{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:45:20Z","timestamp":1768315520424,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T00:00:00Z","timestamp":1419638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.neurobiolaging.2014.12.027","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T23:01:39Z","timestamp":1420066899000},"page":"1333-1341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model"],"prefix":"10.1016","volume":"36","author":[{"given":"Nina","family":"Daschil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin M.","family":"Kniewallner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald J.","family":"Obermair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Hutter-Paier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Windisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Marksteiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Humpel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib1","doi-asserted-by":"crossref","first-page":"H58","DOI":"10.1152\/ajpheart.00476.2012","article-title":"Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development","volume":"304","author":"Abd El-Rahman","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0163-7258(95)00025-9","article-title":"Calcium channels in cerebral arteries","volume":"68","author":"Alborch","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib3","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/CIRCULATIONAHA.111.076950","article-title":"The angiogenic factor secretoneurin induces coronary angiogenesis in a model of myocardial infarction by stimulation of vascular endothelial growth factor signaling in endothelial cells","volume":"126","author":"Albrecht-Schgoer","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0959-4388(03)00066-7","article-title":"Auxiliary subunits: essential components of the voltage-gated calcium channel complex","volume":"13","author":"Arikkath","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/156720206778792948","article-title":"Classic beta-amyloid deposits cluster around large diameter blood vessels rather than capillaries in sporadic Alzheimer's disease","volume":"3","author":"Armstrong","year":"2006","journal-title":"Curr. Neurovasc Res."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib6","doi-asserted-by":"crossref","first-page":"8453","DOI":"10.1523\/JNEUROSCI.23-24-08453.2003","article-title":"Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease","volume":"23","author":"Beckmann","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ceca.2013.06.001","article-title":"How calcium signals in myocytes and pericytes are integrated across in situ microvascular networks and control microvascular tone","volume":"54","author":"Borysova","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.cellbio.16.1.521","article-title":"Structure and regulation of voltage-gated Ca2+ channels","volume":"16","author":"Catterall","year":"2000","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/cne.20693","article-title":"Differential distribution of voltage-gated calcium channel alpha-2 delta (alpha2delta) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia","volume":"491","author":"Cole","year":"2005","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00429-009-0232-6","article-title":"APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis","volume":"214","author":"Crews","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000357383","article-title":"Short- and long-term treatment of mouse cortical primary astrocytes with \u03b2-amyloid differentially regulates the mRNA expression of L-type calcium channels","volume":"93","author":"Daschil","year":"2014","journal-title":"Pharmacology"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3233\/JAD-130560","article-title":"CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-\u03b2 plaques in an Alzheimer's disease mouse model","volume":"37","author":"Daschil","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib13","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid beta-protein precursor","volume":"279","author":"Davis","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib14","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/01.STR.0000014421.15948.67","article-title":"Alzheimer's disease as a vascular disorder: nosological evidence","volume":"33","author":"de la Torre","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/978-1-4020-6191-2_19","article-title":"Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models","volume":"45","author":"Green","year":"2007","journal-title":"Subcell Biochem."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neuron.2014.05.030","article-title":"Cav1.2 calcium channels: just cut out to be regulated?","volume":"82","author":"Groth","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3233\/JAD-2011-101866","article-title":"A\u00a0longitudinal study of behavioral deficits in an A\u03b2PP transgenic mouse model of Alzheimer's disease","volume":"25","author":"Havas","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.exger.2010.11.032","article-title":"Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?","volume":"46","author":"Humpel","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib19","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0306-4522(93)90476-V","article-title":"Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures","volume":"53","author":"Humpel","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuron.2004.08.043","article-title":"The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease","volume":"44","author":"Hutter-Paier","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer's disease","volume":"5","author":"Iadecola","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib22","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.molbrainres.2004.03.008","article-title":"Calcium influx pathways in rat CNS pericytes","volume":"126","author":"Kamouchi","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib23","first-page":"1435","article-title":"The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease","volume":"137","author":"Kawai","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib24","doi-asserted-by":"crossref","first-page":"8617","DOI":"10.1016\/j.biomaterials.2010.07.079","article-title":"Angiogenesis induced by controlled release of neuropeptide substance P","volume":"31","author":"Kohara","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)62995-1","article-title":"Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls","volume":"167","author":"Kumar-Singh","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib26","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1523\/JNEUROSCI.17-04-01339.1997","article-title":"Regional