{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:21:58Z","timestamp":1793496118055,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":318,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Medical Research Council (MRC)\/Wellcome Trust (WT)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.neurobiolaging.2012.04.006","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T08:14:59Z","timestamp":1337156099000},"page":"2231.e7-2231.e14","source":"Crossref","is-referenced-by-count":60,"title":["The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features"],"prefix":"10.1016","volume":"33","author":[{"given":"Eleanna","family":"Kara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Pittman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"de Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Holton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Xiromerisiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Houlden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Revesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/brain\/awm301","article-title":"Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophy","volume":"131","author":"Ahmed","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib2","doi-asserted-by":"crossref","first-page":"10626","DOI":"10.1021\/bi00158a027","article-title":"Structure and novel exons of the human tau gene","volume":"31","author":"Andreadis","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/jnen\/61.6.557","article-title":"Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles","volume":"61","author":"Augustinack","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1017\/S0317167100027499","article-title":"Late progression of post-encephalitic Parkinson's syndrome","volume":"15","author":"Calne","year":"1988","journal-title":"Can. J. Neurol. Sci"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib6","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/mds.21024","article-title":"Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: possible synergy of neurotoxins","volume":"21","author":"Caparros-Lefebvre","year":"2006","journal-title":"Mov. Disord"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ana.410410222","article-title":"Genetic evidence for the involvement of tau in progressive supranuclear palsy","volume":"41","author":"Conrad","year":"1997","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib8","doi-asserted-by":"crossref","first-page":"e31039","DOI":"10.1371\/journal.pone.0031039","article-title":"Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families","volume":"7","author":"Cruchaga","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1046\/j.1365-2990.2003.00463.x","article-title":"Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies","volume":"29","author":"de Silva","year":"2003","journal-title":"Neuropathol. Appl. Neurobiol"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib10","series-title":"Encephalitis Lethargica: Its Sequelae and Treatment","author":"Economo","year":"1931"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/brain\/116.1.281","article-title":"Pathological overlap in cases of parkinsonism associated with neurofibrillary tangles","volume":"116","author":"Geddes","year":"1993","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ng.859","article-title":"Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy","volume":"43","author":"H\u00f6glinger","year":"2011","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib13","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/WNL.56.12.1702","article-title":"Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype","volume":"56","author":"Houlden","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib14","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib16","series-title":"Greenfield's Neuropathology","first-page":"889","article-title":"Disorders of movement and system degenerations","author":"Ince","year":"2008"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib17","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1046\/j.1471-4159.1997.69052087.x","article-title":"A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease","volume":"69","author":"Jicha","year":"1997","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5414\/NPP30003","article-title":"Unclassifiable tauopathy associated with an A152T variation in MAPT exon 7","volume":"30","author":"Kovacs","year":"2011","journal-title":"Clin. Neuropathol"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00005072-199601000-00010","article-title":"Validity and reliability of the preliminary NINDS neuropathologic criteria for progressive supranuclear palsy and related disorders","volume":"55","author":"Litvan","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3940(02)00006-X","article-title":"The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease","volume":"320","author":"Mattila","year":"2002","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib21","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib22","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neurobiolaging.2007.07.013","article-title":"Clinical and pathological features of an Alzheimer's disease patient with the MAPT Delta K280 mutation","volume":"30","author":"Momeni","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.neuron.2004.10.023","article-title":"Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease","volume":"44","author":"Pais\u00e1n-Ru\u00edz","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib24","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/hmg\/ddh138","article-title":"The structure of the tau haplotype in controls and in progressive supranuclear palsy","volume":"13","author":"Pittman","year":"2004","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/humu.20086","article-title":"The role of tau (MAPT) in frontotemporal dementia and related tauopathies","volume":"24","author":"Rademakers","year":"2004","journal-title":"Hum. Mutat"},{"issue":"Suppl 12","key":"10.1016\/j.neurobiolaging.2012.04.006_bib26","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/mds.20547","article-title":"Parkinsonism-dementia complex of Guam","volume":"20","author":"Steele","year":"2005","journal-title":"Mov. Disord"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib27","first-page":"561","article-title":"Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study","volume":"31","author":"Tan","year":"2010","journal-title":"Hum. Mutat"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib28","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1073\/pnas.73.11.4070","article-title":"Tubulin requires tau for growth onto microtubule initiating sites","volume":"73","author":"Witman","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2012.04.006_bib30","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","year":"2010","journal-title":"Nature"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458012002357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458012002357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T07:20:50Z","timestamp":1542957650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458012002357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0197458012002357"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2012.04.006","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}