{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:10:47Z","timestamp":1789953047263,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.neurobiolaging.2018.06.002","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T11:37:00Z","timestamp":1528803420000},"page":"128-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"special_numbering":"C","title":["Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models"],"prefix":"10.1016","volume":"70","author":[{"given":"Claudia","family":"Balducci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Santamaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"La Vitola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Grandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo Roberto","family":"Viscomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten","family":"Beeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-6225","authenticated-orcid":false,"given":"Marco","family":"Gobbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Salmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ottonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-3914","authenticated-orcid":false,"given":"Gianluigi","family":"Forloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1039\/C0OB00303D","article-title":"Tetracycline prevents Abeta oligomer toxicity through an atypical supramolecular interaction","volume":"9","author":"Airoldi","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2460\/javma.1980.176.10.1061","article-title":"Pharmacotherapeutics of the newer tetracyclines","volume":"176","author":"Aronson","year":"1980","journal-title":"J.\u00a0Am. Vet. Med. Assoc."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1136\/jnnp-2014-309871","article-title":"A\u00a0case of variably protease-sensitive prionopathy treated with doxycyclin","volume":"86","author":"Assar","year":"2015","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/JAD-170075","article-title":"Prevention of amyloid-\u03b2 and tau pathologies, associated neurodegeneration, and cognitive deficit by early treatment with a neurotrophic compound","volume":"58","author":"Baazaoui","year":"2017","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib5","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1073\/pnas.0911829107","article-title":"Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein","volume":"107","author":"Balducci","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib6","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.2174\/13816128113199990497","article-title":"In\u00a0vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches","volume":"20","author":"Balducci","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbi.2016.10.012","article-title":"Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by \u03b2-amyloid oligomers in an acute mouse model of Alzheimer\u2019s disease","volume":"60","author":"Balducci","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib8","doi-asserted-by":"crossref","first-page":"14022","DOI":"10.1523\/JNEUROSCI.0284-14.2014","article-title":"Multifunctional liposomes reduce brain \u03b2-amyloid burden and ameliorate memory impairment in Alzheimer's disease mouse models","volume":"34","author":"Balducci","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3233\/JAD-2011-101839","article-title":"The gamma-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice","volume":"24","author":"Balducci","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2741\/s421","article-title":"Object recognition test for studying cognitive impairments in animal models of Alzheimer\u2019s disease","volume":"7","author":"Bengoetxea","year":"2015","journal-title":"Front. Biosci. (Schol Ed)"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nn.3028","article-title":"The toxic Abeta oligomer and Alzheimer\u2019s disease: an emperor in need of clothes","volume":"15","author":"Benilova","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/489013a","article-title":"Alzheimer\u2019s drugs take a new tack","volume":"489","author":"Callaway","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neurobiolaging.2003.09.001","article-title":"Synaptic slaughter in Alzheimer\u2019s disease","volume":"24","author":"Coleman","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib14","doi-asserted-by":"crossref","first-page":"e1888","DOI":"10.1371\/journal.pone.0001888","article-title":"The efficacy of tetracyclines in peripheral and intracerebral prion infection","volume":"3","author":"De Luigi","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.nbd.2010.07.002","article-title":"Tetracycline and its analogues protect Caenorhabditis elegans from beta amyloid-induced toxicity by targeting oligomers","volume":"40","author":"Diomede","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib17","doi-asserted-by":"crossref","first-page":"7857","DOI":"10.1074\/jbc.M112.423954","article-title":"An N-terminal fragment of the prion protein binds to amyloid-beta oligomers and inhibits their neurotoxicity in\u00a0vivo","volume":"288","author":"Fluharty","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib18","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/mds.26624","article-title":"Oligomeropathies and pathogenesis of Alzheimer and Parkinson\u2019s diseases","volume":"31","author":"Forloni","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0014-5793(00)02380-2","article-title":"Anti-amyloidogenic activity of tetracyclines: studies in\u00a0vitro","volume":"487","author":"Forloni","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib20","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1073\/pnas.162195499","article-title":"Tetracyclines affect prion infectivity","volume":"99","author":"Forloni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/1871526510909010023","article-title":"Tetracyclines and prion infectivity","volume":"9","author":"Forloni","year":"2009","journal-title":"Infect Disord. Drug Targets"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainresrev.2006.08.001","article-title":"Congo red and protein aggregation in neurodegenerative diseases","volume":"53","author":"Frid","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib23","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1056\/NEJMe1207995","article-title":"Lifelong management of amyloid-beta metabolism to prevent Alzheimer\u2019s disease","volume":"367","author":"Gandy","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbr.2014.10.025","article-title":"Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents","volume":"285","author":"Grayson","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib25","doi-asserted-by":"crossref","first-page":"C539","DOI":"10.1152\/ajpcell.00047.2010","article-title":"Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature","volume":"299","author":"Griffin","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s40520-016-0637-z","article-title":"Neuroinflammation, immune system and Alzheimer disease: searching for the missing link","volume":"29","author":"Guerriero","year":"2017","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1474-4422(13)70307-7","article-title":"Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial","volume":"13","author":"Haik","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nlm.2004.03.005","article-title":"On the delay-dependent involvement of the hippocampus in object recognition memory","volume":"82","author":"Hammond","year":"2004","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib29","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib30","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib31","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","article-title":"Co-expression of multiple transgenes in mouse CNS: a comparison of strategies","volume":"17","author":"Jankowsky","year":"2001","journal-title":"Biomol. Eng."