{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:18:14Z","timestamp":1791555494987,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.neurobiolaging.2017.01.010","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T04:48:27Z","timestamp":1484628507000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice"],"prefix":"10.1016","volume":"53","author":[{"given":"Sara","family":"Belloli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pannese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Buonsanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Maiorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Grigoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta","family":"Carpinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Monterisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria","family":"Moresco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Panina-Bordignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.neurobiolaging.2017.01.010_bib1","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1007\/s100720200065","article-title":"Striatal dopaminergic denervation in early and late onset Parkinson's disease assessed by PET and the tracer [11C]FECIT: preliminary findings in one patient with autosomal recessive parkinsonism (Park2)","volume":"23","author":"Antonini","year":"2002","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib2","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s11481-014-9540-6","article-title":"Translocator protein 18 kDa negatively regulates inflammation in microglia","volume":"9","author":"Bae","year":"2014","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"issue":"Pt 11","key":"10.1016\/j.neurobiolaging.2017.01.010_bib3","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/brain\/123.11.2321","article-title":"The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in\u00a0vivo imaging of microglia as a measure of disease activity","volume":"123","author":"Banati","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/glia.20459","article-title":"Microglial control of neuronal death and synaptic properties","volume":"55","author":"Bessis","year":"2007","journal-title":"Glia"},{"issue":"Pt 5","key":"10.1016\/j.neurobiolaging.2017.01.010_bib5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1042\/BST0351127","article-title":"Chronic microglial activation and progressive dopaminergic neurotoxicity","volume":"35","author":"Block","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib6","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1084\/jem.194.8.1111","article-title":"A\u00a0DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells","volume":"194","author":"Bouchon","year":"2001","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0197-0186(01)00118-8","article-title":"Peripheral benzodiazepine receptors and mitochondrial function","volume":"40","author":"Casellas","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/glia.21091","article-title":"Translocator protein (18 kDa)\/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state","volume":"59","author":"Choi","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2006.10.029","article-title":"Absence of TREM2 polymorphisms in patients with Alzheimer's disease and frontotemporal lobar degeneration","volume":"411","author":"Fenoglio","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib10","doi-asserted-by":"crossref","first-page":"546.e9","DOI":"10.1016\/j.neurobiolaging.2014.08.001","article-title":"TREM2 analysis and increased risk of Alzheimer's disease","volume":"36","author":"Finelli","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/(SICI)1098-2396(199604)22:4<386::AID-SYN10>3.0.CO;2-W","article-title":"[11C]beta-CIT-FE, a radioligand for quantitation of the dopamine transporter in the living brain using positron emission tomography","volume":"22","author":"Halldin","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11481-009-9171-5","article-title":"Microglia in ALS: the good, the bad, and the resting","volume":"4","author":"Henkel","year":"2009","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib13","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1471-4159.2009.06042.x","article-title":"A\u00a0role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia","volume":"109","author":"Hsieh","year":"2009","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/glia.10353","article-title":"Microglia enhance dorsal root ganglion outgrowth in Schwann cell cultures","volume":"46","author":"Hynds","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nprot.2006.342","article-title":"Protocol for the MPTP mouse model of Parkinson's disease","volume":"2","author":"Jackson-Lewis","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.20142322","article-title":"TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models","volume":"212","author":"Jay","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib17","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1523\/JNEUROSCI.2620-14.2015","article-title":"Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke","volume":"35","author":"Kawabori","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/(SICI)1098-2396(199803)28:3<244::AID-SYN7>3.0.CO;2-A","article-title":"[18F]CFT [(18F)WIN 35,428], a radioligand to study the dopamine transporter with PET: characterization in human subjects","volume":"28","author":"Laakso","year":"1998","journal-title":"Synapse"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11910-007-0036-0","article-title":"New concepts on progressive multiple sclerosis","volume":"7","author":"Lassmann","year":"2007","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pneurobio.2009.08.001","article-title":"The influence of microglia on the pathogenesis of Parkinson's disease","volume":"89","author":"Long-Smith","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib21","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/00006231-200211000-00003","article-title":"The feasibility of statistical parametric mapping for the analysis of positron emission tomography studies using 11C-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)-tropane in patients with movement disorders","volume":"23","author":"Lucignani","year":"2002","journal-title":"Nucl. Med. Commun."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0074-7742(07)82014-9","article-title":"Cyclooxygenase-2, prostaglandin E2, and microglial activation in prion diseases","volume":"82","author":"Minghetti","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.compmedimag.2005.07.002","article-title":"Fast 3D-EM reconstruction using Planograms for stationary planar positron emission mammography camera","volume":"29","author":"Motta","year":"2005","journal-title":"Comput. Med. Imaging Graph."