{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:47:21Z","timestamp":1780969641344,"version":"3.54.1"},"reference-count":86,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.neurobiolaging.2015.06.027","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T05:08:04Z","timestamp":1436332084000},"page":"2687-2701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Nonlinear cerebral atrophy patterns across the Alzheimer's disease continuum: impact of APOE4 genotype"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6155-0642","authenticated-orcid":false,"given":"J.D.","family":"Gispert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"S\u00e1nchez-Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Falcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tucholka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Molinuevo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib1","unstructured":"Alem\u00e1n-G\u00f3mez, Y., Melie-Garc\u00eda, L., Vald\u00e9s-Hernandez, P., 2006. IBASPM: toolbox for automatic parcellation of brain structures. 12th Annual Meeting of the Organization for Human Brain Mapping, Florence, Italy."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.neurobiolaging.2010.05.003","article-title":"3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects","volume":"31","author":"Apostolova","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib3","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.neurobiolaging.2005.08.002","article-title":"Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease","volume":"27","author":"Basso","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib5","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/ana.22333","article-title":"Amyloid-beta associated cortical thinning in clinically normal elderly","volume":"69","author":"Becker","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2010.03.002","article-title":"The Alzheimer's disease neuroimaging initiative: annual change in biomarkers and clinical outcomes","volume":"6","author":"Beckett","year":"2010","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev.clinpsy.032408.153625","article-title":"APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging","volume":"5","author":"Bookheimer","year":"2009","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1212\/WNL.0b013e3181c918b5","article-title":"Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia","volume":"74","author":"Bourgeat","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00401-013-1139-0","article-title":"Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid","volume":"126","author":"Braak","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib10","doi-asserted-by":"crossref","first-page":"20760","DOI":"10.1073\/pnas.1109038108","article-title":"Brain network local interconnectivity loss in aging APOE-4 allele carriers","volume":"108","author":"Brown","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.neuroimage.2008.03.039","article-title":"Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers","volume":"41","author":"Burggren","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2967\/jnumed.110.087031","article-title":"Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG","volume":"53","author":"Carter","year":"2012","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib13","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.nicl.2013.02.006","article-title":"Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease","volume":"2","author":"Chetelat","year":"2013","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ana.21955","article-title":"Relationship between atrophy and beta-amyloid deposition in Alzheimer disease","volume":"67","author":"Chetelat","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib15","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1093\/brain\/awq187","article-title":"Larger temporal volume in elderly with high versus low beta-amyloid deposition","volume":"133","author":"Chetelat","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib16","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1007\/s00259-014-2859-7","article-title":"Astrocytosis measured by (1)(1)C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer's patients","volume":"41","author":"Choo","year":"2014","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib17","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1109\/TMI.2005.857652","article-title":"Comparison and validation of tissue modelization and statistical classification methods in T1-weighted MR brain images","volume":"24","author":"Cuadra","year":"2005","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neurobiolaging.2005.07.003","article-title":"Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment","volume":"27","author":"de Leon","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib19","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.neurobiolaging.2011.02.022","article-title":"CSF tau markers are correlated with hippocampal volume in Alzheimer's disease","volume":"33","author":"de Souza","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib20","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1212\/WNL.59.5.746","article-title":"Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes","volume":"59","author":"den Heijer","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib21","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3174\/ajnr.A3267","article-title":"Apolipoprotein E epsilon4 does not modulate amyloid-beta-associated neurodegeneration in preclinical Alzheimer disease","volume":"34","author":"Desikan","year":"2013","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ana.22509","article-title":"Amyloid-\u03b2 associated volume loss occurs only in the presence of phospho-tau","volume":"70","author":"Desikan","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/cercor\/bhn113","article-title":"The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals","volume":"19","author":"Dickerson","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.pscychresns.2013.09.006","article-title":"APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease","volume":"214","author":"Donix","year":"2013","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuroimage.2010.06.009","article-title":"Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism","volume":"53","author":"Donix","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib26","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1001\/jamaneurol.2013.1062","article-title":"Cross-sectional and longitudinal analysis of the relationship between Abeta deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease","volume":"70","author":"Dore","year":"2013","journal-title":"JAMA Neurol."