{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:21:41Z","timestamp":1791231701138,"version":"4.1.0"},"reference-count":123,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000916","name":"MetLife Foundation","doi-asserted-by":"publisher","award":["P51RR165"],"award-info":[{"award-number":["P51RR165"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"MetLife Foundation","doi-asserted-by":"publisher","award":["P51OD11132"],"award-info":[{"award-number":["P51OD11132"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"MetLife Foundation","doi-asserted-by":"publisher","award":["R21NS077049"],"award-info":[{"award-number":["R21NS077049"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"MetLife Foundation","doi-asserted-by":"publisher","award":["P30 NS050276"],"award-info":[{"award-number":["P30 NS050276"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"MetLife Foundation","doi-asserted-by":"publisher","award":["P50AG025688"],"award-info":[{"award-number":["P50AG025688"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["P01AG026423"],"award-info":[{"award-number":["P01AG026423"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["R21NS080576"],"award-info":[{"award-number":["R21NS080576"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["R21AG051266"],"award-info":[{"award-number":["R21AG051266"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.neurobiolaging.2016.04.019","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T13:16:24Z","timestamp":1462194984000},"page":"185-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Comparative pathobiology of \u03b2-amyloid and the unique susceptibility of humans to Alzheimer's disease"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0680-6246","authenticated-orcid":false,"given":"Rebecca F.","family":"Rosen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Tomidokoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron S.","family":"Farberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeromy","family":"Dooyema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Ciliax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Preuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Neubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Ghiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Harry","family":"LeVine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lary C.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib1","doi-asserted-by":"crossref","first-page":"12790","DOI":"10.1523\/JNEUROSCI.1794-11.2011","article-title":"Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Abeta is induced by pyroglutamate-Abeta formation","volume":"31","author":"Alexandru","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib2","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1212\/WNL.42.9.1681","article-title":"Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s40265-015-0529-0","article-title":"Tau biology and tau-directed therapies for Alzheimer's disease","volume":"76","author":"Bakota","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2202-14-108","article-title":"Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration","volume":"14","author":"Becker","year":"2013","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/archneur.1995.00540250089017","article-title":"Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease","volume":"52","author":"Bierer","year":"1995","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ajpath.2015.09.018","article-title":"Synaptic amyloid-beta oligomers precede p-tau and differentiate high pathology control cases","volume":"186","author":"Bilousova","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/13506120500106958","article-title":"Neurotoxic protein oligomers\u2014what you see is not always what you get","volume":"12","author":"Bitan","year":"2005","journal-title":"Amyloid"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib9","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1073\/pnas.222681699","article-title":"Amyloid beta -protein (Abeta) assembly: abeta 40 and Abeta 42 oligomerize through distinct pathways","volume":"100","author":"Bitan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0896-6273(00)80974-5","article-title":"Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins","volume":"19","author":"Borchelt","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib122","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/archgenpsychiatry.2011.155","article-title":"Cerebrospinal fluid levels of beta-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia","volume":"69","author":"Buchhave","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib12","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2174\/156802606776743066","article-title":"The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease","volume":"6","author":"Catalano","year":"2006","journal-title":"Curr. Top Med. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib13","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1111\/febs.12813","article-title":"The coexistence of an equal amount of Alzheimer's amyloid-beta 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway","volume":"281","author":"Chang","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib14","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1016\/j.neurobiolaging.2013.03.028","article-title":"Brain aging in humans, chimpanzees (Pan troglodytes), and rhesus macaques (Macaca mulatta): magnetic resonance imaging studies of macro- and microstructural changes","volume":"34","author":"Chen","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib15","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/brain\/awv006","article-title":"Rapidly progressive Alzheimer's disease features distinct structures of amyloid-beta","volume":"138","author":"Cohen","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib16","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1212\/WNL.38.11.1682","article-title":"Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease","volume":"38","author":"Crystal","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib17","first-page":"515","article-title":"Cerebral amyloid angiopathy in an aged sooty mangabey (Cercocebus atys)","volume":"63","author":"D'Angelo","year":"2013","journal-title":"Comp. Med."