{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:24:43Z","timestamp":1794003883910,"version":"4.8.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","award":["BX000452"],"award-info":[{"award-number":["BX000452"]}],"id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG014449"],"award-info":[{"award-number":["P01AG014449"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG025204"],"award-info":[{"award-number":["P01AG025204"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG043375"],"award-info":[{"award-number":["R01AG043375"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG052528"],"award-info":[{"award-number":["R01AG052528"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["P30AG010161"],"award-info":[{"award-number":["P30AG010161"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.neurobiolaging.2017.01.022","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T11:46:02Z","timestamp":1486208762000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9499-6926","authenticated-orcid":false,"given":"Zhiping","family":"Mi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Abrahamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Y.","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth N.","family":"Fish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Sweet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott J.","family":"Mufson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos D.","family":"Ikonomovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neurobiolaging.2007.03.007","article-title":"Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease","volume":"29","author":"Akram","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib2","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.neurobiolaging.2010.10.011","article-title":"Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging","volume":"33","author":"Allard","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib3","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/ana.22333","article-title":"Amyloid-beta associated cortical thinning in clinically normal elderly","volume":"69","author":"Becker","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1212\/WNL.59.2.198","article-title":"Natural history of mild cognitive impairment in older persons","volume":"59","author":"Bennett","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1460-9568.2005.04190.x","article-title":"Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism","volume":"22","author":"Brown","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib8","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","article-title":"Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory","volume":"25","author":"Buckner","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib9","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.neurobiolaging.2007.02.013","article-title":"Age-related spatial learning impairment is unrelated to spinophilin immunoreactive spine number and protein levels in rat hippocampus","volume":"29","author":"Calhoun","year":"2008","journal-title":"Neurobiol. Aging"},{"issue":"4 Suppl","key":"10.1016\/j.neurobiolaging.2017.01.022_bib10","first-page":"S1","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's disease","volume":"18","author":"Consensus","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000333122","article-title":"Hippocampal drebrin loss in mild cognitive impairment","volume":"10","author":"Counts","year":"2012","journal-title":"Neuro Degener. Dis."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib12","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/00005072-200606000-00007","article-title":"Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment","volume":"65","author":"Counts","year":"2006","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-4886(80)90150-8","article-title":"Age-related changes in prefrontal cortex of Macaca mulatta: quantitative analysis of dendritic branching patterns","volume":"69","author":"Cupp","year":"1980","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib14","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1046\/j.1460-9568.1998.00137.x","article-title":"Layer-specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex","volume":"10","author":"de Brabander","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ana.10069","article-title":"Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment","volume":"51","author":"DeKosky","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib66","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1046\/j.1365-2818.2001.00958.x","article-title":"Tissue shrinkage and unbiased stereological estimation of particle number and size","volume":"204","author":"Dorph-Petersen","year":"2001","journal-title":"J. Microsc."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib17","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/cercor\/13.9.950","article-title":"Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys","volume":"13","author":"Duan","year":"2003","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib18","first-page":"695","article-title":"Effects of beta-amyloid on resting state functional connectivity within and between networks reflect known patterns of regional vulnerability","volume":"26","author":"Elman","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib19","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1073\/pnas.97.16.9287","article-title":"Spinophilin regulates the formation and function of dendritic spines","volume":"97","author":"Feng","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.brainres.2008.08.060","article-title":"An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections","volume":"1240","author":"Fish","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib21","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1523\/JNEUROSCI.16-21-06830.1996","article-title":"Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus","volume":"16","author":"Gazzaley","year":"1996","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0006-8993(02)02457-5","article-title":"Age-related and laminar-specific dendritic changes in the medial frontal cortex of the rat","volume":"937","author":"Grill","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib23","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0002-9440(10)63436-0","article-title":"Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence","volume":"165","author":"Gylys","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.arr.2016.04.005","article-title":"Synaptic pathology: a shared mechanism in neurological disease","volume":"28","author":"Henstridge","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib25","series-title":"The Oxford Handbook of Memory","first-page":"441","article-title":"Memory in the dementias","author":"Hodges","year":"2000"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib26","series-title":"Functional Neurobiology of Aging","article-title":"Regional and laminar patterns of selective neuronal vulnerability in Alzheimer's disease","author":"Hof","year":"2001"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.tins.2004.07.013","article-title":"The aging brain: morphomolecular senescence of cortical circuits","volume":"27","author":"Hof","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimer's Demen."