{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:40:52Z","timestamp":1788446452562,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["R01AG017870"],"award-info":[{"award-number":["R01AG017870"]}]},{"name":"NIH","award":["R01GM058556"],"award-info":[{"award-number":["R01GM058556"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.neurobiolaging.2010.05.018","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T04:38:09Z","timestamp":1277959089000},"page":"804-813","source":"Crossref","is-referenced-by-count":62,"title":["A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease"],"prefix":"10.1016","volume":"33","author":[{"given":"Suk Ling","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Leung Sang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy Woon Chi","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Wing Cheong","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Chiu Wa","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Fung Kum","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Ann","family":"Driver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Pastorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun Ping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ajhg.2008.10.008","article-title":"Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE","volume":"83","author":"Bertram","year":"2008","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib2","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1093\/hmg\/ddp406","article-title":"Genome-wide association studies in Alzheimer's disease","volume":"18","author":"Bertram","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib3","doi-asserted-by":"crossref","first-page":"R4","DOI":"10.1093\/hmg\/ddq142","article-title":"Current status on Alzheimer disease molecular genetics: from past, to present, to future","volume":"19","author":"Bettens","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib4","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2105\/AJPH.88.9.1337","article-title":"Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset","volume":"88","author":"Brookmeyer","year":"1998","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/07853890802186905","article-title":"Molecular genetics of Alzheimer's disease: an update","volume":"40","author":"Brouwers","year":"2008","journal-title":"Ann. Med"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.neurobiolaging.2009.03.013","article-title":"Meta-analysis of linkage studies for Alzheimer's disease \u2212 a web resource","volume":"30","author":"Butler","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib7","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1111\/j.1471-4159.2006.03995.x","article-title":"Pin1 in Alzheimer's disease","volume":"98","author":"Butterfield","year":"2006","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1212\/01.WNL.0000151980.42337.44","article-title":"Cystatin C as a risk factor for Alzheimer disease","volume":"64","author":"Cathcart","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib9","first-page":"25","article-title":"Reliability and validity of the Cantonese version of the Mini-Mental State Examination \u2212 A preliminary study","volume":"4","author":"Chiu","year":"1994","journal-title":"J. Hong Kong Coll\u00e8ge Psychiatr"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-1119(98)00512-5","article-title":"Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression","volume":"224","author":"Cui","year":"1998","journal-title":"Gene"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1086\/302710","article-title":"The number of trait loci in late-onset Alzheimer disease","volume":"66","author":"Daw","year":"2000","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib13","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/ajmg.b.30689","article-title":"A genomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH Genetic Initiative","volume":"147B","author":"Dickson","year":"2008","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib14","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1001\/jama.1989.03430180093036","article-title":"Prevalence of Alzheimer's disease in a community population of older persons","volume":"262","author":"Evans","year":"1989","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib15","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease. A Meta-Analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib16","series-title":"Alzheimer's Disease International World Alzheimer Report 2009","author":"Ferri","year":"2009"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib17","doi-asserted-by":"crossref","first-page":"e9510","DOI":"10.1371\/journal.pone.0009510","article-title":"Genetic variability in CLU and its association with Alzheimer's disease","volume":"5","author":"Guerreiro","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10549-009-0682-9","article-title":"The functional promoter polymorphism (\u2212842G > C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger","volume":"122","author":"Han","year":"2010","journal-title":"Breast Cancer Res. Treat"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib19","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/nar\/26.1.362","article-title":"Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL","volume":"26","author":"Heinemeyer","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/ajmg.b.30114","article-title":"Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease","volume":"135B","author":"Holmans","year":"2005","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib22","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1101\/gad.4.10.1741","article-title":"Transcription factor AP-four contains multiple dimerization domains that regulate dimer specificity","volume":"4","author":"Hu","year":"1990","journal-title":"Genes Dev"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib23","doi-asserted-by":"crossref","first-page":"12495","DOI":"10.1074\/jbc.M511773200","article-title":"Transcriptional repression of human immunodeficiency virus type 1 by AP-4","volume":"281","author":"Imai","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib24","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.2337\/diabetes.53.9.2467","article-title":"Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes","volume":"53","author":"Jowett","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib25","doi-asserted-by":"crossref","first-page":"15046","DOI":"10.1073\/pnas.0801773105","article-title":"AP4 encodes a c-MYC-inducible repressor of p21","volume":"105","author":"Jung","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sj.mp.4001775","article-title":"Genetic association of ubiquilin with Alzheimer's disease and related quantitative measures","volume":"11","author":"Kamboh","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib27","doi-asserted-by":"crossref","first-page":"13074","DOI":"10.1073\/pnas.0601915103","article-title":"A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells","volume":"103","author":"Kim","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3940(00)01178-2","article-title":"Detection of tau phosphorylated at threonine two hundred and thirty-one in cerebrospinal fluid of Alzheimer's disease patients","volume":"287","author":"Kohnken","year":"2000","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neulet.2006.04.010","article-title":"Association study of the PIN1 gene with Alzheimer's disease","volume":"402","author":"Lambert","year":"2006","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib30","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ncb1818","article-title":"Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance","volume":"11","author":"Lee","year":"2009","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib32","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1093\/hmg\/ddg357","article-title":"Glutathione S-transferase omega-one modifies age-at-onset of Alzheimer disease and Parkinson disease","volume":"12","author":"Li","year":"2003","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib33","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1086\/339815","article-title":"Age at onset in two common neurodegenerative