{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:14:21Z","timestamp":1791144861027,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30870842"],"award-info":[{"award-number":["30870842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30801215"],"award-info":[{"award-number":["30801215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.neurobiolaging.2011.12.023","type":"journal-article","created":{"date-parts":[[2012,1,29]],"date-time":"2012-01-29T23:32:17Z","timestamp":1327879937000},"page":"2661-2677","source":"Crossref","is-referenced-by-count":47,"title":["RETRACTED: Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe\/PS1dE9 mice"],"prefix":"10.1016","volume":"33","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesheng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0165-5728(02)00050-4","article-title":"Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice","volume":"126","author":"Abbas","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib2","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1098\/rstb.2005.1766","article-title":"The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides","volume":"360","author":"Abramov","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib3","first-page":"1800","article-title":"Naproxen and celecoxib do not prevent Alzheimer's disease (AD) in early results from a randomized controlled trial","volume":"22","author":"Lyketsos","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib4","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.2174\/138161210793176572","article-title":"Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease","volume":"16","author":"Agostinho","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib5","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1212\/WNL.54.3.588","article-title":"A randomized controlled trial of prednisone in Alzheimer's disease","volume":"54","author":"Aisen","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/00002093-200104000-00009","article-title":"Pilot tolerability studies of hydroxychloroquine and colchicine in Alzheimer disease","volume":"15","author":"Aisen","year":"2001","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib7","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1001\/jama.289.21.2819","article-title":"Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial","volume":"289","author":"Aisen","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib8","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1212\/WNL.58.7.1050","article-title":"Randomized pilot study of nimesulide treatment in Alzheimer's disease","volume":"58","author":"Aisen","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3233\/JAD-2000-2105","article-title":"Lower counts of astroglia and activated microglia in patients with Alzheimer's disease with regular use of non-steroidal anti-inflammatory drugs","volume":"2","author":"Alafuzoff","year":"2000","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1096\/fasebj.13.1.63","article-title":"TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs","volume":"13","author":"Blasko","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000285514","article-title":"Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology","volume":"7","author":"Cuello","year":"2010","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2006.12.019","article-title":"Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-alpha on long-term potentiation","volume":"1136","author":"Cumiskey","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3940(03)00440-3","article-title":"The inhibition of long-term potentiation in the rat dentate gyrus by pro-inflammatory cytokines is attenuated in the presence of nicotine","volume":"344","author":"Curran","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neurobiolaging.2003.12.026","article-title":"The microglial phagocytic role with specific plaque types in the Alzheimer disease brain","volume":"25","author":"D'Andrea","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib15","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/NEN.0b013e318217a118","article-title":"Brain oligomeric \u03b2-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein\/tau transgenic mice","volume":"70","author":"DaRocha-Souto","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib16","doi-asserted-by":"crossref","first-page":"e1475","DOI":"10.1371\/journal.pone.0001475","article-title":"No effect of one-year treatment with indomethacin on Alzheimer's disease progression: a randomized controlled trial","volume":"3","author":"de Jong","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0304-3940(95)11384-9","article-title":"Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures","volume":"188","author":"Del Bo","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib18","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.neurobiolaging.2003.08.008","article-title":"Inflammation occurs early during the Abeta deposition process in TgCRND8 mice","volume":"25","author":"Dudal","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.nbd.2008.08.001","article-title":"Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study","volume":"32","author":"Edison","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1172\/JCI200318162","article-title":"NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo","volume":"112","author":"Eriksen","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib21","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1523\/JNEUROSCI.4371-06.2007","article-title":"Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid","volume":"27","author":"Fan","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib22","article-title":"Intracellular A\u03b2-oligomers and early inflammation in a model of Alzheimer's disease","author":"Ferretti","year":"2011","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/156720511795255982","article-title":"Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment?","volume":"8","author":"Ferretti","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2006.08.017","article-title":"Characterization of amyloid deposition in the APPswe\/PS1dE9 mouse model of Alzheimer disease","volume":"24","author":"Garcia-Alloza","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib25","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1038\/cddis.2011.50","article-title":"Astrocytes are important mediators of A\u03b2-induced neurotoxicity and tau phosphorylation in primary culture","volume":"2","author":"Garwood","year":"2011","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1471-4159.2004.02743.x","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action","volume":"91","author":"Gasparini","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib27","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neurobiolaging.2005.04.017","article-title":"Common mechanisms of amyloid oligomer pathogenesis in degenerative disease","volume":"27","author":"Glabe","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/archneur.57.6.831","article-title":"Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease","volume":"57","author":"Halliday","year":"2000","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/156720511795256099","article-title":"Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease","volume":"8","author":"Heneka","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib31","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00702-010-0438-z","article-title":"Neuroinflammatory processes in Alzheimer's disease","volume":"117","author":"Heneka","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1742-2094-2-22","article-title":"Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice","volume":"2","author":"Heneka","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2010-1414","article-title":"Neuroinflammation in Alzheimer's disease: mechanisms, pathologic consequences, and potential for therapeutic manipulation","volume":"21","author":"Hensley","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib34","doi-asserted-by":"crossref","first-page":"32676","DOI":"10.1074\/jbc.M703087200","article-title":"Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo","volume":"282","author":"Hoshino","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib35","doi-asserted-by":"crossref","first-page":"18493","DOI":"10.1074\/jbc.M109.003269","article-title":"Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor","volume":"284","author":"Hoshino","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib36","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1517\/13543780903066780","article-title":"An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease","volume":"18","author":"Imbimbo","year":"2009","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3233\/JAD-2010-1366","article-title":"CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease","volume":"20","author":"Imbimbo","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib38","article-title":"Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment?","volume":"2","author":"Imbimbo","year":"2010","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib39","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1056\/NEJMoa010178","article-title":"Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease","volume":"345","author":"in t' Veld","year":"2001","journal-title":"N Engl J. Med."