{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:41:41Z","timestamp":1791265301381,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chercheur d\u2019Avenir"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.neurobiolaging.2016.05.012","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T07:21:17Z","timestamp":1463988077000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Mean arterial pressure change associated with cerebral blood flow in healthy older adults"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-2940","authenticated-orcid":false,"given":"Jeremy","family":"Deverdun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasnime N.","family":"Akbaraly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Charroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Abdennour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Chemouny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Steffener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Portet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bonafe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Molino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Le Bars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Menjot de Champfleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000072920","article-title":"Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population","volume":"22","year":"2003","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1212\/WNL.0b013e3181b7849b","article-title":"Leisure activities and the risk of dementia in the elderly: results from the Three-City Study","volume":"73","author":"Akbaraly","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib3","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2337\/dc10-1644","article-title":"Metabolic syndrome and onset of depressive symptoms in the elderly: findings from the three-city study","volume":"34","author":"Akbaraly","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/mrm.25197","article-title":"Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia","volume":"73","author":"Alsop","year":"2014","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib6","series-title":"Statistical Fact Sheet: Older Americans and Cardiovascular Diseases","year":"2013"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib7","series-title":"Diagnostic and statistical manual of mental disorders: DSM-IV [Internet]","first-page":"866","year":"1994"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib8","doi-asserted-by":"crossref","first-page":"e60085","DOI":"10.1371\/journal.pone.0060085","article-title":"Comparison of regional cerebral blood flow responses to hypoglycemia using pulsed arterial spin labeling and positron emission tomography","volume":"8","author":"Arbel\u00e1ez","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib9","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1002\/mrm.21670","article-title":"Regression algorithm correcting for partial volume effects in arterial spin labeling MRI","volume":"60","author":"Asllani","year":"2008","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib10","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/01.STR.17.6.1084","article-title":"Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors","volume":"17","author":"Awad","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib11","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuroimage.2010.03.008","article-title":"An arterial spin labeling investigation of cerebral blood flow deficits in chronic stroke survivors","volume":"51","author":"Brumm","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jmri.20503","article-title":"Pulsed arterial spin labeling parameter optimization for an elderly population","volume":"23","author":"Campbell","year":"2006","journal-title":"J.\u00a0Magn. Reson. Imaging"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/gerona\/glt101","article-title":"Metabolic syndrome and disability: findings from the prospective three-city study","volume":"69","author":"Carriere","year":"2014","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib14","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.mri.2009.04.002","article-title":"Comparison of pulsed arterial spin labeling encoding schemes and absolute perfusion quantification","volume":"27","author":"Cavu\u015fo\u011flu","year":"2009","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib15","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neuroimage.2010.12.032","article-title":"Age-associated reductions in cerebral blood flow are independent from regional atrophy","volume":"55","author":"Chen","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.alcohol.2008.03.132","article-title":"Alcohol consumption and cerebral blood flow among older adults","volume":"42","author":"Christie","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/bmj.2.6133.325","article-title":"Cerebral blood flow in diabetes mellitus: evidence of abnormal cerebrovascular reactivity","volume":"2","author":"Dandona","year":"1978","journal-title":"Br. Med. J."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0006-8993(95)01077-7","article-title":"Decreased cerebral blood flow during acute hyperglycemia","volume":"703","author":"Duckrow","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib19","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the National Cholesterol Education Program (NCEP)","volume":"285","year":"2001","journal-title":"JAMA (JAMA)"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib20","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1161\/HYPERTENSIONAHA.115.05799","article-title":"Blood pressure is not associated with cerebral blood flow in older persons","volume":"66","author":"Foster-Dingley","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib21","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.2337\/diab.46.11.1840","article-title":"Impairment of cerebrovascular reactivity in long-term type 1 diabetes","volume":"46","author":"F\u00fclesdi","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/mrm.20580","article-title":"Single-shot 3D imaging techniques improve arterial","volume":"54","author":"G\u00fcnther","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib23","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1161\/01.STR.0000231640.32543.11","article-title":"ADMA increases arterial stiffness and decreases cerebral blood flow in