{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:24:14Z","timestamp":1775593454949,"version":"3.50.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["218081"],"award-info":[{"award-number":["218081"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["263762"],"award-info":[{"award-number":["263762"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["126889"],"award-info":[{"award-number":["126889"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EVO","award":["5772708"],"award-info":[{"award-number":["5772708"]}]},{"name":"Strategic Funding of the University of Eastern Finland"},{"name":"Sigrid Juselius Foundation"},{"name":"VPH Dementia Research Enabled by IT","award":["601055"],"award-info":[{"award-number":["601055"]}]}],"content-domain":{"domain":["neurobiologyofaging.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.neurobiolaging.2014.09.003","type":"journal-article","created":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T16:23:12Z","timestamp":1410020592000},"page":"1221.e15-1221.e28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in\u00a0vitro models"],"prefix":"10.1016","volume":"36","author":[{"given":"Henna","family":"Martiskainen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayashree","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niko-Petteri","family":"Nyk\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitja","family":"Kurki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Helisalmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teemu","family":"Natunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Saraj\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisa M.A.","family":"Kurkinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha-Pekka","family":"Pursiheimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas","family":"Rauramaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Alafuzoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha E.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ville","family":"Leinonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annakaisa","family":"Haapasalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri J.","family":"Huttunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1212\/WNL.0b013e3182605801","article-title":"Novel late-onset Alzheimer disease loci variants associate with brain gene expression","volume":"79","author":"Allen","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/gm249","article-title":"The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease","volume":"3","author":"Antunez","year":"2011","journal-title":"Genome Med."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J.\u00a0R. Stat. Soc. Ser. B Stat. Methodol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1471-4159.2008.05433.x","article-title":"ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in\u00a0vitro","volume":"106","author":"Chan","year":"2008","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib8","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/mp.2013.1","article-title":"Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology","volume":"18","author":"Chapuis","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib9","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib10","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00439-012-1154-6","article-title":"The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease","volume":"131","author":"Deng","year":"2012","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/jamaneurol.2013.4560","article-title":"The role of clusterin in amyloid-beta-associated neurodegeneration","volume":"71","author":"Desikan","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1750-3639.1994.tb00838.x","article-title":"GFAP and astrogliosis","volume":"4","author":"Eng","year":"1994","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib13","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ncl.2007.03.009","article-title":"Genetics of Alzheimer's disease: a centennial review","volume":"25","author":"Ertekin-Taner","year":"2007","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib14","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N.\u00a0Engl. J. Med"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib16","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.expneurol.2009.09.011","article-title":"GSK3: a possible link between beta amyloid peptide and tau protein","volume":"223","author":"Hernandez","year":"2010","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib18","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/cercor\/bht101","article-title":"Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study","volume":"24","author":"Hokama","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib19","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3233\/JAD-130854","article-title":"Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients","volume":"38","author":"Hu","year":"2014","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-1119(00)00598-9","article-title":"Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor","volume":"264","author":"Ishibashi","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer's disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3233\/JAD-2012-120946","article-title":"GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients","volume":"33","author":"Kamalainen","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib24","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1038\/tp.2012.45","article-title":"Genome-wide association study of Alzheimer's disease","volume":"2","author":"Kamboh","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib25","doi-asserted-by":"crossref","first-page":"e50976","DOI":"10.1371\/journal.pone.0050976","article-title":"Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains","volume":"7","author":"Karch","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib26","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1523\/JNEUROSCI.4165-12.2013","article-title":"Deletion of Abca7 increases cerebral amyloid-beta accumulation in the J20 mouse model of Alzheimer's disease","volume":"33","author":"Kim","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1227\/NEU.0b013e31827414b3","article-title":"Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus","volume":"72","author":"Koivisto","year":"2013","journal-title":"Neurosurgery"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib28","doi-asserted-by":"crossref","first-page":"e93717","DOI":"10.1371\/journal.pone.0093717","article-title":"Increased gamma-secretase activity in idiopathic normal pressure hydrocephalus patients with beta-amyloid pathology","volume":"9","author":"Laitera","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.gde.2011.02.002","article-title":"Genetics of Alzheimer's disease: new evidences for an old hypothesis?","volume":"21","author":"Lambert","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib30","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/mp.2012.14","article-title":"Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease","volume":"18","author":"Lambert","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib31","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-2990.2011.01195.x","article-title":"Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature","volume":"38","author":"Leinonen","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib34","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ana.22100","article-title":"Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease","volume":"68","author":"Leinonen","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib35","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1006\/exnr.1998.6892","article-title":"Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease","volume":"154","author":"Lidstrom","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib36","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/21650","article-title":"The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein","volume":"399","author":"Lu","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib37","doi-asserted-by":"crossref","first-page":"13320","DOI":"10.1523\/JNEUROSCI.1224-13.2013","article-title":"CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing","volume":"33","author":"Malik","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib38","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0896-6273(90)90342-D","article-title":"Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat","volume":"5","author":"May","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib39","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/nan.12101","article-title":"Review: