{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:45:39Z","timestamp":1791294339957,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["PO1AG14449"],"award-info":[{"award-number":["PO1AG14449"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG10161"],"award-info":[{"award-number":["P30AG10161"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG019610"],"award-info":[{"award-number":["P30AG019610"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RO1AG43775"],"award-info":[{"award-number":["RO1AG43775"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.neurobiolaging.2015.10.012","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T23:48:35Z","timestamp":1445644115000},"page":"147-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment"],"prefix":"10.1016","volume":"37","author":[{"given":"Elliott J.","family":"Mufson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Malek-Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia E.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib1","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/01.wnl.0000219668.47116.e6","article-title":"Neuropathology of older persons without cognitive impairment from two community-based studies","volume":"66","author":"Bennett","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib2","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1212\/01.WNL.0000152982.47274.9E","article-title":"Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions","volume":"8","author":"Bennett","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000087446","article-title":"The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort","volume":"25","author":"Bennett","year":"2005","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib4","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/archneur.61.3.378","article-title":"Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function","volume":"61","author":"Bennett","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1212\/WNL.59.2.198","article-title":"Natural history of mild cognitive impairment in older persons","volume":"59","author":"Bennett","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000333122","article-title":"Hippocampal drebrin loss in mild cognitive impairment","volume":"10","author":"Counts","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0197-4580(92)90027-U","article-title":"Identification of normal and pathological aging in prospectively studied nondemented elderly humans","volume":"l13","author":"Dickson","year":"1992","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib9","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1212\/01.wnl.0000341273.18141.64","article-title":"Factors associated with resistance to dementia despite high Alzheimer disease pathology","volume":"72","author":"Erten-Jones","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib10","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1056\/NEJMe0901965","article-title":"Cool with plaques and tangles","volume":"360","author":"Ewbank","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/(SICI)1096-9861(19990906)411:4<693::AID-CNE13>3.0.CO;2-D","article-title":"Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease","volume":"411","author":"Gilmor","year":"1999","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s004010051163","article-title":"Clinical validity of Braak neuropathological staging in the oldest-old","volume":"99","author":"Gold","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib13","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/archneur.60.5.729","article-title":"Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment","volume":"60","author":"Guillozet","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib14","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1001\/archneur.65.9.1211","article-title":"Role of the neuropathology of Alzheimer disease in dementia in the oldest-old","volume":"65","author":"Haroutunian","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib15","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1212\/WNL.0b013e3181b01077","article-title":"The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life","volume":"73","author":"Iacono","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3233\/JAD-2010-1220","article-title":"Neuropathologic alterations in mild cognitive impairment: a review","volume":"19","author":"Markesbery","year":"2010","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib17","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1177\/002215540004801206","article-title":"Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment","volume":"48","author":"Mitchell","year":"2000","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The consortium to establish a registry for Alzheimer's disease (CERAD). part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/JMN:17:2:101","article-title":"Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease","volume":"17","author":"Morris","year":"2001","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-011-0884-1","article-title":"Mild cognitive impairment: pathology and mechanisms","volume":"123","author":"Mufson","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/exnr.1999.7086","article-title":"Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment","volume":"158","author":"Mufson","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib22","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/NEN.0b013e318272caab","article-title":"Hippocampal proNGF signaling pathways and \u03b2-amyloid levels in mild cognitive impairment and Alzheimer disease","volume":"71","author":"Mufson","year":"2012","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuroscience.2015.03.006","article-title":"Hippocampal plasticity during the progression of Alzheimer's disease","volume":"309","author":"Mufson","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000353687","article-title":"Prefibrillar tau oligomers in mild cognitive impairment and Alzheimer's disease","volume":"13","author":"Mufson","year":"2014","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib25","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2174\/15672050113109990157","article-title":"Resilient brain aging: characterization of discordance between Alzheimer's disease pathology and cognition","volume":"10","author":"Negash","year":"2013","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/NEN.0b013e3181919a48","article-title":"Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship","volume":"68","author":"Nelson","year":"2009","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib27","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-011-0826-y","article-title":"Alzheimer's disease is not \u201cbrain aging\u201d: neuropathological, genetic, and epidemiological human studies","volume":"121","author":"Nelson","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib28","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ajpath.2011.10.027","article-title":"Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease","volume":"180","author":"Perez","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib29","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.biopsych.2013.12.016","article-title":"Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease","volume":"77","author":"Perez","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib30","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.neurobiolaging.2009.04.002","article-title":"Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease","volume":"30","author":"Price","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib31","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer's disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib32","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.neurobiolaging.2007.05.005","article-title":"Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons","volume":"28","author":"Riudavets","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib33","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/01.wnl.0000260698.46517.8f","article-title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment","volume":"68","author":"Scheff","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib34","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2009-1227","article-title":"The neuropathology of older persons with and without dementia from community versus clinic cohorts","volume":"18","author":"Schneider","year":"2009","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib35","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ana.21706","article-title":"The neuropathology of probable Alzheimer disease and mild cognitive impairment","volume":"66","author":"Schneider","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ana.21142","article-title":"Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons","volume":"62","author":"Schneider","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1212\/01.wnl.0000265594.23511.16","article-title":"A\u00a0plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms?","volume":"69","author":"Smith","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0969-9961(02)00019-0","article-title":"Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in \u03b2-amyloid-induced neuronal death","volume":"12","author":"Su","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib39","first-page":"S1","article-title":"The National Institute on Aging, and Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer's disease: consensus recommendations for the postmortem diagnosis of Alzheimer's disease","volume":"18","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0022-510X(70)90063-8","article-title":"Observations on the brains of demented old people","volume":"11","author":"Tomlinson","year":"1970","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2015.10.012_bib41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/archneurol.2011.31","article-title":"Cognitive decline in prodromal Alzheimer's disease and mild cognitive impairment","volume":"68","author":"Wilson","year":"2011","journal-title":"Arch. Neurol."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458015005163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458015005163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T11:50:56Z","timestamp":1537271456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458015005163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":41,"alternative-id":["S0197458015005163"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.10.012","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}