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-2094-2-23","article-title":"Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice","volume":"2","author":"Janelsins","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib41","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1042\/BST0390886","article-title":"Assessing the contribution of inflammation in models of Alzheimer's disease","volume":"39","author":"Johnston","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib42","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1523\/JNEUROSCI.2868-05.2005","article-title":"Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease","volume":"25","author":"Kitazawa","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib43","doi-asserted-by":"crossref","first-page":"11678","DOI":"10.1523\/JNEUROSCI.4665-09.2010","article-title":"Prostaglandin E2-induced synaptic plasticity in neocortical networks of organotypic slice cultures","volume":"30","author":"Koch","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1742-2094-5-37","article-title":"Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation","volume":"5","author":"Lee","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1110\/ps.062514807","article-title":"Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway","volume":"16","author":"Lee","year":"2007","journal-title":"Protein Sci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib46","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1742-2094-8-132","article-title":"Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-\u03b2 generation and inflammatory reactions via inhibition of NF-\u03baB and STAT3 activation in cultured astrocytes and microglial BV-2 cells","volume":"8","author":"Lee","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0006-8993(96)01283-8","article-title":"Interleukin-6 inhibits long-term potentiation in rat hippocampal slices","volume":"748","author":"Li","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib48","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/aps.2010.3","article-title":"The novel squamosamide derivative FLZ enhances BDNF\/TrkB\/CREB signaling and inhibits neuronal apoptosis in APP\/PS1 mice","volume":"31","author":"Li","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib49","doi-asserted-by":"crossref","first-page":"49523","DOI":"10.1074\/jbc.M402034200","article-title":"Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway","volume":"279","author":"Liao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib50","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1523\/JNEUROSCI.20-15-05709.2000","article-title":"Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease","volume":"20","author":"Lim","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib51","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-004-0824-4","article-title":"Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type","volume":"107","author":"Maat-Schieman","year":"2004","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib52","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1212\/WNL.47.2.425","article-title":"Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies","volume":"47","author":"McGeer","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib53","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature06616","article-title":"Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease","volume":"451","author":"Meyer-Luehmann","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib54","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1523\/JNEUROSCI.1306-05.2005","article-title":"Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice","volume":"25","author":"Miao","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib55","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.npep.2008.08.004","article-title":"S14G-Humanin ameliorates Abeta25-35-induced behavioral deficits by reducing neuroinflammatory responses and apoptosis in mice","volume":"42","author":"Miao","year":"2008","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib56","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neurobiolaging.2005.01.018","article-title":"Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes","volume":"27","author":"Miklossy","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib57","doi-asserted-by":"crossref","first-page":"127984","DOI":"10.4061\/2011\/127984","article-title":"A\u03b2 internalization by neurons and glia","volume":"2011","author":"Mohamed","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib58","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0002-9440(10)64603-2","article-title":"Expression of macrophage colony-stimulating factor receptor is increased in the AbetaPP(V717F) transgenic mouse model of Alzheimer's disease","volume":"157","author":"Murphy","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib59","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1523\/JNEUROSCI.18-08-02974.1998","article-title":"Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation","volume":"18","author":"Murray","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib60","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbr.2009.01.039","article-title":"Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"201","author":"O'Leary","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib61","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.neurobiolaging.2006.08.014","article-title":"Inflammatory changes parallel the early stages of Alzheimer disease","volume":"28","author":"Parachikova","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib62","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/glia.20599","article-title":"Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease","volume":"56","author":"Pihlaja","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib63","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1046\/j.0953-816x.2001.01666.x","article-title":"Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse","volume":"14","author":"Qiao","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib64","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1046\/j.1471-4159.2002.01210.x","article-title":"Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species","volume":"83","author":"Qin","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib65","doi-asserted-by":"crossref","first-page":"50970","DOI":"10.1074\/jbc.M307699200","article-title":"Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity","volume":"278","author":"Qin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib66","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/WNL.62.1.66","article-title":"Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study","volume":"62","author":"Reines","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib67","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0169-328X(97)00356-2","article-title":"Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor\/interleukin-6 complex","volume":"55","author":"Ringheim","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib68","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1038\/cddis.2009.2","article-title":"Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease","volume":"1","author":"Rodr\u00edguez","year":"2010","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib69","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1212\/WNL.43.8.1609","article-title":"Clinical