{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:17:21Z","timestamp":1789204641977,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.neurobiolaging.2014.03.040","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T09:05:09Z","timestamp":1400144709000},"page":"S35-S39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"S2","title":["Critical levels of brain atrophy associated with homocysteine and cognitive decline"],"prefix":"10.1016","volume":"35","author":[{"given":"Celeste A.","family":"de Jager","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib1","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1001\/jama.300.15.1774","article-title":"Alzheimer Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial","volume":"300","author":"Aisen","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.freeradbiomed.2009.04.023","article-title":"A\u00a0novel role for vitamin B(12): cobalamins are intracellular antioxidants in\u00a0vitro","volume":"47","author":"Birch","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib3","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1046\/j.1532-5415.2002.50614.x","article-title":"Oxford Project to Investigate Memory and Ageing (OPTIMA). Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people","volume":"50","author":"Budge","year":"2002","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/fampra\/cml008","article-title":"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials","volume":"23","author":"Butler","year":"2006","journal-title":"Fam. Pract."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib5","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib6","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1001\/jama.300.15.1819","article-title":"B\u00a0vitamins for prevention of cognitive decline: insufficient evidence to justify treatment","volume":"300","author":"Clarke","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/gps.2758","article-title":"Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial","volume":"27","author":"de Jager","year":"2012","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib8","doi-asserted-by":"crossref","first-page":"9523","DOI":"10.1073\/pnas.1301816110","article-title":"Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment","volume":"110","author":"Douaud","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0140-6736(07)60109-3","article-title":"Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial","volume":"369","author":"Durga","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/(SICI)1099-1166(200003)15:3<226::AID-GPS98>3.0.CO;2-K","article-title":"Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function","volume":"15","author":"Eastley","year":"2000","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1515\/REVNEURO.2010.21.3.187","article-title":"Structural brain changes in aging: courses, causes and cognitive consequences","volume":"21","author":"Fjell","year":"2010","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib12","doi-asserted-by":"crossref","first-page":"15223","DOI":"10.1523\/JNEUROSCI.3252-09.2009","article-title":"One-year brain atrophy evident in healthy aging","volume":"29","author":"Fjell","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/JAD-2012-111739","article-title":"Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials","volume":"29","author":"Ford","year":"2012","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib14","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1212\/WNL.52.8.1687","article-title":"Correlation between rates of brain atrophy and cognitive decline in AD","volume":"52","author":"Fox","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib15","first-page":"CD004514","article-title":"Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people","volume":"8","author":"Malouf","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000051275","article-title":"Homocysteine and cognitive decline in healthy elderly","volume":"12","author":"McCaddon","year":"2001","journal-title":"Dement Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib17","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/ajcn\/53.2.524","article-title":"Vitamin B-12 status in a macrobiotic community","volume":"53","author":"Miller","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib18","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3945\/an.112.002535","article-title":"The role of B vitamins in preventing and treating cognitive impairment and decline","volume":"3","author":"Morris","year":"2012","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0029665111003296","article-title":"Nutritional determinants of cognitive aging and dementia","volume":"71","author":"Morris","year":"2012","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/ajcn\/85.1.193","article-title":"Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification","volume":"85","author":"Morris","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib21","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1532-5415.2012.04076.x","article-title":"Vitamin B-12 and folate status in relation to decline in scores on the mini-mental state examination in the Framingham heart study","volume":"60","author":"Morris","year":"2012","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/ajcn\/67.2.263","article-title":"Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study","volume":"67","author":"Nyg\u00e5rd","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/ana.20645","article-title":"Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study","volume":"58","author":"Nurk","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/gps.2303","article-title":"Homocysteine as a predictor of cognitive decline in Alzheimer's disease","volume":"25","author":"Oulhaj","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib25","doi-asserted-by":"crossref","first-page":"1731S","DOI":"10.1093\/jn\/136.6.1731S","article-title":"The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease","volume":"136","author":"Refsum","year":"2006","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib26","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.pnpbp.2005.06.026","article-title":"Homocysteine and brain atrophy","volume":"29","author":"Sachdev","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biolpsychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3233\/JAD-2006-9404","article-title":"Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?","volume":"9","author":"Seshadri","year":"2006","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib28","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1073\/pnas.082107399","article-title":"Imaging the progression of Alzheimer pathology through the brain","volume":"99","author":"Smith","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ajcn\/85.1.3","article-title":"Folic acid fortification: the good, the bad, and the puzzle of vitamin B-12","volume":"85","author":"Smith","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/ajcn\/87.3.517","article-title":"Is folic acid good for everyone?","volume":"87","author":"Smith","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib32","doi-asserted-by":"crossref","first-page":"e12244","DOI":"10.1371\/journal.pone.0012244","article-title":"Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial","volume":"5","author":"Smith","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib33","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.neuroimage.2010.04.258","article-title":"Longitudinal changes in cortical thickness associated with normal aging","volume":"52","author":"Thambisetty","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib34","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1212\/01.wnl.0000325581.26991.f2","article-title":"Vitamin B12 status and rate of brain volume loss in community-dwelling elderly","volume":"71","author":"Vogiatzoglou","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib35","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3945\/ajcn.2008.26598","article-title":"Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study","volume":"89","author":"Vogiatzoglou","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neurobiolaging.2014.03.040_bib36","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/ageing\/31.6.440","article-title":"Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people","volume":"31","author":"Williams","year":"2002","journal-title":"Age Ageing"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014003583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014003583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T17:50:29Z","timestamp":1716745829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458014003583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":35,"alternative-id":["S0197458014003583"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.03.040","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Critical levels of brain atrophy associated with homocysteine and cognitive decline","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.03.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}