{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:06:06Z","timestamp":1792292766093,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.neurobiolaging.2013.05.003","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T16:19:26Z","timestamp":1370449166000},"page":"2564-2573","source":"Crossref","is-referenced-by-count":66,"title":["Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease"],"prefix":"10.1016","volume":"34","author":[{"given":"Anika","family":"Saul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Sprenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Bayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Wirths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuron.2010.10.013","article-title":"The genetics of Alzheimer disease: back to the future","volume":"68","author":"Bertram","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0014-4886(03)00252-8","article-title":"Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP\/PS1 transgenic mice","volume":"184","author":"Blanchard","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2174\/156720506779025242","article-title":"Pathways by which Abeta facilitates tau pathology","volume":"3","author":"Blurton-Jones","year":"2006","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib4","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.2353\/ajpath.2007.070403","article-title":"Induction of tau pathology by intracerebral infusion of amyloid-beta-containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice","volume":"171","author":"Bolmont","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0197-4580(97)00056-0","article-title":"Frequency of stages of Alzheimer-related lesions in different age categories","volume":"18","author":"Braak","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-010-0789-4","article-title":"The pathological process underlying Alzheimer's disease in individuals under thirty","volume":"121","author":"Braak","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00401-009-0539-7","article-title":"APP\/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy","volume":"117","author":"Breyhan","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1523\/JNEUROSCI.06-03-00714.1986","article-title":"Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture","volume":"6","author":"Caceres","year":"1986","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib9","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0002-9440(10)63388-3","article-title":"Massive CA1\/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model","volume":"165","author":"Casas","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib10","doi-asserted-by":"crossref","first-page":"17345","DOI":"10.1523\/JNEUROSCI.0172-12.2012","article-title":"Soluble abeta promotes wild-type tau pathology in\u00a0vivo","volume":"32","author":"Chabrier","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib11","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00401-008-0451-6","article-title":"Transient intraneuronal Abeta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP\/PS1KI mice","volume":"116","author":"Christensen","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"Duyckaerts","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0197-4580(97)00047-X","article-title":"Prevalence, incidence and duration of Braak's stages in the general population: can we know?","volume":"18","author":"Duyckaerts","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-007-0312-8","article-title":"Alzheimer disease models and human neuropathology: similarities and differences","volume":"115","author":"Duyckaerts","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib15","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1038\/cddis.2011.50","article-title":"Astrocytes are important mediators of Abeta-induced neurotoxicity and tau phosphorylation in primary culture","volume":"2","author":"Garwood","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib16","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib17","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1062097","article-title":"Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils","volume":"293","author":"Gotz","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1471-4159.2010.07118.x","article-title":"Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to gamma-secretase modulators regardless of their potency and structure","volume":"116","author":"Hahn","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0165-6147(91)90609-V","article-title":"Amyloid deposition as the central event in the aetiology of Alzheimer's disease","volume":"12","author":"Hardy","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib20","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","article-title":"Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration","volume":"68","author":"Hoover","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib21","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.2353\/ajpath.2010.100346","article-title":"A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model","volume":"177","author":"Hurtado","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib22","doi-asserted-by":"crossref","first-page":"196.e29","DOI":"10.1016\/j.neurobiolaging.2010.05.027","article-title":"Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer's disease","volume":"33","author":"Jawhar","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib23","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/j.ajpath.2011.06.025","article-title":"Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration","volume":"179","author":"Jaworski","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/(SICI)1097-4547(19970415)48:2<128::AID-JNR5>3.0.CO;2-E","article-title":"Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau","volume":"48","author":"Jicha","year":"1997","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature11283","article-title":"A\u00a0mutation in APP protects against Alzheimer's disease and age-related cognitive decline","volume":"488","author":"Jonsson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib26","doi-asserted-by":"crossref","first-page":"1518.e1","DOI":"10.1016\/j.neurobiolaging.2012.09.017","article-title":"Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population","volume":"34","author":"Kero","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib27","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1126\/science.1058189","article-title":"Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP","volume":"293","author":"Lewis","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib28","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.neuroscience.2004.09.029","article-title":"Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation","volume":"130","author":"Perez","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib31","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1073\/pnas.092136199","article-title":"Tau is essential to beta-amyloid-induced neurotoxicity","volume":"99","author":"Rapoport","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib32","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.nbd.2005.05.027","article-title":"Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP\/tau transgenic mice","volume":"20","author":"Ribe","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib33","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib34","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/jnr.20996","article-title":"Production of nerve growth factor by beta-amyloid-stimulated astrocytes induces p75NTR-dependent tau hyperphosphorylation in cultured hippocampal neurons","volume":"84","author":"Saez","year":"2006","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib35","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0002-9440(10)63235-X","article-title":"Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease","volume":"164","author":"Schmitz","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib36","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neurobiolaging.2003.09.009","article-title":"Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology","volume":"25","author":"Schonheit","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib37","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1523\/JNEUROSCI.5825-09.2010","article-title":"A\u00a0mouse model of amyloid-\u03b2 oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in\u00a0vivo","volume":"30","author":"Tomiyama","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0165-0270(99)00016-3","article-title":"A\u00a0method to quantify glial fibrillary acidic protein immunoreactivity on the suprachiasmatic nucleus","volume":"88","author":"Vilaplana","year":"1999","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib39","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0197-4580(00)00157-3","article-title":"Conformational change as one of the earliest alterations of tau in Alzheimer's disease","volume":"21","author":"Weaver","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib40","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neurobiolaging.2006.12.004","article-title":"Deficits in working memory and motor performance in the APP\/PS1ki mouse model for Alzheimer's disease","volume":"29","author":"Wirths","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib41","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1750-3639.2002.tb00442.x","article-title":"Intraneuronal APP\/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice","volume":"12","author":"Wirths","year":"2002","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neurobiolaging.2013.05.003_bib42","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458013002017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458013002017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T15:22:39Z","timestamp":1563117759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458013002017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0197458013002017"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.05.003","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}