{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:38:06Z","timestamp":1792035486498,"version":"4.4.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AG037639"],"award-info":[{"award-number":["R01AG037639"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AG027161"],"award-info":[{"award-number":["AG027161"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P50 AG033514"],"award-info":[{"award-number":["P50 AG033514"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32 HD007489"],"award-info":[{"award-number":["T32 HD007489"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UW Institute for Clinical and Translation Research grant","award":["1UL1RR025011"],"award-info":[{"award-number":["1UL1RR025011"]}]},{"name":"Waisman Core Grant","award":["P30 HD003352-45"],"award-info":[{"award-number":["P30 HD003352-45"]}]},{"name":"Geriatric Research, Education, and Clinical Center"},{"name":"William S. Middleton Memorial Veterans Hospital"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.neurobiolaging.2016.03.026","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T23:32:23Z","timestamp":1459899143000},"page":"79-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging"],"prefix":"10.1016","volume":"43","author":[{"given":"Andrew P.","family":"Merluzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Douglas C.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagesh","family":"Adluru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav S.","family":"Suryawanshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozioma C.","family":"Okonkwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce P.","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Sager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Asthana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara B.","family":"Bendlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/00001756-199607290-00013","article-title":"Age-related changes in the fibre composition of the human corpus callosum: sex differences","volume":"7","author":"Aboitiz","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib2","series-title":"Assessment of white matter microstructure in stroke patients using NODDI","first-page":"742","author":"Adluru","year":"2014"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib3","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1212\/01.wnl.0000261482.99569.fb","article-title":"Regional frontal injuries cause distinct impairments in cognitive control","volume":"68","author":"Alexander","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.neurobiolaging.2005.05.023","article-title":"Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region","volume":"26","author":"Allen","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib5","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1093\/brain\/119.6.1983","article-title":"Age and hemisphere effects on dendritic structure","volume":"119","author":"Anderson","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","article-title":"An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging","volume":"125","author":"Andersson","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/mrm.20965","article-title":"Log-Euclidean metrics for fast and simple calculus on diffusion tensors","volume":"56","author":"Arsigny","year":"2006","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib8","first-page":"129","article-title":"Trail making test errors in normal aging, mild cognitive impairment, and dementia","volume":"23","author":"Ashendorf","year":"2008","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12021-011-9109-y","article-title":"An open source multivariate framework for n-tissue segmentation with evaluation on public data","volume":"9","author":"Avants","year":"2011","journal-title":"Neuroinformatics"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/87565641003696775","article-title":"White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three","volume":"35","author":"Bendlin","year":"2010","journal-title":"Dev. Neuropsychol."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib11","first-page":"1915","article-title":"Investigating the long-term effects of systemic chemotherapy on brain white matter using multi-shell diffusion MRI and myelin water imaging","volume":"22","author":"Billiet","year":"2014","journal-title":"Proc. Intl Soc. Mag. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib12","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.neurobiolaging.2015.02.029","article-title":"Age-related microstructural differences quantified using myelin water imaging and advanced diffusion MRI","volume":"36","author":"Billiet","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/1073858407299290","article-title":"Prefrontal cortex and long-term memory encoding: an integrative review of findings from neuropsychology and neuroimaging","volume":"13","author":"Blumenfeld","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib14","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.neurobiolaging.2011.06.001","article-title":"Testing the white matter retrogenesis hypothesis of cognitive aging","volume":"33","author":"Brickman","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib15","doi-asserted-by":"crossref","first-page":"e0123656","DOI":"10.1371\/journal.pone.0123656","article-title":"White matter changes of neurite density and fiber orientation dispersion during human brain maturation","volume":"10","author":"Chang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1212\/01.wnl.0000194256.15247.83","article-title":"White matter damage on diffusion tensor imaging correlates with age-related cognitive decline","volume":"66","author":"Charlton","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput. Biomed. Res."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuroscience.2012.09.077","article-title":"Dendritic spine changes associated with normal aging","volume":"251","author":"Dickstein","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib19","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.neuroimage.2015.02.010","article-title":"Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI","volume":"111","author":"Eaton-Rosen","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib20","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1023\/A:1006926428699","article-title":"Ballooning of myelin sheaths in normally aged macaques","volume":"27","author":"Feldman","year":"1998","journal-title":"J.\u00a0Neurocytology"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib21","unstructured":"Figini, M., Baselli, G., Riva, M., Bello, L., Zhang, H., Bizzi, A., (2014) NODDI performs better than DTI in brain tumors with vasogenic edema. Presented at: Joint Annual Meeting ISMRM-ESMRMB, Milan, Italy. http:\/\/discovery.ucl.ac.uk\/1455609\/; http:\/\/submissions.mirasmart.com\/ismrm2014\/proceedings\/files\/0271.pdf."