{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:32Z","timestamp":1792787252362,"version":"4.5.0"},"reference-count":204,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":502,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"National Institute on Aging, National Institutes of Health, Department of Health and Human Services","award":["Z01 AG000950-06"],"award-info":[{"award-number":["Z01 AG000950-06"]}]},{"name":"Fundacao para a Ciencia e Tecnologia","award":["SFRH\/BD\/27,442\/2006"],"award-info":[{"award-number":["SFRH\/BD\/27,442\/2006"]}],"id":[{"id":"https:\/\/ror.org\/00snfqn58","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.neurobiolaging.2010.03.025","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T04:24:10Z","timestamp":1278044650000},"page":"437-456","source":"Crossref","is-referenced-by-count":233,"title":["The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE"],"prefix":"10.1016","volume":"33","author":[{"given":"Rita J.","family":"Guerreiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah R.","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1755-8794-1-44","article-title":"A genome-wide association study for late-onset Alzheimer's disease using DNA pooling","volume":"1","author":"Abraham","year":"2008","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0065-2776(08)60654-9","article-title":"Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21)","volume":"46","author":"Ahearn","year":"1989","journal-title":"Adv Immunol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.1156409","article-title":"Genetic mapping in human disease","volume":"322","author":"Altshuler","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1385\/JMN:23:3:157","article-title":"APOE genotype effects on Alzheimer's disease onset and epidemiology","volume":"23","author":"Ashford","year":"2004","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neulet.2004.12.065","article-title":"An autosomal genomic screen for dementia in an extended Amish family","volume":"379","author":"Ashley-Koch","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ajmg.b.30074","article-title":"Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms","volume":"132B","author":"Avramopoulos","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1212\/WNL.59.1.118","article-title":"Linkage analysis of Alzheimer disease with psychosis","volume":"59","author":"Bacanu","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib9","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1532-5415.1996.tb01362.x","article-title":"Weight loss precedes dementia in community-dwelling older adults","volume":"44","author":"Barrett-Connor","year":"1996","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/ajmg.10648","article-title":"Evidence for parent of origin effect in late-onset Alzheimer disease","volume":"114","author":"Bassett","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajhg.2008.12.008","article-title":"Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease","volume":"84","author":"Beecham","year":"2009","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10.1016\/j.neurobiolaging.2010.03.025_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ajmg.b.30993","article-title":"APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure","volume":"153B","author":"Bekris","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib13","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/sj.jcbfm.9600419","article-title":"Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system","volume":"27","author":"Bell","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ajhg.2008.10.008","article-title":"Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE","volume":"83","author":"Bertram","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib16","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrn2494","article-title":"Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses","volume":"9","author":"Bertram","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0169-328X(95)00097-C","article-title":"Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease","volume":"33","author":"Bertrand","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/hmg\/ddg007","article-title":"Results of a high-resolution genome screen of 437 Alzheimer's disease families","volume":"12","author":"Blacker","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/sj.ejhg.5201966","article-title":"Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease","volume":"16","author":"Blom","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib20","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ng.f.136","article-title":"Common and rare variants in multifactorial susceptibility to common diseases","volume":"40","author":"Bodmer","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib21","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1046\/j.1471-4159.1996.67031324.x","article-title":"Clusterin (Apo J) protects against in vitro amyloid-beta (1\u201340) neurotoxicity","volume":"67","author":"Boggs","year":"1996","journal-title":"J Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib22","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1212\/WNL.55.5.731","article-title":"The very high prevalence of AD in an Arab population is not explained by APOE epsilon4 allele frequency","volume":"55","author":"Bowirrat","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1468-1331.2001.00183.x","article-title":"Prevalence of Alzheimer's type dementia in an elderly Arab population","volume":"8","author":"Bowirrat","year":"2001","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1084\/jem.188.3.431","article-title":"Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide","volume":"188","author":"Bradt","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib25","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1212\/01.wnl.0000176061.33817.90","article-title":"Change in body mass index and risk of incident Alzheimer disease","volume":"65","author":"Buchman","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib26","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.neurobiolaging.2009.03.013","article-title":"Meta-analysis of linkage studies for Alzheimer's disease \u2212 a web resource","volume":"30","author":"Butler","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib27","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1093\/brain\/awl237","article-title":"Phenotype associated with APP duplication in five families","volume":"129","author":"Cabrejo","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(08)70022-X","article-title":"DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA","volume":"7","author":"Camargos","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/10290","article-title":"Characterization of single-nucleotide polymorphisms in coding regions of human genes","volume":"22","author":"Cargill","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ng.305","article-title":"Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease","volume":"41","author":"Carrasquillo","year":"2009","journal-title":"Nat