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib18","doi-asserted-by":"crossref","first-page":"12926","DOI":"10.1073\/pnas.0903200106","article-title":"Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation","volume":"106","author":"Eisele","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib19","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1126\/science.1194516","article-title":"Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis","volume":"330","author":"Eisele","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib20","first-page":"155","article-title":"Cerebral beta-amyloid angiopathy in aged squirrel monkeys","volume":"22","author":"Elfenbein","year":"2007","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fnagi.2013.00099","article-title":"PiB fails to map amyloid deposits in cerebral cortex of aged dogs with canine cognitive dysfunction","volume":"5","author":"Fast","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fncel.2015.00191","article-title":"Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease","volume":"9","author":"Ferreira","year":"2015","journal-title":"Front. Cell Neurosc."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib23","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s11357-011-9355-9","article-title":"Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging","volume":"34","author":"Finch","year":"2012","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib24","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.neurobiolaging.2014.10.025","article-title":"Commentary: is Alzheimer's disease uniquely human?","volume":"36","author":"Finch","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0197-4580(99)00053-6","article-title":"The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms","volume":"20","author":"Finch","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib26","doi-asserted-by":"crossref","first-page":"13629","DOI":"10.1523\/JNEUROSCI.1353-14.2014","article-title":"Alzheimer's disease-like pathology induced by amyloid-beta oligomers in nonhuman primates","volume":"34","author":"Forny-Germano","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib27","series-title":"The mouse brain in stereotaxic coordinates","author":"Franklin","year":"2007"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00401-014-1339-2","article-title":"Abeta seeds resist inactivation by formaldehyde","volume":"128","author":"Fritschi","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0197-4580(96)00164-9","article-title":"A\u00a0beta40 is a major form of beta-amyloid in nonhuman primates","volume":"17","author":"Gearing","year":"1996","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0197-4580(97)00012-2","article-title":"beta-Amyloid (A beta) deposition in the brains of aged orangutans","volume":"18","author":"Gearing","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s004010100429","article-title":"Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition","volume":"103","author":"Geula","year":"2002","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib32","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1021\/jp5040954","article-title":"Activity and architecture of pyroglutamate-modified amyloid-beta (AbetapE3-42) pores","volume":"118","author":"Gillman","year":"2014","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00401-011-0912-1","article-title":"The presence of Abeta seeds, and not age per se, is critical to the initiation of Abeta deposition in the brain","volume":"123","author":"Hamaguchi","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib34","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1021\/cr3000994","article-title":"The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization","volume":"112","author":"Hamley","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib36","doi-asserted-by":"crossref","first-page":"32131","DOI":"10.1074\/jbc.M114.594846","article-title":"Monoclonal antibodies against Abeta42 fibrils distinguish multiple aggregation state polymorphisms in\u00a0vitro and in Alzheimer disease brain","volume":"289","author":"Hatami","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib37","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.bbadis.2013.03.016","article-title":"A\u00a0canine model of human aging and Alzheimer's disease","volume":"1832","author":"Head","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib38","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/embor.2013.137","article-title":"Seeded strain-like transmission of beta-amyloid morphotypes in APP transgenic mice","volume":"14","author":"Heilbronner","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib39","doi-asserted-by":"crossref","first-page":"15157","DOI":"10.1021\/bi061850f","article-title":"Solution state characterization of amyloid beta-derived diffusible ligands","volume":"45","author":"Hepler","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib40","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/(SICI)1096-9861(19990712)409:4<567::AID-CNE4>3.0.CO;2-J","article-title":"Brain weight throughout the life span of the chimpanzee","volume":"409","author":"Herndon","year":"1999","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0197-4580(98)00054-2","article-title":"Brain weight does not\u00a0decrease with age in adult rhesus monkeys","volume":"19","author":"Herndon","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib42","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.2174\/138161212799315885","article-title":"Nonhuman primate models of Alzheimer-like cerebral proteopathy","volume":"18","author":"Heuer","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib43","doi-asserted-by":"crossref","first-page":"77sr1","DOI":"10.1126\/scitranslmed.3002369","article-title":"Alzheimer's disease: the challenge of the second century","volume":"3","author":"Holtzman","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib44","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00401-012-0943-2","article-title":"Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study","volume":"123","author":"Ikonomovic","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib45","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.neuron.2013.12.003","article-title":"Biomarker modeling of Alzheimer's disease","volume":"80","author":"Jack","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib47","doi-asserted-by":"crossref","first-page":"28176","DOI":"10.1074\/jbc.M803159200","article-title":"The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity","volume":"283","author":"Jan","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib48","doi-asserted-by":"crossref","first-page":"e0133272","DOI":"10.1371\/journal.pone.0133272","article-title":"Systematic