{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:04:07Z","timestamp":1793351047880,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000943","name":"Australian Commonwealth Scientific Industrial and research Organization","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000943","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001798","name":"Edith Cowan University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001798","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mental Health Research institute (MHRI), Alzheimer's Australia"},{"name":"National Ageing Research Institute"},{"name":"Austin Health, CogState Ltd."},{"name":"Hollywood Private Hospital"},{"name":"Sir Charles Gardner Hospital"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002986","name":"Dementia Collaborative Research Centres","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002986","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008716","name":"Science and Industry Endowment Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008716","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.neurobiolaging.2013.05.006","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T02:01:50Z","timestamp":1371002510000},"page":"2457-2464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"title":["BDNF Val66Met, A\u03b2 amyloid, and cognitive decline in preclinical Alzheimer's disease"],"prefix":"10.1016","volume":"34","author":[{"given":"Yen Ying","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Laws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Pietrzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karra D.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bourgeat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Salvado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Darby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley I.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep J.","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1037\/0894-4105.21.2.158","article-title":"Longitudinal change in cognitive performance among individuals with mild cognitive impairment","volume":"21","author":"Albert","year":"2007","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/archneurol.2009.307","article-title":"Effects of aerobic exercise on mild cognitive impairment: a controlled trial","volume":"67","author":"Baker","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nature Genet."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib5","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/gps.3875","article-title":"Sociodemographic characteristics, clinical factors, and genetic polymorphisms associated with Alzheimer's disease","volume":"28","author":"Bicalho","year":"2012","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopsych.2005.09.022","article-title":"BDNF Val66Met\u00a0allele is associated with reduced hippocampal volume in healthy subjects","volume":"59","author":"Bueller","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib7","doi-asserted-by":"crossref","first-page":"22687","DOI":"10.1073\/pnas.1012851108","article-title":"CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease","volume":"107","author":"Caccamo","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/brain\/awq383","article-title":"Independent contribution of temporal \u03b2-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease","volume":"134","author":"Ch\u00e9telat","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1212\/WNL.0b013e318246d67a","article-title":"Accelerated cortical atrophy in cognitively normal elderly with high \u03b2-amyloid deposition","volume":"78","author":"Ch\u00e9telat","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0169-328X(97)00125-3","article-title":"Brain-derived neurotrophic factor is reduced in Alzheimer's disease","volume":"49","author":"Connor","year":"1997","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2007.06.011","article-title":"Exercise builds brain health: key roles of growth factor cascades and inflammation","volume":"30","author":"Cotman","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/hipo.20809","article-title":"Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks","volume":"21","author":"Dennis","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib14","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1017\/S1041610209009405","article-title":"The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease","volume":"21","author":"Ellis","year":"2009","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2217\/fnl.11.44","article-title":"Brain-derived neurotrophic factor: the link between amyloid-\u03b2 and memory loss","volume":"6","author":"Fahnestock","year":"2011","journal-title":"Future Neurol."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ajmg.b.30986","article-title":"Sexually dimorphic effect of the val66met polymorphism of BDNF on susceptibility to Alzheimer's disease: new data and meta-analysis","volume":"153B","author":"Fukumoto","year":"2010","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib17","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1523\/JNEUROSCI.5053-06.2007","article-title":"Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells","volume":"27","author":"Garzon","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib18","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003","article-title":"Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance","volume":"23","author":"Hariri","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.mp.4001799","article-title":"The brain-derived neurotrophic factor val66met polymorphism is associated with age-related change in reasoning skills","volume":"11","author":"Harris","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib20","doi-asserted-by":"crossref","unstructured":"Intlekofer, K.A., Cotman, C.W. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol. Dis. epub ahead of print. http:\/\/dx.doi.org\/10.1016\/j.nbd.2012.06.011.","DOI":"10.1016\/j.nbd.2012.06.011"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awm336","article-title":"11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment","volume":"131","author":"Jack","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib22","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/brain\/awp062","article-title":"Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: Implications for sequence of pathological events in Alzheimer's disease","volume":"132","author":"Jack","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ana.23588","article-title":"miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model","volume":"72","author":"Lee","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib24","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1212\/WNL.0b013e31826e9ae6","article-title":"Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults","volume":"79","author":"Lim","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib25","series-title":"The Biology of Alzheimer Disease","first-page":"181","article-title":"Biochemistry of amyloid \u03b2-protein and amyloid deposits in Alzheimer Disease","author":"Masters","year":"2012"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00702-004-0210-3","article-title":"Brain-derived neurotrophic factor gene polymorphisms and sporadic Alzheimer's disease","volume":"112","author":"Matsushita","year":"2005","journal-title":"J.\u00a0Neur. Transm."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000339358","article-title":"Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease","volume":"33","author":"Nagata","year":"2012","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib28","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","article-title":"Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the preclinical stages of Alzheimer's disease","volume":"93","author":"Peng","year":"2005","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib29","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.neurobiolaging.2010.04.007","article-title":"Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging","volume":"31","author":"Rowe","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib30","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/mp.2009.64","article-title":"BDNF modulates normal human hippocampal ageing","volume":"15","author":"Sambataro","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging and the Alzheimer's Association workgroup","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/sj.mp.4000952","article-title":"Association between the BDNF 196 A\/G polymorphism and sporadic Alzheimer's disease","volume":"7","author":"Ventriglia","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib33","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1093\/brain\/aws125","article-title":"Regional dynamics of amyloid-\u03b2 deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB\u2013PET longitudinal study","volume":"135","author":"Villain","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib34","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.22248","article-title":"Longitudinal assessment of A\u03b2 and cognition in aging and Alzheimer disease","volume":"69","author":"Villemagne","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib35","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1001\/archgenpsychiatry.2010.194","article-title":"The brain-derived neurotrophic factor val66met polymorphism and prediction of neural risk for Alzheimer disease","volume":"68","author":"Voineskos","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2013.05.006_bib36","first-page":"802","article-title":"Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease","volume":"21","author":"Xu","year":"2010","journal-title":"Mol. Neurosci."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458013002042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458013002042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:20:27Z","timestamp":1759317627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458013002042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0197458013002042"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.05.006","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BDNF Val66Met, A\u03b2 amyloid, and cognitive decline in preclinical Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}