{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T05:38:30Z","timestamp":1672897110562},"reference-count":89,"publisher":"Elsevier BV","issue":"9","content-domain":{"domain":["patient-research.elsevier.com","neurobiologyofaging.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.neurobiolaging.2014.02.024","type":"journal-article","created":{"date-parts":[[2014,3,2]],"date-time":"2014-03-02T03:02:58Z","timestamp":1393729378000},"page":"2029-2038","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reverse engineering of Alzheimer's disease based on biomarker pathways analysis"],"prefix":"10.1016","volume":"35","author":[{"given":"Joanna L.","family":"Richens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"O'Shea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/1354750X.2010.536995","article-title":"Combined measurement of PEDF, haptoglobin and tau in cerebrospinal fluid improves the diagnostic discrimination between Alzheimer's disease and other dementias","volume":"16","author":"Abraham","year":"2011","journal-title":"Biomarkers"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.imbio.2011.07.023","article-title":"Complement activation as a biomarker for Alzheimer's disease","volume":"217","author":"Aiyaz","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib3","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1074\/mcp.R200007-MCP200","article-title":"The human plasma proteome: history, character, and diagnostic prospects","volume":"1","author":"Anderson","year":"2002","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1074\/mcp.M300127-MCP200","article-title":"The human plasma proteome: a nonredundant list developed by combination of four separate sources","volume":"3","author":"Anderson","year":"2004","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib5","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1021\/pr3001546","article-title":"Label-free quantitative LC-MS proteomics of Alzheimer's disease and normally aged human brains","volume":"11","author":"Andreev","year":"2012","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib6","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1111\/j.1471-4159.2009.06412.x","article-title":"Amyloid beta serves as an NGF-like neurotrophic factor or acts as a NGF antagonist depending on its concentration","volume":"111","author":"Arevalo","year":"2009","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib7","doi-asserted-by":"crossref","first-page":"e54662","DOI":"10.1371\/journal.pone.0054662","article-title":"Urinary microRNA profiling in the nephropathy of type 1 diabetes","volume":"8","author":"Argyropoulos","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00439-010-0924-2","article-title":"Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease","volume":"129","author":"Belbin","year":"2011","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuron.2010.10.013","article-title":"The genetics of Alzheimer disease: back to the future","volume":"68","author":"Bertram","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exger.2009.08.004","article-title":"Blood cell markers in Alzheimer Disease: amyloid precursor protein form ratio in platelets","volume":"45","author":"Borroni","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/NEN.0b013e3181aed9e6","article-title":"Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease","volume":"68","author":"Bruno","year":"2009","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature09788","article-title":"Caspase signalling controls microglia activation and neurotoxicity","volume":"472","author":"Burguillos","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1755-5949.2009.00115.x","article-title":"TGF-beta1 pathway as a new target for neuroprotection in Alzheimer's disease","volume":"17","author":"Caraci","year":"2009","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3233\/JAD-2011-101932","article-title":"Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions","volume":"24","author":"Carrasquillo","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib15","first-page":"2181","article-title":"Plasma level of chitinase 3-like 1 protein increases in patients with early Alzheimer's disease","volume":"258","author":"Choi","year":"2011","journal-title":"J.\u00a0Neurol."},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2014.02.024_bib16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1538-7836.2009.03376.x","article-title":"Fibrinogen, a possible key player in Alzheimer's disease","volume":"7","author":"Cortes-Canteli","year":"2009","journal-title":"J.\u00a0Thromb. Haemost."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib17","doi-asserted-by":"crossref","first-page":"e18850","DOI":"10.1371\/journal.pone.0018850","article-title":"Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis","volume":"6","author":"Craig-Schapiro","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-62703-450-0_14","article-title":"Building models using reactome pathways as templates","volume":"1021","author":"Croft","year":"2013","journal-title":"Methods Mol. Biol."},{"issue":"Database issue","key":"10.1016\/j.neurobiolaging.2014.02.024_bib19","doi-asserted-by":"crossref","first-page":"D691","DOI":"10.1093\/nar\/gkq1018","article-title":"Reactome: a database of reactions, pathways and biological processes","volume":"39","author":"Croft","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.chembiol.2013.03.018","article-title":"Pathway databases: making chemical and biological sense of the genomic data flood","volume":"20","author":"D'Eustachio","year":"2013","journal-title":"Chem. Biol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib21","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2174\/187152710793237458","article-title":"Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease","volume":"9","author":"da Cruz e Silva","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.embor.7400897","article-title":"Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease","volume":"8","author":"De Strooper","year":"2007","journal-title":"EMBO Rep."},{"issue":"Suppl 2","key":"10.1016\/j.neurobiolaging.2014.02.024_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3233\/JAD-2011-110017","article-title":"BACE1 as a potential biomarker for Alzheimer's disease","volume":"24","author":"Decourt","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3233\/JAD-2011-111007","article-title":"CSF Abeta1-42 levels and glucose metabolism in Alzheimer's disease","volume":"27","author":"Dumurgier","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3233\/JAD-2011-091153","article-title":"Increased CSF-BACE1 activity associated with decreased hippocampus volume in Alzheimer's disease","volume":"25","author":"Ewers","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.exger.2009.09.005","article-title":"Blood-based biomarkers of microvascular pathology in Alzheimer's disease","volume":"45","author":"Ewers","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/157488408784293723","article-title":"Amyloid beta protein and tau in cerebrospinal fluid and plasma as biomarkers for dementia: a review of recent literature","volume":"3","author":"Frankfort","year":"2008","journal-title":"Curr. clin. pharmacol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib28","first-page":"1775","article-title":"[Serum proteomic analysis on metastasis-associated proteins of hepatocellular carcinoma]","volume":"29","author":"Fu","year":"2009","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2105-11-56","article-title":"Biana: a software framework for compiling biological interactions