},{"issue":"Pt 6","key":"10.1016\/j.neurobiolaging.2017.01.022_bib29","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/brain\/awn016","article-title":"Post-mortem correlates of in\u00a0vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease","volume":"131","author":"Ikonomovic","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/(SICI)1096-9861(19971006)386:4<661::AID-CNE11>3.0.CO;2-N","article-title":"Life-span dendritic and spine changes in areas 10 and 18 of human cortex: a quantitative Golgi study","volume":"386","author":"Jacobs","year":"1997","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib31","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1093\/cercor\/bhn242","article-title":"The electrotonic structure of pyramidal neurons contributing to prefrontal cortical circuits in macaque monkeys is significantly altered in aging","volume":"19","author":"Kabaso","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib32","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/NEN.0b013e31829ecc89","article-title":"Dendritic spine density, morphology, and fibrillar actin content surrounding amyloid-beta plaques in a mouse model of amyloid-beta deposition","volume":"72","author":"Kirkwood","year":"2013","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib33","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1093\/cercor\/bhu151","article-title":"Disrupted intrinsic networks link amyloid-beta pathology and impaired cognition in prodromal Alzheimer's disease","volume":"25","author":"Koch","year":"2015","journal-title":"Cereb. Cortex"},{"issue":"Pt 7","key":"10.1016\/j.neurobiolaging.2017.01.022_bib34","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1093\/brain\/aws127","article-title":"Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta","volume":"135","author":"Koffie","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib35","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1073\/pnas.0811698106","article-title":"Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques","volume":"106","author":"Koffie","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib36","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.npp.1301233","article-title":"Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys","volume":"32","author":"Konopaske","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib37","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1523\/JNEUROSCI.3501-06.2007","article-title":"Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease","volume":"27","author":"Lacor","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0197-4580(02)00004-0","article-title":"Aging and sex influence the anatomy of the rat anterior cingulate cortex","volume":"23","author":"Markham","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib39","first-page":"1293","article-title":"Diffuse plaques do not accentuate synapse loss in Alzheimer's disease","volume":"137","author":"Masliah","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib40","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib41","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1212\/01.wnl.0000228230.26044.a4","article-title":"[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease","volume":"67","author":"Mintun","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1385\/JMN:17:2:101","article-title":"Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease","volume":"17","author":"Morris","year":"2001","journal-title":"J.\u00a0Mol. Neurosci."},{"issue":"Pt 7","key":"10.1016\/j.neurobiolaging.2017.01.022_bib45","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1093\/brain\/awu103","article-title":"Within-patient correspondence of amyloid-beta and intrinsic network connectivity in Alzheimer's disease","volume":"137","author":"Myers","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"issue":"Pt 11","key":"10.1016\/j.neurobiolaging.2017.01.022_bib47","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1093\/brain\/awm238","article-title":"Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease","volume":"130","author":"Pike","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib48","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.neurobiolaging.2009.04.002","article-title":"Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease","volume":"30","author":"Price","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib49","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A\u00a0default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2016.02.030","article-title":"Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology","volume":"42","author":"Scheff","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"3 Suppl","key":"10.1016\/j.neurobiolaging.2017.01.022_bib51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2006-9S312","article-title":"Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus","volume":"9","author":"Scheff","year":"2006","journal-title":"J.\u00a0Alzheimer's Dis."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib52","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3233\/JAD-141518","article-title":"Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease","volume":"43","author":"Scheff","year":"2015","journal-title":"J.\u00a0Alzheimer's Dis."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib53","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.neurobiolaging.2005.09.012","article-title":"Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment","volume":"27","author":"Scheff","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib54","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3233\/JAD-122353","article-title":"Synapse stability in the precuneus early in the progression of Alzheimer's disease","volume":"35","author":"Scheff","year":"2013","journal-title":"J.\u00a0Alzheimer's Dis."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib55","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer's disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib56","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.biopsych.2009.08.024","article-title":"Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly","volume":"67","author":"Sheline","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12017-009-8109-7","article-title":"Functional alterations in memory networks in early Alzheimer's disease","volume":"12","author":"Sperling","year":"2010","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib58","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2009.07.003","article-title":"Amyloid deposition is associated with impaired default network function in older persons without dementia","volume":"63","author":"Sperling","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib59","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1523\/JNEUROSCI.1879-05.2005","article-title":"Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy","volume":"25","author":"Spires","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib60","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/npp.2008.67","article-title":"Reduced dendritic spine density in auditory cortex of subjects with schizophrenia","volume":"34","author":"Sweet","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib61","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1074\/mcp.M115.056580","article-title":"Apolipoprotein E*4 (APOE*4) genotype is associated with altered levels of glutamate signaling proteins and synaptic coexpression networks in the prefrontal cortex in mild to moderate Alzheimer disease","volume":"15","author":"Sweet","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib62","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/cercor\/bhg121","article-title":"Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys","volume":"14","author":"Tang","year":"2004","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib63","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib64","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0014-4886(80)90151-X","article-title":"Age-related changes in prefrontal cortex of Macaca mulatta: synaptic density","volume":"69","author":"Uemura","year":"1980","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.01.022_bib65","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/brcg.2001.1500","article-title":"Neuronal changes in normal human aging and Alzheimer's disease","volume":"49","author":"Uylings","year":"2002","journal-title":"Brain Cogn."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017300301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017300301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:31:54Z","timestamp":1794000714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458017300301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":66,"alternative-id":["S0197458017300301"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.01.022","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}