},{"issue":"Suppl 3","key":"10.1016\/j.neurobiolaging.2015.06.027_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3233\/JAD-2011-0043","article-title":"Disease tracking markers for Alzheimer's disease at the prodromal (MCI) stage","volume":"26","author":"Drago","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib28","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.neurobiolaging.2009.12.008","article-title":"Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals","volume":"32","author":"Driscoll","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neurobiolaging.2006.10.030","article-title":"Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E epsilon 4","volume":"29","author":"Espeseth","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ana.21559","article-title":"Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly","volume":"65","author":"Fagan","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neulet.2010.05.092","article-title":"Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults","volume":"479","author":"Fan","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"Suppl 3","key":"10.1016\/j.neurobiolaging.2015.06.027_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/JAD-2011-0002","article-title":"Presence of ApoE epsilon4 allele associated with thinner frontal cortex in middle age","volume":"26","author":"Fennema-Notestine","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pneurobio.2014.02.004","article-title":"What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus","volume":"117","author":"Fjell","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib34","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/cercor\/bhp279","article-title":"Brain atrophy in healthy aging is related to CSF levels of Abeta1-42","volume":"20","author":"Fjell","year":"2010","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib35","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/archneur.62.6.953","article-title":"Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment","volume":"62","author":"Fleisher","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.biopsych.2011.02.017","article-title":"Cognitively preserved subjects with transitional cerebrospinal fluid beta-amyloid 1-42 values have thicker cortex in Alzheimer's disease vulnerable areas","volume":"70","author":"Fortea","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.24186","article-title":"Cerebrospinal fluid beta-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease","volume":"76","author":"Fortea","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archneurol.2007.27","article-title":"Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve","volume":"65","author":"Fotenos","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease","volume":"6","author":"Frisoni","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib40","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.neurobiolaging.2007.08.019","article-title":"The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease","volume":"30","author":"Glodzik-Sobanska","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib41","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1001\/archneur.62.5.770","article-title":"Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease","volume":"62","author":"Hampel","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib42","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.neuroimage.2003.08.003","article-title":"Validating cluster size inference: random field and permutation methods","volume":"20","author":"Hayasaka","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib43","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1212\/WNL.0b013e3181b879ac","article-title":"Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease","volume":"73","author":"Henneman","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jalz.2013.07.003","article-title":"Coalition against Major Diseases\/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer's disease","volume":"10","author":"Hill","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib45","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/archneurol.2011.70","article-title":"Amyloid-dependent and amyloid-independent stages of Alzheimer disease","volume":"8","author":"Hyman","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2014.11.002","article-title":"The transitional association between beta-amyloid pathology and regional brain atrophy","author":"Insel","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"issue":"Pt 3","key":"10.1016\/j.neurobiolaging.2015.06.027_bib49","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awm336","article-title":"11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment","volume":"131","author":"Jack","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib50","first-page":"856","article-title":"Shapes of the trajectories of 5 major biomarkers of Alzheimer disease","volume":"69","author":"Jack","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib51","doi-asserted-by":"crossref","first-page":"a006213","DOI":"10.1101\/cshperspect.a006213","article-title":"Brain imaging in Alzheimer disease","volume":"2","author":"Johnson","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib52","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3233\/JAD-2010-100114","article-title":"Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study","volume":"21","author":"Julkunen","year":"2010","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib53","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1093\/brain\/awt145","article-title":"In\u00a0vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease","volume":"136","author":"Kreisl","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib54","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.neuroimage.2004.10.016","article-title":"No epsilon4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects","volume":"24","author":"Lemaitre","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib55","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3233\/JAD-2010-100201","article-title":"Effect of APOE epsilon4 allele on cortical thicknesses and volumes: the AddNeuroMed study","volume":"21","author":"Liu","year":"2010","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/jmri.22003","article-title":"Adaptive non-local means denoising of MR images with spatially varying noise levels","volume":"31","author":"Manjon","year":"2010","journal-title":"J.\u00a0Magn. Reson. Imaging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib57","doi-asserted-by":"crossref","first-page":"e97608","DOI":"10.1371\/journal.pone.0097608","article-title":"APOE epsilon4 is associated with disproportionate progressive hippocampal atrophy in AD","volume":"9","author":"Manning","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib59","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.neurobiolaging.2013.08.027","article-title":"Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults","volume":"35","author":"Mattsson","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib58","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1001\/jamaneurol.2014.446","article-title":"Emerging beta-amyloid pathology and accelerated cortical atrophy","volume":"71","author":"Mattsson","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib60","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3233\/JAD-130203","article-title":"The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study","volume":"36","author":"Molinuevo","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"issue":"Pt 