{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:51:59Z","timestamp":1790229119739,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["AG13616"],"award-info":[{"award-number":["AG13616"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["AG032554"],"award-info":[{"award-number":["AG032554"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["AG035137"],"award-info":[{"award-number":["AG035137"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["AG022374"],"award-info":[{"award-number":["AG022374"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health-National Center for Research Resources","award":["M01RR0096"],"award-info":[{"award-number":["M01RR0096"]}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"crossref","award":["IIRG-09-132030"],"award-info":[{"award-number":["IIRG-09-132030"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.neurobiolaging.2011.03.003","type":"journal-article","created":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T09:34:24Z","timestamp":1303724064000},"page":"624.e1-624.e9","source":"Crossref","is-referenced-by-count":9,"title":["Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease"],"prefix":"10.1016","volume":"33","author":[{"given":"Lisa","family":"Mosconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"McHugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schantel","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pirraglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Glodzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"De Santi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Vallabhajosula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony J.","family":"de Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1212\/WNL.36.7.922","article-title":"Risk factors for clinically diagnosed Alzheimer's disease","volume":"36","author":"Amaducci","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib2","article-title":"Effects of ApoEIV and maternal history of dementia on hippocampal atrophy","author":"Andrawis","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S1472-6483(10)61946-3","article-title":"Mitochondrial DNA point mutation in human oocytes is associated with maternal age","volume":"1","author":"Barritt","year":"2000","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jalz.2009.11.003","article-title":"White matter is altered with parental family history of Alzheimer's disease","volume":"6","author":"Bendlin","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s100480050041","article-title":"Paternal age is a risk factor for Alzheimer disease in the absence of a major gene","volume":"1","author":"Bertram","year":"1998","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1532-5415.1982.tb05065.x","article-title":"Alzheimer's disease and maternal age","volume":"30","author":"Cohen","year":"1982","journal-title":"J. Am. Geriatr. Soc"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/432053a","article-title":"Resourceful imprinting","volume":"432","author":"Constancia","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1542\/peds.107.6.e86","article-title":"The epidemiology of mental retardation of unknown cause","volume":"107","author":"Croen","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib9","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.191044198","article-title":"Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-d-glucose\/positron-emission tomography (FDG\/PET)","volume":"98","author":"de Leon","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1037\/0894-4105.22.4.469","article-title":"Robust and conventional neuropsychological norms: Diagnosis and prediction of age-related cognitive decline","volume":"22","author":"De Santi","year":"2008","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib11","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1212\/WNL.0b013e3181c67833","article-title":"Association of parental dementia with cognitive and brain MRI measures in middle-aged adults","volume":"73","author":"Debette","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib12","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s00259-003-1194-1","article-title":"Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study","volume":"30","author":"Drzezga","year":"2003","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1212\/WNL.47.1.254","article-title":"Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance","volume":"47","author":"Edland","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/(SICI)1096-8628(19990820)88:4<378::AID-AJMG15>3.0.CO;2-8","article-title":"Genetic epidemiological study of maternal and paternal transmission of Alzheimer's disease","volume":"88","author":"Ehrenkrantz","year":"1999","journal-title":"Am. J. Med. Genet"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1001\/archneur.1991.00530180051017","article-title":"Association of decreased paternal age and late-onset Alzheimer's disease","volume":"48","author":"Farrer","year":"1991","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ana.410250511","article-title":"Assessment of genetic risk for Alzheimer's disease among first-degree relatives","volume":"25","author":"Farrer","year":"1989","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: A general linear approach","volume":"2","author":"Friston","year":"1995","journal-title":"Hum. Brain Mapp"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib18","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1001\/archneur.64.12.1743","article-title":"Variability of Age at Onset in Siblings with Familial Alzheimer Disease","volume":"64","author":"Gomez-Tortosa","year":"2007","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/jama.287.3.329","article-title":"Risk of dementia among white and African American relatives of patients with Alzheimer disease","volume":"287","author":"Green","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The Amyloid Hypothesis of Alzheimer's disease: Progress and Problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib21","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1056\/NEJMp048087","article-title":"Advanced