{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:21:38Z","timestamp":1790680898193,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"German Federal Ministry for Education and Research","award":["01GI0422"],"award-info":[{"award-number":["01GI0422"]}]},{"DOI":"10.13039\/100007333","name":"Alzheimer\u2019s Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DOD ADNI","award":["W81XWH-12-2\u20130012"],"award-info":[{"award-number":["W81XWH-12-2\u20130012"]}]},{"DOI":"10.13039\/100007333","name":"ADNI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007742","name":"BioClinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007742","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biogen Idec Inc"},{"name":"Bristol-Myers Squibb Company"},{"name":"Eisai Inc"},{"name":"Elan Pharmaceuticals, Inc"},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"F. Hoffmann-La Roche Ltd","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005061","name":"Innogenetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005061","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IXICO Ltd."},{"name":"Janssen Alzheimer Immunotherapy Research & Development, LLC"},{"name":"Johnson & Johnson Pharmaceutical Research& Development LLC"},{"name":"Medpace, Inc"},{"DOI":"10.13039\/100004334","name":"Merck & Co, Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Meso Scale Diagnostics, LLC"},{"name":"NeuroRx Research"},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pfizer Inc"},{"name":"Piramal Imaging"},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Synarc Inc"},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alzheimer Nederland and Stichting VUmc fonds"},{"DOI":"10.13039\/501100010573","name":"Stichting Dioraphte","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010573","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.neurobiolaging.2014.12.007","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T06:47:14Z","timestamp":1418280434000},"page":"1605.e13-1605.e20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease"],"prefix":"10.1016","volume":"36","author":[{"given":"Eva","family":"Louwersheimer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-3987","authenticated-orcid":false,"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Heilmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A.L.","family":"Pijnenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"van Swieten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henne","family":"Holstege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"Van der Flier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"Abecasis","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000332017","article-title":"Impact of SORL1 single nucleotide polymorphisms on Alzheimer's disease cerebrospinal fluid markers","volume":"32","author":"Alexopoulos","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajhg.2008.12.008","article-title":"Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease","volume":"84","author":"Beecham","year":"2009","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1001\/archneurol.2011.788","article-title":"Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain","volume":"69","author":"Caglayan","year":"2012","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuron.2013.02.026","article-title":"GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease","volume":"78","author":"Cruchaga","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib6","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archneur.65.12.1640","article-title":"Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease","volume":"65","author":"Cuenco","year":"2008","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib7","first-page":"143","article-title":"CAMDEX-N: the Dutch version of the Cambridge Examination for Mental Disorders of the Elderly with automatic data processing","volume":"2","author":"Derix","year":"1991","journal-title":"Gerontol. Geriatr"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib8","doi-asserted-by":"crossref","first-page":"12877","DOI":"10.1523\/JNEUROSCI.4582-08.2008","article-title":"Loss of LR11\/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease","volume":"28","author":"Dodson","year":"2008","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib9","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/01.jnen.0000228205.19915.20","article-title":"LR11\/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease","volume":"65","author":"Dodson","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib10","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.neurobiolaging.2005.05.032","article-title":"Multicenter assessment of reliability of cranial MRI","volume":"27","author":"Ewers","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib11","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib12","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00406-012-0295-x","article-title":"SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer's disease","volume":"262","author":"Guo","year":"2012","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib15","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng0613-712a","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"45","author":"Harold","year":"2013","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib16","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1093\/bioinformatics\/btp596","article-title":"genome-wide interaction analysis guided by a priori information","volume":"25","author":"Herold","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","article-title":"The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods","volume":"27","author":"Jack","year":"2008","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib19","doi-asserted-by":"crossref","first-page":"22788","DOI":"10.1074\/jbc.M100857200","article-title":"Activation and functional characterization of the mosaic receptor SorLA\/LR11","volume":"276","author":"Jacobsen","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib20","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3233\/JAD-2010-091711","article-title":"Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels","volume":"21","author":"Kauwe","year":"2010","journal-title":"J. Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neulet.2009.06.014","article-title":"SORL1 is genetically associated with Alzheimer disease in a Japanese population","volume":"461","author":"Kimura","year":"2009","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neulet.2008.05.049","article-title":"Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease","volume":"440","author":"Kolsch","year":"2008","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib23","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1159\/000210388","article-title":"Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network","volume":"27","author":"Kornhuber","year":"2009","journal-title":"Dement. Geriatr. Cogn. Disord"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib24","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib25","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib26","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3233\/JAD-2010-100126","article-title":"Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study","volume":"20","author":"Laumet","year":"2010","journal-title":"J. Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib27","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1212\/01.wnl.0000280581.39755.89","article-title":"Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease","volume":"70","author":"Lee","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.nbd.2007.09.001","article-title":"SORL1 variants and risk of late-onset Alzheimer's disease","volume":"29","author":"Li","year":"2008","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib31","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/WNR.0b013e3282f13e7a","article-title":"St George-Hyslop P, Mayeux R, Farrer LA. Association between SORL1 and Alzheimer's disease in a genome-wide study","volume":"18","author":"Meng","year":"2007","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1373\/clinchem.2009.130518","article-title":"Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease","volume":"56","author":"Mulder","year":"2010","journal-title":"Clin. Chem"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib33","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/WAD.0b013e3181e6a575","article-title":"Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population","volume":"24","author":"Ning","year":"2010","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib34","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0002-9440(10)63163-X","article-title":"Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up","volume":"164","author":"Nixon","year":"2004","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1212\/WNL.0b013e31827f0889","article-title":"Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia","volume":"80","author":"Ossenkoppele","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib36","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.neuroimage.2010.12.081","article-title":"APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease","volume":"55","author":"Pievani","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-2010-100561","article-title":"Cerebrospinal fluid markers for Alzheimer's disease over the lifespan: effects of age and the APOEepsilon4 genotype","volume":"22","author":"Popp","year":"2010","journal-title":"J. Alzheimers Dis"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bcp.2012.12.007","article-title":"Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease","volume":"86","author":"Popp","year":"2013","journal-title":"Biochem. Pharmacol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib39","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1212\/01.WNL.0000128088.08695.05","article-title":"APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42","volume":"62","author":"Prince","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib40","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib41","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1093\/hmg\/ddu372","article-title":"SUCLG2 identified as both a determinator of CSF Abeta1-42 levels and an attenuator of cognitive decline in Alzheimer's disease","volume":"23","author":"Ramirez","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1001\/archneurol.2010.346","article-title":"Meta-analysis of the association between variants in SORL1 and Alzheimer disease","volume":"68","author":"Reitz","year":"2011","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib43","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2009.04.006","article-title":"Endophenotypes in normal brain morphology and Alzheimer's disease: a review","volume":"164","author":"Reitz","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10048-009-0210-4","article-title":"Sequence variation in SORL1 and dementia risk in Swedes","volume":"11","author":"Reynolds","year":"2010","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib45","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease","volume":"39","author":"Rogaeva","year":"2007","journal-title":"Nat. Genet"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib46","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale for Alzheimer's disease","volume":"141","author":"Rosen","year":"1984","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib47","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jalz.2010.03.013","article-title":"Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans","volume":"6","author":"Saykin","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib48","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00868807","article-title":"Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: interobserver reliability","volume":"242","author":"Scheltens","year":"1995","journal-title":"J Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib49","article-title":"Allelic and locus heterogeneity","author":"Scriver","year":"2005","journal-title":"Encyclopedia of life sciences"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib50","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"Seshadri","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib51","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21610","article-title":"Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects","volume":"65","author":"Shaw","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib52","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.neuroimage.2010.01.042","article-title":"Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort","volume":"53","author":"Shen","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib53","first-page":"1836","volume":"70","author":"Sluimer","year":"2008","journal-title":"Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors. Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib54","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib55","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.neurobiolaging.2007.10.013","article-title":"SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese","volume":"30","author":"Tan","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib56","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s00415-006-0120-4","article-title":"Comprehensive dissection of the medial temporal lobe in AD: measurement of hippocampus, amygdala, entorhinal, perirhinal and parahippocampal cortices using MRI","volume":"253","author":"Teipel","year":"2006","journal-title":"J. Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib57","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S1474-4422(10)70306-9","article-title":"Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE varepsilon4 allele","volume":"10","author":"van der Flier","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib58","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3233\/JAD-132306","article-title":"Optimizing Patient Care. Research: The Amsterdam Dementia Cohort","volume":"41","author":"van der Flier","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib59","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1212\/01.wnl.0000228222.17111.2a","article-title":"The effect of APOE genotype on clinical phenotype in Alzheimer disease","volume":"67","author":"van der Flier","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2014.12.007_bib60","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1017\/S0033291709005492","article-title":"Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset","volume":"39","author":"van der Vlies","year":"2009","journal-title":"Psychol Med"},{"issue":"30 Suppl","key":"10.1016\/j.neurobiolaging.2014.12.007_bib61","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.3233\/JAD-2011-111028","article-title":"Cholesterol and late-life cognitive decline","volume":"2","author":"van Vliet","year":"2012","journal-title":"J. Alzheimers Dis"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014008045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014008045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:23:19Z","timestamp":1759317799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458014008045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0197458014008045"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.12.007","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}