{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:35:37Z","timestamp":1783690537017,"version":"3.55.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.neurobiolaging.2017.12.011","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T23:48:16Z","timestamp":1513727296000},"page":"92-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease"],"prefix":"10.1016","volume":"64","author":[{"given":"Paige E.","family":"Cramer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee C.","family":"Gentzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith Q.","family":"Tanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Vardigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Manfre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Lodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Renger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Zerbinatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Uslaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib2","first-page":"741","article-title":"Immunocytochemical characterization of Tau proteins during cerebral aging of the lemurian primate Microcebus murinus","volume":"III 318","author":"Bons","year":"1995","journal-title":"C\u00a0R. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0197-4580(92)90016-Q","article-title":"Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus","volume":"13","author":"Bons","year":"1992","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0197-4580(94)90115-5","article-title":"Identification of amyloid beta protein in the brain of the small, short-lived lemurian primate Microcebus murinus","volume":"15","author":"Bons","year":"1994","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib5","first-page":"1383","article-title":"Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits","volume":"137","author":"Cork","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib6","article-title":"Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain","volume":"283","author":"Cox","year":"2016","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/jmp.12044","article-title":"Correlations between serum levels of beta amyloid, cerebrospinal levels of tau and phospho tau, and delayed response tasks in young and aged cynomolgus monkeys (Macaca fascicularis)","volume":"42","author":"Darusman","year":"2013","journal-title":"J.\u00a0Med. Primatol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib8","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0140-6736(76)91936-X","article-title":"Selective loss of central cholinergic neurons in Alzheimer's disease","volume":"2","author":"Davies","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.arr.2016.01.006","article-title":"Opportunities and challenges in developing relevant animal models for Alzheimer's disease","volume":"26","author":"De Felice","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/dev.420220307","article-title":"The performance of human infants on a measure of frontal cortex function, the delayed response task","volume":"22","author":"Diamond","year":"1989","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib11","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1037\/0735-7044.103.3.526","article-title":"Successful performance by monkeys with lesions of the hippocampal formation on AB and object retrieval, two tasks that mark developmental changes in human infants","volume":"103","author":"Diamond","year":"1989","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib12","first-page":"386","article-title":"Theory and practice of histological techniques","volume":"17","author":"Downie","year":"1990"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib13","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1523\/JNEUROSCI.6410-09.2010","article-title":"Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment","volume":"30","author":"Dumitriu","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00213-013-3260-0","article-title":"The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey","volume":"231","author":"Eddins","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neurobiolaging.2017.07.006","article-title":"Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease","volume":"59","author":"Edler","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib16","doi-asserted-by":"crossref","first-page":"12217","DOI":"10.1523\/JNEUROSCI.4116-15.2016","article-title":"Network patterns associated with navigation behaviors are altered in aged nonhuman primates","volume":"36","author":"Engle","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib17","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1073\/pnas.91.20.9382","article-title":"Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease","volume":"91","author":"Gearing","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib18","doi-asserted-by":"crossref","first-page":"e0178048","DOI":"10.1371\/journal.pone.0178048","article-title":"The use of preferred social stimuli as rewards for rhesus macaques in behavioural neuroscience","volume":"12","author":"Gray","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib19","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s11357-011-9278-5","article-title":"Neuronal and morphological bases of cognitive decline in aged rhesus monkeys","volume":"34","author":"Hara","year":"2012","journal-title":"Age"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s004010000183","article-title":"Abnormally phosphorylated protein tau in the cortex of aged individuals of various mammalian orders","volume":"100","author":"Hartig","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0166-4328(96)02256-5","article-title":"Patterns of cognitive decline in aged rhesus monkeys","volume":"87","author":"Herndon","year":"1997","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib22","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1212\/01.WNL.0000156914.16988.56","article-title":"CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment","volume":"64","author":"Herukka","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnana.2012.00029","article-title":"Monkey in the middle: why non-human primates are needed to bridge the gap in resting-state investigations","volume":"6","author":"Hutchison","year":"2012","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib25","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0306-4522(98)00481-3","article-title":"Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits","volume":"90","author":"Jentsch","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s002130050865","article-title":"Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval\/detour deficits in monkeys","volume":"142","author":"Jentsch","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.24546","article-title":"Tau