Genet"},{"issue":"suppl","key":"10.1016\/j.neurobiolaging.2010.03.025_bib31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/4482","article-title":"Population genetics \u2212 making sense out of sequence","volume":"21","author":"Chakravarti","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/hmg\/3.4.569","article-title":"Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q132 chromosomal region","volume":"3","author":"Chartier-Harlin","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib33","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s00439-005-0071-3","article-title":"Population stratification confounds genetic association studies among Latinos","volume":"118","author":"Choudhry","year":"2006","journal-title":"Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib34","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.neurobiolaging.2008.02.008","article-title":"Whole genome analysis in a consanguineous family with early onset Alzheimer's disease","volume":"30","author":"Clarimon","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib35","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4088\/JCP.v68n0419","article-title":"A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease","volume":"68","author":"Coon","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1469-1809.1999.6340301.x","article-title":"Apolipoprotein E (APOE) allele distribution in the world","volume":"63","author":"Corbo","year":"1999","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"Corder","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib38","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1046\/j.1469-1809.2001.6550473.x","article-title":"A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease","volume":"65","author":"Curtis","year":"2001","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cne.903340205","article-title":"Localization of sulfated glycoprotein-two\/clusterin mRNA in the rat brain by in situ hybridization","volume":"334","author":"Danik","year":"1993","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib41","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1086\/302710","article-title":"The number of trait loci in late-onset Alzheimer disease","volume":"66","author":"Daw","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib42","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0140-6736(05)67382-5","article-title":"Genetic linkage studies","volume":"366","author":"Dawn Teare","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib43","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1021\/bi00474a025","article-title":"Apolipoprotein J: structure and tissue distribution","volume":"29","author":"de Silva","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0896-6273(03)00205-8","article-title":"Aph-one, Pen-two, and Nicastrin with Presenilin generate an active gamma-Secretase complex","volume":"38","author":"De Strooper","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0896-6273(03)00850-X","article-title":"ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo","volume":"41","author":"deMattos","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib46","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1073\/pnas.162228299","article-title":"Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease","volume":"99","author":"deMattos","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib47","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0168-9525(01)02416-7","article-title":"Ever since Knudson","volume":"17","author":"Devilee","year":"2001","journal-title":"Trends Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib48","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1126\/science.1168979","article-title":"A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis","volume":"323","author":"Di Fede","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib49","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1073\/pnas.86.18.7260","article-title":"Changes in brain gene expression shared by scrapie and Alzheimer disease","volume":"86","author":"Duguid","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib50","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.2111583","article-title":"Cleavage of amyloid beta peptide during constitutive processing of its precursor","volume":"248","author":"Esch","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/hmg\/ddg037","article-title":"Identification of multiple loci for Alzheimer disease in a consanguineous Israeli\u2013Arab community","volume":"12","author":"Farrer","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib52","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4161\/cc.4.4.1591","article-title":"Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model","volume":"4","author":"Fearnhead","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib53","article-title":"Examination of the current top candidate genes for AD in a genome-wide association study","author":"Feulner","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib54","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/archneurol.2008.582","article-title":"Midlife and late-life obesity and the risk of dementia: cardiovascular health study","volume":"66","author":"Fitzpatrick","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib55","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease","volume":"63","author":"Gatz","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/bj2930027","article-title":"The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex","volume":"293","author":"Ghiso","year":"1993","journal-title":"Biochem J"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib57","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/hmg\/ddi493","article-title":"Extended tracts of homozygosity in outbred human populations","volume":"15","author":"Gibson","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0304-3940(95)11565-7","article-title":"Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid","volume":"191","author":"Golabek","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib59","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1056\/NEJMp0806284","article-title":"Common genetic variation and human traits","volume":"360","author":"Goldstein","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1467-789X.2003.00091.x","article-title":"Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders","volume":"4","author":"Goossens","year":"2003","journal-title":"Obes Rev"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib61","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/hmg\/ddm031","article-title":"Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants","volume":"16","author":"Grupe","year":"2007","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1016\/j.neurobiolaging.2010.03.025_bib62","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neurobiolaging.2008.06.012","article-title":"Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP","volume":"31","author":"Guerreiro","year":"2010","journal-title":"Neurobiol