{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:48:26Z","timestamp":1791416906123,"version":"4.3.3"},"reference-count":59,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.neurobiolaging.2010.09.002","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T09:26:23Z","timestamp":1287653183000},"page":"1045-1053","source":"Crossref","is-referenced-by-count":16,"title":["Prepulse inhibition in patients with fragile X-associated tremor ataxia syndrome"],"prefix":"10.1016","volume":"33","author":[{"given":"Andrea","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ballinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi J.","family":"Hagerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hessl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1212\/01.wnl.0000269781.10417.7b","article-title":"Volumetric brain changes in females with fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"69","author":"Adams","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/ajmg.b.31046","article-title":"Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers","volume":"153B","author":"Adams","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib3","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.neuropharm.2008.06.035","article-title":"Serotonin depletion in the dorsal and ventral hippocampus: effects on locomotor hyperactivity, prepulse inhibition and learning and memory","volume":"55","author":"Adams","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ajmg.a.32211","article-title":"A quantitative assessment of tremor and ataxia in FMR1 premutation carriers using CATSYS","volume":"146","author":"Aguilar","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2003.09.014","article-title":"Genetic influences on prepulse inhibition of startle reflex in humans","volume":"353","author":"Anokhin","year":"2003","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib6","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/mds.21493","article-title":"Fragile X-associated tremor\/ataxia syndrome: Clinical features, genetics, and testing guidelines","volume":"22","author":"Berry-Kravis","year":"2007","journal-title":"Mov. Disord"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1469-8986.1988.tb01897.x","article-title":"The startle response to acoustic stimuli near startle threshold: effects of stimulus rise and fall time, duration, and intensity","volume":"25","author":"Blumenthal","year":"1988","journal-title":"Psychophysiology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-8986.2005.00271.x","article-title":"Committee report: Guidelines for human startle eyeblink electromyographic studies","volume":"42","author":"Blumenthal","year":"2005","journal-title":"Psychophysiology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s002130100810","article-title":"Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies","volume":"156","author":"Braff","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1037\/h0027307","article-title":"Inhibition of startle response to acoustic stimulation produced by visual prestimulation","volume":"67","author":"Buckland","year":"1969","journal-title":"J. Comp. Physiol. Psychol"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0006-3223(98)00294-7","article-title":"Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population","volume":"45","author":"Cadenhead","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib12","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/0091-3057(92)90503-8","article-title":"Hippocampal modulation of acoustic startle and prepulse inhibition in the rat","volume":"43","author":"Caine","year":"1992","journal-title":"Pharmacol. Biochem. Behav"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib13","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib14","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1212\/01.wnl.0000239837.57475.3a","article-title":"Molecular and imaging correlates of the fragile X-associated tremor\/ataxia syndrome","volume":"67","author":"Cohen","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/schbul\/sbm146","article-title":"Impaired prepulse inhibition and prepulse-elicited reactivity but intact reflex circuit excitability in unmedicated schizophrenia patients: a comparison with healthy subjects and medicated schizophrenia patients","volume":"35","author":"Csomor","year":"2009","journal-title":"Schizophr. Bull"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.nbd.2008.04.002","article-title":"Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice","volume":"31","author":"de Vrij","year":"2008","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib17","first-page":"725","article-title":"Standardization of a neuromotor test battery: the CATSYS system","volume":"21","author":"Despres","year":"2000","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-1781(03)00161-6","article-title":"Prepulse inhibition of acoustic startle in subjects with schizophrenia treated with olanzapine or haloperidol","volume":"120","author":"Duncan","year":"2003","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00213-002-1372-z","article-title":"Effect of treatment status on prepulse inhibition of acoustic startle in schizophrenia","volume":"167","author":"Duncan","year":"2003","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini Mental State\u201d","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.mp.4001432","article-title":"Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice","volume":"9","author":"Frankland","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s002130051130","article-title":"Assessing prepulse inhibition of startle in wild-type and knockout mice","volume":"147","author":"Geyer","year":"1999","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib23","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/sj.mp.4001159","article-title":"Mouse genetic models for prepulse inhibition: an early review","volume":"7","author":"Geyer","year":"2002","journal-title":"Mol. Psychiatry"},{"issue":"suppl 5","key":"10.1016\/j.neurobiolaging.2010.09.002_bib24","first-page":"A2452","article-title":"Intranuclear neuronal inclusions in two female carriers of the fragile X premutation","volume":"73","author":"Greco","year":"2003","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/brain\/awh683","article-title":"Neuropathology of fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"129","author":"Greco","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1037\/0894-4105.22.1.48","article-title":"Cognitive profile of fragile X premutation carriers with and without fragile X-associated tremor\/ataxia syndrome","volume":"22","author":"Grigsby","year":"2008","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jns.2006.05.016","article-title":"Impairment in the cognitive functioning of men with fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"248","author":"Grigsby","year":"2006","journal-title":"J. Neurol. Sci"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib28","first-page":"2256","article-title":"Behavioral Dyscontrol Scale: Manual, 2nd Ed edited by Hagerman, R. J., Coffey, S.M., Maselli, R., Soontarapornchai, K., Brunberg, J.A., Leehey, M.A., Zhang, L., Gane, L.W., Fenton-Farrell, G., Tassone, F., Hagerman, P.J., 2007","volume":"143","author":"Grigsby","year":"1996","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.57.1.127","article-title":"Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X","volume":"57","author":"Hagerman","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib29a","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/ajmg.a.31920","article-title":"Neuropathy as a presenting feature in fragile X-associated tremor\/ataxia syndrome","volume":"143","author":"Hagerman","year":"2007","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib30","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neurobiolaging.2003.11.005","article-title":"Prepulse inhibition in patients