positron emission tomographic imaging in aging and early Alzheimer disease","volume":"79","author":"Johnson","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/525193a","article-title":"Neurodegeneration: amyloid-beta pathology induced in humans","volume":"525","author":"Jucker","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature12481","article-title":"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases","volume":"501","author":"Jucker","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib30","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.neurobiolaging.2013.03.023","article-title":"Development of amyloid burden in African Green monkeys","volume":"34","author":"Kalinin","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib31","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1373\/clinchem.2013.202937","article-title":"Clinical utility and analytical challenges in measurement of cerebrospinal fluid amyloid-beta(1-42) and tau proteins as Alzheimer disease biomarkers","volume":"59","author":"Kang","year":"2013","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib32","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.neurobiolaging.2009.05.018","article-title":"Age-associated cerebral atrophy in mouse lemur primates","volume":"32","author":"Kraska","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib33","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1124\/jpet.115.226712","article-title":"The M1 muscarinic positive allosteric modulator PQCA improves performance on translatable tests of memory and attention in rhesus monkeys","volume":"355","author":"Lange","year":"2015","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib34","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.arr.2011.07.001","article-title":"The grey mouse lemur: a non-human primate model for ageing studies","volume":"11","author":"Languille","year":"2012","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0002-9440(10)63296-8","article-title":"Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet","volume":"165","author":"Lemere","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1089\/rej.2006.9.77","article-title":"Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys, and humans","volume":"9","author":"Lemere","year":"2006","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib37","first-page":"1358","article-title":"Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex","volume":"145","author":"Martin","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib38","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1073\/pnas.88.4.1461","article-title":"Amyloid precursor protein in aged nonhuman primates","volume":"88","author":"Martin","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1749-6632.2009.04944.x","article-title":"CSF biomarkers: pinpointing Alzheimer pathogenesis","volume":"1180","author":"Mattsson","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib40","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2217\/bmm.09.65","article-title":"Alzheimer's disease and CSF biomarkers: key challenges for broad clinical applications","volume":"3","author":"Mattsson","year":"2009","journal-title":"Biomark. Med."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/jama.2009.1064","article-title":"CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment","volume":"302","author":"Mattsson","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib42","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0197-4580(94)00064-6","article-title":"Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: colocalization with amyloid plaques","volume":"15","author":"Mufson","year":"1994","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1373\/clinchem.2009.130518","article-title":"Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease","volume":"56","author":"Mulder","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib44","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.neurobiolaging.2008.07.007","article-title":"Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery","volume":"31","author":"Nagahara","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainres.2009.12.005","article-title":"Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition","volume":"1315","author":"Oikawa","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib46","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1002\/cne.23428","article-title":"Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla)","volume":"521","author":"Perez","year":"2013","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neurobiolaging.2015.12.017","article-title":"Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei)","volume":"39","author":"Perez","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib48","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.neuroscience.2007.07.014","article-title":"Synapses are lost during aging in the primate prefrontal cortex","volume":"152","author":"Peters","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib49","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.exger.2006.09.013","article-title":"Aging affects executive functions and memory in mouse lemur primates","volume":"42","author":"Picq","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib50","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.neurobiolaging.2010.09.009","article-title":"Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments","volume":"33","author":"Picq","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib51","doi-asserted-by":"crossref","first-page":"e29610","DOI":"10.1371\/journal.pone.0029610","article-title":"Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging","volume":"6","author":"Podtelezhnikov","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib52","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0197-4580(87)90038-8","article-title":"Age differences in recognition memory of the rhesus monkey (Macaca mulatta)","volume":"8","author":"Presty","year":"1987","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib53","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0197-4580(91)90077-W","article-title":"Recognition memory deficits in a subpopulation of aged monkeys resemble the effects of medial temporal lobe damage","volume":"12","author":"Rapp","year":"1991","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib54","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/cne.21744","article-title":"Tauopathy with paired helical filaments in an aged chimpanzee","volume":"509","author":"Rosen","year":"2008","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib55","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/jnen\/59.1.39","article-title":"Filamentous