{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:07:37Z","timestamp":1792868857455,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"FP5 framework LipiDiet project","award":["QLK-2002-172"],"award-info":[{"award-number":["QLK-2002-172"]}]},{"name":"FP7 project LipiDiDiet","award":["211696"],"award-info":[{"award-number":["211696"]}]},{"name":"London and Middlesex Alzheimer's Association"},{"name":"Marion and Chester Fish Alzheimer's Disease Research"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP49546"],"award-info":[{"award-number":["MOP49546"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.neurobiolaging.2011.07.014","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T23:21:42Z","timestamp":1316042502000},"page":"831.e21-831.e31","source":"Crossref","is-referenced-by-count":78,"title":["Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight"],"prefix":"10.1016","volume":"33","author":[{"given":"Zareen","family":"Amtul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Uhrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Rozmahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Beyreuther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1054\/plef.2002.0453","article-title":"The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice","volume":"67","author":"Akisu","year":"2002","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib2","doi-asserted-by":"crossref","first-page":"6100","DOI":"10.1074\/jbc.M110.183608","article-title":"Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques","volume":"286","author":"Amtul","year":"2011","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neulet.2010.06.046","article-title":"Phospholipids and a phospholipid-rich diet alter the in vitro amyloid-beta peptide levels and amyloid-beta 42\/40 ratios","volume":"481","author":"Amtul","year":"2010","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1750-3639.2010.00449.x","article-title":"Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer's disease","volume":"21","author":"Amtul","year":"2011","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib5","series-title":"DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: Is it time to evaluate composite lipid diet?","author":"Amtul","year":"2011"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib6","first-page":"68","article-title":"Prostaglandins and other lipid mediators in Alzheimer's disease","author":"Bazan","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1089\/neu.1995.12.791","article-title":"Mediators of injury in neurotrauma: intracellular signal transduction and gene expression","volume":"12","author":"Bazan","year":"1995","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1385\/JMN:27:2:185","article-title":"Inhibition of ligand binding to G protein-coupled receptors by arachidonic acid","volume":"27","author":"Bordayo","year":"2005","journal-title":"J. Mol. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.18388\/abp.2007_3235","article-title":"Amyloid beta enhances cytosolic phospholipase A2 level and arachidonic acid release via nitric oxide in APP-transfected PC12 cells","volume":"54","author":"Chalimoniuk","year":"2007","journal-title":"Acta Biochim. Pol"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib10","doi-asserted-by":"crossref","first-page":"21562","DOI":"10.1074\/jbc.M100710200","article-title":"Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein","volume":"276","author":"Chishti","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s000110050367","article-title":"Opioids, NSAIDs and 5-lipoxygenase inhibitors act synergistically in brain via arachidonic acid metabolism","volume":"48","author":"Christie","year":"1999","journal-title":"Inflamm. Res"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib12","first-page":"49","article-title":"Lipids, depression and suicide","volume":"29","author":"Colin","year":"2003","journal-title":"Encephale"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib13","doi-asserted-by":"crossref","first-page":"e1959","DOI":"10.1371\/journal.pone.0001959","article-title":"Spatial relational memory requires hippocampal adult neurogenesis","volume":"3","author":"Dupret","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuron.2005.11.027","article-title":"The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells","volume":"49","author":"Eljaschewitsch","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib15","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2967\/jnumed.107.049619","article-title":"Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET","volume":"49","author":"Esposito","year":"2008","journal-title":"J. Nucl. Med"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib15a","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2007"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-5728(94)00140-J","article-title":"Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids","volume":"56","author":"Gallai","year":"1995","journal-title":"J. Neuroimmunol"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib18","series-title":"McCance and Widdowson's the Composition of Foods","author":"Holland","year":"1991"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib19","doi-asserted-by":"crossref","first-page":"32676","DOI":"10.1074\/jbc.M703087200","article-title":"Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo","volume":"282","author":"Hoshino","year":"2007","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib20","doi-asserted-by":"crossref","first-page":"22908","DOI":"10.1074\/jbc.271.37.22908","article-title":"Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay","volume":"271","author":"Ida","year":"1996","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF03401938","article-title":"Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems","volume":"6","author":"Jensen","year":"2000","journal-title":"Mol. Med"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF02761775","article-title":"Inhibition of antagonist and agonist binding to the human brain muscarinic receptor by arachidonic acid","volume":"10","author":"Kjome","year":"1998","journal-title":"J. Mol. