{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:16:52Z","timestamp":1793146612136,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006020","name":"Center for Translational Molecular Medicine","doi-asserted-by":"crossref","award":["02N-101"],"award-info":[{"award-number":["02N-101"]}],"id":[{"id":"10.13039\/501100006020","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008398","name":"Internationale Stichting Alzheimer Onderzoek","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008398","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Joint Programming Neurodegenerative Disease"},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Alzheimer Association"},{"name":"Van Alkemade Keuls fonds"},{"DOI":"10.13039\/501100006020","name":"Center for Translational Molecular Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006020","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.neurobiolaging.2013.07.005","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T20:00:17Z","timestamp":1376769617000},"page":"152-158","source":"Crossref","is-referenced-by-count":205,"title":["MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid"],"prefix":"10.1016","volume":"35","author":[{"given":"Mareike","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bea","family":"Kuiperij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen A.","family":"Claassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"K\u00fcsters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel M.","family":"Verbeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib1","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1182\/blood-2010-09-308684","article-title":"Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system","volume":"117","author":"Baraniskin","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/neuonc\/nor169","article-title":"Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma","volume":"14","author":"Baraniskin","year":"2012","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib4","doi-asserted-by":"crossref","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","article-title":"Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease","volume":"285","author":"Cui","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mrfmmm.2011.03.004","article-title":"Extracellular microRNA: a new source of biomarkers","volume":"717","author":"Etheridge","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12031-012-9731-7","article-title":"In\u00a0vivo microRNA detection and quantitation in cerebrospinal fluid","volume":"47","author":"Gallego","year":"2012","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib7","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/sj.bjc.6606076","article-title":"The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis","volume":"104","author":"Gee","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib8","doi-asserted-by":"crossref","DOI":"10.3791\/3874","article-title":"MicroRNA detection in prostate tumors by quantitative real-time PCR (qPCR)","author":"Gordanpour","year":"2012","journal-title":"J.\u00a0Vis. Exp. 63"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib9","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.urolonc.2009.01.027","article-title":"A\u00a0robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer","volume":"28","author":"Hanke","year":"2010","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib10","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer's disease correlates with increased BACE1\/\u03b2-secretase expression","volume":"105","author":"H\u00e9bert","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nsmb.1762","article-title":"MicroRNA assassins: factors that regulate the disappearance of miRNAs","volume":"17","author":"Kai","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.cell.2010.03.039","article-title":"Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs","volume":"141","author":"Krol","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2011.05.044","article-title":"Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells","volume":"499","author":"Li","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib14","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.neurobiolaging.2010.04.034","article-title":"MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice","volume":"33","author":"Liu","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/WNR.0b013e3280148e8b","article-title":"Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus","volume":"18","author":"Lukiw","year":"2007","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib16","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/WNR.0b013e32835542b0","article-title":"Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA","volume":"23","author":"Lukiw","year":"2012","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib17","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jinorgbio.2007.06.004","article-title":"Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells","volume":"101","author":"Lukiw","year":"2007","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib18","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.M805371200","article-title":"An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells","volume":"283","author":"Lukiw","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib20","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1523\/JNEUROSCI.0027-10.2010","article-title":"SIRT1 is essential for normal cognitive function and synaptic plasticity","volume":"30","author":"Michan","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib21","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-2010-091603","article-title":"MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study","volume":"21","author":"Nelson","year":"2010","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib23","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1158\/1078-0432.CCR-09-0736","article-title":"Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection","volume":"15","author":"Park","year":"2009","journal-title":"Clin. Cancer Res."},{"issue":"suppl 1","key":"10.1016\/j.neurobiolaging.2013.07.005_bib24","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1186\/1755-8794-6-S1-S14","article-title":"A\u00a0novel method for the normalization of microRNA RT-PCR data","volume":"6","author":"Qureshi","year":"2013","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib25","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.molcel.2011.08.021","article-title":"MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes","volume":"43","author":"Rissland","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib26","first-page":"263","article-title":"MicroRNA expression in Alzheimer blood mononuclear cells","volume":"1","author":"Schipper","year":"2007","journal-title":"Gene Regul. Syst. Biol."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2009.04.052","article-title":"Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex","volume":"459","author":"Sethi","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21610","article-title":"Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects","volume":"65","author":"Shaw","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1471-4159.2010.07097.x","article-title":"In\u00a0vivo regulation of amyloid precursor protein neuronal splicing by microRNAs","volume":"116","author":"Smith","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib30","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10620-011-1981-7","article-title":"Identification of suitable reference genes for qPCR analysis of serum microRNA in gastric cancer patients","volume":"57","author":"Song","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib31","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/neuonc\/nos074","article-title":"MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity","volume":"14","author":"Teplyuk","year":"2012","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib32","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1093\/nar\/gkr254","article-title":"Characterization of extracellular circulating microRNA","volume":"39","author":"Turchinovich","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1126\/science.1139089","article-title":"Control of stress-dependent cardiac growth and gene expression by a microRNA","volume":"316","author":"van Rooij","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.mehy.2011.11.019","article-title":"The potential role of microRNA-146 in Alzheimer's disease: biomarker or therapeutic target?","volume":"78","author":"Wang","year":"2012","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00401-010-0756-0","article-title":"Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter","volume":"121","author":"Wang","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib36","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1523\/JNEUROSCI.5065-07.2008","article-title":"The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1","volume":"28","author":"Wang","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00702-008-0177-6","article-title":"Combined CSF tau, p-tau181 and amyloid-beta 38\/40\/42 for diagnosing Alzheimer's disease","volume":"116","author":"Welge","year":"2009","journal-title":"J.\u00a0Neural. Transm."},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib38","doi-asserted-by":"crossref","first-page":"e15546","DOI":"10.1371\/journal.pone.0015546","article-title":"MicroRNA-related cofilin abnormality in Alzheimer's disease","volume":"5","author":"Yao","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.neurobiolaging.2013.07.005_bib39","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1038\/emboj.2011.327","article-title":"microRNA-34c is a novel target to treat dementias","volume":"30","author":"Zovoilis","year":"2011","journal-title":"EMBO J."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458013003102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458013003102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T02:09:22Z","timestamp":1646359762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458013003102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0197458013003102"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.07.005","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}