{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:49:03Z","timestamp":1790434143730,"version":"4.1.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["#RF-2010-2313220"],"award-info":[{"award-number":["#RF-2010-2313220"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.neurobiolaging.2017.05.024","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T20:51:50Z","timestamp":1496782310000},"page":"206-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Structural and functional brain signatures of C9orf72 in motor neuron disease"],"prefix":"10.1016","volume":"57","author":[{"given":"Federica","family":"Agosta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar M.","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilo","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo Gioele","family":"Spinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teuta","family":"Domi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Copetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Falzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lunetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Comi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Falini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Quattrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-0479","authenticated-orcid":false,"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0028-3932(99)00146-3","article-title":"Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)","volume":"38","author":"Abrahams","year":"2000","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.neurobiolaging.2013.09.041","article-title":"Resting state functional connectivity alterations in primary lateral sclerosis","volume":"35","author":"Agosta","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib3","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/hbm.23124","article-title":"Structural brain correlates of cognitive and behavioral impairment in MND","volume":"37","author":"Agosta","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bandl.2013.06.003","article-title":"Disruption of structural connectivity along the dorsal and ventral language pathways in patients with nonfluent and semantic variant primary progressive aphasia: a DT MRI study and a literature review","volume":"127","author":"Agosta","year":"2013","journal-title":"Brain Lang."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib5","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/hbm.22286","article-title":"Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS","volume":"35","author":"Agosta","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jmedgenet-2014-102360","article-title":"A\u00a0blinded international study on the reliability of genetic testing for GGGGCC-repeat expansions in C9orf72 reveals marked differences in results among 14 laboratories","volume":"51","author":"Akimoto","year":"2014","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00401-011-0911-2","article-title":"p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND\/ALS","volume":"122","author":"Al-Sarraj","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s10072-007-0791-3","article-title":"The Frontal Behavioural Inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer's disease","volume":"28","author":"Alberici","year":"2007","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib9","series-title":"Non-linear Registration, Aka Spatial Normalisation","author":"Andersson","year":"2007"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuron.2013.02.004","article-title":"Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD\/ALS","volume":"77","author":"Ash","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib11","first-page":"189","article-title":"Raven's coloured progressive matrices: normative values on 305 adult normal controls","volume":"2","author":"Basso","year":"1987","journal-title":"Funct. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1098\/rstb.2005.1634","article-title":"Investigations into resting-state connectivity using independent component analysis","volume":"360","author":"Beckmann","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1212\/WNL.0b013e31829c5eee","article-title":"Multiparametric MRI study of ALS stratified for the C9orf72 genotype","volume":"81","author":"Bede","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib14","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/jnnp-2014-308172","article-title":"Patterns of cerebral and cerebellar white matter degeneration in ALS","volume":"86","author":"Bede","year":"2015","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib15","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1212\/01.wnl.0000437313.80913.2c","article-title":"Basal ganglia involvement in amyotrophic lateral sclerosis","volume":"81","author":"Bede","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroimage.2006.09.018","article-title":"Probabilistic diffusion tractography with multiple fibre orientations: what can we gain?","volume":"34","author":"Behrens","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1440-1789.2012.01332.x","article-title":"Frontotemporal lobar degeneration with TDP-43 proteinopathy and chromosome 9p repeat expansion in C9ORF72: clinicopathologic correlation","volume":"33","author":"Bigio","year":"2013","journal-title":"Neuropathology"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.nicl.2016.02.008","article-title":"Patterns of regional cerebellar atrophy in genetic frontotemporal dementia","volume":"11","author":"Bocchetta","year":"2016","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib19","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/jnnp.2009.204081","article-title":"Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family","volume":"82","author":"Boxer","year":"2011","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph. Lateral Scler. Other Mot. Neuron Disord"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib22","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1474-4422(12)70014-5","article-title":"Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study","volume":"11","author":"Byrne","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib23","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000117297","article-title":"The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery","volume":"36","author":"Carlesimo","year":"1996","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib24","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/jnnp.2010.235952","article-title":"Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study","volume":"82","author":"Chio","year":"2011","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"issue":"Pt 