trial of indomethacin in Alzheimer's disease","volume":"43","author":"Rogers","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib70","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/156720509790147070","article-title":"Amyloid deposition and inflammation in APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"6","author":"Ruan","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib71","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.0503839103","article-title":"Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma","volume":"103","author":"Sastre","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib72","first-page":"20","article-title":"NSAIDs: How they Work and their Prospects as Therapeutics in Alzheimer's Disease","volume":"2","author":"Sastre","year":"2010","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijdevneu.2005.11.014","article-title":"Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms","volume":"24","author":"Sastre","year":"2006","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib74","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1742-2094-5-25","article-title":"Interactions between APP secretases and inflammatory mediators","volume":"5","author":"Sastre","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib75","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.nbd.2004.10.022","article-title":"Episodic-like memory deficits in the APPswe\/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities","volume":"18","author":"Savonenko","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib76","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1212\/WNL.53.1.197","article-title":"A double-blind, placebo-controlled trial of diclofenac\/misoprostol in Alzheimer's disease","volume":"53","author":"Scharf","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib77","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.ajpath.2011.05.047","article-title":"Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease","volume":"179","author":"Serrano-Pozo","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib78","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0969-9961(03)00069-X","article-title":"Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice","volume":"14","author":"Sheng","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib79","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000096588","article-title":"Long-term efficacy and safety of celecoxib in Alzheimer's disease","volume":"23","author":"Soininen","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib80a","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.48.3.626","article-title":"Risk of Alzheimer's disease and duration of NSAID use","volume":"48","author":"Stewart","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib80","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000078501","article-title":"Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review","volume":"23","author":"Szekely","year":"2004","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib81","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1471-4159.2000.0750634.x","article-title":"The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK","volume":"75","author":"Tancredi","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib82","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0304-3940(92)90071-E","article-title":"Tumor necrosis factor alters synaptic transmission in rat hippocampal slices","volume":"146","author":"Tancredi","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib83","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0304-3940(01)01592-0","article-title":"Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576","volume":"301","author":"Tehranian","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib84","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/sj.npp.1300690","article-title":"A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment","volume":"30","author":"Thal","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib85","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1097\/00001756-200110290-00024","article-title":"Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation","volume":"12","author":"Thomas","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib86","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1523\/JNEUROSCI.20-18-06811.2000","article-title":"The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases","volume":"20","author":"Vereker","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000070857","article-title":"Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography","volume":"50","author":"Versijpt","year":"2003","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib88","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.brainres.2010.08.023","article-title":"miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-\u03b2 type II receptor","volume":"1357","author":"Wang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib89","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/35102591","article-title":"A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity","volume":"414","author":"Weggen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib90","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neurobiolaging.2008.06.011","article-title":"Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP\/PS1KI mouse model of Alzheimer's disease","volume":"31","author":"Wirths","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib91","first-page":"1005","article-title":"Inflammation in Alzheimer disease: driving force, bystander or beneficial response?","volume":"12","author":"Wyss-Coray","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib92","doi-asserted-by":"crossref","first-page":"680","DOI":"10.2353\/ajpath.2007.060378","article-title":"Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice","volume":"170","author":"Yamamoto","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib93","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.1523\/JNEUROSCI.23-20-07504.2003","article-title":"Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease","volume":"23","author":"Yan","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib95a","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1212\/WNL.59.6.880","article-title":"Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study","volume":"59","author":"Zandi","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib94","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-2094-8-3","article-title":"Microglial MAC1 receptor and PI3K are essential in mediating \u03b2-amyloid peptide-induced microglial activation and subsequent neurotoxicity","volume":"8","author":"Zhang","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib95","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bbr.2011.03.072","article-title":"Soluble A\u03b2 levels correlate with cognitive deficits in the 12-month-old APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"222","author":"Zhang","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2011.12.023_bib96","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1742-2094-8-150","article-title":"The contribution of activated astrocytes to A\u03b2 production: Implications for Alzheimer's disease pathogenesis","volume":"8","author":"Zhao","year":"2011","journal-title":"J. Neuroinflammation"}],"updated-by":[{"DOI":"10.1016\/j.neurobiolaging.2016.01.005","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"record-id":"13363"},{"DOI":"10.1016\/j.neurobiolaging.2016.01.005","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000}}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458011005689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458011005689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:06:42Z","timestamp":1742382402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458011005689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":98,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0197458011005689"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.12.023","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}