI","volume":"127","author":"Werring","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib43","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1212\/01.wnl.0000249119.95747.1f","article-title":"Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD","volume":"67","author":"Yoshita","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2008.09.001_bib44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0197-4580(02)00066-0","article-title":"The vascular lesions in vascular and mixed dementia: the weight of functional neuroanatomy","volume":"24","author":"Zekry","year":"2003","journal-title":"Neurobiol. Aging"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745800800328X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745800800328X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T03:27:38Z","timestamp":1545708458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019745800800328X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S019745800800328X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2008.09.001","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}