{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:28:35Z","timestamp":1767904115156,"version":"3.49.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institute of Children Health and Human Development","award":["HD02274"],"award-info":[{"award-number":["HD02274"]}]},{"name":"National Institute of Children Health and Human Development","award":["HD036071"],"award-info":[{"award-number":["HD036071"]}]},{"name":"National Institute of Health","award":["1 P01 ES11269"],"award-info":[{"award-number":["1 P01 ES11269"]}]},{"name":"National Institute of Health","award":["R01 ES 015359"],"award-info":[{"award-number":["R01 ES 015359"]}]},{"name":"U.S. Environmental Protection Agency through the Science to Achieve Results","award":["R829388"],"award-info":[{"award-number":["R829388"]}]},{"name":"U.S. Environmental Protection Agency through the Science to Achieve Results","award":["R833292"],"award-info":[{"award-number":["R833292"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1 TR000002"],"award-info":[{"award-number":["UL1 TR000002"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.neurobiolaging.2013.11.009","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T09:24:51Z","timestamp":1384593891000},"page":"1189-1197","source":"Crossref","is-referenced-by-count":33,"title":["Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor\/ataxia syndrome"],"prefix":"10.1016","volume":"35","author":[{"given":"Dalyir I.","family":"Pretto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhur","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-224X","authenticated-orcid":false,"given":"Zhengyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blythe","family":"Durbin-Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Berman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Noctor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randi J.","family":"Hagerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac N.","family":"Pessah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10519-005-2792-4","article-title":"Examination of the effect of the polymorphic CGG repeat in the FMR1 gene on cognitive performance","volume":"35","author":"Allen","year":"2005","journal-title":"Behav. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib2","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1073\/pnas.94.8.4155","article-title":"Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance","volume":"94","author":"Arriza","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/jn.00449.2010","article-title":"Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis","volume":"104","author":"Auerbach","year":"2010","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4088\/JCP.v67n0112","article-title":"Psychiatric phenotype of the fragile X-associated tremor\/ataxia syndrome (FXTAS) in males: newly described fronto-subcortical dementia","volume":"67","author":"Bacalman","year":"2006","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib5","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1172\/JCI63141","article-title":"Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics","volume":"122","author":"Bagni","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","article-title":"The mGluR theory of fragile X mental retardation","volume":"27","author":"Bear","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1601-183X.2005.00135.x","article-title":"Therapeutic implications of the mGluR theory of fragile X mental retardation","volume":"4","author":"Bear","year":"2005","journal-title":"Genes Brain Behav."},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2013.11.009_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1528-1167.2012.03486.x","article-title":"Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation","volume":"53","author":"Berman","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib9","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1093\/hmg\/dds118","article-title":"Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone","volume":"21","author":"Cao","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib10","doi-asserted-by":"crossref","first-page":"13831","DOI":"10.1074\/jbc.M112.441055","article-title":"Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion","volume":"288","author":"Cao","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/hmg\/ddp479","article-title":"Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration","volume":"19","author":"Chen","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib12","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ajhg.2009.09.007","article-title":"Incidence of fragile X syndrome by newborn screening for methylated FMR1 DNA","volume":"85","author":"Coffee","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0079-6123(08)60428-8","article-title":"Properties and localization of glutamate transporters","volume":"116","author":"Danbolt","year":"1998","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/978-3-7091-0932-8_23","article-title":"Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation\/s to spine dysmorphogenesis","volume":"970","author":"De Rubeis","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archneurol.2008.535","article-title":"Episodic ataxia associated with\u00a0EAAT1 mutation C186S affecting glutamate reuptake","volume":"66","author":"de Vries","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nlm.2011.12.006","article-title":"Female CGG knock-in mice modeling the fragile X premutation are impaired on a skilled forelimb reaching task","volume":"97","author":"Diep","year":"2012","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/375599a0","article-title":"An excitatory amino-acid transporter with properties of a ligand-gated chloride channel","volume":"375","author":"Fairman","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2353\/jmoldx.2009.080173","article-title":"Screening for expanded alleles of the FMR1 gene in blood spots from newborn males in a Spanish population","volume":"11","author":"Fernandez-Carvajal","year":"2009","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1373\/clinchem.2009.136101","article-title":"A\u00a0novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome","volume":"56","author":"Filipovic-Sadic","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/hmg\/ddp497","article-title":"Fibroblast phenotype in male carriers of FMR1 premutation alleles","volume":"19","author":"Garcia-Arocena","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib22","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1093\/brain\/awf184","article-title":"Neuronal intranuclear inclusions in a new cerebellar tremor\/ataxia syndrome among fragile X carriers","volume":"125","author":"Greco","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/brain\/awh683","article-title":"Neuropathology of fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"129","author":"Greco","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/mgme.2001.3225","article-title":"Fragile X syndrome: a model of gene-brain-behavior relationships","volume":"74","author":"Hagerman","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.57.1.127","article-title":"Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X","volume":"57","author":"Hagerman","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2147\/CIA.S1794","article-title":"Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems","volume":"3","author":"Hagerman","year":"2008","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib27","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1093\/hmg\/ddt055","article-title":"Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse","volume":"22","author":"Higashimori","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbr.2011.03.039","article-title":"Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice","volume":"222","author":"Hunsaker","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib29","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/hmg\/dds525","article-title":"Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in fragile X premutation mice","volume":"22","author":"Iliff","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib30","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/cercor\/10.10.1038","article-title":"Dendritic spine structural anomalies in fragile-X mental retardation syndrome","volume":"10","author":"Irwin","year":"2000","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib31","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.291.4.460","article-title":"Penetrance of the fragile X-associated tremor\/ataxia syndrome in a premutation carrier population","volume":"291","author":"Jacquemont","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002804","article-title":"Translating glutamate: from pathophysiology to treatment","volume":"3","author":"Javitt","year":"2011","journal-title":"Sci. Transl Med."