Aging"},{"issue":"3","key":"10.1016\/j.neurobiolaging.2010.03.025_bib203","doi-asserted-by":"crossref","first-page":"e9510","DOI":"10.1371\/journal.pone.0009510","article-title":"Genetic Variability in CLU and Its Association with Alzheimer's Disease","volume":"5","author":"Guerreiro","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib63","series-title":"Vascular Dementia in Clinical Practice","article-title":"Control of vascular risk factors","author":"Gustafson","year":"2009"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib64","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1001\/archinte.163.13.1524","article-title":"An 18-year follow-up of overweight and risk of Alzheimer disease","volume":"163","author":"Gustafson","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib65","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1212\/WNL.0b013e3181c0d4b6","article-title":"Adiposity indicators and dementia over 32 years in Sweden","volume":"73","author":"Gustafson","year":"2009","journal-title":"Neurology"},{"issue":"Nos. 6","key":"10.1016\/j.neurobiolaging.2010.03.025_bib66","first-page":"910","article-title":"The ACE Insertion Deletion polymorphism relates to dementia by metabolic phenotype, APOEvarepsilon4, and age of dementia onset","volume":"31","author":"Gustafson","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib67","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/359322a0","article-title":"Amyloid beta-peptide is produced by cultured cells during normal metabolism","volume":"359","author":"Haass","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib68","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ajmg.b.30257","article-title":"A genome-wide linkage analysis of dementia in the Amish","volume":"141B","author":"Hahs","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib69","doi-asserted-by":"crossref","first-page":"18644","DOI":"10.1074\/jbc.272.30.18644","article-title":"Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-two\/megalin","volume":"272","author":"Hammad","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib70","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/hmg\/ddm224","article-title":"Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease","volume":"16","author":"Hamshere","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib71","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(96)01030-2","article-title":"Amyloid, the presenilins and Alzheimer's disease","volume":"20","author":"Hardy","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib72","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1471-4159.2009.06181.x","article-title":"The amyloid hypothesis for Alzheimer's disease: a critical reappraisal","volume":"110","author":"Hardy","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib73","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0304-3940(01)01910-3","article-title":"Presenilin mutations line up along transmembrane alpha-helices","volume":"306","author":"Hardy","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib74","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1056\/NEJMra0808700","article-title":"Genomewide association studies and human disease","volume":"360","author":"Hardy","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib75","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1600-0854.2007.00694.x","article-title":"Evidence for CALM in directing VAMP2 trafficking","volume":"9","author":"Harel","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib76","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib77","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0140-6736(05)67531-9","article-title":"What makes a good genetic association study?","volume":"366","author":"Hattersley","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib78","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/01.wad.0000213814.43047.86","article-title":"Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study","volume":"20","author":"Hayden","year":"2006","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib79","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1111\/j.1742-4658.2005.04691.x","article-title":"A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence","volume":"272","author":"Henricson","year":"2005","journal-title":"FEBS J"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib80","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJMp0808934","article-title":"Genomewide association studies \u2212 illuminating biologic pathways","volume":"360","author":"Hirschhorn","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib81","first-page":"1075","article-title":"The neuropathological changes associated with normal brain aging","volume":"11","author":"Hof","year":"1996","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib82","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2165\/00023210-200721060-00002","article-title":"Effect of HMG-CoA reductase inhibitors on beta-amyloid peptide levels: implications for Alzheimer's disease","volume":"21","author":"Hoglund","year":"2007","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib83","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/ajmg.b.30515","article-title":"Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis","volume":"144B","author":"Hollingworth","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib84","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/ajmg.b.30114","article-title":"Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease","volume":"135B","author":"Holmans","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib85","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/archneur.1996.00550030017010","article-title":"Apolipoprotein E epsilon4\/four in a neuropathologically normal very elderly individual","volume":"53","author":"Hyman","year":"1996","journal-title":"Arch Neurol"},{"issue":"7063","key":"10.1016\/j.neurobiolaging.2010.03.025_bib86","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib87","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng749","article-title":"Replication validity of genetic association studies","volume":"29","author":"Ioannidis","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib88","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0968-0004(92)90325-4","article-title":"Clusterin: the intriguing guises of a widely expressed glycoprotein","volume":"17","author":"Jenne","year":"1992","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib89","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1357-2725(01)00155-8","article-title":"Clusterin","volume":"34","author":"Jones","year":"2002","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib90","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1161\/01.ATV.20.10.2255","article-title":"Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men","volume":"20","author":"Kalmijn","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib91","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/S0895-7061(99)00252-6","article-title":"Risk