{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:59:34Z","timestamp":1792133974543,"version":"4.4.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.neurobiolaging.2018.06.004","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T11:37:58Z","timestamp":1528717078000},"page":"70-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"special_numbering":"C","title":["The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier"],"prefix":"10.1016","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0433-5759","authenticated-orcid":false,"given":"Shino","family":"Magaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrick","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Khanlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry V.","family":"Vinters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1055\/s-0030-1268865","article-title":"Spontaneous intracerebral hemorrhage","volume":"30","author":"Aguilar","year":"2010","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00401-003-0796-9","article-title":"Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology - a pilot study","volume":"107","author":"Attems","year":"2004","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2990.2010.01137.x","article-title":"Review: sporadic cerebral amyloid angiopathy","volume":"37","author":"Attems","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00401-004-0822-6","article-title":"Amyloid \u03b2 peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology","volume":"107","author":"Attems","year":"2004","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jns.2010.08.030","article-title":"Capillary CAA and perivascular A\u03b2-deposition: two distinct features of Alzheimer\u2019s disease pathology","volume":"299","author":"Attems","year":"2010","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10571-015-0273-8","article-title":"Lymphatic clearance of the brain: perivascular, paravascular, and significance for neurodegenerative diseases","volume":"36","author":"Bakker","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jns.2012.07.010","article-title":"The vascular factor in Alzheimer\u2019s disease: a study in Golgi technique and electron microscopy","volume":"322","author":"Baloyannis","year":"2012","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib9","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/brain\/awn261","article-title":"Consequence of A\u03b2 immunization on the vasculature of human Alzheimer\u2019s disease brain","volume":"131","author":"Boche","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/nan.12042","article-title":"Review: cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy","volume":"39","author":"Carare","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib12","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/ars.2011.3895","article-title":"Amyloid beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy","volume":"15","author":"Carrano","year":"2011","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000334916","article-title":"Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy","volume":"10","author":"Carrano","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jnnp-2011-301308","article-title":"Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum","volume":"83","author":"Charidimou","year":"2012","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib15","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/STROKEAHA.115.009090","article-title":"White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden?","volume":"46","author":"Charidimou","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib16","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1161\/STROKEAHA.114.005568","article-title":"White matter perivascular spaces are related to cortical superficial siderosis in cerebral amyloid angiopathy","volume":"45","author":"Charidimou","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s004010050386","article-title":"Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer\u2019s disease patients","volume":"91","author":"Claudio","year":"1995","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib18","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neurobiolaging.2014.10.030","article-title":"Fibrin deposited in the Alzheimer\u2019s disease brain promotes neuronal degeneration","volume":"36","author":"Cortes-Canteli","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib19","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1212\/WNL.46.6.1592","article-title":"Cerebral amyloid angiopathy in the brains of patients with Alzheimer\u2019s disease: the CERAD experience, part XV","volume":"46","author":"Ellis","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s004010000195","article-title":"Pathological features of cerebral cortical capillaries are doubled in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"100","author":"Farkas","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0301-0082(00)00068-X","article-title":"Cerebral microvascular pathology in aging and Alzheimer\u2019s disease","volume":"64","author":"Farkas","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neurobiolaging.2007.07.015","article-title":"Blood-brain barrier: ageing and microvascular disease - systematic review and meta-analysis","volume":"30","author":"Farrall","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1365-2362.2002.00994.x","article-title":"Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer\u2019s disease brain and damage the blood-brain barrier","volume":"32","author":"Fiala","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.STR.14.6.915","article-title":"Cerebral amyloid angiopathy: incidence and complications in the aging brain. I. Cerebral hemorrhage","volume":"14","author":"Gilbert","year":"1983","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib26","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/STROKEAHA.111.627562","article-title":"Amyloid-\u03b2 contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy","volume":"43","author":"Hartz","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib27","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/jcbfm.2013.76","article-title":"The APOE \u025b4\/\u025b4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer\u2019s