{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:30:57Z","timestamp":1767983457039,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","neurobiologyofaging.org","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.neurobiolaging.2018.02.011","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T12:05:07Z","timestamp":1518869107000},"page":"181.e3-181.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia"],"prefix":"10.1016","volume":"66","author":[{"given":"St\u00e9phanie","family":"Philtjens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Van Mossevelde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4381-8040","authenticated-orcid":false,"given":"Julie","family":"van der Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-1900","authenticated-orcid":false,"given":"Eline","family":"Wauters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubina","family":"Dillen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Ivanoiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Sieben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiana","family":"Willems","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-8141","authenticated-orcid":false,"given":"Luisa","family":"Benussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-1957","authenticated-orcid":false,"given":"Roberta","family":"Ghidoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Binetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-6378","authenticated-orcid":false,"given":"Pau","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Diez-Fairen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miquel","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Miltenberger-Milt\u00e9nyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merce","family":"Boada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Sorbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ros\u00e1rio","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Clarim\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Sanchez-Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Llad\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estrella","family":"G\u00f3mez-Tortosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen","family":"Van den Broeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Cras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"De Deyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-9785","authenticated-orcid":false,"given":"Sebastiaan","family":"Engelborghs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-992X","authenticated-orcid":false,"given":"Marc","family":"Cruts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Van Broeckhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/jnnp-2013-307035","article-title":"Validation of the new consensus criteria for the diagnosis of corticobasal degeneration","volume":"85","author":"Alexander","year":"2014","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib3","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ajhg.2010.11.002","article-title":"Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma","volume":"87","author":"Carrasquillo","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib4","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","article-title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","volume":"442","author":"Cruts","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib5","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/humu.22117","article-title":"Locus-specific mutation databases for neurodegenerative brain diseases","volume":"33","author":"Cruts","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib6","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1016\/j.neurobiolaging.2013.04.022","article-title":"The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding","volume":"34","author":"De Muynck","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/molbev\/msw005","article-title":"267 Spanish exomes reveal population-specific differences in disease-related genetic variation","volume":"33","author":"Dopazo","year":"2016","journal-title":"Mol. Biol. Evol."},{"issue":"Pt 3","key":"10.1016\/j.neurobiolaging.2018.02.011_bib9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/brain\/awn352","article-title":"Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members","volume":"132","author":"Finch","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/21678421.2016.1213852","article-title":"Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis","volume":"17","author":"Gaastra","year":"2016","journal-title":"Amyotroph. Lateral Scler. Front. Degen."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1750-1326-7-33","article-title":"Progranulin regulates neuronal outgrowth independent of sortilin","volume":"7","author":"Gass","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib13","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1212\/01.wnl.0000325058.10218.fc","article-title":"Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration","volume":"71","author":"Ghidoni","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S1474-4422(11)70261-7","article-title":"A\u00a0C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study","volume":"11","author":"Gijselinck","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib15","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1212\/WNL.0000000000002220","article-title":"Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort","volume":"85","author":"Gijselinck","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib16","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/1533317507306662","article-title":"New genes, new dilemmas: FTLD genetics and its implications for families","volume":"22","author":"Goldman","year":"2007","journal-title":"Am. J. Alzheimer's Dis. Other Dement."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/humu.20873","article-title":"Simultaneous mutation and copy number variation (CNV) detection by multiplex PCR-based GS-FLX sequencing","volume":"30","author":"Goossens","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib18","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib19","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuron.2010.09.034","article-title":"Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin","volume":"68","author":"Hu","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib20","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib21","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A\u00a0general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.47.1.1","article-title":"Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop","volume":"47","author":"Litvan","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","article-title":"Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update","volume":"119","author":"Mackenzie","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib25","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib26","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib27","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib28","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1002\/cne.22430","article-title":"Progranulin expression in the developing and adult murine brain","volume":"518","author":"Petkau","year":"2010","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00401-015-1436-x","article-title":"Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease","volume":"130","author":"Pottier","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nsmb.1543","article-title":"Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain","volume":"16","author":"Quistgaard","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"Pt 9","key":"10.1016\/j.neurobiolaging.2018.02.011_bib31","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A\u00a0hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nbt.2053","article-title":"Optimized filtering reduces the error rate in detecting genomic variants by short-read sequencing","volume":"30","author":"Reumers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib34","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1212\/WNL.0b013e31826e25df","article-title":"SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"79","author":"Rubino","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib35","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3233\/JAD-2010-101032","article-title":"Low serum progranulin predicts the presence of mutations: a prospective study","volume":"22","author":"Schofield","year":"2010","journal-title":"J.\u00a0Alzheimer's Dis."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib36","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","article-title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","volume":"37","author":"Skibinski","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib37","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ana.21621","article-title":"Serum biomarker for progranulin-associated frontotemporal lobar degeneration","volume":"65","author":"Sleegers","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/humu.22244","article-title":"A\u00a0pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats","volume":"34","author":"van der Zee","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib39","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/humu.23161","article-title":"TBK1 mutation spectrum in an extended European patient cohort with frontotemporal dementia and amyotrophic lateral sclerosis","volume":"38","author":"van der Zee","year":"2017","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00401-014-1298-7","article-title":"Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration","volume":"128","author":"van der Zee","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng1332","article-title":"Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein","volume":"36","author":"Watts","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib42","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1101\/gr.2754005","article-title":"novoSNP, a novel computational tool for sequence variation discovery","volume":"15","author":"Weckx","year":"2005","journal-title":"Genome Res."},{"key":"10.1016\/j.neurobiolaging.2018.02.011_bib43","doi-asserted-by":"crossref","first-page":"e21023","DOI":"10.1371\/journal.pone.0021023","article-title":"C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking","volume":"6","author":"Zheng","year":"2011","journal-title":"PLoS One"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745801830054X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019745801830054X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T21:20:31Z","timestamp":1535059231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019745801830054X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":43,"alternative-id":["S019745801830054X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.02.011","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}