abeta analysis in Drosophila reveals high toxicity for the 1-42, 3\u201342 and 11-42 peptides, and emphasizes N- and C-terminal residues","volume":"10","author":"Jonson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib49","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/nm.2224","article-title":"The benefits and limitations of animal models for translational research in neurodegenerative diseases","volume":"16","author":"Jucker","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib50","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1523\/JNEUROSCI.20-10-03606.2000","article-title":"Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice","volume":"20","author":"Kane","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib51","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1523\/JNEUROSCI.4849-06.2007","article-title":"Abeta40 inhibits amyloid deposition in\u00a0vivo","volume":"27","author":"Kim","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib52","doi-asserted-by":"crossref","first-page":"10598","DOI":"10.1523\/JNEUROSCI.2990-05.2005","article-title":"Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain","volume":"25","author":"Klunk","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib53","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1074\/jbc.271.8.4077","article-title":"Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains","volume":"271","author":"Kuo","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib54","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/bbrc.1997.7083","article-title":"Isolation, chemical characterization, and quantitation of A beta 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits","volume":"237","author":"Kuo","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib55","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1038\/emboj.2010.211","article-title":"Neurotoxicity of Alzheimer's disease Abeta peptides is induced by small changes in the Abeta42 to Abeta40 ratio","volume":"29","author":"Kuperstein","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib56","doi-asserted-by":"crossref","first-page":"14488","DOI":"10.1523\/JNEUROSCI.3088-11.2011","article-title":"Soluble Abeta seeds are potent inducers of cerebral beta-amyloid deposition","volume":"31","author":"Langer","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib57","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0002-9440(10)63296-8","article-title":"Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet","volume":"165","author":"Lemere","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib58","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/rej.2008.0677","article-title":"Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease?","volume":"11","author":"Lemere","year":"2008","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib59","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.neurobiolaging.2008.05.026","article-title":"Molecular polymorphism of Abeta in Alzheimer's disease","volume":"31","author":"Levine","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0076-6879(99)09009-6","article-title":"Chemical modifications of deposited amyloid-beta peptides","volume":"309","author":"Lowenson","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib61","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cell.2013.08.035","article-title":"Molecular structure of beta-amyloid fibrils in Alzheimer's disease brain tissue","volume":"154","author":"Lu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib62","doi-asserted-by":"crossref","first-page":"10957","DOI":"10.1523\/JNEUROSCI.0673-07.2007","article-title":"Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography","volume":"27","author":"Maeda","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuron.2005.06.030","article-title":"Abeta42 is essential for parenchymal and vascular amyloid deposition in mice","volume":"47","author":"McGowan","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib64","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/bip.22283","article-title":"Context dependence of protein misfolding and structural strains in neurodegenerative diseases","volume":"100","author":"Mehta","year":"2013","journal-title":"Biopolymers"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib65","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1126\/science.1131864","article-title":"Exogenous induction of cerebral {beta}-amyloidogenesis is governed by agent and host","volume":"313","author":"Meyer-Luehmann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib66","doi-asserted-by":"crossref","first-page":"10810","DOI":"10.1021\/bi0508237","article-title":"Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques","volume":"44","author":"Miravalle","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib67","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1038\/srep09349","article-title":"Titration of biologically active amyloid-beta seeds in a transgenic mouse model of Alzheimer's disease","volume":"5","author":"Morales","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib68","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/mp.2011.120","article-title":"De novo induction of amyloid-beta deposition in\u00a0vivo","volume":"17","author":"Morales","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib69","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-131535","article-title":"Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-beta load and cognitive decline in Alzheimer's disease","volume":"39","author":"Morawski","year":"2014","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib123","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0014-5793(95)01491-8","article-title":"Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype","volume":"379","author":"Morelli","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib70","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1074\/jbc.R800030200","article-title":"Relevance of transgenic mouse models to human Alzheimer disease","volume":"284","author":"Morrissette","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib71","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1021\/ja8092604","article-title":"Amyloid beta protein: abeta40 inhibits Abeta42 oligomerization","volume":"131","author":"Murray","year":"2009","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib72","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib73","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00401-014-1371-2","article-title":"Tau