expression and cellular localization of the alpha1 and beta subunit of high voltage-activated calcium channels in rat brain","volume":"17","author":"Ludwig","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1165\/rcmb.4635","article-title":"Airway smooth muscle cells express functional neurokinin-1 receptors and the nerve-derived preprotachykinin-a gene: regulation by passive sensitization","volume":"28","author":"Maghni","year":"2003","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib28","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1073\/pnas.0709788105","article-title":"Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease","volume":"105","author":"Meyer","year":"2008","journal-title":"PNAS"},{"issue":"3 Suppl 33","key":"10.1016\/j.neurobiolaging.2014.12.027_bib29","first-page":"24","article-title":"Regulation of substance P mRNA expression in human dermal microvascular endothelial cells","volume":"22","author":"Milner","year":"2004","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1460-9568.2003.02728.x","article-title":"Brain capillaries and cholinergic neurons persist in organotypic brain slices in the absence of blood flow","volume":"18","author":"Moser","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib31","series-title":"Modulation of Presynaptic Calcium Channels, Springer Science\u00a0+ Business Media Dordrecht","first-page":"29","article-title":"Neuronal functions of auxiliary calcium channel subunits","author":"Obermair","year":"2013"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib32","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1046\/j.1365-2141.2002.03969.x","article-title":"Human bone marrow angiogenesis: in\u00a0vitro modulation by substance P and neurokinin A","volume":"119","author":"Pelletier","year":"2002","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-5793(00)01124-8","article-title":"Beta subunit heterogeneity of L-type Ca(2+) channels in smooth muscle tissues","volume":"467","author":"Reimer","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib34","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.addr.2007.08.013","article-title":"Transgenic animal models of neurodegenerative diseases and their application to treatment development","volume":"59","author":"Rockenstein","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib35","first-page":"153","article-title":"Network excitability dysfunction in Alzheimer's disease: insights from in\u00a0vitro and in\u00a0vivo models","volume":"21","author":"Santos","year":"2010","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib36","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neuroscience.2010.02.037","article-title":"Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons","volume":"167","author":"Schlick","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1124\/jpet.103.050013","article-title":"Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation","volume":"306","author":"Seegers","year":"2003","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib38","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/NEN.0b013e3182933788","article-title":"Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease","volume":"72","author":"Serrano-Pozo","year":"2013","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0029-7844(94)00368-N","article-title":"Substance P: endothelial localization and pharmacology in the human ovarian vein","volume":"85","author":"Stones","year":"1995","journal-title":"Obstet. Gynecol."},{"issue":"Pt 5","key":"10.1016\/j.neurobiolaging.2014.12.027_bib40","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1042\/BST0340903","article-title":"Role of voltage-gated L-type Ca2+ channel isoforms for brain function","volume":"34","author":"Striessnig","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1474-9726.2007.00295.x","article-title":"Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store","volume":"6","author":"Thibault","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib42","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jneumeth.2011.07.021","article-title":"Organotypic vibrosections: novel whole sagittal brain cultures","volume":"201","author":"Ullrich","year":"2011","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0014-2999(95)00818-7","article-title":"Induction of endothelial cell differentiation into capillary-like structures by substance P","volume":"298","author":"Wiedermann","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.brainres.2007.01.080","article-title":"Localization and expression of substance P in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M\/N671L) mutations","volume":"1143","author":"Willis","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib45","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3233\/JAD-2010-091117","article-title":"L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M\/N671L) mutations","volume":"20","author":"Willis","year":"2010","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3233\/JAD-2008-13202","article-title":"Chromogranin B and secretogranin II in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M\/N671L) mutations and in Alzheimer patients","volume":"13","author":"Willis","year":"2008","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib47","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1523\/JNEUROSCI.1836-13.2013","article-title":"Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model","volume":"33","author":"Xie","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib48","doi-asserted-by":"crossref","first-page":"F862","DOI":"10.1152\/ajprenal.00321.2010","article-title":"Voltage-gated divalent currents in descending vasa recta pericytes","volume":"299","author":"Zhang","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.neurobiolaging.2014.12.027_bib49","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1172\/JCI117557","article-title":"Nitric oxide mediates angiogenesis in\u00a0vivo and endothelial cell growth and migration in\u00a0vitro promoted by substance P","volume":"94","author":"Ziche","year":"1994","journal-title":"J.\u00a0Clin. Invest."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014008446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458014008446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T04:10:38Z","timestamp":1566187838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458014008446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0197458014008446"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.12.027","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.12.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}