{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:39:10Z","timestamp":1769053150069,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.neurobiolaging.2010.12.005","type":"journal-article","created":{"date-parts":[[2011,1,23]],"date-time":"2011-01-23T09:19:06Z","timestamp":1295774346000},"page":"758.e1-758.e7","source":"Crossref","is-referenced-by-count":16,"title":["Frontotemporal lobar degeneration genome wide association study replication confirms a risk locus shared with amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"32","author":[{"given":"Sara","family":"Rollinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Mead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Snowden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Halliwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Usher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Neary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Pickering-Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib2","article-title":"Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family","author":"Boxer","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neulet.2005.12.056","article-title":"CHMP2B mutations are not a common cause of frontotemporal lobar degeneration","volume":"398","author":"Cannon","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib4","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","article-title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","volume":"442","author":"Cruts","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib5","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"Gabriel","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib6","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/archneurol.2010.82","article-title":"Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"67","author":"Gijselinck","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib7","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1056\/NEJMra0808700","article-title":"Genomewide association studies and human disease","volume":"360","author":"Hardy","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib8","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib9","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S1474-4422(10)70184-8","article-title":"Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study","volume":"9","author":"Laaksovirta","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib10","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1212\/WNL.0b013e3181a55f1c","article-title":"Chromosome 9p-linked families with frontotemporal dementia associated with motor neuron disease","volume":"72","author":"Le Ber","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2377-8-32","article-title":"Pedigree with frontotemporal lobar degeneration\u2013motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9","volume":"8","author":"Luty","year":"2008","journal-title":"BMC Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00401-008-0460-5","article-title":"Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations","volume":"117","author":"Mackenzie","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","article-title":"Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update","volume":"119","author":"Mackenzie","year":"2010","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib14","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0140-6736(99)05207-1","article-title":"Molecular classification of the dementias","volume":"355","author":"Mann","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib15","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1212\/01.wnl.0000200048.53766.b4","article-title":"A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia","volume":"66","author":"Morita","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib16","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/jnnp.53.1.23","article-title":"Frontal lobe dementia and motor neuron disease","volume":"53","author":"Neary","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib19","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/brain\/awm331","article-title":"Frequency and clinical characteristics of progranulin (PGRN) mutation carriers in the Manchester Frontotemporal Lobar Degeneration cohort: Comparison to MAPT mutation patients","volume":"131","author":"Pickering-Brown","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib20","first-page":"39","article-title":"The complex aetiology of frontotemporal lobar degeneration","volume":"114","author":"Pickering-Brown","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib21","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S1474-4422(10)70197-6","article-title":"Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study","volume":"9","author":"Shatunov","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib22","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","article-title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","volume":"37","author":"Skibinski","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib23","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/379378","article-title":"A comparison of bayesian methods for haplotype reconstruction from population genotype data","volume":"73","author":"Stephens","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib24","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/319501","article-title":"A new statistical method for haplotype reconstruction from population data","volume":"68","author":"Stephens","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1001\/archneur.64.2.240","article-title":"Three families with amyotrophic lateral sclerosis and frontotemporal dementia with evidence of linkage to chromosome 9p","volume":"64","author":"Valdmanis","year":"2007","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/ng.536","article-title":"Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions","volume":"42","author":"Van Deerlin","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib27","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/ng.442","article-title":"Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis","volume":"41","author":"van Es","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.neurobiolaging.2010.12.005_bib28","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/brain\/awl030","article-title":"Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2\u201321.3","volume":"129","author":"Vance","year":"2006","journal-title":"Brain"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010005221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458010005221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T09:56:12Z","timestamp":1544003772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458010005221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0197458010005221"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2010.12.005","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}