humans","volume":"37","author":"Kielstein","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib24","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/01.STR.14.5.720","article-title":"Effects of smoking on regional cerebral blood flow in neurologically normal subjects","volume":"14","author":"Kubota","year":"1983","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/01.HYP.0000153094.09615.11","article-title":"Antihypertensive therapy increases cerebral blood flow and carotid distensibility in hypertensive elderly subjects","volume":"45","author":"Lipsitz","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib26","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1161\/01.STR.31.8.1897","article-title":"Dynamic regulation of middle cerebral artery blood flow velocity in aging and hypertension","volume":"8","author":"Lipsitz","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib27","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/mrm.23286","article-title":"Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics","volume":"68","author":"Liu","year":"2011","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib28","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/(SICI)1522-2594(199906)41:6<1246::AID-MRM22>3.0.CO;2-N","article-title":"Quipss IIWith thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling","volume":"41","author":"Luh","year":"1999","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3174\/ajnr.A4094","article-title":"Regional cerebral arterial transit time hemodynamics correlate with vascular risk factors and cognitive function in men with coronary artery disease","volume":"36","author":"MacIntosh","year":"2014","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib30","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/jcbfm.1991.121","article-title":"Decreases in regional cerebral blood flow with normal aging","volume":"11","author":"Martin","year":"1991","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib31","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1113\/expphysiol.2013.076455","article-title":"Assessment of dynamic cerebral autoregulation and cerebrovascular CO2 reactivity in ageing by measurements of cerebral blood flow and cortical oxygenation","volume":"99","author":"Oudegeest-Sander","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib32","first-page":"161","article-title":"Cerebral autoregulation","volume":"2","author":"Paulson","year":"1990","journal-title":"Cerebrovasc. Brain Metab. Rev."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib34","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1212\/WNL.0000000000001537","article-title":"Risk and protective factors for cognitive impairment in persons aged 85 years and older","volume":"84","author":"Roberts","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib35","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/jhh.2009.56","article-title":"Association between arterial stiffness and cerebrovascular resistance in the elderly","volume":"24","author":"Robertson","year":"2010","journal-title":"J.\u00a0Hum. Hypertens."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib36","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.atherosclerosis.2012.09.003","article-title":"Hyperglycemia and arterial stiffness: the atherosclerosis risk in the communities study","volume":"225","author":"Rubin","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib37","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1212\/01.wnl.0000436618.48402.da","article-title":"Total cerebral blood flow and mortality in old age: a 12-year follow-up study","volume":"81","author":"Sabayan","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib38","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib39","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jalz.2009.04.1233","article-title":"Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging","volume":"5","author":"Schuff","year":"2009","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-510X(02)00010-2","article-title":"Dynamics of cerebral blood flow autoregulation in hypertensive patients","volume":"195","author":"Traon","year":"2002","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib41","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1161\/HYPERTENSIONAHA.112.200972","article-title":"Intensive blood pressure lowering increases cerebral blood flow in older subjects with hypertension","volume":"61","author":"Tryambake","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib42","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/jcbfm.2008.13","article-title":"Cerebral autoregulation: an overview of current concepts and methodology with special focus on the elderly","volume":"28","author":"van Beek","year":"2008","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib43","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/mrm.21515","article-title":"Pitfalls of MRI measurement of white matter perfusion based on arterial spin labeling","volume":"59","author":"van Gelderen","year":"2008","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib44","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/jmri.10372","article-title":"Pediatric perfusion imaging using pulsed arterial spin labeling","volume":"18","author":"Wang","year":"2003","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib45","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/oby.2011.16","article-title":"Elevated BMI is associated with decreased blood flow in the prefrontal cortex using SPECT imaging in healthy adults","volume":"19","author":"Willeumier","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.neurobiolaging.2016.05.012_bib46","first-page":"1341","article-title":"Heterogeneity of cerebral blood flow in Alzheimer disease and vascular dementia","volume":"24","author":"Yoshikawa","year":"2003","journal-title":"AJNR Am. J. Neuroradiol."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016300811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458016300811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T23:55:18Z","timestamp":1718582118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458016300811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":44,"alternative-id":["S0197458016300811"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.05.012","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mean arterial pressure change associated with cerebral blood flow in healthy older adults","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2016.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}