diseases is genetically controlled","volume":"70","author":"Li","year":"2002","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib34","first-page":"1877","article-title":"Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy","volume":"118","author":"Lim","year":"2008","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbadis.2004.10.003","article-title":"Pinning down phosphorylated tau and tauopathies","volume":"1739","author":"Lim","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib36","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature01832","article-title":"Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration","volume":"424","author":"Liou","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib37","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/carcin\/bgp171","article-title":"A novel functional variant (\u2212842G > C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity","volume":"30","author":"Lu","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tibs.2004.02.002","article-title":"Pinning down cell signaling, cancer and Alzheimer's disease","volume":"29","author":"Lu","year":"2004","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nchembio.2007.35","article-title":"Prolyl cis-trans isomerization as a molecular timer","volume":"3","author":"Lu","year":"2007","journal-title":"Nat. Chem. Biol"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib40","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/380544a0","article-title":"A human peptidyl-prolyl isomerase essential for regulation of mitosis","volume":"380","author":"Lu","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib41","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nrm2261","article-title":"The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease","volume":"8","author":"Lu","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib42","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/21650","article-title":"The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein","volume":"399","author":"Lu","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib43","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.neurobiolaging.2004.08.010","article-title":"The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease","volume":"26","author":"Ma","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib44","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1017\/S1041610209990068","article-title":"Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a southern Chinese community","volume":"21","author":"Ma","year":"2009","journal-title":"Int. Psychogeriatr"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib45","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.neurobiolaging.2006.12.011","article-title":"Association of prostaglandin-endoperoxide synthase2 (PTGS2) in polymorphisms and Alzheimer's disease in Chinese","volume":"29","author":"Ma","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib46","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/ng1337","article-title":"The effects of human population structure on large genetic association studies","volume":"36","author":"Marchini","year":"2004","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib47","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nm0406-392","article-title":"Protein twists and turns in Alzheimer disease","volume":"12","author":"Maudsley","year":"2006","journal-title":"Nat. Med"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib48","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/332557a0","article-title":"Enhancer binding factors AP-four and AP-1 act in concert to activate SV40 late transcription in vitro","volume":"332","author":"Mermod","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2007.03.071","article-title":"Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease","volume":"419","author":"Nowotny","year":"2007","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib50","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature04543","article-title":"The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production","volume":"440","author":"Pastorino","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib51","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0092-8674(00)80273-1","article-title":"Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent","volume":"89","author":"Ranganathan","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib52","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease","volume":"39","author":"Rogaeva","year":"2007","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib53","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1128\/MCB.22.15.5281-5295.2002","article-title":"PIN1 is an E2F target gene essential for Neu\/Ras-induced transformation of mammary epithelial cells","volume":"22","author":"Ryo","year":"2002","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib54","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0197-4580(03)00011-3","article-title":"Interleukin-1B polymorphism is associated with age at onset of Alzheimer's disease","volume":"24","author":"Sciacca","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neurobiolaging.2005.11.009","article-title":"PIN1 promoter polymorphisms are associated with Alzheimer's disease","volume":"28","author":"Segat","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib56","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.neurobiolaging.2005.05.005","article-title":"Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis","volume":"27","author":"Sultana","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib57","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.clinbiochem.2005.11.014","article-title":"Evaluation of an algorithm of tagging SNPs selection by linkage disequilibrium","volume":"39","author":"Tang","year":"2006","journal-title":"Clin. Biochem"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib58","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/archneur.65.3.329","article-title":"Genome-wide association studies in Alzheimer disease","volume":"65","author":"Waring","year":"2008","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib59","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1086\/423393","article-title":"Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p132","volume":"75","author":"Wijsman","year":"2004","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib60","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/ncb0505-435","article-title":"Phosphorylation-specific prolyl isomerization: is there an underlying theme?","volume":"7","author":"Wulf","year":"2005","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib61","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1126\/science.278.5345.1957","article-title":"Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism","volume":"278","author":"Yaffe","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib62","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1044-7431(03)00164-7","article-title":"Adaptor protein complex 4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2","volume":"24","author":"Yap","year":"2003","journal-title":"Mol. Cell. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib63","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1097-2765(05)00083-3","article-title":"Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins","volume":"6","author":"Zhou","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neurobiolaging.2010.05.018_bib64","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s000180050026","article-title":"Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism","volume":"56","author":"Zhou","year":"1999","journal-title":"Cell. Mol. Life Sci"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010002320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010002320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T22:24:16Z","timestamp":1544394256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458010002320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0197458010002320"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2010.05.018","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}