{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:43:35Z","timestamp":1792035815380,"version":"4.4.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.neurobiolaging.2014.02.030","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T12:15:37Z","timestamp":1400156137000},"page":"S65-S73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"special_numbering":"S2","title":["Saturated and trans fats and dementia: a systematic review"],"prefix":"10.1016","volume":"35","author":[{"given":"Neal D.","family":"Barnard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Bunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulka","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1001\/jama.298.11.1300","article-title":"Association of apolipoprotein E genotypes with lipid levels and coronary risk","volume":"298","author":"Bennett","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1474-4422(05)70284-2","article-title":"Risk of dementia in diabetes mellitus: a systematic review","volume":"5","author":"Biessels","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib3","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1212\/WNL.44.7.1246","article-title":"Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study","volume":"44","author":"Breteler","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/JGP.0b013e31823032a9","article-title":"The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH through life study","volume":"20","author":"Cherbuin","year":"2012","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib5","first-page":"7","article-title":"MRC\/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial","volume":"9326","author":"Collins","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1212\/01.wnl.0000319647.15752.7b","article-title":"Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study","volume":"71","author":"Cramer","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib7","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/archneurol.2010.144","article-title":"Dietary antioxidants and long-term risk of dementia","volume":"67","author":"Devore","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib8","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1212\/01.WNL.0000038345.77753.46","article-title":"Diet and risk of dementia: does fat matter? the Rotterdam Study","volume":"59","author":"Engelhart","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib9","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1001\/jama.287.24.3223","article-title":"Dietary intake of antioxidants and risk of Alzheimer disease","volume":"28","author":"Englehart","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/gps.1969","article-title":"Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study","volume":"23","author":"Eskelinen","year":"2008","journal-title":"Int. J. Geriatr. Psychiatr"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib11","first-page":"RA359","article-title":"Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection","volume":"11","author":"Haag","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/jnnp.2008.150433","article-title":"Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study","volume":"80","author":"Haag","year":"2009","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib13","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib14","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/WNL.52.7.1397","article-title":"Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment","volume":"52","author":"Jack","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib15","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/ana.410420514","article-title":"Dietary fat intake and the risk of incident dementia in the Rotterdam Study","volume":"42","author":"Kalmijn","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1006\/bbrc.1998.9652","article-title":"Elevated low-density lipoprotein in Alzheimer's disease correlates with brain A\u03b2 levels","volume":"252","author":"Kuo","year":"1998","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000093478","article-title":"Fat intake at midlife and risk of dementia and Alzheimer\u2019s disease: a population-based study","volume":"22","author":"Laitinen","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1017\/S0007114500002506","article-title":"Gene-nutrient interactions: dietary behaviour associated with high coronary heart disease risk particularly affects serum LDL cholesterol in apolipoprotein E (4-carrying free-living individuals","volume":"84","author":"Loktionov","year":"2000","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib19","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1001\/archneur.59.8.1258","article-title":"Caloric intake and the risk of Alzheimer disease","volume":"59","author":"Luchsinger","year":"2002","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib20","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/archneur.60.2.194","article-title":"Dietary fats and the risk of incident Alzheimer\u2019s disease","volume":"60","author":"Morris","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib22","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1212\/01.WNL.0000123250.82849.B6","article-title":"Dietary fat intake and 6-year cognitive change in an older biracial community population","volume":"62","author":"Morris","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib23","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/ajcn.81.2.508","article-title":"Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change","volume":"81","author":"Morris","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1532-5415.2011.03402.x","article-title":"Monounsaturated, trans, and saturated fatty acids and cognitive decline in women","volume":"59","author":"Naqvi","year":"2011","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib25","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1212\/WNL.0b013e31822f0435","article-title":"Glucose tolerance status and risk of dementia in the community: the Hisayama study","volume":"77","author":"Ohara","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ana.23593","article-title":"Dietary fat types and 4-year cognitive change in community-dwelling older women","volume":"72","author":"Okereke","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib29","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1056\/NEJMcp0910237","article-title":"Mild cognitive impairment","volume":"364","author":"Petersen","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ncb1001-905","article-title":"Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide","volume":"3","author":"Puglielli","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nn0403-345","article-title":"Alzheimer\u2019s disease: the cholesterol connection","volume":"6","author":"Puglielli","year":"2003","journal-title":"Nat. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3233\/JAD-2012-120862","article-title":"Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia","volume":"32","author":"Roberts","year":"2012","journal-title":"J.\u00a0Alzheimer\u2019s Dis."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00041433-200202000-00005","article-title":"Apolipoprotein E and diets: a case of gene-nutrient interaction?","volume":"13","author":"Rubin","year":"2002","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib34","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/S0140-6736(10)60408-4","article-title":"Lipid-induced insulin resistance: unravelling the mechanism","volume":"375","author":"Samuel","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib35","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/S0140-6736(02)11600-X","article-title":"Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomized controlled trial","volume":"360","author":"Shepherd","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/13825589608256619","article-title":"Definition, course, and outcome of mild cognitive impairment","volume":"3","author":"Smith","year":"1996","journal-title":"Aging Neuropsychol. Cogn."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib37","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.exger.2006.03.017","article-title":"Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging","volume":"41","author":"Solfrizzi","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib38","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.neurobiolaging.2005.09.026","article-title":"Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging","volume":"27","author":"Solfrizzi","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000231980","article-title":"Midlife serum cholesterol and increased risk of Alzheimer\u2019s and vascular dementia three decades later","volume":"28","author":"Solomon","year":"2009","journal-title":"Dement Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neurobiolaging.2014.02.030_bib40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/pds.3381","article-title":"Statins in the prevention of dementia and Alzheimer's disease: a meta-analysis of observational studies and an assessment of confounding","volume":"22","author":"Wong","year":"2013","journal-title":"Pharmacoepidemiol. Drug Saf."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014003558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014003558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T09:56:09Z","timestamp":1565430969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458014003558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":40,"alternative-id":["S0197458014003558"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.02.030","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Saturated and trans fats and dementia: a systematic review","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}