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pneurobio.2014.02.004","article-title":"What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus","volume":"117","author":"Fjell","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib23","doi-asserted-by":"crossref","first-page":"15223","DOI":"10.1523\/JNEUROSCI.3252-09.2009","article-title":"One-year brain atrophy evident in healthy aging","volume":"29","author":"Fjell","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib24","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/cercor\/bhn232","article-title":"High consistency of regional cortical thinning in aging across multiple samples","volume":"19","author":"Fjell","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib25","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.neurobiolaging.2013.04.006","article-title":"Critical ages in the life course of the adult brain: nonlinear subcortical aging","volume":"34","author":"Fjell","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib27","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.neuroimage.2015.01.045","article-title":"Neurite orientation dispersion and density imaging of the healthy cervical spinal cord in\u00a0vivo","volume":"111","author":"Grussu","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib28","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1037\/0894-4105.14.2.224","article-title":"The cognitive correlates of white matter abnormalities in normal aging: a quantitative review","volume":"14","author":"Gunning-Dixon","year":"2000","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib29","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0028-3932(03)00129-5","article-title":"Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study","volume":"41","author":"Gunning-Dixon","year":"2003","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/cercor\/bhh003","article-title":"Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging","volume":"14","author":"Head","year":"2004","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuroimage.2014.12.009","article-title":"One diffusion acquisition and different white matter models: how does microstructure change in human early development based on WMTI and NODDI?","volume":"107","author":"Jelescu","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib32","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib33","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.neurobiolaging.2005.05.016","article-title":"Changes in volume with age\u2013consistency and interpretation of observed effects","volume":"26","author":"Jernigan","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib34","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/hbm.22099","article-title":"Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging","volume":"34","author":"Jeurissen","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroimage.2012.06.081","article-title":"White matter integrity, fiber count, and other fallacies: the do's and don'ts of diffusion MRI","volume":"73","author":"Jones","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib36","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/archneur.1994.00540210073015","article-title":"A\u00a0validation study of the dementia questionnaire","volume":"51","author":"Kawas","year":"1994","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib37","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.neuroimage.2010.01.064","article-title":"A\u00a0robust method to estimate the intracranial volume across MRI field strengths (1.5 T and 3T)","volume":"50","author":"Keihaninejad","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2009.08.058","article-title":"Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk","volume":"1297","author":"Kennedy","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neuroimage.2015.12.033","article-title":"Age effects and sex differences in human brain white matter of young to middle-aged adults: a DTI, NODDI, and q-space study","volume":"128","author":"Kodiweera","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib40","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neuroimage.2014.03.057","article-title":"Assessing white matter microstructure of the newborn with multi-shell diffusion MRI and biophysical compartment models","volume":"96","author":"Kunz","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib41","doi-asserted-by":"crossref","first-page":"10937","DOI":"10.1523\/JNEUROSCI.5302-10.2011","article-title":"Longitudinal development of human brain wiring continues from childhood into adulthood","volume":"31","author":"Lebel","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.nicl.2014.07.013","article-title":"Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging","volume":"5","author":"Lemkaddem","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib43","series-title":"Neuropsychological Assessment","author":"Lezak","year":"2004"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib44","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.neuroimage.2003.11.004","article-title":"Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time","volume":"21","author":"Madden","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib45","first-page":"1000","article-title":"An investigation of brain neurite density and dispersion in multiple sclerosis using single shell diffusion imaging","volume":"61","author":"Magnollay","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib46","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/cne.10714","article-title":"Marked loss of myelinated nerve fibers in the human brain with age","volume":"462","author":"Marner","year":"2003","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib48","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hbm.20934","article-title":"Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease","volume":"31","author":"Mueller","year":"2010","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib49","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/hipo.20614","article-title":"Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields","volume":"19","author":"Mueller","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib50","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1016\/j.neurobiolaging.2015.02.022","article-title":"Superficial white matter as a novel substrate of age-related cognitive decline","volume":"36","author":"Nazeri","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib51","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1523\/JNEUROSCI.3979-14.2015","article-title":"Functional consequences of neurite orientation dispersion and density in humans across the adult lifespan","volume":"35","author":"Nazeri","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00429-011-0308-y","article-title":"Morphological