{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:54:47Z","timestamp":1771523687982,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.neurobiolaging.2017.03.005","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T05:15:54Z","timestamp":1489468554000},"page":"163-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan"],"prefix":"10.1016","volume":"54","author":[{"suffix":"III","given":"Harry","family":"LeVine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Peter","family":"Spielmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey","family":"Matveev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Macchiavello","family":"Cauvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Paul","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina L.","family":"Beckett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"McCarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira T.","family":"Lott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Doran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jalz.2015.07.490","article-title":"The pattern of amyloid accumulation in the brains of adults with Down syndrome","volume":"12","author":"Annus","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1001\/archneur.64.3.431","article-title":"Molecular imaging with Pittsburgh compound B confirmed at autopsy: a case report","volume":"64","author":"Bacskai","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.nbd.2010.05.018","article-title":"Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle","volume":"39","author":"Beckett","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/JAD-2012-120655","article-title":"Postmortem Pittsburgh compound B (PiB) binding increases with Alzheimer's disease progression","volume":"32","author":"Beckett","year":"2012","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib5","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/archneurol.2009.279","article-title":"Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report","volume":"66","author":"Cairns","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbadis.2011.10.001","article-title":"Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome","volume":"1822","author":"Cenini","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"Pt A","key":"10.1016\/j.neurobiolaging.2017.03.005_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nbd.2014.05.001","article-title":"Early detection of Alzheimer's disease using PiB and FDG PET","volume":"72","author":"Cohen","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00401-012-1025-1","article-title":"Correspondence between in\u00a0vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques","volume":"124","author":"Driscoll","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jalz.2011.09.229","article-title":"Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B","volume":"8","author":"Handen","year":"2012","journal-title":"Alzheimers Dement."},{"issue":"Pt 9","key":"10.1016\/j.neurobiolaging.2017.03.005_bib10","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1093\/brain\/awu173","article-title":"Cognitive functioning in relation to brain amyloid-beta in healthy adults with Down syndrome","volume":"137","author":"Hartley","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2174\/1567205012666151020114607","article-title":"Aging in Down syndrome and the development of Alzheimer's disease neuropathology","volume":"13","author":"Head","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archneur.1995.00540280065020","article-title":"Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome","volume":"52","author":"Hof","year":"1995","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00401-012-0943-2","article-title":"Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study","volume":"123","author":"Ikonomovic","year":"2012","journal-title":"Acta Neuropathol."},{"issue":"Pt 6","key":"10.1016\/j.neurobiolaging.2017.03.005_bib14","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/brain\/awn016","article-title":"Post-mortem correlates of in\u00a0vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease","volume":"131","author":"Ikonomovic","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib15","doi-asserted-by":"crossref","first-page":"a006213","DOI":"10.1101\/cshperspect.a006213","article-title":"Brain imaging in Alzheimer disease","volume":"2","author":"Johnson","year":"2012","journal-title":"Cold Spring Harb Perspect. Med."},{"issue":"Pt 1","key":"10.1016\/j.neurobiolaging.2017.03.005_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/brain\/awq349","article-title":"Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh compound B positron emission tomography patient with Alzheimer's disease","volume":"134","author":"Kadir","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib18","doi-asserted-by":"crossref","first-page":"10598","DOI":"10.1523\/JNEUROSCI.2990-05.2005","article-title":"Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain","volume":"25","author":"Klunk","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib19","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1523\/JNEUROSCI.0730-07.2007","article-title":"Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees","volume":"27","author":"Klunk","year":"2007","journal-title":"J.\u00a0Neurosci."},{"issue":"Pt 7","key":"10.1016\/j.neurobiolaging.2017.03.005_bib20","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/brain\/awn107","article-title":"PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease","volume":"131","author":"Koivunen","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib21","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archneur.1989.00520440031017","article-title":"A\u00a0prospective study of Alzheimer disease in Down syndrome","volume":"46","author":"Lai","year":"1989","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib22","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1001\/archneurol.2011.36","article-title":"Using positron emission tomography and carbon 11-labeled Pittsburgh compound B to image brain fibrillar beta-amyloid in adults with Down syndrome: safety, acceptability, and feasibility","volume":"68","author":"Landt","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jalz.2015.05.013","article-title":"The effects of normal aging on amyloid-beta deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B","volume":"12","author":"Lao","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib24","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/exnr.1997.6777","article-title":"Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis","volume":"150","author":"Leverenz","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/B978-0-444-54299-1.00006-6","article-title":"Neurological phenotypes for Down syndrome across the life span","volume":"197","author":"Lott","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib26","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1474-4422(10)70112-5","article-title":"Cognitive deficits and associated neurological complications in individuals with Down's syndrome","volume":"9","author":"Lott","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib27","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1021\/jm030026b","article-title":"Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents","volume":"46","author":"Mathis","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib28","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1016\/j.bmcl.2014.09.075","article-title":"Tritium-labeled (E,E)-2,5-bis(4'-hydroxy-3'-carboxystyryl)benzene as a probe for beta-amyloid fibrils","volume":"24","author":"Matveev","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib29","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/jnc.12815","article-title":"A\u00a0distinct subfraction of Abeta is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain","volume":"131","author":"Matveev","year":"2014","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib30","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1212\/01.wnl.0000228230.26044.a4","article-title":"[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease","volume":"67","author":"Mintun","year":"2006","journal-title":"Neurology"},{"issue":"Pt\u00a07","key":"10.1016\/j.neurobiolaging.2017.03.005_bib31","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1093\/brain\/awt142","article-title":"Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue","volume":"136","author":"Ni","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1192\/bjp.180.5.405","article-title":"Genetic and host factors for dementia in Down's syndrome","volume":"180","author":"Schupf","year":"2002","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","article-title":"The evolution of preclinical Alzheimer's disease: implications for prevention trials","volume":"84","author":"Sperling","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib34","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1001\/archneurol.2009.285","article-title":"High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types","volume":"66","author":"Villemagne","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib35","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.bbadis.2015.11.007","article-title":"Cerebrovascular contributions to\u00a0aging\u00a0and Alzheimer's disease in Down syndrome","volume":"1862","author":"Wilcock","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2017.03.005_bib36","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ana.410170310","article-title":"Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome","volume":"17","author":"Wisniewski","year":"1985","journal-title":"Ann. Neurol."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017300763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017300763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T14:03:01Z","timestamp":1568901781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458017300763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":36,"alternative-id":["S0197458017300763"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.03.005","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}