aggregation and its interplay with amyloid-beta","volume":"129","author":"Nisbet","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib74","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature11060","article-title":"Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta","volume":"485","author":"Nussbaum","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib75","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1074\/jbc.M111.264473","article-title":"Structural basis for increased toxicity of pathological abeta42:abeta40 ratios in Alzheimer disease","volume":"287","author":"Pauwels","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib76","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1002\/cne.23428","article-title":"Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla)","volume":"521","author":"Perez","year":"2013","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib77","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1126\/science.1105850","article-title":"Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils","volume":"307","author":"Petkova","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib78","first-page":"186","article-title":"Beta-amyloid is different in normal aging and in Alzheimer disease","volume":"34","author":"Piccini","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib79","doi-asserted-by":"crossref","first-page":"23895","DOI":"10.1074\/jbc.270.41.23895","article-title":"Amino-terminal deletions enhance aggregation of beta-amyloid peptides in\u00a0vitro","volume":"270","author":"Pike","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib80","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-5-2","article-title":"Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease","volume":"5","author":"Portelius","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib81","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00401-010-0690-1","article-title":"Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease","volume":"120","author":"Portelius","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib82","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000369465","article-title":"Brain amyloid-beta fragment signatures in pathological ageing and Alzheimer's disease by hybrid immunoprecipitation mass spectrometry","volume":"15","author":"Portelius","year":"2015","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib83","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neulet.2006.09.044","article-title":"An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid","volume":"409","author":"Portelius","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib84","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib85","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/jnen\/62.9.885","article-title":"Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view","volume":"62","author":"Revesz","year":"2003","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib86","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1111\/j.1471-4159.1993.tb09834.x","article-title":"Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue","volume":"61","author":"Roher","year":"1993","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib87","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00401-009-0583-3","article-title":"Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease","volume":"119","author":"Rosen","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib88","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/cne.21744","article-title":"Tauopathy with paired helical filaments in an aged chimpanzee","volume":"509","author":"Rosen","year":"2008","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib89","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1471-4159.2011.07551.x","article-title":"Exogenous seeding of cerebral beta-amyloid deposition in betaAPP-transgenic rats","volume":"120","author":"Rosen","year":"2012","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib90","first-page":"1916","article-title":"SDS-PAGE\/immunoblot detection of Abeta multimers in human cortical tissue homogenates using antigen-epitope retrieval","volume":"38","author":"Rosen","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib91","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neurobiolaging.2009.02.011","article-title":"PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease","volume":"32","author":"Rosen","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib92","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jms.739","article-title":"Quantification of the A beta peptide in Alzheimer's plaques by laser dissection microscopy combined with mass spectrometry","volume":"40","author":"Rufenacht","year":"2005","journal-title":"J.\u00a0Mass Spectrom."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib93","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0006-8993(97)00624-0","article-title":"Characterization of amyloid beta protein species in cerebral amyloid angiopathy of a squirrel monkey by immunocytochemistry and enzyme-linked immunosorbent assay","volume":"764","author":"Sawamura","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib94","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1021\/bi900818a","article-title":"Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides","volume":"48","author":"Schlenzig","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib95","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1471-4159.2012.07707.x","article-title":"N-Terminal pyroglutamate formation of Abeta38 and Abeta40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation","volume":"121","author":"Schlenzig","year":"2012","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib96","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1212\/WNL.0b013e31825fdf18","article-title":"Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers","volume":"79","author":"Scholl","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib97","series-title":"Alzheimer Disease","first-page":"293","article-title":"Biology of beta-amyloid precursor protein and the mechanism of Alzheimer disease","author":"Selkoe","year":"1999"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib98","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nm.2460","article-title":"Resolving controversies on the path to Alzheimer's