{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:36:55Z","timestamp":1770413815040,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israeli Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.neurobiolaging.2012.04.003","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T02:53:26Z","timestamp":1336100006000},"page":"2230.e13-2230.e21","source":"Crossref","is-referenced-by-count":6,"title":["Hippocampus neuronal metabolic gene expression outperforms whole tissue data in accurately predicting Alzheimer's disease progression"],"prefix":"10.1016","volume":"33","author":[{"given":"Shiri","family":"Stempler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yedael Y.","family":"Waldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eytan","family":"Ruppin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib3","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1073\/pnas.0308512100","article-title":"Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses","volume":"101","author":"Blalock","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/jnr.10087","article-title":"Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia?","volume":"66","author":"Blass","year":"2001","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuropharm.2010.04.005","article-title":"Oxidative stress in Alzheimer disease: a possibility for prevention","volume":"59","author":"Bonda","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1750-3639.2008.00171.x","article-title":"Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death","volume":"19","author":"Bossers","year":"2009","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach. Learn"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3233\/JAD-2010-1375","article-title":"Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration","volume":"20","author":"Butterfield","year":"2010","journal-title":"J. Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0169-328X(94)90147-3","article-title":"Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease","volume":"24","author":"Chandrasekaran","year":"1994","journal-title":"Brain Res. Mol. Brain Res"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1001\/archneur.56.7.857","article-title":"Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease","volume":"56","author":"Clark","year":"1999","journal-title":"Arch. Neurol"},{"issue":"suppl","key":"10.1016\/j.neurobiolaging.2012.04.003_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0924-977X(95)00032-K","article-title":"A theory of the evolutionary origins of psychosis","volume":"5","author":"Crow","year":"1995","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib12","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1073\/pnas.0610772104","article-title":"Global reconstruction of the human metabolic network based on genomic and bibliomic data","volume":"104","author":"Duarte","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10863-009-9243-5","article-title":"Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease","volume":"41","author":"Ferrer","year":"2009","journal-title":"J. Bioenerg. Biomembr"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0197-4580(99)00053-6","article-title":"The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms","volume":"20","author":"Finch","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib16","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.1019164108","article-title":"Rapid metabolic evolution in human prefrontal cortex","volume":"108","author":"Fu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib17","doi-asserted-by":"crossref","first-page":"xi","DOI":"10.1196\/annals.1427.039","article-title":"Mitochondria and oxidative stress in neurodegenerative disorders","volume":"1147","author":"Gibson","year":"2008","journal-title":"Preface. Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.nbd.2011.07.013","article-title":"Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease","volume":"45","author":"Ginsberg","year":"2012","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0006-3223(03)00322-6","article-title":"Single-cell molecular biology: implications for diagnosis and treatment of neurologic disease","volume":"54","author":"Hinkle","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.neurobiolaging.2004.06.016","article-title":"Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role","volume":"26","author":"Ho","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3233\/JAD-2002-4505","article-title":"Tau, where are we now?","volume":"4","author":"Johnson","year":"2002","journal-title":"J. Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib22","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1523\/JNEUROSCI.23-09-03607.2003","article-title":"Single-cell microarray analysis in hippocampus CA1: demonstration and validation of cellular heterogeneity","volume":"23","author":"Kamme","year":"2003","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00702-003-0096-5","article-title":"Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function","volume":"111","author":"Kennedy","year":"2004","journal-title":"J. Neural Transm"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib24","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/gb-2008-9-8-r124","article-title":"Metabolic changes in schizophrenia and human brain evolution","volume":"9","author":"Khaitovich","year":"2008","journal-title":"Genome Biol"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib25","doi-asserted-by":"crossref","first-page":"R356","DOI":"10.1016\/j.cub.2006.03.082","article-title":"Positive selection on gene expression in the human brain","volume":"16","author":"Khaitovich","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/gps.1903","article-title":"Methylenetetrahydrofolate reductase gene and risk of Alzheimer's disease in Koreans","volume":"23","author":"Kim","year":"2008","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000204766","article-title":"Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk","volume":"27","author":"Li","year":"2009","journal-title":"Dement. Geriatr. Cogn. Disord"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neurobiolaging.2008.05.013","article-title":"Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology","volume":"31","author":"Liang","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib29","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1073\/pnas.0709259105","article-title":"Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons","volume":"105","author":"Liang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib30","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib31","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer's disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib32","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3233\/JAD-2010-1410","article-title":"Translational research in genomics of Alzheimer's disease: a review of current practice and future perspectives","volume":"20","author":"Mihaescu","year":"2010","journal-title":"J. Alzheimers Dis"},{"issue":"Database issue","key":"10.1016\/j.neurobiolaging.2012.04.003_bib33","doi-asserted-by":"crossref","first-page":"D1002","DOI":"10.1093\/nar\/gkq1040","article-title":"ArrayExpress update\u2014an archive of microarray and high-throughput sequencing-based functional genomics experiments","volume":"39","author":"Parkinson","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1089\/106652702760138592","article-title":"A paradigm for class prediction using gene expression profiles","volume":"9","author":"Radmacher","year":"2002","journal-title":"J. Comput. Biol"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3233\/JAD-2009-0917","article-title":"Integrating gene expression and phenotypic information to analyze Alzheimer's disease","volume":"16","author":"Ray","year":"2009","journal-title":"J. Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nbd.2007.12.007","article-title":"Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease","volume":"30","author":"Reed","year":"2008","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib37","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes","volume":"101","author":"Su","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbadis.2009.09.013","article-title":"Abnormal mitochondrial dynamics and neurodegenerative diseases","volume":"1802","author":"Su","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib39","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.neurobiolaging.2005.09.021","article-title":"Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD","volume":"27","author":"Sultana","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib40","first-page":"269","article-title":"Ultrastructural studies in Alzheimer's presenile dementia","volume":"44","author":"Terry","year":"1964","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1474-9726.2007.00329.x","article-title":"Aging and regulated protein degradation: who has the UPPer hand?","volume":"6","author":"Vernace","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib42","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/nar\/gkq009","article-title":"Translation efficiency in humans: tissue specificity, global optimization and differences between developmental stages","volume":"38","author":"Waldman","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1385\/JMN:27:1:023","article-title":"Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease","volume":"27","author":"Wang","year":"2005","journal-title":"J. Mol. Neurosci"},{"issue":"suppl 1","key":"10.1016\/j.neurobiolaging.2012.04.003_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1471-4159.2009.05867.x","article-title":"The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease","volume":"109","author":"Wang","year":"2009","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib45","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2009.03.011","article-title":"Genetic control of human brain transcript expression in Alzheimer disease","volume":"84","author":"Webster","year":"2009","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2012.04.003_bib46","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3233\/JAD-2006-9207","article-title":"Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease","volume":"9","author":"Zhu","year":"2006","journal-title":"J. Alzheimers Dis"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458012002321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458012002321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T06:34:50Z","timestamp":1561703690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458012002321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0197458012002321"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2012.04.003","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}