{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T06:20:43Z","timestamp":1793514043527,"version":"4.5.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.neurobiolaging.2015.12.020","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T17:15:17Z","timestamp":1451927717000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"C","title":["Higher body mass index in older adults is associated with lower gray matter volume: implications for memory performance"],"prefix":"10.1016","volume":"40","author":[{"given":"Shahrzad","family":"Kharabian Masouleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Ar\u00e9lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Horstmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Lampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy A.","family":"Kipping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Luck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffi G.","family":"Riedel-Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias L.","family":"Schroeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stumvoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Villringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja Veronica","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib1","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1111\/j.1467-789X.2010.00825.x","article-title":"Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies","volume":"12","author":"Anstey","year":"2011","journal-title":"Obes. Rev."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib2","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1212\/01.wnl.0000324925.95210.6d","article-title":"Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology","volume":"71","author":"Beeri","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib3","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging","volume":"6","author":"Behrens","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib4","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jalz.2014.08.104","article-title":"Self-reported sleep disturbance is associated with Alzheimer's disease risk in men","volume":"11","author":"Benedict","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib5","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/ene.12083","article-title":"Obesity and impaired cognitive functioning in the elderly: a population-based cross-sectional study (NEDICES)","volume":"20","author":"Benito-Le\u00f3n","year":"2013","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/scan\/nsp053","article-title":"The principled control of false positives in neuroimaging","volume":"4","author":"Bennett","year":"2009","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1467-789X.2008.00473.x","article-title":"Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis","volume":"9","author":"Beydoun","year":"2008","journal-title":"Obes. Rev."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib84","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/jnnp.2005.069583","article-title":"Increased cortical atrophy in patients with Alzheimer\u2019s disease and type 2 diabetes mellitus","volume":"77","author":"Biessels","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1474-4422(08)70021-8","article-title":"Cognition and diabetes: a lifespan perspective","volume":"7","author":"Biessels","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/ijo.2012.13","article-title":"Late-life obesity is associated with smaller global and regional gray matter volumes: a voxel-based morphometric study","volume":"37","author":"Brooks","year":"2013","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuron.2004.09.006","article-title":"Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate","volume":"44","author":"Buckner","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1001\/archneurol.2010.38","article-title":"Reduced lean mass in early Alzheimer disease and its association with brain atrophy","volume":"67","author":"Burns","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib12","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1056\/NEJMoa1215740","article-title":"Glucose levels and risk of dementia","volume":"369","author":"Crane","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib13","doi-asserted-by":"crossref","first-page":"R685","DOI":"10.1016\/j.cub.2014.06.031","article-title":"Obesity: cognitive impairment and the failure to \u201cEat right\u201d","volume":"24","author":"Davidson","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.nbd.2014.04.012","article-title":"Neuroprotective effects of leptin in the context of obesity and metabolic disorders","volume":"72PA","author":"Davis","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1023832305702","article-title":"Alzheimer' disease as a disconnection syndrome?","volume":"13","author":"Delbeuck","year":"2003","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib16","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/hbm.21353","article-title":"Midlife obesity and trajectories of brain volume changes in older adults","volume":"33","author":"Driscoll","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib17","first-page":"10","article-title":"Age-related changes in processing speed: unique contributions of cerebellar and prefrontal cortex","volume":"4","author":"Eckert","year":"2010","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib18","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1002\/hbm.21389","article-title":"Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus\u2014a DTI tractography study","volume":"33","author":"Eckert","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2005.08.019","article-title":"Obesity, diabetes and cognitive deficit: the Framingham Heart study","volume":"26 Suppl 1","author":"Elias","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3233\/JAD-141086","article-title":"2003-2013: a decade of body mass index, Alzheimer's disease, and dementia","volume":"43","author":"Emmerzaal","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib21","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.neuron.2012.12.002","article-title":"The role of medial prefrontal cortex in memory and decision making","volume":"76","author":"Euston","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib85","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1212\/WNL.43.9.1683","article-title":"Pathologic correlates of incidental MRI white matter signal hyperintensities","volume":"43","author":"Fazekas","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib22","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/oby.2009.161","article-title":"Obesity and lowered cognitive performance in a Canadian First Nations population","volume":"17","author":"Fergenbaum","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2337\/diabetes.52.1.149","article-title":"Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia","volume":"52","author":"Ferguson","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib24","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neurobiolaging.2013.10.095","article-title":"Cognitive decline is mediated by gray matter changes during middle age","volume":"35","author":"Ferreira","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/archneurol.2008.582","article-title":"Midlife and late-life obesity and the risk of dementia: cardiovascular health study","volume":"66","author":"Fitzpatrick","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1515\/REVNEURO.2010.21.3.187","article-title":"Structural brain changes in aging: courses, causes and cognitive