{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:35:50Z","timestamp":1792892150827,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG026572"],"award-info":[{"award-number":["P01AG026572"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["IIRG-10\u2013172459"],"award-info":[{"award-number":["IIRG-10\u2013172459"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.neurobiolaging.2016.02.011","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T21:07:26Z","timestamp":1455916046000},"page":"69-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"special_numbering":"C","title":["Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease"],"prefix":"10.1016","volume":"42","author":[{"given":"Liqin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisu","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Woody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta D.","family":"Brinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ana.24135","article-title":"Sex modifies the APOE-related risk of developing Alzheimer disease","volume":"75","author":"Altmann","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib18","unstructured":"Alzheimer's Association, 2015. Women with Mild Cognitive Impairment Decline Twice as Fast as Men with the Condition. Available at: www.alz.org. Accessed August 10, 2015."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib2","unstructured":"Alzheimer's Society, 2015. The progression of Alzheimer's disease and other dementias. Available at: http:\/\/www.alzheimers.org.uk. Accessed April 2, 2015."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib4","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1136\/jnnp.2007.136903","article-title":"Risk profiles for mild cognitive impairment and progression to dementia are gender specific","volume":"79","author":"Artero","year":"2008","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/archpsyc.62.6.685","article-title":"Sex differences in the clinical manifestations of Alzheimer disease pathology","volume":"62","author":"Barnes","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2014.02.005","article-title":"Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?","volume":"118","author":"Bassil","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib7","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1212\/WNL.0b013e3182752eef","article-title":"Insulin-like growth factors in the brain and their potential clinical implications","volume":"79","author":"Benarroch","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib8","doi-asserted-by":"crossref","first-page":"2325.e17","DOI":"10.1016\/j.neurobiolaging.2011.01.001","article-title":"Structural brain changes in normal individuals with a maternal history of Alzheimer's","volume":"32","author":"Berti","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrneurol.2009.213","article-title":"Alzheimer disease: new light on an old CLU","volume":"6","author":"Bertram","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00002093-199910000-00007","article-title":"Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease","volume":"13","author":"Bretsky","year":"1999","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tips.2008.12.006","article-title":"Estrogen-induced plasticity from cells to circuits: predictions for cognitive function","volume":"30","author":"Brinton","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jalz.2010.11.007","article-title":"National estimates of the prevalence of Alzheimer's disease in the United States","volume":"7","author":"Brookmeyer","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib13","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1089\/jwh.2012.3789","article-title":"Sex and gender differences in Alzheimer's disease: recommendations for future research","volume":"21","author":"Carter","year":"2012","journal-title":"J.\u00a0Womens Health (Larchmt)"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib14","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1017\/S1355617711000452","article-title":"Women have farther to fall: gender differences between Normal elderly and Alzheimer's disease in verbal memory engender better detection of Alzheimer's disease in women","volume":"17","author":"Chapman","year":"2011","journal-title":"J.\u00a0Int. Neuropsychol. Soc."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib15","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.brainresbull.2012.05.006","article-title":"Clusterin in neurological disorders: molecular perspectives and clinical relevance","volume":"88","author":"Charnay","year":"2012","journal-title":"Brain Res. Bull"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib16","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.metabol.2010.07.033","article-title":"Association of the clusterin gene polymorphisms with type 2 diabetes mellitus","volume":"60","author":"Daimon","year":"2011","journal-title":"Metabolism"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib17","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib19","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archpsyc.55.9.809","article-title":"The relationship between age, sex, and the incidence of dementia and Alzheimer disease: a meta-analysis","volume":"55","author":"Gao","year":"1998","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1530\/jrf.0.0690453","article-title":"Graafian follicle growth and replacement in anovulatory ovaries of ageing C57BL\/6J mice","volume":"69","author":"Gosden","year":"1983","journal-title":"J.\u00a0Reprod. Fertil."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4236\/psych.2012.36068","article-title":"Bonston naming test: gender differences in older adults with and without Alzheimer's dementia","volume":"3","author":"Hall","year":"2012","journal-title":"Psychology"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib22","series-title":"Women's Brains Appear More Vulnerable to Alzheimer's than Men's","author":"Hamilton","year":"2015"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib23","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib24","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1212\/WNL.0b013e31820e7b74","article-title":"Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease","volume":"76","author":"Honea","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib25","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1080\/13803395.2012.712676","article-title":"Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis","volume":"34","author":"Irvine","year":"2012","journal-title":"J.\u00a0Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0006-8993(98)00363-1","article-title":"Initiation and propagation stages of beta-amyloid are associated with distinctive apolipoprotein E, age, and gender profiles","volume":"798","author":"Johnson","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib27","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.bbrc.2011.04.111","article-title":"SREBP-1c regulates glucose-stimulated hepatic clusterin expression","volume":"408","author":"Kim","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib28","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data using the comparative Ct method","volume":"3","author":"Livak","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib30","unstructured":"McBride R. Pharma Counts Just 3 Alzheimer's Drug Wins in 13 Years (101 Losses). Available at: http:\/\/wwwfiercebiotechcom\/story\/pharma-counts-just-3-alzheimers-drug-wins-13-years-101-losses\/2012-09-14. Accessed September 14,\u00a02012."