maternal age-how old is too old?","volume":"351","author":"Heffner","year":"2004","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1192\/bjp.157.2.273","article-title":"Is parental age related to the risk of Alzheimer's disease?","volume":"157","author":"Hofman","year":"1990","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1212\/WNL.0b013e3181c918cb","article-title":"Reduced Gray Matter Volume in Normal Adults with a Maternal Family History of Alzheimer Disease","volume":"74","author":"Honea","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib24","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s00259-008-0833-y","article-title":"Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment and Alzheimer's disease","volume":"35","author":"Li","year":"2008","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib25","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/archpsyc.58.4.361","article-title":"Advancing paternal age and the risk of schizophrenia","volume":"58","author":"Malaspina","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib27","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/1479-7364-4-3-170","article-title":"Maternal transmission of Alzheimer's disease: Prodromal metabolic phenotype and the search for genes","volume":"4","author":"Mosconi","year":"2010","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib29","doi-asserted-by":"crossref","first-page":"19067","DOI":"10.1073\/pnas.0705036104","article-title":"Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism","volume":"104","author":"Mosconi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib30","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neurobiolaging.2006.12.008","article-title":"Hippocampal hypometabolism predicts cognitive decline from normal aging","volume":"29","author":"Mosconi","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib31","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.biopsych.2010.07.011","article-title":"Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's","volume":"68","author":"Mosconi","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1212\/01.wnl.0000333247.51383.43","article-title":"Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer's","volume":"72","author":"Mosconi","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib33","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1073\/pnas.0914141107","article-title":"Increased fibrillar amyloid-\u03b2 burden in normal individuals with a family history of late-onset Alzheimer's disease","volume":"107","author":"Mosconi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib34","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1212\/01.WNL.0000163856.13524.08","article-title":"Reduced hippocampal metabolism in mild cognitive impairment and Alzheimer's disease: automated FDG-PET image analysis","volume":"64","author":"Mosconi","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib35","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2967\/jnumed.107.045385","article-title":"Multi-center standardized FDG-PET diagnosis of Mild Cognitive Impairment, Alzheimer's disease and other dementias","volume":"49","author":"Mosconi","year":"2008","journal-title":"J. Nucl. Med"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib36","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/0140-6736(91)93060-M","article-title":"Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility","volume":"337","author":"Navot","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib37","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1043-2760(00)00277-0","article-title":"Genomic Imprinting, Uniparental Disomy and Foetal Growth","volume":"11","author":"Preece","year":"2000","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib38","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1001\/archpsyc.63.9.1026","article-title":"Advancing paternal age and autism","volume":"63","author":"Reichenberg","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"issue":"suppl 2","key":"10.1016\/j.neurobiolaging.2011.03.003_bib39","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1093\/ije\/20.Supplement_2.S21","article-title":"Maternal Age and Alzheimer's disease: A collaborative Re-analysis of Case-control studies","volume":"20","author":"Rocca","year":"1991","journal-title":"Int. J. Epidemiol"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archpsyc.62.5.565","article-title":"Variability of familial risk of Alzheimer disease across the late life span","volume":"62","author":"Silverman","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/archneur.1989.00520370040016","article-title":"A community-based study of parental age at the birth of patients with dementia of the Alzheimer type","volume":"46","author":"Urakami","year":"1989","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1192\/bjp.140.3.249","article-title":"A study of familial factors in Alzheimer's disease","volume":"140","author":"Whalley","year":"1982","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/geronj\/41.1.40","article-title":"Fertility and parental age in Alzheimer's disease","volume":"41","author":"White","year":"1986","journal-title":"J. Gerontol"},{"key":"10.1016\/j.neurobiolaging.2011.03.003_bib44","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1017\/S0967199405003382","article-title":"The maternal age effect: a hypothesis based on oxidative phosphorylation","volume":"13","author":"Wilding","year":"2005","journal-title":"Zygote"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458011000601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458011000601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T05:27:21Z","timestamp":1543814841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458011000601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0197458011000601"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.03.003","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}