stratification in hypertension: new insights from the Framingham Study","volume":"13","author":"Kannel","year":"2000","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib92","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1136\/jnnp.2008.161703","article-title":"Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease","volume":"80","author":"Kasuga","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib93","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1093\/hmg\/ddh286","article-title":"A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity","volume":"13","author":"Katzov","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib94","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ana.21099","article-title":"Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation","volume":"61","author":"Kauwe","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib95","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/hmg\/8.2.237","article-title":"A full genome scan for late onset Alzheimer's disease","volume":"8","author":"Kehoe","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib96","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0006-8993(95)00482-6","article-title":"Deposition of apolipoproteins E and J in senile plaques is topographically determined in both Alzheimer's disease and Down's syndrome brain","volume":"685","author":"Kida","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib97","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/emm.2001.16","article-title":"Cell-free expression and functional reconstitution of CALM in clathrin assembly","volume":"33","author":"Kim","year":"2001","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib98","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1093\/hmg\/ddp323","article-title":"Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity","volume":"18","author":"Kim","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib99","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2165\/00023210-200216070-00001","article-title":"Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention","volume":"16","author":"Kivipelto","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib100","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/archneur.62.10.1556","article-title":"Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease","volume":"62","author":"Kivipelto","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib101","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm0296-224","article-title":"Alzheimer-associated presenilins one and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells","volume":"2","author":"Kovacs","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib102","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1056\/NEJMp0810107","article-title":"Genetic risk prediction \u2212 are we there yet?","volume":"360","author":"Kraft","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib103","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1212\/WNL.59.1.59","article-title":"Contribution of APOE promoter polymorphisms to Alzheimer's disease risk","volume":"59","author":"Lambert","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib104","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.neurobiolaging.2010.03.025_bib105","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-Wide Association Study Identifies Variants at CLU and CR1 Associated With Alzheimer's Disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib106","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1093\/hmg\/6.12.2151","article-title":"Distortion of allelic expression of apolipoprotein E in Alzheimer's disease","volume":"6","author":"Lambert","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib107","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1126\/science.274.5287.536","article-title":"The new genomics: global views of biology","volume":"274","author":"Lander","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib108","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1126\/science.2884728","article-title":"Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children","volume":"236","author":"Lander","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib109","doi-asserted-by":"crossref","first-page":"35352","DOI":"10.1074\/jbc.M507217200","article-title":"A nine-transmembrane domain topology for presenilin 1","volume":"280","author":"Laudon","year":"2005","journal-title":"J. Biol Chem"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0197-4580(00)00096-8","article-title":"Midlife blood pressure and dementia: the Honolulu-Asia aging study","volume":"21","author":"Launer","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib111","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1001\/archneur.65.11.1518","article-title":"Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci","volume":"65","author":"Lee","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib112","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/archneur.63.11.1591","article-title":"Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease","volume":"63","author":"Lee","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib113","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/sj.mp.4001538","article-title":"Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics","volume":"9","author":"Lee","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib114","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/geno.1996.0266","article-title":"Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene","volume":"34","author":"Levy-Lahad","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib115","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib116","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1212\/01.wnl.0000178989.87072.11","article-title":"Serum cholesterol and risk of Alzheimer disease: a community-based cohort study","volume":"65","author":"Li","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib117","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/archneurol.2007.3","article-title":"Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease","volume":"65","author":"Li","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib118","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/humu.20399","article-title":"Long contiguous stretches of homozygosity in the human genome","volume":"27","author":"Li","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib119","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1086\/339815","article-title":"Age at onset in two common neurodegenerative diseases is genetically