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/156720511795256035","article-title":"The role of microglial cell subsets in Alzheimer's disease","volume":"8","author":"Naert","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.expneurol.2009.04.024","article-title":"Protective effects of microglia in multiple sclerosis","volume":"225","author":"Napoli","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib26","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1468-1331.2010.03311.x","article-title":"Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family","volume":"18","author":"Numasawa","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-015-0040-9","article-title":"TREM2 in CNS homeostasis and neurodegenerative disease","volume":"10","author":"Painter","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib54","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00401-010-0722-x","article-title":"Contribution of systemic inflammation to chronic neurodegeneration","volume":"120","author":"Perry","year":"2010","journal-title":"Acta Neuropathologica"},{"issue":"Pt 11","key":"10.1016\/j.neurobiolaging.2017.01.010_bib29","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/brain\/awn217","article-title":"Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation","volume":"131","author":"Piccio","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib30","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/eji.200636837","article-title":"Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis","volume":"37","author":"Piccio","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pneurobio.2010.06.009","article-title":"Microglia and neuroprotection: from in\u00a0vitro studies to therapeutic applications","volume":"92","author":"Polazzi","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib32","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1172\/JCI77983","article-title":"TREM2 sustains microglial expansion during aging and response to demyelination","volume":"125","author":"Poliani","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3233\/RNN-2000-00132","article-title":"The parkinsonian toxin MPTP: action and mechanism","volume":"16","author":"Przedborski","year":"2000","journal-title":"Restorative Neurol. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1326-8-19","article-title":"TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease","volume":"8","author":"Rayaprolu","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2015.02.008","article-title":"The relation between alpha-synuclein and microglia in Parkinson's disease: recent developments","volume":"302","author":"Sanchez-Guajardo","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib36","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1046\/j.1471-4159.2002.01243.x","article-title":"Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia","volume":"83","author":"Schmid","year":"2002","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib37","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1111\/j.1460-9568.2004.03729.x","article-title":"Distribution and signaling of TREM2\/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia","volume":"20","author":"Sessa","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib38","doi-asserted-by":"crossref","first-page":"e52982","DOI":"10.1371\/journal.pone.0052982","article-title":"Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke","volume":"8","author":"Sieber","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/glia.22385","article-title":"Animal models for studying microglia: the first, the popular, and the new","volume":"61","author":"Sieger","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molbrainres.2004.09.017","article-title":"The MPTP model of Parkinson's disease","volume":"134","author":"Smeyne","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib41","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1371\/journal.pmed.0040124","article-title":"TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis","volume":"4","author":"Takahashi","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib42","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.20041611","article-title":"Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2","volume":"201","author":"Takahashi","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib43","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1042\/BST20150058","article-title":"The methodology of TSPO imaging with positron emission tomography","volume":"43","author":"Turkheimer","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib44","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.4049\/jimmunol.177.6.3520","article-title":"Cutting edge: TREM-2 attenuates macrophage activation","volume":"177","author":"Turnbull","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/glia.21245","article-title":"Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis","volume":"60","author":"Van Der Putten","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib46","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/glia.20558","article-title":"Translocator protein 18 kDa is involved in the regulation of reactive gliosis","volume":"55","author":"Veiga","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1742-2094-7-32","article-title":"Chronic upregulation of activated microglia immunoreactive for galectin-3\/Mac-2 and nerve growth factor following diffuse axonal injury","volume":"7","author":"Venkatesan","year":"2010","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib48","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib49","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1084\/jem.20151948","article-title":"TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques","volume":"213","author":"Wang","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib50","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/glia.22988","article-title":"Targeting microglia for the treatment of Alzheimer's Disease","volume":"64","author":"Wes","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib51","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00259-011-2041-4","article-title":"The translocator protein ligand [(1)(8)F]DPA-714 images glioma and activated microglia in\u00a0vivo","volume":"39","author":"Winkeler","year":"2012","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib52","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s11481-009-9174-2","article-title":"CNS inflammation and macrophage\/microglial biology associated with HIV-1 infection","volume":"4","author":"Yadav","year":"2009","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"key":"10.1016\/j.neurobiolaging.2017.01.010_bib53","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/1742-2094-9-176","article-title":"Acute injury in the peripheral nervous system triggers an alternative macrophage response","volume":"9","author":"Ydens","year":"2012","journal-title":"J.\u00a0Neuroinflammation"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017300180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017300180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T14:47:44Z","timestamp":1749912464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458017300180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":54,"alternative-id":["S0197458017300180"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.01.010","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}