with Alzheimer's disease","volume":"25","author":"Hejl","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ajmg.b.30858","article-title":"Prepulse inhibition in fragile X syndrome: feasibility, reliability, and implications for treatment","volume":"150B","author":"Hessl","year":"2009","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1037\/0033-295X.87.2.175","article-title":"Reflex modification in the domain of startle. I","volume":"87","author":"Hoffman","year":"1980","journal-title":"Psychol. Rev"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/brain\/awh650","article-title":"Protein composition of the intranuclear inclusions of FXTAS","volume":"129","author":"Iwahashi","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib34","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1086\/374321","article-title":"Fragile X premutation tremor\/ataxia syndrome: molecular, clinical, and neuroimaging correlates","volume":"72","author":"Jacquemont","year":"2003","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib35","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.neuroimage.2005.03.002","article-title":"Structural brain correlates of prepulse inhibition of the acoustic startle response in healthy humans","volume":"26","author":"Kumari","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/archpsyc.57.6.609","article-title":"Prepulse inhibition of the startle response in men with schizophrenia: effects of age of onset of illness, symptoms, and medication","volume":"57","author":"Kumari","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib37","first-page":"245","article-title":"Prepulse inhibition mechanisms and cognitive processes: a review and model","volume":"98","author":"Larrauri","year":"2006","journal-title":"EXS"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0013-4694(56)90090-6","article-title":"The relation between the startle reaction and the non-specific EEG response to sudden stimuli with a discussion on the mechanism of arousal","volume":"8","author":"Larsson","year":"1956","journal-title":"Electroencephalogr. Clin. Neurophysiol"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib39","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/01.wnl.0000281692.98200.f5","article-title":"FMR1 CGG repeat length predicts motor dysfunction in premutation carriers","volume":"70","author":"Leehey","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib40","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.neubiorev.2009.02.001","article-title":"Top-down modulation of prepulse inhibition of the startle reflex in humans and rats","volume":"3","author":"Li","year":"2009","journal-title":"Neurosci. Biobehav. Rev"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0031-9384(98)00143-7","article-title":"Prepulse inhibition following lesions of the inferior colliculus: prepulse intensity functions","volume":"65","author":"Li","year":"1998","journal-title":"Physiol. Behav"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib42","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S1388-2457(03)00076-2","article-title":"Neurophysiological study of facial chorea in patients with Huntington's disease","volume":"114","author":"Munoz","year":"2003","journal-title":"Clin. Neurophysiol"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib43","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1469-8986.1989.tb03149.x","article-title":"Long-term habituation and sensitization of the acoustic startle response in the normal adult human","volume":"26","author":"Ornitz","year":"1989","journal-title":"Psychophysiology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib44","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/jnnp.2003.035022","article-title":"Disturbance of sensory filtering in dementia with Lewy bodies: comparison with Parkinson's disease dementia and Alzheimer's disease","volume":"76","author":"Perriol","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib45","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1037\/0735-7044.119.6.1546","article-title":"Neural network model of prepulse inhibition","volume":"119","author":"Schmajuk","year":"2005","journal-title":"Behav. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib46","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s002130100799","article-title":"Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges","volume":"156","author":"Swerdlow","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib47","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0022-3565(25)23018-X","article-title":"Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat","volume":"256","author":"Swerdlow","year":"1991","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/jnnp.58.2.192","article-title":"Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease","volume":"58","author":"Swerdlow","year":"1995","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biopsycho.2004.07.002","article-title":"Prepulse inhibition of perceived stimulus intensity: paradigm assessment","volume":"69","author":"Swerdlow","year":"2005","journal-title":"Biol. Psychol"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib50","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1038\/npp.2009.7","article-title":"The effects of memantine on prepulse inhibition","volume":"34","author":"Swerdlow","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4161\/rna.1.2.1035","article-title":"FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"1","author":"Tassone","year":"2004","journal-title":"RNA Biol"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1440-1819.2006.01460.x","article-title":"Prepulse inhibition of acoustic startle response in mild cognitive impairment and mild dementia of Alzheimer type","volume":"60","author":"Ueki","year":"2006","journal-title":"Psychiatry Clin. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib53","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.clinph.2004.02.014","article-title":"Abnormalities of prepulse inhibition do not depend on blink reflex excitability: a study in Parkinson's disease and Huntington's disease","volume":"115","author":"Valls-Sole","year":"2004","journal-title":"Clin. Neurophysiol"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib54","series-title":"Wechsler Adult Intelligence Scale-Third Edition (WAIS-III) - administration and scoring manual","author":"Wechsler","year":"1997"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib55","series-title":"Wechsler Memory Scale-Third Edition (WMS-III) - administration and scoring manual","author":"Wechsler","year":"1997"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib56","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0006-3223(99)00229-2","article-title":"Effective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients","volume":"47","author":"Weike","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib57","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s00415-008-0758-1","article-title":"The auditory startle response in parkinsonism may reveal the extent but not type of pathology","volume":"255","author":"Williams","year":"2008","journal-title":"J. Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.09.002_bib58","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0006-8993(88)90716-0","article-title":"Anatomical distribution and response patterns of reticular neurons active in relation to acoustic startle","volume":"457","author":"Wu","year":"1988","journal-title":"Brain Res"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010003775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010003775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:35:00Z","timestamp":1740616500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458010003775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0197458010003775"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2010.09.002","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}