{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:35:35Z","timestamp":1759336535260,"version":"build-2065373602"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.neurobiolaging.2017.12.008","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T13:02:07Z","timestamp":1513602127000},"page":"159.e1-159.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Heterozygous TYROBP deletion (PLOSLFIN) is not a strong risk factor for cognitive impairment"],"prefix":"10.1016","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1218-4014","authenticated-orcid":false,"given":"Karri","family":"Kaivola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilja","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-7187","authenticated-orcid":false,"given":"Elmo","family":"Saarentaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kiviharju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ville","family":"Rantalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan G.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo E.","family":"Strandberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomo","family":"Polvikoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Myllykangas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pentti J.","family":"Tienari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJMoa044160","article-title":"Trajectories of growth among children who have coronary events as adults","volume":"353","author":"Barker","year":"2005","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib2","doi-asserted-by":"crossref","first-page":"240.e1","DOI":"10.1016\/j.neurobiolaging.2017.06.019","article-title":"Mutations in TYROBP are not a common cause of dementia in a Turkish cohort","volume":"58","author":"Darwent","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib3","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1007\/s00125-006-0459-1","article-title":"Patterns of growth among children who later develop type 2 diabetes or its risk factors","volume":"49","author":"Eriksson","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib4","doi-asserted-by":"crossref","first-page":"2890.e1","DOI":"10.1016\/j.neurobiolaging.2013.06.005","article-title":"Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family","volume":"34","author":"Guerreiro","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib5","first-page":"1","article-title":"Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia","volume":"232","author":"Hakola","year":"1972","journal-title":"Acta Psychiatr. Scand. Suppl."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature11283","article-title":"A\u00a0mutation in APP protects against Alzheimer's disease and age-related cognitive decline","volume":"488","author":"Jonsson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer's disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib8","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/ije\/dys127","article-title":"No association between body size at birth and leucocyte telomere length in adult life\u2013evidence from three cohort studies","volume":"41","author":"Kajantie","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib9","doi-asserted-by":"crossref","first-page":"1518.e1","DOI":"10.1016\/j.neurobiolaging.2012.09.017","article-title":"Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population","volume":"34","author":"Kero","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jns.2006.09.019","article-title":"A\u00a0novel compound heterozygous mutation in the DAP12 gene in a patient with Nasu-Hakola disease","volume":"252","author":"Kuroda","year":"2007","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib11","doi-asserted-by":"crossref","first-page":"e114679","DOI":"10.1371\/journal.pone.0114679","article-title":"Maternal grand multiparity and the risk of severe mental disorders in adult offspring","volume":"9","author":"Lahti","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib12","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/1531-8249(199909)46:3<382::AID-ANA14>3.0.CO;2-5","article-title":"Genetic association of alpha-2-macroglobulin with Alzheimer's disease in a Finnish elderly population","volume":"46","author":"Myllykangas","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/77153","article-title":"Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts","volume":"25","author":"Paloneva","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib15","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1056\/NEJM199511093331902","article-title":"Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein","volume":"333","author":"Polvikoski","year":"1995","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2016.07.028","article-title":"TYROBP genetic variants in early-onset Alzheimer's disease","volume":"48","author":"Pottier","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"Purcell","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib18","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/jnnp.74.6.720","article-title":"Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older","volume":"74","author":"Rahkonen","year":"2003","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib19","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease","volume":"49","author":"Sims","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib20","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jalz.2014.05.1751","article-title":"R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia","volume":"10","author":"Slattery","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyv310","article-title":"Cohort Profile: The Helsinki Businessmen Study (HBS)","volume":"45","author":"Strandberg","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s40266-013-0055-2","article-title":"Detailed cognitive function and use of drugs with anticholinergic properties in older people: a community-based cross-sectional study","volume":"30","author":"Uusvaara","year":"2013","journal-title":"Drugs Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib23","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/sj.ijo.0803612","article-title":"Birth size, adult body composition and muscle strength in later life","volume":"31","author":"Yliharsila","year":"2007","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.neurobiolaging.2017.12.008_bib24","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2013.03.030","article-title":"Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease","volume":"153","author":"Zhang","year":"2013","journal-title":"Cell."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017304037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017304037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:28:08Z","timestamp":1759318088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458017304037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":24,"alternative-id":["S0197458017304037"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.12.008","relation":{},"ISSN":["0197-4580"],"issn-type":[{"type":"print","value":"0197-4580"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterozygous TYROBP deletion (PLOSLFIN) is not a strong risk factor for cognitive impairment","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}