3","key":"10.1016\/j.neurobiolaging.2017.05.024_bib25","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/brain\/awr365","article-title":"Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72","volume":"135","author":"Cooper-Knock","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cortex.2014.01.002","article-title":"Microstructural white matter correlates of emotion recognition impairment in Amyotrophic Lateral Sclerosis","volume":"53","author":"Crespi","year":"2014","journal-title":"Cortex"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib28","doi-asserted-by":"crossref","first-page":"13848","DOI":"10.1073\/pnas.0601417103","article-title":"Consistent resting-state networks across healthy subjects","volume":"103","author":"Damoiseaux","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/jmg.2008.062463","article-title":"Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis","volume":"46","author":"Daoud","year":"2009","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/2051-5960-2-70","article-title":"Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72","volume":"2","author":"Davidson","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"Dejesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s100720300015","article-title":"How many camels are there in Italy? Cognitive estimates standardised on the Italian population","volume":"24","author":"Della Sala","year":"2003","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib33","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1001\/jamaneurol.2013.6002","article-title":"Frontotemporal dementia associated with the C9ORF72 mutation: a unique clinical profile","volume":"71","author":"Devenney","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib35","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1073\/pnas.1602413113","article-title":"Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates","volume":"113","author":"Eklund","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib36","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.0811879106","article-title":"Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele","volume":"106","author":"Filippini","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib37","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib38","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.nicl.2016.10.014","article-title":"Longitudinal imaging in C9orf72 mutation carriers: relationship to phenotype","volume":"12","author":"Floeter","year":"2016","journal-title":"NeuroImage Clin."},{"issue":"Pt 10","key":"10.1016\/j.neurobiolaging.2017.05.024_bib39","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/brain\/awr099","article-title":"White matter damage in primary progressive aphasias: a diffusion tensor tractography study","volume":"134","author":"Galantucci","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00401-013-1237-z","article-title":"Mechanisms of toxicity in C9FTLD\/ALS","volume":"127","author":"Gendron","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib41","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","article-title":"Accurate and robust brain image alignment using boundary-based registration","volume":"48","author":"Greve","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib43","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0730-725X(99)00077-6","article-title":"Mapping eddy current induced fields for the correction of diffusion-weighted echo planar images","volume":"17","author":"Horsfield","year":"1999","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/jnnp-2012-303507","article-title":"Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis","volume":"84","author":"Irwin","year":"2013","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib45","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","article-title":"A\u00a0global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib47","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/WNN.0000000000000008","article-title":"Psychosis and hallucinations in frontotemporal dementia with the C9ORF72 mutation: a detailed clinical cohort","volume":"26","author":"Kertesz","year":"2013","journal-title":"Cogn. Behav. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s100720070065","article-title":"Wisconsin card sorting test: a new global score, with Italian norms, and its relationship with the Weigl sorting test","volume":"21","author":"Laiacona","year":"2000","journal-title":"Neurol. Sci."},{"issue":"Pt 11","key":"10.1016\/j.neurobiolaging.2017.05.024_bib49","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/brain\/awu248","article-title":"Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion","volume":"137","author":"Lee","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib50","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00401-013-1232-4","article-title":"The neuropathology associated with repeat expansions in the C9ORF72 gene","volume":"127","author":"Mackenzie","year":"2014","journal-title":"Acta Neuropathol."},{"issue":"Pt 3","key":"10.1016\/j.neurobiolaging.2017.05.024_bib51","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/brain\/awr361","article-title":"Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features","volume":"135","author":"Mahoney","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib52","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/2051-5960-1-68","article-title":"Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72","volume":"1","author":"Mann","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib53","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1212\/WNL.0000000000001495","article-title":"C9orf72 promoter hypermethylation is neuroprotective: neuroimaging and neuropathologic evidence","volume":"84","author":"McMillan","year":"2015","journal-title":"Neurology"},{"issue":"Pt 9","key":"10.1016\/j.neurobiolaging.2017.05.024_bib54","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1093\/brain\/awu162","article-title":"Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis","volume":"137","author":"Menke","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib55","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/jnnp-2015-311945","article-title":"Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk","volume":"87","author":"Menke","year":"2016","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib56","series-title":"Batteria per l'Analisi del Deficit Afasico. B.A.D.A","author":"Miceli","year":"1994"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib57","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10072-012-1130-x","article-title":"Forward and backward span for verbal and visuo-spatial data: standardization and normative data from an Italian adult population","volume":"34","author":"Monaco","year":"2012","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib58","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/jnnp-2013-307223","article-title":"Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy","volume":"86","author":"Montuschi","year":"2015","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib59","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.neuroimage.2008.06.012","article-title":"Probabilistic