and analyzing networks","volume":"11","author":"Garcia-Garcia","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib30","doi-asserted-by":"crossref","first-page":"9290","DOI":"10.1074\/jbc.M211899200","article-title":"Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway","volume":"278","author":"Gianni","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JAD-2009-1055","article-title":"Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes","volume":"17","author":"Golanska","year":"2009","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib32","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3233\/JAD-2011-110884","article-title":"Amyloid-beta42 activates the expression of BACE1 through the JNK pathway","volume":"27","author":"Guglielmotto","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exger.2009.10.010","article-title":"Total and phosphorylated tau protein as biological markers of Alzheimer's disease","volume":"45","author":"Hampel","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib34","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib35","doi-asserted-by":"crossref","first-page":"982","DOI":"10.2174\/156720512803251156","article-title":"Matrix Metalloproteinase-2 and epidermal growth factor are decreased in platelets of Alzheimer patients","volume":"9","author":"Hochstrasser","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/gps.2628","article-title":"Alzheimer's disease genetics: current knowledge and future challenges","volume":"26","author":"Hollingworth","year":"2011","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib37","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-62703-107-3_11","article-title":"Analysis strategy of protein-protein interaction networks","volume":"939","author":"Hu","year":"2013","journal-title":"Methods Mol. Biol."},{"issue":"Web Server issue","key":"10.1016\/j.neurobiolaging.2014.02.024_bib39","doi-asserted-by":"crossref","first-page":"W225","DOI":"10.1093\/nar\/gkt401","article-title":"VisANT 4.0: integrative network platform to connect genes, drugs, diseases and therapies","volume":"41","author":"Hu","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"10.1016\/j.neurobiolaging.2014.02.024_bib40","doi-asserted-by":"crossref","first-page":"W115","DOI":"10.1093\/nar\/gkp406","article-title":"VisANT 3.5: multi-scale network visualization, analysis and inference based on the gene ontology","volume":"37","author":"Hu","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"Pt 11","key":"10.1016\/j.neurobiolaging.2014.02.024_bib41","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1093\/brain\/awl279","article-title":"Proteome-based plasma biomarkers for Alzheimer's disease","volume":"129","author":"Hye","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/JAD-2009-1062","article-title":"Altered subcellular distribution of c-Abl in Alzheimer's disease","volume":"17","author":"Jing","year":"2009","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib43","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.005751","article-title":"Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome","volume":"10","author":"Johnson","year":"2011","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib44","doi-asserted-by":"crossref","first-page":"e13950","DOI":"10.1371\/journal.pone.0013950","article-title":"Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease","volume":"5","author":"Jones","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/bioinformatics\/btm536","article-title":"MetaNetter: inference and visualization of high-resolution metabolomic networks","volume":"24","author":"Jourdan","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1559-0275-10-6","article-title":"Protein expression profiling of nuclear membrane protein reveals potential biomarker of human hepatocellular carcinoma","volume":"10","author":"Khan","year":"2013","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib47","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib48","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/hmg\/dds491","article-title":"Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis","volume":"22","author":"Lee","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neulet.2011.08.057","article-title":"The vitamin D receptor gene is associated with Alzheimer's disease","volume":"504","author":"Lehmann","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib50","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/bioinformatics\/btn061","article-title":"In silico Biochemical Reaction Network Analysis (IBRENA): a package for simulation and analysis of reaction networks","volume":"24","author":"Liu","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib51","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neurobiolaging.2009.03.011","article-title":"Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease","volume":"32","author":"Marksteiner","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jocn.2009.05.037","article-title":"Increased acidic fibroblast growth factor concentrations in the serum and cerebrospinal fluid of patients with Alzheimer's disease","volume":"17","author":"Mashayekhi","year":"2010","journal-title":"J.\u00a0Clin. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib53","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0197-4580(95)00050-O","article-title":"PDGF is associated with neuronal and glial alterations of Alzheimer's disease","volume":"16","author":"Masliah","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib54","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1073\/pnas.0904998106","article-title":"Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation","volume":"106","author":"Matrone","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib55","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/01.jnen.0000229238.05748.12","article-title":"Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels","volume":"65","author":"Matsui","year":"2006","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib56","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/jama.2009.1064","article-title":"CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment","volume":"302","author":"Mattsson","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib57","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/nar\/30.1.306","article-title":"Predictome: a database of putative functional links between proteins","volume":"30","author":"Mellor","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib58","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3233\/JAD-2011-101551","article-title":"CSF amyloid-beta peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease","volume":"24","author":"Mollenhauer","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-2990.2011.01181.x","article-title":"Commentary: the three new pathways leading to Alzheimer's disease","volume":"37","author":"Morgan","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib60","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib61","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s10571-011-9688-z","article-title":"Gamma-secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease","volume":"31","author":"Nakayama","year":"2011","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib62","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s12017-008-8035-0","article-title":"Maximizing the potential of plasma amyloid-beta as a diagnostic biomarker for Alzheimer's disease","volume":"10","author":"Oh","year":"2008","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib63","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/S0140-6736(12)60476-0","article-title":"Future medicine shaped by an interdisciplinary new biology","volume":"379","author":"O'Shea","year":"2012","journal-title":"The Lancet"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib64","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1515\/CCLM.2011.087","article-title":"Amyloid beta (Abeta) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer's disease","volume":"49","author":"Prvulovic","year":"2011","journal-title":"Clin. Chem. Lab Med."