therapeutics","volume":"17","author":"Selkoe","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib99","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.3544219","article-title":"Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease","volume":"235","author":"Selkoe","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib100","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bmcl.2008.12.069","article-title":"Synthesis of 18F-labelled 2-(4'-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB","volume":"19","author":"Serdons","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib101","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/biom6010006","article-title":"Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and\u00a0other tauopathies, and possible neuroprotective strategies","volume":"6","author":"Simic","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib102","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nrneurol.2012.241","article-title":"Preclinical Alzheimer disease\u2014the challenges ahead","volume":"9","author":"Sperling","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib103","doi-asserted-by":"crossref","first-page":"10329","DOI":"10.1073\/pnas.1408968111","article-title":"Distinct synthetic Abeta prion strains producing different amyloid deposits in bigenic mice","volume":"111","author":"Stohr","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib104","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.1073\/pnas.1206555109","article-title":"Purified and synthetic Alzheimer's amyloid beta (Abeta) prions","volume":"109","author":"Stohr","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib105","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3233\/JAD-141986","article-title":"Diagnostic accuracy of cerebrospinal fluid amyloid-beta isoforms for early and differential dementia diagnosis","volume":"45","author":"Struyfs","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib106","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0197-4580(95)02062-4","article-title":"Carboxy terminal of beta-amyloid deposits in aged human, canine, and polar bear brains","volume":"17","author":"Tekirian","year":"1996","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib107","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00005072-199801000-00009","article-title":"N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits","volume":"57","author":"Tekirian","year":"1998","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib108","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1046\/j.1471-4159.1999.0731584.x","article-title":"Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42","volume":"73","author":"Tekirian","year":"1999","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib109","doi-asserted-by":"crossref","first-page":"36883","DOI":"10.1074\/jbc.M504038200","article-title":"Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques","volume":"280","author":"Tomidokoro","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib110","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00259-005-1780-5","article-title":"PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease","volume":"32","author":"Toyama","year":"2005","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib111","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0196-9781(02)00059-1","article-title":"Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice","volume":"23","author":"Walker","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib112","series-title":"Alzheimer Disease","first-page":"233","article-title":"The neurobiology of aging in nonhuman primates","author":"Walker","year":"1999"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib113","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0197-4580(87)90067-4","article-title":"Senile plaques in aged squirrel monkeys","volume":"8","author":"Walker","year":"1987","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib114","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF00307691","article-title":"Amyloid in the brains of aged squirrel monkeys","volume":"80","author":"Walker","year":"1990","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib115","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s004010051190","article-title":"Apolipoprotein E4 promotes the early deposition of Abeta42 and then Abeta40 in the elderly","volume":"100","author":"Walker","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib116","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00401-013-1083-z","article-title":"Oligomers, fact or artefact? SDS-PAGE induces dimerization of beta-amyloid in human brain samples","volume":"125","author":"Watt","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib117","doi-asserted-by":"crossref","first-page":"10323","DOI":"10.1073\/pnas.1408900111","article-title":"Serial propagation of distinct strains of Abeta prions from Alzheimer's disease patients","volume":"111","author":"Watts","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib118","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1073\/pnas.1019034108","article-title":"Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease","volume":"108","author":"Watts","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib119","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12035-007-0029-7","article-title":"Heat shock proteins and amateur chaperones in amyloid-beta accumulation and clearance in Alzheimer's disease","volume":"35","author":"Wilhelmus","year":"2007","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib120","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nn.4117","article-title":"Persistence of Abeta seeds in APP null mouse brain","volume":"18","author":"Ye","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.04.019_bib121","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/bpa.12252","article-title":"Progression of seed-induced abeta deposition within the limbic connectome","volume":"25","author":"Ye","year":"2015","journal-title":"Brain Pathol."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016300562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016300562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T22:44:42Z","timestamp":1565390682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458016300562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":123,"alternative-id":["S0197458016300562"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.04.019","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative pathobiology of \u03b2-amyloid and the unique susceptibility of humans to Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}