controlled","volume":"70","author":"Li","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1086\/518720","article-title":"A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population","volume":"81","author":"Liu","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib121","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib122","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib123","doi-asserted-by":"crossref","first-page":"15054","DOI":"10.1073\/pnas.192582999","article-title":"Finding genetic contributions to sporadic disease: a recessive locus at 12q24 commonly contributes to patent ductus arteriosus","volume":"99","author":"Mani","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib124","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1042\/bj3160671","article-title":"Apolipoprotein J and Alzheimer's amyloid beta solubility","volume":"316","author":"Matsubara","year":"1996","journal-title":"Biochem J"},{"issue":"6","key":"10.1016\/j.neurobiolaging.2010.03.025_bib125","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0896-6273(90)90342-D","article-title":"Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat","volume":"5","author":"May","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib126","first-page":"22","article-title":"Innate immunity in Alzheimer's disease: a model for local inflammatory reactions","volume":"1","author":"McGeer","year":"2001","journal-title":"Mol Interv"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib127","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0304-3940(89)90843-4","article-title":"Activation of the classical complement pathway in brain tissue of Alzheimer patients","volume":"107","author":"McGeer","year":"1989","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib128","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0006-8993(92)90071-G","article-title":"Distribution of clusterin in Alzheimer brain tissue","volume":"579","author":"McGeer","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib129","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1620\/tjem.174.269","article-title":"Pathological proteins in senile plaques","volume":"174","author":"McGeer","year":"1994","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib130","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1471-4914(02)02422-X","article-title":"The possible role of complement activation in Alzheimer disease","volume":"8","author":"McGeer","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib131","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/bj3280045","article-title":"Stress-induced transcription of the clusterin\/apoJ gene","volume":"328","author":"Michel","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib132","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1212\/01.WNL.0000161870.78572.A5","article-title":"High total cholesterol levels in late life associated with a reduced risk of dementia","volume":"64","author":"Mielke","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib133","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ajmg.10183","article-title":"Full genome screen for Alzheimer disease: stage II analysis","volume":"114","author":"Myers","year":"2002","journal-title":"Am J Med Genet"},{"issue":"Nos. 3","key":"10.1016\/j.neurobiolaging.2010.03.025_bib134","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10048-009-0182-4","article-title":"Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease","volume":"10","author":"Nalls","year":"2009","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib135","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000026149","article-title":"Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease","volume":"17","author":"Notkola","year":"1998","journal-title":"Neuroepidemiology"},{"issue":"Nos. 2","key":"10.1016\/j.neurobiolaging.2010.03.025_bib136","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainresrev.2009.05.007","article-title":"Clusterin: A forgotten player in Alzheimer's disease","volume":"61","author":"Nuutinen","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib137","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1006\/bbrc.1994.2580","article-title":"Purification and characterization of brain clusterin","volume":"204","author":"Oda","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib138","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1006\/exnr.1995.1080","article-title":"Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1\u201342) and forms slowly sedimenting A beta complexes that cause oxidative stress","volume":"136","author":"Oda","year":"1995","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib139","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1086\/341034","article-title":"A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region","volume":"71","author":"Olson","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ana.21415","article-title":"Characterization of PLA2G6 as a locus for dystonia-parkinsonism","volume":"65","author":"Paisan-Ruiz","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib141","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/BST0330553","article-title":"Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide","volume":"33","author":"Pangalos","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib142","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/ajmg.1608","article-title":"Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: findings in Swedish twins","volume":"105","author":"Pedersen","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib143","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jama.1997.03550150041033","article-title":"Complete genomic screen in late-onset familial Alzheimer disease","volume":"278","author":"Pericak-Vance","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib144","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0531-5565(00)00196-0","article-title":"Identification of novel genes in late-onset Alzheimer's disease","volume":"35","author":"Pericak-Vance","year":"2000","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib145","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/aje\/kwi092","article-title":"Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study","volume":"161","author":"Podewils","year":"2005","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib146","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib147","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1474-4422(05)70141-1","article-title":"The age-dependent relation of blood pressure to cognitive function and dementia","volume":"4","author":"Qiu","year":"2005","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib148","first-page":"3497","article-title":"Genetics of early-onset Alzheimer dementia","author":"Rademakers","year":"2003","journal-title":"Scientific World Journal"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib149","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1158\/0008-5472.375.65.2","article-title":"Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias","volume":"65","author":"Raghavan","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib150","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/jmg.2005.033456","article-title":"Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update","volume":"42","author":"Raux","year":"2005","journal-title":"J