disease patients","volume":"33","author":"Hultman","year":"2013","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00401-006-0099-z","article-title":"The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: a regional comparison","volume":"112","author":"Jeynes","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1749-6632.1999.tb07821.x","article-title":"The blood-brain barrier and cerebrovascular pathology in Alzheimer\u2019s disease","volume":"893","author":"Kalaria","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00001756-199502000-00018","article-title":"Differential degeneration of the cerebral microvasculature in Alzheimer\u2019s disease","volume":"6","author":"Kalaria","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0006-8993(95)01250-8","article-title":"Increased collagen content of cerebral microvessels in Alzheimer\u2019s disease","volume":"705","author":"Kalaria","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib32","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.bbadis.2015.08.024","article-title":"Deposition of amyloid \u03b2 in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy","volume":"1862","author":"Keable","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/nan.12295","article-title":"Early changes in extracellular matrix in Alzheimer\u2019s disease","volume":"43","author":"Lepelletier","year":"2017","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib35","first-page":"19","article-title":"Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue","volume":"3","author":"Love","year":"2014","journal-title":"Am. J. Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neulet.2006.03.047","article-title":"Amyloid beta-peptide1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells","volume":"401","author":"Marco","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00401-016-1560-2","article-title":"Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer\u2019s disease-related microvascular cerebral amyloid angiopathy","volume":"131","author":"Merlini","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib39","first-page":"1","article-title":"The cerebrovascular basement membrane: role in the clearance of \u03b2-amyloid and cerebral amyloid angiopathy. Front","volume":"6","author":"Morris","year":"2014","journal-title":"Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib40","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bbadis.2015.12.016","article-title":"Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer\u2019s disease","volume":"1862","author":"Nelson","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib41","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.nbd.2014.12.006","article-title":"Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease","volume":"74","author":"Pienaar","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2015.00136","article-title":"Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer\u2019s disease: the role, regulation and restoration of LRP1","volume":"7","author":"Ramanathan","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib43","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1097\/NEN.0b013e3181fab558","article-title":"Characteristics of dyshoric capillary cerebral amyloid angiopathy","volume":"69","author":"Richard","year":"2010","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF03402043","article-title":"Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer\u2019s disease","volume":"9","author":"Roher","year":"2003","journal-title":"Mol. Med."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib45","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ana.20596","article-title":"Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy","volume":"58","author":"Rosand","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib48","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1212\/WNL.50.4.966","article-title":"A\u00a0population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer\u2019s disease and vascular dementia","volume":"50","author":"Skoog","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib49","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1750-3639.2009.00322.x","article-title":"Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy","volume":"20","author":"Soontornniyomkij","year":"2010","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib50","first-page":"734","article-title":"A\u00a0morphometric study of the blood-brain barrier in Alzheimer\u2019s disease","volume":"67","author":"Stewart","year":"1992","journal-title":"Lab. Invest."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib51","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.neurobiolaging.2008.01.017","article-title":"Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances","volume":"30","author":"Thal","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib52","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/jnen\/61.3.282","article-title":"Two types of sporadic cerebral amyloid angiopathy","volume":"61","author":"Thal","year":"2002","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib53","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/j.1582-4934.2008.00411.x","article-title":"Parenchymal and vascular A\u03b2-deposition and its effects on the degeneration of neurons and cognition in Alzheimer\u2019s disease","volume":"12","author":"Thal","year":"2008","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib54","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00401-008-0366-2","article-title":"Cerebral amyloid angiopathy and its relationship to Alzheimer\u2019s disease","volume":"115","author":"Thal","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib55","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00401-010-0707-9","article-title":"Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer\u2019s disease","volume":"120","author":"Thal","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib56","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neulet.2003.08.048","article-title":"Negative association between amyloid plaques and cerebral amyloid angiopathy in Alzheimer\u2019s