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib24","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1073\/pnas.95.11.6448","article-title":"Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins","volume":"95","author":"Lambert","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib25","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1073\/pnas.032395699","article-title":"The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain","volume":"99","author":"Lichtenthaler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib26","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib27","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.neuropharm.2004.02.012","article-title":"Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta","volume":"46","author":"Matsumoto","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib28","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer's disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib29","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","article-title":"Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease","volume":"46","author":"McLean","year":"1999","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/abbi.1993.1112","article-title":"Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease","volume":"301","author":"Miller","year":"1993","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib31","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1212\/01.WNL.0000123250.82849.B6","article-title":"Dietary fat intake and 6-year cognitive change in an older biracial community population","volume":"62","author":"Morris","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib32","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0006-2952(97)00665-5","article-title":"Identification and characterization of a novel delta6\/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent","volume":"55","author":"Obukowicz","year":"1998","journal-title":"Biochem. Pharmacol"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib33","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jaci.2006.08.009","article-title":"The role of leukotrienes in airway inflammation","volume":"118","author":"Ogawa","year":"2006","journal-title":"J. Allergy Clin. Immunol"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib34","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.nbd.2006.04.013","article-title":"Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP\/PS1 transgenic mice","volume":"23","author":"Oksman","year":"2006","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0095-5108(18)30294-X","article-title":"Hypoxic-ischemic encephalopathy","volume":"22","author":"Palmer","year":"1995","journal-title":"Clin. Perinatol"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib36","first-page":"65","article-title":"Eicosanoids in synaptic transmission","volume":"8","author":"Piomelli","year":"1994","journal-title":"Crit. Rev. Neurobiol"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib37","doi-asserted-by":"crossref","first-page":"8550","DOI":"10.1073\/pnas.86.21.8550","article-title":"Inhibition of Ca2+\/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites","volume":"86","author":"Piomelli","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib38","doi-asserted-by":"crossref","first-page":"50970","DOI":"10.1074\/jbc.M307699200","article-title":"Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity","volume":"278","author":"Qin","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0005-2760(91)90231-6","article-title":"On the conformational, physical properties and functions of polyunsaturated acyl chains","volume":"1085","author":"Rabinovich","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0006-8993(85)90411-1","article-title":"Brain muscarinic receptors in senile dementia","volume":"336","author":"Rinne","year":"1985","journal-title":"Brain Res"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib41","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/nn.2213","article-title":"Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease","volume":"11","author":"Sanchez-Mejia","year":"2008","journal-title":"Nat. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib42","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1073\/pnas.0611718104","article-title":"Paradoxical influence of hippocampal neurogenesis on working memory","volume":"104","author":"Saxe","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib43","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/BF02536595","article-title":"Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis","volume":"26","author":"Shimizu","year":"1991","journal-title":"Lipids"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib44","first-page":"229","article-title":"Inhibitors of the arachidonic acid cascade in the management of ocular inflammation","volume":"312","author":"Srinivasan","year":"1989","journal-title":"Prog. Clin. Biol. Res"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/scientificamerican1200-76","article-title":"Piecing together Alzheimer's","volume":"283","author":"St George-Hyslop","year":"2000","journal-title":"Sci. Am"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI200113416","article-title":"Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes","volume":"108","author":"Tilley","year":"2001","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib48","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1096\/fj.04-3620rev","article-title":"Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs","volume":"19","author":"Townsend","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.neurobiolaging.2011.07.014_bib49","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tins.2005.02.001","article-title":"Neurovascular mechanisms of Alzheimer's neurodegeneration","volume":"28","author":"Zlokovic","year":"2005","journal-title":"Trends Neurosci"}],"updated-by":[{"DOI":"10.1016\/j.neurobiolaging.2017.12.007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000}}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458011002995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458011002995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T17:30:01Z","timestamp":1592933401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458011002995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0197458011002995"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.07.014","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}