{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:32:20Z","timestamp":1783477940932,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Japan National Hospital Organization","award":["H22-NHO-03"],"award-info":[{"award-number":["H22-NHO-03"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.neurobiolaging.2015.08.027","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T18:01:18Z","timestamp":1441648878000},"page":"3306-3313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease"],"prefix":"10.1016","volume":"36","author":[{"given":"Tomoko","family":"Oeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kohsaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwiyoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harutoshi","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 9","key":"10.1016\/j.neurobiolaging.2015.08.027_bib1","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1093\/brain\/awv179","article-title":"Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations","volume":"138","author":"Alcalay","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1212\/WNL.0b013e318245f476","article-title":"Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers","volume":"78","author":"Anheim","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib3","first-page":"1095","article-title":"Quantitative assessment of cerebral blood flow in patients with Alzheimer's disease by SPECT","volume":"38","author":"Bartenstein","year":"1997","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jamaneurol.2014.2950","article-title":"Evolution of Prodromal clinical markers of Parkinson disease in a GBA mutation-positive cohort","volume":"72","author":"Beavan","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1212\/01.WNL.0000072482.70963.D7","article-title":"Gaucher's disease with Parkinson's disease: clinical and pathological aspects","volume":"61","author":"Bembi","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1212\/WNL.0b013e318225ab77","article-title":"GBA-associated PD presents with nonmotor characteristics","volume":"77","author":"Brockmann","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/mds.26071","article-title":"GBA-associated Parkinson's disease: reduced survival and more rapid progression in a prospective longitudinal study","volume":"30","author":"Brockmann","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib8","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1001\/jamaneurol.2013.1274","article-title":"Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations","volume":"70","author":"Chahine","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13024-015-0010-2","article-title":"Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies","volume":"10","author":"Chiasserini","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib10","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1212\/01.wnl.0000276989.17578.02","article-title":"Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease","volume":"69","author":"Clark","year":"2007","journal-title":"Neurology"},{"issue":"Pt 12","key":"10.1016\/j.neurobiolaging.2015.08.027_bib11","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1093\/brain\/awu291","article-title":"Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation","volume":"137","author":"Fishbein","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib12","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1212\/01.wnl.0000304039.11891.29","article-title":"Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset","volume":"70","author":"Gan-Or","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ana.23614","article-title":"Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains","volume":"72","author":"Gegg","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","article-title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease","volume":"51","author":"Gibb","year":"1988","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"issue":"Pt 8","key":"10.1016\/j.neurobiolaging.2015.08.027_bib15","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1093\/brain\/aws174","article-title":"The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow","volume":"135","author":"Goker-Alpan","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/jmg.2004.024455","article-title":"Parkinsonism among Gaucher disease carriers","volume":"41","author":"Goker-Alpan","year":"2004","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bcmd.2006.02.004","article-title":"Increased incidence of Parkinson disease among relatives of patients with Gaucher disease","volume":"36","author":"Halperin","year":"2006","journal-title":"Blood Cells Mol. Dis"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/mds.21956","article-title":"The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years","volume":"23","author":"Hely","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000106613","article-title":"Reduction of regional cerebral blood flow and cognitive impairment in patients with Alzheimer's disease: evaluation of an observer-independent analytic approach","volume":"8","author":"Hirsch","year":"1997","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib20","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1086\/302925","article-title":"Analysis and classification of 304 mutant alleles in patients with type 1 and type 3 Gaucher disease","volume":"66","author":"Koprivica","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib21","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.parkreldis.2015.04.028","article-title":"Presenting symptoms of GBA-related Parkinson's disease","volume":"21","author":"Kresojevic","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/hmg\/ddq454","article-title":"Large-scale screening of the Gaucher's disease-related glucocerebrosidase gene in Europeans with Parkinson's disease","volume":"20","author":"Lesage","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib23","doi-asserted-by":"crossref","first-page":"935.e3","DOI":"10.1016\/j.neurobiolaging.2013.09.019","article-title":"Clinicogenetic study of GBA mutations in patients with familial Parkinson's disease","volume":"35","author":"Li","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ymgme.2003.11.004","article-title":"Glucocerebrosidase mutations in subjects with parkinsonism","volume":"81","author":"Lwin","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/(SICI)1096-8652(199907)61:3<216::AID-AJH12>3.0.CO;2-B","article-title":"Parkinson's syndrome preceding clinical manifestation of Gaucher's disease","volume":"61","author":"Machaczka","year":"1999","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib26","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.pjnns.2014.07.005","article-title":"Cognitive impairment in carriers of glucocerebrosidase gene mutation in Parkinson disease patients","volume":"48","author":"Malec-Litwinowicz","year":"2014","journal-title":"Neurol. Neurochir. Pol."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib28","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib29","first-page":"1238","article-title":"A\u00a0diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET","volume":"36","author":"Minoshima","year":"1995","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib30","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/archneurol.2009.72","article-title":"Mutations for Gaucher disease confer high susceptibility to Parkinson disease","volume":"66","author":"Mitsui","year":"2009","journal-title":"Arch. Neurol."},{"issue":"Pt 3","key":"10.1016\/j.neurobiolaging.2015.08.027_bib31","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/brain\/awt367","article-title":"Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease","volume":"137","author":"Murphy","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib32","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/qjmed\/89.9.691","article-title":"Occurrence of Parkinson's syndrome in type I Gaucher disease","volume":"89","author":"Neudorfer","year":"1996","journal-title":"QJM"},{"issue":"Pt 7","key":"10.1016\/j.neurobiolaging.2015.08.027_bib33","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/awp044","article-title":"Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1212\/01.wnl.0000327823.81237.d1","article-title":"Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset","volume":"72","author":"Nichols","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jns.2015.06.030","article-title":"Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease","volume":"356","author":"Noelker","year":"2015","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1468-1331.2008.02372.x","article-title":"Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease","volume":"16","author":"Sawada","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib37","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1038\/ncomms5028","article-title":"iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis","volume":"5","author":"Schondorf","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/mds.24045","article-title":"Glucocerebrosidase mutations confer a greater risk of dementia during Parkinson's disease course","volume":"27","author":"Seto-Salvia","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib39","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib40","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s11910-013-0368-x","article-title":"The association between ss-glucocerebrosidase mutations and parkinsonism","volume":"13","author":"Swan","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/mgme.2001.3201","article-title":"Gaucher disease and parkinsonism: a phenotypic and genotypic characterization","volume":"73","author":"Tayebi","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1096-7192(03)00071-4","article-title":"Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?","volume":"79","author":"Tayebi","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib43","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson's disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib44","doi-asserted-by":"crossref","first-page":"e1005065","DOI":"10.1371\/journal.pgen.1005065","article-title":"Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein","volume":"11","author":"Uemura","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neurobiolaging.2015.08.027_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1744-9081-8-57","article-title":"Glucocerebrosidase L444P mutation confers genetic risk for Parkinson's disease in central China","volume":"8","author":"Wang","year":"2012","journal-title":"Behav. Brain Funct."},{"issue":"Pt 2","key":"10.1016\/j.neurobiolaging.2015.08.027_bib46","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/brain\/aws318","article-title":"Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort","volume":"136","author":"Winder-Rhodes","year":"2013","journal-title":"Brain"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458015004443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458015004443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T07:31:43Z","timestamp":1567150303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458015004443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0197458015004443"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.08.027","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}