Med Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib151","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuron.2007.05.022","article-title":"GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers","volume":"54","author":"Reiman","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib152","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archneur.61.5.705","article-title":"Relation of plasma lipids to Alzheimer disease and vascular dementia","volume":"61","author":"Reitz","year":"2004","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib153","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1212\/01.WNL.0000129988.68657.FA","article-title":"Hereditary dementia with intracerebral hemorrhages and cerebral amyloid angiopathy","volume":"63","author":"Remes","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib154","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/NMM:2:1:01","article-title":"The solved and unsolved mysteries of the genetics of early-onset Alzheimer's disease","volume":"2","author":"Rogaeva","year":"2002","journal-title":"Neuromol Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib156","doi-asserted-by":"crossref","first-page":"10016","DOI":"10.1073\/pnas.89.21.10016","article-title":"Complement activation by beta-amyloid in Alzheimer disease","volume":"89","author":"Rogers","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib157","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1136\/jnnp.2006.113514","article-title":"APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage","volume":"78","author":"Rovelet-Lecrux","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib158","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ng1718","article-title":"APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy","volume":"38","author":"Rovelet-Lecrux","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib159","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI117407","article-title":"Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils","volume":"94","author":"Sanan","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib160","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/01.STR.0000077926.49330.64","article-title":"Angiotensin-converting enzyme gene polymorphism and carotid artery wall thickness: a meta-analysis","volume":"34","author":"Sayed-Tabatabaei","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib161","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1086\/379083","article-title":"Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22","volume":"73","author":"Scott","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib162","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib163","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1439760","article-title":"Production of the Alzheimer amyloid beta protein by normal proteolytic processing","volume":"258","author":"Shoji","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib164","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/clinchem\/41.8.1068","article-title":"Apolipoprotein E: an important gene and protein to follow in laboratory medicine","volume":"41","author":"Siest","year":"1995","journal-title":"Clin Chem"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/sj.ejhg.5201946","article-title":"Expanded high-resolution genetic study of 109 Swedish families with Alzheimer's disease","volume":"16","author":"Sillen","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/ddl436","article-title":"Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals","volume":"16","author":"Simon-Sanchez","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib167","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/ng.487","article-title":"Genome-wide association study reveals genetic risk underlying Parkinson's disease","volume":"41","author":"Simon-Sanchez","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib168","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S1474-4422(08)70241-2","article-title":"Genome-wide association studies in neurological disorders","volume":"7","author":"Simon-Sanchez","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib169","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.it.2008.11.003","article-title":"Complement activation and inhibition: a delicate balance","volume":"30","author":"Sjoberg","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib170","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0140-6736(96)90608-X","article-title":"15-year longitudinal study of blood pressure and dementia","volume":"347","author":"Skoog","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib171","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1093\/brain\/awl203","article-title":"APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy","volume":"129","author":"Sleegers","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib172","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/exnr.1994.1044","article-title":"Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol","volume":"126","author":"Sparks","year":"1994","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib173","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1097\/00004872-199715120-00059","article-title":"The deletion\/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk","volume":"15","author":"Staessen","year":"1997","journal-title":"J Hypertens"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib174","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/archneur.62.1.55","article-title":"A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study","volume":"62","author":"Stewart","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib175","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1001\/archneur.64.1.103","article-title":"Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study","volume":"64","author":"Stewart","year":"2007","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib176","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1161\/HYPERTENSIONAHA.109.128744","article-title":"Change in blood pressure and incident dementia: a 32-year prospective study","volume":"54","author":"Stewart","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib177","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7326\/0003-4819-138-1-200301070-00007","article-title":"Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study","volume":"138","author":"Strazzullo","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib178","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/exnr.1994.1019","article-title":"Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype","volume":"125","author":"Strittmatter","year":"1994","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib179","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1073\/pnas.90.17.8098","article-title":"Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib180","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0169-328X(00)00149-2","article-title":"Detection