fibre tracking: differentiation of connections from chance events","volume":"42","author":"Morris","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: a primer with examples","volume":"15","author":"Nichols","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib61","first-page":"477","article-title":"Tre test clinici di ricerca e produzione lessicale. Taratura su soggetti normali","volume":"47","author":"Novelli","year":"1986","journal-title":"Arch. Psicol Neurol. Psichiatr"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib62","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.schres.2014.09.007","article-title":"Does diffusion MRI tell us anything about the white matter? An overview of methods and pitfalls","volume":"161","author":"O'Donnell","year":"2015","journal-title":"Schizophr Res."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib63","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF02333660","article-title":"Verbal and spatial immediate memory span: normative data from 1355 adults and 1112 children","volume":"8","author":"Orsini","year":"1987","journal-title":"Ital. J. Neurol. Sci."},{"issue":"Pt 11","key":"10.1016\/j.neurobiolaging.2017.05.024_bib64","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1093\/brain\/awt243","article-title":"Executive deficits, not processing speed relates to abnormalities in distinct prefrontal tracts in amyotrophic lateral sclerosis","volume":"136","author":"Pettit","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib65","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/jnnp-2011-300188","article-title":"The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study","volume":"83","author":"Phukan","year":"2012","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib66","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroimage.2015.02.064","article-title":"ICA-AROMA: a robust ICA-based strategy for removing motion artifacts from fMRI data","volume":"112","author":"Pruim","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib67","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1212\/WNL.0b013e31826c1aa1","article-title":"The ALS-FTD-Q: a new screening tool for behavioral disturbances in ALS","volume":"79","author":"Raaphorst","year":"2012","journal-title":"Neurology"},{"issue":"Pt 9","key":"10.1016\/j.neurobiolaging.2017.05.024_bib68","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib69","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A\u00a0hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib70","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1474-4422(14)70233-9","article-title":"C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib71","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","article-title":"Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib72","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1212\/WNL.0b013e318268452e","article-title":"Frontotemporal dementia due to C9ORF72 mutations: clinical and imaging features","volume":"79","author":"Sha","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib73","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1073\/pnas.0905267106","article-title":"Correspondence of the brain's functional architecture during activation and rest","volume":"106","author":"Smith","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2017.05.024_bib74","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib75","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib76","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/17482960802654364","article-title":"Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis","volume":"10","author":"Strong","year":"2009","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib77","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1440-1789.2011.01286.x","article-title":"An MND\/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline","volume":"32","author":"Troakes","year":"2012","journal-title":"Neuropathology"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib78","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.nbd.2003.12.012","article-title":"Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study","volume":"15","author":"Turner","year":"2004","journal-title":"Neurobiol. Dis."},{"issue":"Pt 5","key":"10.1016\/j.neurobiolaging.2017.05.024_bib79","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/brain\/awg117","article-title":"Sporadic lower motor neuron disease with adult onset: classification of subtypes","volume":"126","author":"van den Berg-Vos","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib80","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1212\/WNL.0000000000002135","article-title":"Brain morphologic changes in asymptomatic C9orf72 repeat expansion carriers","volume":"85","author":"Walhout","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib81","first-page":"245","article-title":"On the psychology of so-called processes of abstraction","volume":"103","author":"Weigl","year":"1927","journal-title":"Z.\u00a0f\u00fcr Psychol."},{"key":"10.1016\/j.neurobiolaging.2017.05.024_bib82","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1136\/jnnp-2016-313959","article-title":"Widespread structural brain involvement in ALS is not limited to the C9orf72 repeat expansion","volume":"87","author":"Westeneng","year":"2016","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"issue":"Pt 3","key":"10.1016\/j.neurobiolaging.2017.05.024_bib83","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/brain\/aws001","article-title":"Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics","volume":"135","author":"Whitwell","year":"2012","journal-title":"Brain"},{"issue":"1 Suppl","key":"10.1016\/j.neurobiolaging.2017.05.024_bib84","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.neuroimage.2008.10.055","article-title":"Bayesian analysis of neuroimaging data in FSL","volume":"45","author":"Woolrich","year":"2009","journal-title":"Neuroimage"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017301914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017301914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T22:55:50Z","timestamp":1535756150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458017301914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":84,"alternative-id":["S0197458017301914"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.05.024","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural and functional brain signatures of C9orf72 in motor neuron disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.05.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}