{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:12:30Z","timestamp":1793419950132,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.neurobiolaging.2010.08.016","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T09:26:23Z","timestamp":1287653183000},"page":"1034-1044","source":"Crossref","is-referenced-by-count":78,"title":["Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression"],"prefix":"10.1016","volume":"33","author":[{"given":"Melissa A.","family":"Bradley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Xiong-Fister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Markesbery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Lovell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib2","series-title":"Current Protocols in Immunology","year":"2001"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0022-510X(89)90197-4","article-title":"Alzheimer's disease: amyloid plaques in the cerebellum","volume":"93","author":"Braak","year":"1989","journal-title":"J. Neurol. Sci"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib4","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.freeradbiomed.2010.02.016","article-title":"Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer's disease (PCAD)","volume":"48","author":"Bradley","year":"2010","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2005.12.017","article-title":"Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-noenal, in brain from persons with mild cognitive impairment","volume":"397","author":"Butterfield","year":"2006","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1046\/j.1471-4159.1999.0720751.x","article-title":"Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease","volume":"72","author":"Calingansan","year":"1999","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0891-5849(95)00066-7","article-title":"Inhibition of adenine nucleotide translocator by lipid peroxidation products","volume":"19","author":"Chen","year":"1995","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib8","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11064-006-9071-5","article-title":"Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease","volume":"31","author":"Ding","year":"2006","journal-title":"Neurochem. Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib9","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.1523\/JNEUROSCI.3040-05.2005","article-title":"Ribosome dysfunction Is an early event in Alzheimer's disease","volume":"25","author":"Ding","year":"2005","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neulet.2003.11.047","article-title":"4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease","volume":"356","author":"Drake","year":"2004","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1124\/jpet.106.109173","article-title":"Levels of 4-hydroxynonenal and malondialdehyde are increased in brain of human chronic users of methamphetamine","volume":"319","author":"Fitzmaurice","year":"2006","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib12","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1046\/j.1471-4159.1998.71052034.x","article-title":"Increased nuclear DNA oxidation in the brain in Alzheimer's disease","volume":"71","author":"Gabbita","year":"1998","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.febslet.2004.04.037","article-title":"NF-kB activation mechanism of 4-hydroxyhexenal via NIK\/IKK and p38 MAPK pathway","volume":"566","author":"Je","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib14","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1194\/jlr.M600091-JLR200","article-title":"Formation of nepsilon-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification","volume":"47","author":"Kawai","year":"2006","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib15","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1074\/jbc.271.11.6033","article-title":"4-Hydroxyhexenal is a potent inducer of the mitochondrial permeability transition","volume":"271","author":"Kristal","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.freeradbiomed.2004.05.011","article-title":"Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation","volume":"37","author":"Lee","year":"2004","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib17","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/j.1432-1033.2004.04042.x","article-title":"Induction of endothelial apoptosis by 4-hydroxyhexenal","volume":"271","author":"Lee","year":"2004","journal-title":"Eur. J. Biochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib18","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/jn\/135.5.1027","article-title":"Lead exposure and (n-3) fatty acid deficiency during rat neonatal development alter liver, plasma, and brain polyunsaturated fatty acid composition","volume":"135","author":"Lim","year":"2005","journal-title":"J. Nutr"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib19","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.freeradbiomed.2004.11.005","article-title":"Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations","volume":"38","author":"Liu","year":"2005","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib20","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1471-4159.2007.05175.x","article-title":"Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation","volume":"105","author":"Long","year":"2008","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib21","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1021\/tx900147g","article-title":"Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation","volume":"22","author":"LoPachin","year":"2009","journal-title":"Chem. Res. Toxicol"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib22","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1212\/WNL.51.6.1562","article-title":"Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease","volume":"51","author":"Lovell","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib23","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1471-4159.1999.0720771.x","article-title":"Increase DNA oxidation and decreased levels of repair products in Alzheimer's Disease ventricular CSF","volume":"72","author":"Lovell","year":"1999","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib24","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0891-5849(00)00346-4","article-title":"Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures","volume":"29","author":"Lovell","year":"2000","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0006-8993(99)02335-5","article-title":"Decreased base excision repair and increased helicase activity in Alzheimer's disease brain","volume":"855","author":"Lovell","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0197-4580(00)00235-9","article-title":"Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures","volume":"22","author":"Lovell","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib27","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1523\/JNEUROSCI.17-03-01046.1997","article-title":"Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation","volume":"17","author":"Mark","year":"1997","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib28","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/ana.20629","article-title":"Lipid Peroxidation is an early event in the brain in amnestic mild cognitive impairment","volume":"58","author":"Markesbery","year":"2005","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0197-4580(98)00009-8","article-title":"Four-Hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease","volume":"19","author":"Markesbery","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/archneur.63.1.38","article-title":"Neuropathologic substrate of mild cognitive impairment","volume":"63","author":"Markesbery","year":"2006","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib31","first-page":"385","article-title":"Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde","volume":"94","author":"McGarth","year":"2001","journal-title":"Q. J. Med"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib32","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ana.410360510","article-title":"Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease","volume":"36","author":"Mecocci","year":"1994","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib34","first-page":"437","article-title":"Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4","volume":"150","author":"Montine","year":"1997","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.nbd.2007.06.002","article-title":"A-beta solubility and deposition during AD progression and in APP x PS-1 knock-in mice","volume":"27","author":"Murphy","year":"2007","journal-title":"Neurobiol. Disord"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0197-4580(97)00057-2","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer's disease","volume":"18","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest even in Alzhiemer's disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib38","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/j.1530-0277.2001.tb02187.x","article-title":"Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of low n-3 fatty acid diet","volume":"25","author":"Pawlosky","year":"2001","journal-title":"Alcohol. Clin. Exp. Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib39","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0014-5793(00)02323-1","article-title":"Phosphorylated, but not native, tau protein assembles following reaction with lipid peroxidation product, 4-hydroxy-2-nonenal","volume":"486","author":"Perez","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib40","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1046\/j.1432-1033.2002.02794.x","article-title":"Formation of aberrant phosphotau fibrillar polymers in neural cells","volume":"269","author":"Perez","year":"2002","journal-title":"Eur. J. Biochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Peterson","year":"1999","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF03033161","article-title":"Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease","volume":"5","author":"Pocernich","year":"2003","journal-title":"Neurotox. Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.molbrainres.2004.10.024","article-title":"Proteomic analysis of oxidatively modified proteins induced by mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat","volume":"133","author":"Pocernich","year":"2005","journal-title":"Mol. Brain Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nbd.2007.12.007","article-title":"Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease","volume":"30","author":"Reed","year":"2008","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/324163a0","article-title":"Analysis of enzymatically amplified beta-globin and hla-dq alpha DNA with allele-specific oligonucleotide probes","volume":"324","author":"Saiki","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib46","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s11745-001-0805-6","article-title":"Mechanisms of action of docosahexxaenoic acid in the nervous system","volume":"36","author":"Salem","year":"2001","journal-title":"Lipids"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib47","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1212\/WNL.55.3.370","article-title":"\u201cPreclincal\u201d AD revisited: Neuropathology of cognitively older adults","volume":"55","author":"Schmitt","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib48","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1523\/JNEUROSCI.23-12-04913.2003","article-title":"The identification and characterization of oxidized RNAs in Alzheimer's disease","volume":"23","author":"Shan","year":"2003","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib49","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.freeradbiomed.2008.06.003","article-title":"Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain","volume":"45","author":"Shao","year":"2008","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib50","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1471-4159.1982.tb07962.x","article-title":"The influence of bicuculline-induced seizures on free fatty acid concentrations in cerebral cortex, hippocampus, and cerebellum","volume":"39","author":"Siesjo","year":"1982","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib51","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1179\/174313208X327973","article-title":"Improved predictive model for pre-symptomatic mild cognitive impairment and Alzheimer's disease","volume":"30","author":"Smith","year":"2008","journal-title":"Neurol. Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib52","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neurobiolaging.2005.05.005","article-title":"Oxidative modfication and down-regulation of PinI in Alzheimer's disease hippocampus: a redox proteomics analysis","volume":"27","author":"Sultana","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib53","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1046\/j.1471-4159.2000.0751234.x","article-title":"In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitipe of tau induced by 4-hydroxy-2-nonenal modification","volume":"75","author":"Takeda","year":"2000","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib54","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jpsychires.2007.12.002","article-title":"The cerebellum in mild cognitive impairment and Alzheimer's disease \u2212 a structural MRI study","volume":"42","author":"Thomann","year":"2008","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib55","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0005-2760(90)90118-H","article-title":"four-hydroxhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid","volume":"1043","author":"Van Kuijk","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib56","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1471-4159.2005.03615.x","article-title":"Increase oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment","volume":"96","author":"Wang","year":"2006","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib57","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1074\/jbc.M110913200","article-title":"High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal","volume":"277","author":"Wataya","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib58","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0006-8993(98)01279-7","article-title":"Cellbellar atropy in Alzheimer's disease \u2212 clinicopathological correlations","volume":"818","author":"Wegiel","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib59","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neurobiolaging.2005.06.004","article-title":"Increase levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in mild cognitive impairment and early Alzheimer's disease","volume":"27","author":"Williams","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib60","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0891-5849(99)00268-3","article-title":"Survival of hippocampal and cortical neurons in a mixture of MEM+ and B-27 supplemented neurobasal medium","volume":"28","author":"Xie","year":"2000","journal-title":"Free Radic. Bio. Med"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib61","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/BF00687584","article-title":"Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by beta protein immunostain","volume":"77","author":"Yamaguchi","year":"1989","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurobiolaging.2010.08.016_bib62","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.freeradbiomed.2004.03.007","article-title":"Oxidative stress protomes tau dephosphorlation in neuronal cells: The roles of Cdk5 and PP1","volume":"36","author":"Zambrano","year":"2004","journal-title":"Free Radic. Biol. Med"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010003647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010003647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T18:18:26Z","timestamp":1559758706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458010003647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0197458010003647"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2010.08.016","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}