tau pathology in nerve cells, astrocytes, and oligodendrocytes of aged baboons","volume":"59","author":"Schultz","year":"2000","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib56","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0197-4580(00)00176-7","article-title":"Age-related progression of tau pathology in brains of baboons","volume":"21","author":"Schultz","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib57","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nm.2460","article-title":"Resolving controversies on the path to Alzheimer's therapeutics","volume":"17","author":"Selkoe","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib58","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.3544219","article-title":"Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease","volume":"235","author":"Selkoe","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib59","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1093\/cercor\/bhq210","article-title":"Volumetric correlates of spatiotemporal working and recognition memory impairment in aged rhesus monkeys","volume":"21","author":"Shamy","year":"2011","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib60","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/nbdi.1996.0017","article-title":"beta-Amyloid protein precursor in Microcebus murinus: genotyping and brain localization","volume":"3","author":"Silhol","year":"1996","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib61","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib62","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1111\/j.1532-5415.2010.03001.x","article-title":"Cerebrospinal fluid biomarkers in Alzheimer's disease: are the hypotheses more dynamic than the biomarkers?","volume":"58","author":"Spies","year":"2010","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"issue":"Pt 3","key":"10.1016\/j.neurobiolaging.2017.12.011_bib63","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/brain\/113.3.617","article-title":"Cognitive and motor deficits in the acquisition of an object retrieval\/detour task in MPTP-treated monkeys","volume":"113","author":"Taylor","year":"1990","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib64","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1037\/0735-7044.104.4.564","article-title":"Cognitive and motor deficits in the performance of an object retrieval task with a barrier-detour in monkeys (Cercopithecus aethiops sabaeus) treated with MPTP: long-term performance and effect of transparency of the barrier","volume":"104","author":"Taylor","year":"1990","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib65","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib66","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1073\/pnas.93.24.13438","article-title":"Memory systems in the brain and localization of a memory","volume":"93","author":"Thompson","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib67","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00401-007-0200-2","article-title":"Silver diagnosis in neuropathology: principles, practice and revised interpretation","volume":"113","author":"Uchihara","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib68","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00401-004-0947-7","article-title":"Silver stains distinguish tau-positive structures in corticobasal degeneration\/progressive supranuclear palsy and in Alzheimer's disease\u2013Comparison between Gallyas and Campbell-Switzer methods","volume":"109","author":"Uchihara","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib69","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0197-4580(93)90067-L","article-title":"The incidence of senile plaques and multiple infarction in aged macaque brain","volume":"14","author":"Uno","year":"1993","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib70","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1749-6632.1993.tb23058.x","article-title":"The age of biosenescence and the incidence of cerebral beta-amyloidosis in aged captive rhesus monkeys","volume":"695","author":"Uno","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib71","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00213-012-2788-8","article-title":"The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque","volume":"225","author":"Uslaner","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib72","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1007\/s00213-014-3813-x","article-title":"Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey","volume":"232","author":"Vardigan","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib73","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1474-4422(09)70139-5","article-title":"Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study","volume":"8","author":"Visser","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib74","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0197-4580(87)90067-4","article-title":"Senile plaques in aged squirrel monkeys","volume":"8","author":"Walker","year":"1987","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib75","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF00307691","article-title":"Amyloid in the brains of aged squirrel monkeys","volume":"80","author":"Walker","year":"1990","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib76","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1126\/science.7058341","article-title":"Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain","volume":"215","author":"Whitehouse","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib77","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0306-4522(97)00075-4","article-title":"Contrasting effects of excitotoxic lesions of the prefrontal cortex on the behavioural response to D-amphetamine and presynaptic and postsynaptic measures of striatal dopamine function in monkeys","volume":"80","author":"Wilkinson","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2017.12.011_bib78","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.neurobiolaging.2014.01.139","article-title":"Age-associated changes of cerebrospinal fluid amyloid-beta and tau in cynomolgus monkeys","volume":"35","author":"Yue","year":"2014","journal-title":"Neurobiol. Aging"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017304062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458017304062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:26:52Z","timestamp":1759318012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458017304062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":78,"alternative-id":["S0197458017304062"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.12.011","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}