{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:55:49Z","timestamp":1789044949722,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.neurobiolaging.2016.05.003","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T21:16:31Z","timestamp":1462914991000},"page":"30-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease"],"prefix":"10.1016","volume":"45","author":[{"given":"Andrew J.","family":"Phipps","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillippa C.","family":"Taberlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Woodhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib1","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1016\/j.neurobiolaging.2015.09.001","article-title":"Loss of calbindin-D25K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease","volume":"36","author":"Ahmadian","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3233\/JAD-2012-111223","article-title":"Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex","volume":"29","author":"Bakulski","year":"2012","journal-title":"J.\u00a0Alzheimer Dis."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib4","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.mad.2013.08.005","article-title":"Epigenetic changes in the progression of Alzheimer's disease","volume":"134","author":"Bradley-Whitman","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrg2540","article-title":"Linking DNA methylation and histone modification: patterns and paradigms","volume":"10","author":"Cedar","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib6","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.neurobiolaging.2013.02.021","article-title":"Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients","volume":"34","author":"Chouliaras","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib7","doi-asserted-by":"crossref","first-page":"e1000602","DOI":"10.1371\/journal.pgen.1000602","article-title":"Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context","volume":"5","author":"Christensen","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib8","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neurobiolaging.2013.11.031","article-title":"Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain","volume":"35","author":"Coppieters","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib9","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nn.3504","article-title":"DNA methylation regulates associative reward learning","volume":"16","author":"Day","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib10","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/exnr.1998.7010","article-title":"Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease","volume":"156","author":"Dickson","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0306-4522(01)00169-5","article-title":"The morphological phenotype of \u03b2-amyloid plaques and associated neuritic changes in Alzheimer's disease","volume":"105","author":"Dickson","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"Duyckaerts","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nn.2514","article-title":"Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons","volume":"13","author":"Feng","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib15","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/j.neurobiolaging.2015.07.003","article-title":"Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP\/PS1 transgenic model of Alzheimer's disease","volume":"36","author":"Fernandez-Martos","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(96)01030-2","article-title":"Amyloid, the presenilins and Alzheimer's disease","volume":"20","author":"Hardy","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/cne.903010105","article-title":"Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex","volume":"301","author":"Hof","year":"1990","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/cne.903010106","article-title":"Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: II. Primary and secondary visual cortex","volume":"301","author":"Hof","year":"1990","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0304-3940(93)90504-E","article-title":"Calretinin-immunoreactive neocortical interneurons are unaffected in Alzheimer's disease","volume":"152","author":"Hof","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-5728(89)90115-X","article-title":"Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease","volume":"24","author":"Itagaki","year":"1989","journal-title":"J.\u00a0Neuroimmunol."},{"issue":"2","key":"10.1016\/j.neurobiolaging.2016.05.003_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tibs.2005.12.008","article-title":"Genomic DNA methylation: the mark and its mediators","volume":"31","author":"Klose","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/nan.12183","article-title":"Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease","volume":"41","author":"Lashley","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib23","doi-asserted-by":"crossref","first-page":"15763","DOI":"10.1074\/jbc.M511767200","article-title":"Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus","volume":"281","author":"Levenson","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib24","doi-asserted-by":"crossref","first-page":"1237905","DOI":"10.1126\/science.1237905","article-title":"Global epigenomic reconfiguration during mammalian brain development","volume":"341","author":"Lister","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib25","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.neurobiolaging.2014.03.013","article-title":"Altered arginine metabolism in Alzheimer's disease brains","volume":"35","author":"Liu","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jgg.2013.10.002","article-title":"Methylation modifications in eukaryotic messenger RNA","volume":"41","author":"Liu","year":"2014","journal-title":"J.\u00a0Genet. Genomics"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib27","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nn.3792","article-title":"The epigenetic landscape of Alzheimer's disease","volume":"17","author":"Lord","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib28","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nn.3782","article-title":"Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease","volume":"17","author":"Lunnon","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib29","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1016\/j.neurobiolaging.2015.08.017","article-title":"Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease","volume":"36","author":"Mastroeni","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib30","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.neurobiolaging.2008.12.005","article-title":"Epigenetic changes in Alzheimer's disease: decrements in DNA methylation","volume":"31","author":"Mastroeni","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib31","doi-asserted-by":"crossref","first-page":"e6617","DOI":"10.1371\/journal.pone.0006617","article-title":"Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease","volume":"4","author":"Mastroeni","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnana.2013.00030","article-title":"Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models","volume":"7","author":"Mitew","year":"2013","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib33","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.neuron.2015.05.018","article-title":"Epigenomic signatures of neuronal diversity in the mammalian brain","volume":"86","author":"Mo","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1440-1789.2004.00571.x","article-title":"Neuropathological diagnostic criteria for Alzheimer's disease","volume":"24","author":"Murayama","year":"2004","journal-title":"Neuropathology"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nn.2751","article-title":"Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory","volume":"14","author":"Murray","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.nbd.2014.11.023","article-title":"Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain","volume":"74","author":"Narayan","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0197-0186(01)00040-7","article-title":"Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease","volume":"39","author":"Rogers","year":"2001","journal-title":"Neurochem. Int."},{"issue":"Pt 10","key":"10.1016\/j.neurobiolaging.2016.05.003_bib38","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1093\/brain\/awt237","article-title":"DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease","volume":"136","author":"Sanchez-Mut","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/NEN.0b013e3182933788","article-title":"Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in alzheimer disease","volume":"72","author":"Serrano-Pozo","year":"2013","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib40","doi-asserted-by":"crossref","first-page":"e895","DOI":"10.1371\/journal.pone.0000895","article-title":"DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons","volume":"2","author":"Siegmund","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fphar.2012.00014","article-title":"Microglia function in Alzheimer's disease","volume":"3","author":"Solito","year":"2012","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib42","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1093\/nar\/gks144","article-title":"Widespread occurrence of 5-methylcytosine\u00a0in human coding and non-coding RNA","volume":"40","author":"Squires","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib43","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neuroscience.2009.02.037","article-title":"Loss of nonphosphorylated neurofilament immunoreactivity in temporal cortical areas in Alzheimer's disease","volume":"160","author":"Thangavel","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(94)90310-7","article-title":"Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease","volume":"62","author":"Vickers","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(03)02429-6","article-title":"Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease","volume":"971","author":"Vickers","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02736773","article-title":"Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient","volume":"6","author":"West","year":"1995","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00401-008-0458-z","article-title":"Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease","volume":"117","author":"Woodhouse","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2016.05.003_bib49","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J.\u00a0Neurosci."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016300641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016300641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T10:04:23Z","timestamp":1567850663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458016300641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":49,"alternative-id":["S0197458016300641"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.05.003","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}