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib31","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1089\/dna.1997.16.939","article-title":"Ancient divergence of insulin and insulin-like growth factor","volume":"16","author":"McRory","year":"1997","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1212\/WNL.57.1.89","article-title":"A\u00a0gender difference in the association between APOE genotype and age-related cognitive decline","volume":"57","author":"Mortensen","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib33","first-page":"1778","article-title":"Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease","volume":"47","author":"Mosconi","year":"2006","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib34","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/1479-7364-4-3-170","article-title":"Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes","volume":"4","author":"Mosconi","year":"2010","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib35","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrd3842","article-title":"Sting of Alzheimer's failures offset by upcoming prevention trials","volume":"11","author":"Mullard","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib36","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1095\/biolreprod24.4.784","article-title":"Altered profiles of estradiol and progesterone associated with prolonged estrous cycles and persistent vaginal cornification in aging C57BL\/6J mice","volume":"24","author":"Nelson","year":"1981","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainresrev.2009.05.007","article-title":"Clusterin: a forgotten player in Alzheimer's disease","volume":"61","author":"Nuutinen","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib38","first-page":"803","article-title":"Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women","volume":"58","author":"Payami","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib39","first-page":"3","article-title":"Sex and gender differences in clinical medicine","author":"Regitz-Zagrosek","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib40","unstructured":"Rice S. As Drug Trials Fail, Alzheimer's Researchers Look toward Prevention. Available at: http:\/\/wwwmodernhealthcarecom\/article\/20140125\/MAGAZINE\/301259969#. Accessed January 25,\u00a02014."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib41","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/ERC-09-0140","article-title":"The clusterin paradigm in prostate and breast carcinogenesis","volume":"17","author":"Rizzi","year":"2010","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0065-230X(09)05007-6","article-title":"Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis","volume":"105","author":"Sala","year":"2009","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib43","first-page":"1","article-title":"[Sex differences in Alzheimer's disease]","volume":"22","author":"Schmidt","year":"2008","journal-title":"Neuropsychiatr."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib44","unstructured":"Schnabel J. Why Do All the Large Alzheimer's Drug Trials Fail?. Available at: http:\/\/wwwdanaorg\/News\/Why_Do_All_the_Large_Alzheimer_s_Drug_Trials_Fail_\/. Accessed July 8,\u00a02013."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib3","unstructured":"Statista, 2015. Average life expectancy at birth in 2014 by continent (in years). Available at: www.statista.com. Accessed July 5, 2015."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib45","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.bbadis.2013.09.010","article-title":"The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives","volume":"1842","author":"Swerdlow","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib46","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jalz.2013.02.003","article-title":"2013 Alzheimer's disease facts and figures","volume":"9","author":"Thies","year":"2013","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib47","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/dneu.20778","article-title":"Toward a comprehensive neurobiology of IGF-I","volume":"70","author":"Torres-Aleman","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib48","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000351207","article-title":"The molecular chaperone apolipoprotein J\/Clusterin as a sensor of oxidative stress: implications in therapeutic approaches\u2014a mini-review","volume":"59","author":"Trougakos","year":"2013","journal-title":"Gerontology"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib49","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s11682-013-9272-x","article-title":"Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction","volume":"8","author":"Ungar","year":"2014","journal-title":"Brain Imag. Behav."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib50","doi-asserted-by":"crossref","first-page":"556.e3","DOI":"10.1016\/j.neurobiolaging.2010.10.017","article-title":"IGF-I gene variability is associated with an increased risk for AD","volume":"32","author":"Vargas","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib51","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neulet.2012.10.015","article-title":"Insulin-like growth factor 1 (IGF1) polymorphism is associated with Alzheimer's disease in Han Chinese","volume":"531","author":"Wang","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib52","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000342546","article-title":"Role of insulin-like growth factors in growth, development and feeding","volume":"106","author":"Wit","year":"2013","journal-title":"World Rev. Nutr. Diet."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib53","doi-asserted-by":"crossref","first-page":"R234","DOI":"10.1186\/gb-2007-8-11-r234","article-title":"Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender","volume":"8","author":"Xu","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib54","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease","volume":"106","author":"Yao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib55","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/BST20120260","article-title":"Metabolic triad in brain aging: mitochondria, insulin\/IGF-1 signalling and JNK signalling","volume":"41","author":"Yin","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib56","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12035-012-8237-1","article-title":"The role of clusterin in Alzheimer's disease: pathways, pathogenesis, and therapy","volume":"45","author":"Yu","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib57","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1001\/jama.288.17.2123","article-title":"Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study","volume":"288","author":"Zandi","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib58","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1210\/en.2008-0715","article-title":"A\u00a0select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in\u00a0vitro and in\u00a0vivo","volume":"150","author":"Zhao","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.neurobiolaging.2016.02.011_bib59","doi-asserted-by":"crossref","first-page":"e31267","DOI":"10.1371\/journal.pone.0031267","article-title":"Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles","volume":"7","author":"Zhao","year":"2012","journal-title":"PLoS One"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016001548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016001548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T09:49:32Z","timestamp":1718358572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458016001548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":59,"alternative-id":["S0197458016001548"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.02.011","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}