consequences","volume":"21","author":"Fjell","year":"2010","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib27","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.jcmg.2014.06.014","article-title":"Brain imaging changes associated with risk factors for cardiovascular and cerebrovascular disease in asymptomatic patients","volume":"7","author":"Friedman","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/hbm.460010306","article-title":"Assessing the significance of focal activations using their spatial extent","volume":"1","author":"Friston","year":"1994","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib29","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1212\/01.wnl.0000327670.62378.c0","article-title":"Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence","volume":"71","author":"Garibotto","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib86","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/mrm.10171","article-title":"Generalized autocalibrating partially parallel acquisitions (GRAPPA)","volume":"47","author":"Griswold","year":"2002","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.comppsych.2006.05.001","article-title":"Elevated body mass index is associated with executive dysfunction in otherwise healthy adults","volume":"48","author":"Gunstad","year":"2007","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib32","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1474-4422(06)70526-9","article-title":"Adiposity indices and dementia","volume":"5","author":"Gustafson","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib33","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/oby.20332","article-title":"Dyslipidemia links obesity to early cerebral neurochemical alterations","volume":"21","author":"Haley","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib34","series-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-based Approach","author":"Hayes","year":"2013"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib35","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.neurobiolaging.2010.04.006","article-title":"Obesity is linked with lower brain volume in 700 AD and MCI patients","volume":"31","author":"Ho","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib36","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fnhum.2011.00058","article-title":"Obesity-related differences between women and men in brain structure and goal-directed behavior","volume":"5","author":"Horstmann","year":"2011","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib37","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.neuroimage.2009.04.072","article-title":"Is the brain the essential in hypertension?","volume":"47","author":"Jennings","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib38","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/mp.2014.187","article-title":"Cigarette smoking and thinning of the brain's cortex","volume":"20","author":"Karama","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib39","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1212\/01.wnl.0000435561.00234.ee","article-title":"Higher glucose levels associated with lower memory and reduced hippocampal microstructure","volume":"81","author":"Kerti","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib40","doi-asserted-by":"crossref","first-page":"10541","DOI":"10.1523\/JNEUROSCI.3456-08.2008","article-title":"Activity in the medial temporal lobe predicts memory strength, whereas activity in the prefrontal cortex predicts recollection","volume":"28","author":"Kirwan","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib41","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/archneur.62.10.1556","article-title":"Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease","volume":"62","author":"Kivipelto","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib42","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neuroimage.2010.02.062","article-title":"Topography of connections between human prefrontal cortex and mediodorsal thalamus studied with diffusion tractography","volume":"51","author":"Klein","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib87","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1037\/0882-7974.12.2.277","article-title":"Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for depression among community-residing older adults","volume":"12","author":"Lewinsohn","year":"1997","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib43","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1186\/s12889-015-1983-z","article-title":"The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany","volume":"15","author":"Loeffler","year":"2015","journal-title":"BMC Public Health"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neurobiolaging.2006.09.001","article-title":"Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: a possible window of opportunity effect","volume":"29","author":"Lord","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbadis.2011.08.003","article-title":"Diffusion tensor imaging of cerebral white matter integrity in cognitive aging","volume":"1822","author":"Madden","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11065-009-9113-2","article-title":"Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging","volume":"19","author":"Madden","year":"2009","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib47","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nn.3324","article-title":"Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging","volume":"16","author":"Mander","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pscychresns.2013.06.004","article-title":"Frontal cortical thinning and subcortical volume reductions in early adulthood obesity","volume":"214","author":"Marqu\u00e9s-Iturria","year":"2013","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1123\/jpah.7.1.127","article-title":"Population reach and recruitment bias in a maintenance RCT in physically active older adults","volume":"7","author":"Martinson","year":"2010","journal-title":"J.\u00a0Phys. Act. Health"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib50","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.39.9.1159","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease","volume":"39","author":"Morris","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib51","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jalz.2014.11.003","article-title":"Statins and brain integrity in older adults: secondary analysis of the Health ABC study","volume":"11","author":"Nadkarni","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib52","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A\u00a02 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/13854040903482848","article-title":"Assessing mental flexibility: neuroanatomical and neuropsychological correlates of the Trail Making test in elderly people","volume":"24","author":"Oosterman","year":"2010","journal-title":"Clin. Neuropsychol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib54","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.neuroimage.2006.01.047","article-title":"Brain abnormalities in human obesity: a voxel-based morphometric study","volume":"31","author":"Pannacciulli","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib55","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S2213-8587(13)70125-6","article-title":"Diabetes drugs and neurological disorders: new views and therapeutic possibilities","volume":"2","author":"Patrone","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib56","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1523\/JNEUROSCI.1553-10.2010","article-title":"A\u00a0general factor of brain white matter integrity predicts information processing speed in healthy older people","volume":"30","author":"Penke","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.orcp.2014.05.001","article-title":"Examining the relationship between obesity and cognitive function: a systematic literature review","volume":"9","author":"Prickett","year":"2015","journal-title":"Obes. Res. Clin. Pract."