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib65","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm1653","article-title":"Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins","volume":"13","author":"Ray","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1465-9921-10-29","article-title":"Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease","volume":"10","author":"Richens","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib66","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1021\/pr900487y","article-title":"Avoiding nonspecific interactions in studies of the plasma proteome: practical solutions to prevention of nonspecific interactions for label-free detection of low-abundance plasma proteins","volume":"8","author":"Richens","year":"2009","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib68","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1001\/archneurol.2011.642","article-title":"Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations","volume":"69","author":"Ringman","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib69","doi-asserted-by":"crossref","first-page":"35282","DOI":"10.1074\/jbc.M110785200","article-title":"Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc\/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain","volume":"277","author":"Russo","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib70","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/archgenpsychiatry.2010.196","article-title":"The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels","volume":"68","author":"Schjeide","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib71","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"Seshadri","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2004.11.013","article-title":"Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes","volume":"27","author":"Strekalova","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11682-011-9136-1","article-title":"Amyloid\u00a0pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort","volume":"6","author":"Swaminathan","year":"2012","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib74","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.expneurol.2004.07.009","article-title":"Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease","volume":"190","author":"Tacconi","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib75","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ana.22448","article-title":"Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease","volume":"70","author":"Tarawneh","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib76","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/archgenpsychiatry.2010.78","article-title":"Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease","volume":"67","author":"Thambisetty","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib77","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00005072-199903000-00009","article-title":"Evidence for neuroprotective effects of acidic fibroblast growth factor in Alzheimer disease","volume":"58","author":"Thorns","year":"1999","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib78","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3233\/JAD-2011-111505","article-title":"Identification of SPARC-like 1 protein as part of a biomarker panel for Alzheimer's disease in cerebrospinal fluid","volume":"28","author":"Vafadar-Isfahani","year":"2012","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib79","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1515\/CCLM.2011.086","article-title":"Tau and p-tau as CSF biomarkers in dementia: a meta-analysis","volume":"49","author":"van Harten","year":"2011","journal-title":"Clin. Chem. Lab Med."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib80","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/ana.20593","article-title":"APOA1 polymorphism influences risk for early-onset nonfamiliar AD","volume":"58","author":"Vollbach","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib81","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1471-4159.2004.02858.x","article-title":"Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42\/40 ratios","volume":"92","author":"Walker","year":"2005","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib82","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cca.2010.10.015","article-title":"A\u00a0single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese population","volume":"412","author":"Wang","year":"2011","journal-title":"Clin. Chim. Acta"},{"issue":"Web Server issue","key":"10.1016\/j.neurobiolaging.2014.02.024_bib83","doi-asserted-by":"crossref","first-page":"W124","DOI":"10.1093\/nar\/gkq499","article-title":"PINT: pathways INtegration tool","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib84","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.bbrc.2009.10.093","article-title":"Alzheimer's disease and notch signaling","volume":"390","author":"Woo","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib85","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neurobiolaging.2005.12.002","article-title":"Alpha2beta1 and alphaVbeta1 integrin signaling pathways mediate amyloid-beta-induced neurotoxicity","volume":"28","author":"Wright","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib86","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bbrc.2004.06.142","article-title":"Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease","volume":"321","author":"Yamagata","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib87","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/bioinformatics\/btp701","article-title":"Pandora, a pathway and network discovery approach based on common biological evidence","volume":"26","author":"Zhang","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib88","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ejps.2011.02.009","article-title":"Curcumin activates Wnt\/beta-catenin signaling pathway through inhibiting the activity of GSK-3beta in APPswe transfected SY5Y cells","volume":"42","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.neurobiolaging.2014.02.024_bib89","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbrc.2011.07.040","article-title":"Wnt\/beta-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity","volume":"412","author":"Zhou","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014002309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014002309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T02:51:31Z","timestamp":1565232691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458014002309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":89,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0197458014002309"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.02.024","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reverse engineering of Alzheimer's disease based on biomarker pathways analysis","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.02.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}