},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2018.06.002_bib33","first-page":"S67","article-title":"Molecular mechanisms of amyloid oligomers toxicity","volume":"33","author":"Kayed","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbi.2017.04.007","article-title":"Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-\u03b2 oligomers in mice","volume":"64","author":"Kincheski","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib35","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0025-7125(16)30039-6","article-title":"Tetracyclines","volume":"79","author":"Klein","year":"1995","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib36","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1128\/AAC.47.11.3630-3633.2003","article-title":"Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines","volume":"47","author":"Krakauer","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib37","doi-asserted-by":"crossref","first-page":"21253","DOI":"10.1074\/jbc.M112.355156","article-title":"Specific soluble oligomers of amyloid-\u03b2 peptide undergo replication and form non-fibrillar aggregates in interfacial environments","volume":"287","author":"Kumar","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib38","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neurobiolaging.2010.03.024","article-title":"Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer\u2019s disease mouse model through modulation of neuroinflammation","volume":"33","author":"Lee","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib39","doi-asserted-by":"crossref","first-page":"12756","DOI":"10.1002\/anie.201406357","article-title":"A\u00a0hexameric peptide barrel as building block of amyloid-\u03b2 protofibrils","volume":"53","author":"Lendel","year":"2014","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib40","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature04533","article-title":"A\u00a0specific amyloid-beta protein assembly in the brain impairs memory","volume":"440","author":"Lesn\u00e9","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib41","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib42","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1532-5415.2004.52109.x","article-title":"A\u00a0randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer\u2019s disease","volume":"52","author":"Loeb","year":"2004","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib43","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0002-9440(10)65184-X","article-title":"Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer\u2019s disease","volume":"155","author":"Lue","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jconrel.2017.05.013","article-title":"Multifunctional liposomes delay phenotype progression and prevent memory impairment in a presymptomatic stage mouse model of Alzheimer disease","volume":"258","author":"Mancini","year":"2017","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib45","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/brain\/awq065","article-title":"The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia","volume":"133","author":"Mc Donald","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib46","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","article-title":"Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer\u2019s disease","volume":"46","author":"McLean","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/gps.3846","article-title":"A\u00a0multicenter, blinded, randomized, factorial controlled trial of doxycycline and rifampin for treatment of Alzheimer\u2019s disease: the DARAD trial","volume":"28","author":"Molloy","year":"2013","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib48","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nlm.2013.07.002","article-title":"Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research","volume":"105","author":"Morris","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib49","doi-asserted-by":"crossref","first-page":"a006338","DOI":"10.1101\/cshperspect.a006338","article-title":"Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction","volume":"2","author":"Mucke","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib50","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/jnnp-2014-310127","article-title":"Rethinking of doxycycline therapy in Creutzfeldt-Jakob disease","volume":"86","author":"Pocchiari","year":"2015","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1747-0285.2005.00318.x","article-title":"Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism","volume":"67","author":"Porat","year":"2006","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0149-7634(00)00048-8","article-title":"The immune system and memory consolidation: a role for the cytokine IL-1beta","volume":"25","author":"Rachal Pugh","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib53","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1037\/0735-7044.111.4.667","article-title":"Impaired recognition memory in patients with lesions limited to the hippocampal formation","volume":"111","author":"Reed","year":"1997","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jne.12476","article-title":"Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid beta (A\u03b21-40) administration in mice","volume":"29","author":"Santos","year":"2017","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib55","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ebiom.2016.03.035","article-title":"The role of amyloid-\u03b2 oligomers in toxicity, propagation, and immunotherapy","volume":"6","author":"Sengupta","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib56","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrn2154","article-title":"Recognition memory and the medial temporal lobe: a new perspective","volume":"8","author":"Squire","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib57","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1021\/jm400161p","article-title":"A\u00a0new face for old antibiotics: tetracyclines in treatment of amyloidoses","volume":"56","author":"Stoilova","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib58","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cell.2006.09.014","article-title":"Dendritic protein synthesis, synaptic plasticity, and memory","volume":"127","author":"Sutton","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib59","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1006\/jmbi.2000.3840","article-title":"Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in\u00a0vitro","volume":"300","author":"Tagliavini","year":"2000","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib60","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bbr.2010.10.036","article-title":"The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1beta expression","volume":"217","author":"Tarr","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib61","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib62","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1136\/jnnp-2016-313541","article-title":"Doxycycline in early CJD: a double-blinded randomised phase II and observational study","volume":"88","author":"Varges","year":"2017","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib63","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1742-2094-11-85","article-title":"Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment","volume":"11","author":"Vasconcelos","year":"2014","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib64","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/exnr.1999.7085","article-title":"The levels of soluble versus insoluble brain Abeta distinguish Alzheimer\u2019s disease from normal and pathologic aging","volume":"158","author":"Wang","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib65","doi-asserted-by":"crossref","first-page":"e0127865","DOI":"10.1371\/journal.pone.0127865","article-title":"Amyloid \u03b2 oligomeric species present in the lag phase of amyloid formation","volume":"10","author":"Wolff","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2018.06.002_bib66","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrjanheikki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458018302069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458018302069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T22:58:05Z","timestamp":1751669885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458018302069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":66,"alternative-id":["S0197458018302069"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.06.002","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}