the genetics of Alzheimer's disease; putting flesh on the bones","volume":"40","author":"Medway","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib41","doi-asserted-by":"crossref","first-page":"e98619","DOI":"10.1371\/journal.pone.0098619","article-title":"Multiplex assay for live-cell monitoring of cellular fates of amyloid-beta precursor protein (APP)","volume":"9","author":"Merezhko","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nrd2311","article-title":"Universal strategies in research and drug discovery based on protein-fragment complementation assays","volume":"6","author":"Michnick","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib43","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib44","doi-asserted-by":"crossref","first-page":"e80700","DOI":"10.1371\/journal.pone.0080700","article-title":"Effects of NR1H3 genetic variation on the expression of liver X receptor alpha and the progression of Alzheimer's disease","volume":"8","author":"Natunen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JAD-130104","article-title":"Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease","volume":"37","author":"Natunen","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jneuroim.2006.11.032","article-title":"Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis","volume":"184","author":"Neumann","year":"2007","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib47","doi-asserted-by":"crossref","first-page":"20120362","DOI":"10.1098\/rstb.2012.0362","article-title":"Expression quantitative trait loci: present and future","volume":"368","author":"Nica","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib48","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.neuint.2005.12.005","article-title":"Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms","volume":"48","author":"Nilselid","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainresrev.2009.05.007","article-title":"Clusterin: a forgotten player in Alzheimer's disease","volume":"61","author":"Nuutinen","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib50","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1074\/jbc.M111.309385","article-title":"Gamma-aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation","volume":"287","author":"Nykanen","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib51","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neurobiolaging.2013.08.002","article-title":"Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood","volume":"35","author":"Proitsi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib52","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/jnnp-2011-303849","article-title":"APOE4 predicts amyloid-beta in cortical brain biopsy but not idiopathic normal pressure hydrocephalus","volume":"83","author":"Pyykko","year":"2012","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib53","series-title":"R: A Language and Environment for Statistical Computing","year":"2009"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib54","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nmeth979","article-title":"A\u00a0highly sensitive protein-protein interaction assay based on Gaussia luciferase","volume":"3","author":"Remy","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib55","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000355256","article-title":"Prospective flutemetamol positron emission tomography and histopathology in normal pressure hydrocephalus","volume":"13","author":"Rinne","year":"2014","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3233\/JAD-2005-8304","article-title":"Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine","volume":"8","author":"Rivera","year":"2005","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib57","doi-asserted-by":"crossref","first-page":"E559","DOI":"10.1073\/pnas.1100745108","article-title":"ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1","volume":"108","author":"Sannerud","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib58","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e3182563bd0","article-title":"CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings","volume":"78","author":"Seppala","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib59","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.neurobiolaging.2008.05.015","article-title":"Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain","volume":"31","author":"Simpson","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib60","series-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","first-page":"397","article-title":"Limma: linear models for microarray data","author":"Smyth","year":"2005"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib61","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib62","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1038\/tp.2011.17","article-title":"Alzheimer's risk variants in the clusterin gene are associated with alternative splicing","volume":"1","author":"Szymanski","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib63","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1371\/journal.pmed.0040124","article-title":"TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis","volume":"4","author":"Takahashi","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib64","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ana.410140502","article-title":"Senile dementia of the Alzheimer type","volume":"14","author":"Terry","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib65","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuroimage.2011.07.056","article-title":"Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment","volume":"59","author":"Thambisetty","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib66","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1093\/hmg\/dds238","article-title":"MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies","volume":"21","author":"Trabzuni","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib67","doi-asserted-by":"crossref","first-page":"e16266","DOI":"10.1371\/journal.pone.0016266","article-title":"Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease","volume":"6","author":"Twine","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib68","series-title":"Resampling-based Multiple Testing: Examples and Methods for P-value Adjustment","author":"Westfall","year":"1993"},{"key":"10.1016\/j.neurobiolaging.2014.09.003_bib69","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0166-2236(98)01264-8","article-title":"The amphiphysin family of proteins and their role in endocytosis at the synapse","volume":"21","author":"Wigge","year":"1998","journal-title":"Trends Neurosci."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014005983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014005983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T08:50:13Z","timestamp":1717318213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458014005983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0197458014005983"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.09.003","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in\u00a0vitro models","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}