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib58","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S2213-8587(15)00033-9","article-title":"BMI and risk of dementia in two million people over two decades: a retrospective cohort study","volume":"3","author":"Qizilbash","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hbm.20870","article-title":"Brain structure and obesity","volume":"31","author":"Raji","year":"2010","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib60","first-page":"1","article-title":"Ageing and the Brain","author":"Raz","year":"2005","journal-title":"Encycl. Life Sci."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib61","first-page":"820956","article-title":"The relationship between executive function and obesity in children and adolescents: a systematic literature review","volume":"2013","author":"Reinert","year":"2013","journal-title":"J.\u00a0Obes."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib62","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/STROKEAHA.111.000792","article-title":"Long-term cognitive impairment after first-ever ischemic stroke in young adults","volume":"44","author":"Schaapsmeerders","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib63","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/j.neubiorev.2013.07.015","article-title":"Is obesity a brain disease?","volume":"37","author":"Shefer","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib64","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1467-789X.2011.00920.x","article-title":"A\u00a0review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment","volume":"12","author":"Smith","year":"2011","journal-title":"Obes. Rev."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib65","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.neurobiolaging.2015.05.004","article-title":"Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults","volume":"36","author":"Sprecher","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib66","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1016\/j.neuropsychologia.2012.08.023","article-title":"Memory signals from the thalamus: early thalamocortical phase synchronization entrains gamma oscillations during long-term memory retrieval","volume":"50","author":"Staudigl","year":"2012","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib67","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1002\/hbm.22142","article-title":"Cerebral blood flow and gray matter volume covariance patterns of cognition in aging","volume":"34","author":"Steffener","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib68","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuroimage.2013.10.051","article-title":"Impact of image acquisition on voxel-based-morphometry investigations of age-related structural brain changes","volume":"87","author":"Streitb\u00fcrger","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib69","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/oby.2007.4","article-title":"Relationship between body mass index and gray matter volume in 1,428 healthy individuals","volume":"16","author":"Taki","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib70","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuron.2006.09.020","article-title":"Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology","volume":"52","author":"Uhlhaas","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib71","series-title":"International Standard Classification of Education","year":"1997"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib72","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1212\/01.wnl.0000324268.45138.86","article-title":"Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial","volume":"71","author":"Van de Rest","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib73","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1212\/WNL.0000000000000550","article-title":"Vascular risk and A\u03b2 interact to reduce cortical thickness in AD vulnerable brain regions","volume":"83","author":"Villeneuve","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib74","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neurobiolaging.2013.11.011","article-title":"Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging","volume":"35","author":"Walhovd","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib75","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/hbm.20916","article-title":"Structural brain differences and cognitive functioning related to body mass index in older females","volume":"31","author":"Walther","year":"2010","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib76","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuroimage.2005.08.057","article-title":"Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample","volume":"29","author":"Wen","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib78","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1136\/bmj.38446.466238.E0","article-title":"Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study","volume":"330","author":"Whitmer","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib77","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1212\/01.wnl.0000306313.89165.ef","article-title":"Central obesity and increased risk of dementia more than three decades later","volume":"71","author":"Whitmer","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib79","first-page":"1","article-title":"Does the brain shrink as the waist expands?","volume":"20","author":"Willette","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib80","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1212\/01.wnl.0000238079.00472.3a","article-title":"Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele","volume":"67","author":"Wishart","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib81","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuroimage.2013.12.058","article-title":"Cluster-extent based thresholding in fMRI analyses: pitfalls and recommendations","volume":"91","author":"Woo","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib82","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neubiorev.2014.02.005","article-title":"Prefrontal cortex and executive functions in healthy adults: a meta-analysis of structural neuroimaging studies","volume":"42","author":"Yuan","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2015.12.020_bib83","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/ana.410170605","article-title":"Amnesia in monkeys after lesions of the mediodorsal nucleus of the thalamus","volume":"17","author":"Zola-Morgan","year":"1985","journal-title":"Ann. Neurol."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458015006363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458015006363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T15:49:05Z","timestamp":1718293745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458015006363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":87,"alternative-id":["S0197458015006363"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.12.020","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Higher body mass index in older adults is associated with lower gray matter volume: implications for memory performance","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}