5","key":"10.1016\/j.neurobiolaging.2015.06.027_bib61","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/brain\/awn320","article-title":"Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects","volume":"132","author":"Mormino","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib62","doi-asserted-by":"crossref","first-page":"e6501","DOI":"10.1371\/journal.pone.0006501","article-title":"Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease","volume":"4","author":"Potkin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib63","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/2013.jamaneurol.286","article-title":"Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease","volume":"70","author":"Protas","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib64","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJM199603213341202","article-title":"Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E","volume":"334","author":"Reiman","year":"1996","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib65","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/ana.410440226","article-title":"Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease","volume":"44","author":"Reiman","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib66","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1001\/archneurol.2011.167","article-title":"The dynamics of cortical and hippocampal atrophy in Alzheimer disease","volume":"68","author":"Sabuncu","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib67","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/ana.22315","article-title":"Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Abeta1-42","volume":"68","author":"Schott","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib68","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neurobiolaging.2010.07.012","article-title":"Nonlinear time course of brain volume loss in cognitively normal and impaired elders","volume":"33","author":"Schuff","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"Pt 4","key":"10.1016\/j.neurobiolaging.2015.06.027_bib69","first-page":"1067","article-title":"MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers","volume":"132","author":"Schuff","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib70","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S1474-4422(07)70106-0","article-title":"Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study","volume":"6","author":"Shaw","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib71","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1002\/hbm.22447","article-title":"Genetic influence of apolipoprotein E4 genotype on hippocampal morphometry: an N\u00a0= 725 surface-based Alzheimer's disease neuroimaging initiative study","volume":"35","author":"Shi","year":"2014","journal-title":"Hum. Brain Mapp."},{"issue":"19 Pt 2","key":"10.1016\/j.neurobiolaging.2015.06.027_bib73","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1212\/01.wnl.0000311446.61861.e3","article-title":"Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors","volume":"70","author":"Sluimer","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib74","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1073\/pnas.090106797","article-title":"Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease","volume":"97","author":"Small","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.\u00a0S. A."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib75","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1001\/archneurol.2009.272","article-title":"Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition","volume":"66","author":"Storandt","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib76","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s11682-012-9171-6","article-title":"CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer's pathological cascade","volume":"6","author":"Stricker","year":"2012","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib77","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3233\/JAD-131085","article-title":"Validation of the AD-CSF-index in autopsy-confirmed Alzheimer's disease patients and healthy controls","volume":"41","author":"Struyfs","year":"2014","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib78","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.biopsych.2004.07.021","article-title":"Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele","volume":"56","author":"Sunderland","year":"2004","journal-title":"Biol. Psychiatry"},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2015.06.027_bib79","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/15622975.2011.603222","article-title":"Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes","volume":"12","author":"Teipel","year":"2011","journal-title":"World J. Biol. Psychiatry"},{"issue":"Suppl 3","key":"10.1016\/j.neurobiolaging.2015.06.027_bib80","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3233\/JAD-2011-0006","article-title":"Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data","volume":"26","author":"Tosun","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib81","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.neurobiolaging.2010.04.030","article-title":"Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study","volume":"31","author":"Tosun","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib82","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neuroimage.2011.07.059","article-title":"The effects of APOE on the functional architecture of the resting brain","volume":"59","author":"Trachtenberg","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib83","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.neurobiolaging.2010.03.009","article-title":"The effects of APOE-epsilon4 on the BOLD response","volume":"33","author":"Trachtenberg","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib84","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib85","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1212\/WNL.0b013e3181af79e5","article-title":"MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations","volume":"73","author":"Vemuri","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib86","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.06.027_bib87","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1073\/pnas.1001412107","article-title":"Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional\u2013executive network function in Alzheimer's disease","volume":"107","author":"Wolk","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458015003395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458015003395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T22:10:15Z","timestamp":1717971015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458015003395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":86,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0197458015003395"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.06.027","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonlinear cerebral atrophy patterns across the Alzheimer's disease continuum: impact of APOE4 genotype","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}