of complement alternative pathway mRNA and proteins in the Alzheimer's disease brain","volume":"81","author":"Strohmeyer","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib181","first-page":"191","article-title":"[Analysis of the 80 kDa antigen in senile plaque amyloid]","volume":"69","author":"Takamaru","year":"1994","journal-title":"Hokkaido Igaku Zasshi"},{"issue":"1","key":"10.1016\/j.neurobiolaging.2010.03.025_bib204","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/9004","article-title":"Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis","volume":"1","author":"Takei","year":"1999","journal-title":"Nat Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib182","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archinte.163.9.1053","article-title":"Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study","volume":"163","author":"Tan","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib183","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0197-4580(01)00301-3","article-title":"Complement in Alzheimer's disease: opportunities for modulating protective and pathogenic events","volume":"22","author":"Tenner","year":"2001","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib184","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1093\/hmg\/ddn268","article-title":"Accounting for ancestry: population substructure and genome-wide association studies","volume":"17","author":"Tian","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib185","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/ana.21321","article-title":"A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia","volume":"63","author":"Tomiyama","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib186","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s004019570001","article-title":"Early complement components in Alzheimer's disease brains","volume":"91","author":"Veerhuis","year":"1996","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib187","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0169-328X(92)90017-6","article-title":"Complement gene expression in human brain: comparison between normal and Alzheimer disease cases","volume":"14","author":"Walker","year":"1992","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib188","first-page":"19","article-title":"Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis","volume":"1","author":"Webster","year":"2009","journal-title":"Int J Mol Epidemiol Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib189","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1006\/bbrc.1995.2852","article-title":"Multivalent binding of complement protein C1Q to the amyloid beta-peptide (A beta) promotes the nucleation phase of A beta aggregation","volume":"217","author":"Webster","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib190","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0197-4580(97)00042-0","article-title":"Molecular and cellular characterization of the membrane attack complex","volume":"18","author":"Webster","year":"1997","journal-title":"Alzheimer's Dis Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib191","first-page":"45249","article-title":"Apolipoprotein E: structure-function relationships","author":"Weisgraber","year":"1994","journal-title":"Adv Protein Chem"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib192","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/156720507780362047","article-title":"Body mass index in midlife and risk of Alzheimer disease and vascular dementia","volume":"4","author":"Whitmer","year":"2007","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib193","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1212\/01.wnl.0000306313.89165.ef","article-title":"Central obesity and increased risk of dementia more than three decades later","volume":"71","author":"Whitmer","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib194","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1212\/01.WNL.0000149519.47454.F2","article-title":"Midlife cardiovascular risk factors and risk of dementia in late life","volume":"64","author":"Whitmer","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib195","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0968-0004(99)01534-0","article-title":"Clusterin is a secreted mammalian chaperone","volume":"25","author":"Wilson","year":"2000","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib196","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1016\/S0021-9258(18)53497-9","article-title":"Genomic organization and expression of the rat TRPM-two (clusterin) gene, a gene implicated in apoptosis","volume":"268","author":"Wong","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib197","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1136\/jmg.2003.016873","article-title":"A new method for autozygosity mapping using single nucleotide polymorphisms (SNPs) and EXCLUDEAR","volume":"41","author":"Woods","year":"2004","journal-title":"J Med Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib198","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0378-1119(90)90310-N","article-title":"Genomic organization of the human amyloid beta-protein precursor gene","volume":"87","author":"Yoshikai","year":"1990","journal-title":"Gene"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib199","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1212\/WNL.45.6.1161","article-title":"Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study","volume":"45","author":"Yoshitake","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib200","first-page":"11","article-title":"Human apolipoprotein E isoprotein subclasses are genetically determined","volume":"33","author":"Zannis","year":"1981","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2009.07.005","article-title":"Complement and Immune Defense: From Innate Immunity to Human Diseases","volume":"126","author":"Zipfel","year":"2009","journal-title":"Immunol Lett"},{"key":"10.1016\/j.neurobiolaging.2010.03.025_bib202","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/0024-3205(96)00310-4","article-title":"Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood\u2013brain barrier","volume":"59","author":"Zlokovic","year":"1996","journal-title":"Life Sci"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010002204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010002204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T17:38:10Z","timestamp":1685641090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458010002204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":204,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0197458010002204"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2010.03.025","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}