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib33","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1212\/01.WNL.0000172638.58172.5a","article-title":"Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures","volume":"65","author":"Jen","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/360467a0","article-title":"Primary structure and functional characterization of a high-affinity glutamate transporter","volume":"360","author":"Kanai","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib35","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1093\/hmg\/10.14.1449","article-title":"Reduced FMRP and increased FMR1 transcription is proportionally associated with CGG repeat number in intermediate-length and premutation carriers","volume":"10","author":"Kenneson","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib36","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/01.wnl.0000281692.98200.f5","article-title":"FMR1 CGG repeat length predicts motor dysfunction in premutation carriers","volume":"70","author":"Leehey","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/B978-0-444-51892-7.00023-1","article-title":"Fragile X-associated tremor\/ataxia syndrome","volume":"103","author":"Leehey","year":"2012","journal-title":"Handb Clin. Neurol."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib38","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.1523\/JNEUROSCI.18-21-08751.1998","article-title":"The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain","volume":"18","author":"Lehre","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib39","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1093\/hmg\/dds207","article-title":"Signaling defects in iPSC-derived fragile X premutation neurons","volume":"21","author":"Liu","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1017\/S1740925X0700066X","article-title":"Cerebellar Bergmann glia: an important model to study neuron-glia interactions","volume":"3","author":"Lopez-Bayghen","year":"2007","journal-title":"Neuron Glia Biol."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib41","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2174\/18744672113069990033","article-title":"SLC1 glutamate transporters and diseases: psychiatric diseases and pathological pain","volume":"6","author":"Nakagawa","year":"2013","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib42","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.biopsych.2012.09.017","article-title":"Lifting the mood on treating fragile X","volume":"72","author":"Osterweil","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib43","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/jhg.2009.121","article-title":"Examination of FMR1 transcript and protein levels among 74 premutation carriers","volume":"55","author":"Peprah","year":"2010","journal-title":"J.\u00a0Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib44","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(91)90125-I","article-title":"Absence of expression of the FMR-1 gene in fragile X syndrome","volume":"66","author":"Pieretti","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib45","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/360464a0","article-title":"Cloning and expression of a rat brain L-glutamate transporter","volume":"360","author":"Pines","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib46","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1523\/JNEUROSCI.1081-09.2009","article-title":"Glutamate transporter coupling to Na,K-ATPase","volume":"29","author":"Rose","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib47","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/emboj.2010.21","article-title":"Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients","volume":"29","author":"Sellier","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib48","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.celrep.2013.02.004","article-title":"Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor\/ataxia syndrome","volume":"3","author":"Sellier","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1756-6606-6-15","article-title":"Fragile X mental retardation protein and synaptic plasticity","volume":"6","author":"Sidorov","year":"2013","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib50","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1073\/pnas.89.22.10955","article-title":"Structure, expression, and functional analysis of a Na(+)-dependent glutamate\/aspartate transporter from rat brain","volume":"89","author":"Storck","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0168-0102(93)90082-2","article-title":"Expression cloning of a rat glutamate transporter","volume":"16","author":"Tanaka","year":"1993","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0304-3940(93)90829-A","article-title":"Cloning and expression of a glutamate transporter from mouse brain","volume":"159","author":"Tanaka","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib53","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1086\/302720","article-title":"Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome","volume":"66","author":"Tassone","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib54","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1136\/jmg.2003.012518","article-title":"Intranuclear inclusions in neural cells with premutation alleles in fragile X associated tremor\/ataxia syndrome","volume":"41","author":"Tassone","year":"2004","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4161\/rna.1.2.1035","article-title":"FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"1","author":"Tassone","year":"2004","journal-title":"RNA Biol."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2353\/jmoldx.2008.070073","article-title":"A\u00a0rapid polymerase chain reaction-based screening method for identification of all expanded alleles of the fragile X (FMR1) gene in newborn and high-risk populations","volume":"10","author":"Tassone","year":"2008","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib57","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/gm401","article-title":"FMR1 CGG allele size and prevalence ascertained through newborn screening in the United States","volume":"4","author":"Tassone","year":"2012","journal-title":"Genome Med."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib58","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1046\/j.1471-4159.2001.00087.x","article-title":"Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid","volume":"76","author":"Ueda","year":"2001","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib59","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2005.03.007","article-title":"Cognitive decline, neuromotor and behavioural disturbances in a mouse model for fragile-X-associated tremor\/ataxia syndrome (FXTAS)","volume":"162","author":"Van Dam","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2013.11.009_bib60","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/glia.20139","article-title":"Glial glutamate transporter expression patterns in brains from multiple mammalian species","volume":"49","author":"Williams","year":"2005","journal-title":"Glia"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458013005770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458013005770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T03:00:19Z","timestamp":1596855619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458013005770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0197458013005770"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.11.009","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}