{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:44:03Z","timestamp":1774525443019,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging, grant number","doi-asserted-by":"publisher","award":["AG000723-07"],"award-info":[{"award-number":["AG000723-07"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neurobiologyofaging.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.neurobiolaging.2014.09.026","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T14:56:11Z","timestamp":1413298571000},"page":"1007-1012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Loss of NEIL1 causes defects in olfactory function in mice"],"prefix":"10.1016","volume":"36","author":[{"given":"Chandrika","family":"Canugovi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Misiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Scheibye-Knudsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah L.","family":"Croteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark P.","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilhelm A.","family":"Bohr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.dnarep.2013.07.005","article-title":"DNA-repair in mild cognitive impairment and Alzheimer's disease","volume":"12","author":"Bucholtz","year":"2013","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib2","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.dnarep.2013.04.010","article-title":"The role of DNA repair in brain related disease pathology","volume":"12","author":"Canugovi","year":"2013","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib3","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.neurobiolaging.2014.01.004","article-title":"Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease","volume":"35","author":"Canugovi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib4","doi-asserted-by":"crossref","first-page":"14948","DOI":"10.1073\/pnas.1204156109","article-title":"Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice","volume":"109","author":"Canugovi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/194589240301700311","article-title":"Age-related olfactory dysfunction: cellular and molecular characterization in the rat","volume":"17","author":"Conley","year":"2003","journal-title":"Am. J. Rhinol."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib6","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.2466\/24.27.PMS.117x15z5","article-title":"Memories evoked by odors stimulating the olfactory nerve versus odors stimulating both the olfactory and trigeminal nerves: possible qualitative differences?","volume":"117","author":"Czerniawska","year":"2013","journal-title":"Percept Mot. Skills"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.nbd.2011.10.026","article-title":"Olfaction in Parkinson's disease and related disorders","volume":"46","author":"Doty","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib8","unstructured":"Doty, R.L. 2013. The Scientist Magazine."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib9","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1212\/WNL.43.5.962","article-title":"Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease","volume":"43","author":"Doty","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib10","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1001\/archneur.1997.00550210061014","article-title":"Olfactory dysfunction in patients with head trauma","volume":"54","author":"Doty","year":"1997","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0197-4580(02)00019-2","article-title":"Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases","volume":"23","author":"Floyd","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1134\/S000629791101010X","article-title":"Eukaryotic endonuclease VIII-like proteins: new components of the base excision DNA repair system 1","volume":"76","author":"Grin","year":"2011","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib13","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/j.1471-4159.1992.tb10990.x","article-title":"Reactive oxygen species and the central nervous system","volume":"59","author":"Halliwell","year":"1992","journal-title":"J.Neurochem."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/qjmed\/92.8.473","article-title":"Is Parkinson's disease a primary olfactory disorder?","volume":"92","author":"Hawkes","year":"1999","journal-title":"QJM"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1248\/bpb.27.480","article-title":"Human DNA glycosylases involved in the repair of oxidatively damaged DNA 1","volume":"27","author":"Ide","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib16","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1096\/fj.07-104836","article-title":"Impaired olfaction in mice lacking aquaporin-4 water channels","volume":"22","author":"Lu","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mito.2013.10.007","article-title":"A\u00a0short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseases","volume":"16","author":"Mantha","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib18","article-title":"Limbic systems for emotion and for memory, but no single limbic system","author":"Rolls","year":"2013","journal-title":"Cortex"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib19","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1152\/physrev.1972.52.4.864","article-title":"Synaptic organization of the mammalian olfactory bulb","volume":"52","author":"Shepherd","year":"1972","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jns.2013.06.033","article-title":"A\u00a0brief olfactory test for Alzheimer's disease","volume":"333","author":"Stamps","year":"2013","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/chemse\/28.1.25","article-title":"Detection thresholds for phenyl ethyl alcohol using serial dilutions in different solvents","volume":"28","author":"Tsukatani","year":"2003","journal-title":"Chem. Senses"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/JCP.0b013e3181aba5a5","article-title":"Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil","volume":"29","author":"Velayudhan","year":"2009","journal-title":"J.\u00a0Clin. Psychopharmacol."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib23","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s11064-011-0694-9","article-title":"Age-related decline in DNA polymerase beta activity in rat brain and tissues 2","volume":"37","author":"Vyjayanti","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib24","doi-asserted-by":"crossref","first-page":"15410","DOI":"10.1523\/JNEUROSCI.1909-09.2009","article-title":"Olfactory impairment predicts brain atrophy in Parkinson's disease","volume":"29","author":"Wattendorf","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib25","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1093\/nar\/gkm605","article-title":"Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment","volume":"35","author":"Weissman","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4236\/jbbs.2012.22020","article-title":"Influence of iron deficiency on olfactory behavior in weanling rats","volume":"2","author":"Wessling-Resnick","year":"2012","journal-title":"J.\u00a0Behav. Brain Sci."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1523\/JNEUROSCI.4622-09.2010","article-title":"Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model","volume":"30","author":"Wesson","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib28","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.dnarep.2006.10.017","article-title":"The mechanics of base excision repair, and its relationship to aging and disease","volume":"6","author":"Wilson","year":"2007","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib29","article-title":"Olfactory behavioral testing in the adult mouse","volume":"23","author":"Witt","year":"2009","journal-title":"J.\u00a0Vis. Exp"},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib30","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1073\/pnas.81.15.4899","article-title":"Ability to smell androstenone is genetically determined","volume":"81","author":"Wysocki","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2014.09.026_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0824s48","article-title":"Simple behavioral assessment of mouse olfaction","author":"Yang","year":"2009","journal-title":"Curr. Protoc. Neurosci."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014006320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014006320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T01:36:46Z","timestamp":1565919406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458014006320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0197458014006320"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.09.026","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of NEIL1 causes defects in olfactory function in mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.09.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}