changes in nerve cells during normal aging","volume":"216","author":"Pannese","year":"2011","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib53","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1037\/0735-7044.117.6.1169","article-title":"Hypertension and the brain: vulnerability of the prefrontal regions and executive functions","volume":"117","author":"Raz","year":"2003","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1037\/0894-4105.21.2.149","article-title":"Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults","volume":"21","author":"Raz","year":"2007","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib55","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1007\/PL00014170","article-title":"Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer\u2019s and other dementing processes","volume":"249","author":"Reisberg","year":"1999","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib56","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/0891988705281882","article-title":"Middle-aged children of persons with Alzheimer\u2019s disease: APOE genotypes and cognitive function in the Wisconsin Registry for Alzheimer\u2019s Prevention","volume":"18","author":"Sager","year":"2005","journal-title":"J.\u00a0Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib57","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/cercor\/bhh032","article-title":"Thinning of the cerebral cortex in aging","volume":"14","author":"Salat","year":"2004","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib58","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.neurobiolaging.2004.09.017","article-title":"Age-related alterations in white matter microstructure measured by diffusion tensor imaging","volume":"26","author":"Salat","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib59","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1096-9861(20010122)429:4<541::AID-CNE3>3.0.CO;2-5","article-title":"Effects of age on nerve fibers in the rhesus monkey optic nerve","volume":"429","author":"Sandell","year":"2001","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib60","series-title":"Rey auditory verbal learning test: a handbook","author":"Schmidt","year":"1996"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib61","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib62","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fnagi.2011.00002","article-title":"Hippocampal subfield volumes: age, vascular risk, and correlation with associative memory","volume":"3","author":"Shing","year":"2011","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib63","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrn3085","article-title":"A\u00a0pathophysiological framework of hippocampal dysfunction in ageing and disease","volume":"12","author":"Small","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib65","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.neuroimage.2015.05.023","article-title":"In\u00a0vivo histology of the myelin g-ratio with magnetic resonance imaging","volume":"118","author":"Stikov","year":"2015","journal-title":"NeuroImage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib66","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neubiorev.2006.06.002","article-title":"Diffusion tensor imaging and aging","volume":"30","author":"Sullivan","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib67","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0197-4580(97)00155-3","article-title":"Age-induced white matter changes in the human brain: a stereological investigation","volume":"18","author":"Tang","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib68","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10545-014-9780-x","article-title":"White matter microstructure pathology in classic galactosemia revealed by neurite orientation dispersion and density imaging","volume":"38","author":"Timmers","year":"2015","journal-title":"J.\u00a0Inherit. Metab. Dis."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib69","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0887-6177(03)00039-8","article-title":"Trail making test A and B: normative data stratified by age and education","volume":"19","author":"Tombaugh","year":"2004","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib70","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/brcg.2001.1500","article-title":"Neuronal changes in normal human aging and Alzheimer's disease","volume":"49","author":"Uylings","year":"2002","journal-title":"Brain Cogn."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib71","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.neurobiolaging.2009.05.013","article-title":"Consistent neuroanatomical age-related volume differences across multiple samples","volume":"32","author":"Walhovd","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib72","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.nicl.2015.08.017","article-title":"Clinically feasible NODDI characterization of glioma using multiband EPI at 7T","volume":"9","author":"Wen","year":"2015","journal-title":"Neuroimage: Clin."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib73","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1093\/cercor\/bhp280","article-title":"Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry","volume":"20","author":"Westlye","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib74","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.eplepsyres.2013.11.004","article-title":"Advanced diffusion imaging sequences could aid assessing patients with focal cortical dysplasia and epilepsy","volume":"108","author":"Winston","year":"2014","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib75","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuroimage.2007.02.050","article-title":"Hybrid diffusion imaging","volume":"36","author":"Wu","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib76","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in\u00a0vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.03.026_bib77","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.media.2006.06.004","article-title":"Deformable registration of diffusion tensor MR images with explicit orientation optimization","volume":"10","author":"Zhang","year":"2006","journal-title":"Med. Image Anal."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016300173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016300173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T13:24:31Z","timestamp":1536845071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458016300173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":77,"alternative-id":["S0197458016300173"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.03.026","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}