disease","volume":"352","author":"Tian","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib57","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.0305-1846.2003.00510.x","article-title":"Relationships between arteriosclerosis, cerebral amyloid angiopathy and myelin loss from cerebral cortical white matter in Alzheimer\u2019s disease","volume":"30","author":"Tian","year":"2004","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib58","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2990.2006.00732.x","article-title":"Relationships in Alzheimer\u2019s disease between the extent of A\u03b2 deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen","volume":"32","author":"Tian","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib59","first-page":"463","article-title":"Blood\u2013brain barrier permeability precedes senile plaque formation in an Alzheimer disease model","volume":"10","author":"Ujiie","year":"2003","journal-title":"Microcirculation"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2202-5-37","article-title":"Aging is associated with increased collagen type IV accumulation in the basal lamina of human cerebral microvessels","volume":"5","author":"Uspenskaia","year":"2004","journal-title":"BMC Neurosci."},{"issue":"Suppl 5","key":"10.1016\/j.neurobiolaging.2018.06.004_bib61","doi-asserted-by":"crossref","first-page":"v2","DOI":"10.1136\/jnnp.2005.082867","article-title":"Epidemiology and risk factors of dementia","volume":"76","author":"van der Flier","year":"2005","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib62","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/0271678X15620434","article-title":"Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces","volume":"36","author":"van Veluw","year":"2015","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2011.09.049","article-title":"Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort","volume":"505","author":"Viggars","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib64","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/01.STR.18.2.311","article-title":"Cerebral amyloid angiopathy. A critical review","volume":"18","author":"Vinters","year":"1987","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib65","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ana.1055","article-title":"Cerebral amyloid angiopathy: a microvascular link between parenchymal and vascular dementia?","volume":"49","author":"Vinters","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib66","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-pathol-020712-163927","article-title":"Emerging concepts in Alzheimer\u2019s disease","volume":"10","author":"Vinters","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib67","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/01913129409023202","article-title":"Microvasculature in brain biopsy specimens from patients with Alzheimer\u2019s disease: an immunohistochemical and ultrastructural study","volume":"18","author":"Vinters","year":"1994","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib68","first-page":"299","article-title":"Cerebral amyloid angiopathy: clinicopathologic features and pathogenesis","volume":"Vol. 2","author":"Vinters","year":"2015"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib69","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/ana.410300503","article-title":"Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study","volume":"30","author":"Vonsattel","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib70","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.STR.0000058480.77236.B3","article-title":"Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?","volume":"34","author":"Wardlaw","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib71","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-009-0498-z","article-title":"Microvasculature changes and cerebral amyloid angiopathy in Alzheimer\u2019s disease and their potential impact on therapy","volume":"118","author":"Weller","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib72","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/bpa.12218","article-title":"White matter changes in dementia: role of impaired drainage of interstitial fluid","volume":"25","author":"Weller","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","article-title":"Perivascular drainage of amyloid-\u03b2 peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer\u2019s disease","volume":"18","author":"Weller","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib75","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.1997.tb48468.x","article-title":"Amyloid angiopathy and blood-brain barrier changes in Alzheimer\u2019s disease","volume":"826","author":"Wisniewski","year":"1997","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib76","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1161\/STROKEAHA.108.528299","article-title":"Neuropathological correlates of temporal pole white matter hyperintensities in CADASIL","volume":"40","author":"Yamamoto","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib77","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1093\/brain\/aws271","article-title":"Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias","volume":"135","author":"Yarchoan","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib78","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1016\/j.neurobiolaging.2015.08.008","article-title":"APOE and cerebral amyloid angiopathy in community-dwelling older persons","volume":"36","author":"Yu","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib79","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s004010050935","article-title":"Amyloid angiopathy of the human brain: immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells","volume":"96","author":"Zhang","year":"1998","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib80","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/STROKEAHA.108.533174","article-title":"Cerebral amyloid angiopathy progressive disruption of the neurovascular unit","volume":"40","author":"Zipfel","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib81","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neurobiolaging.2006.05.016","article-title":"Microvascular injury and blood-brain barrier leakage in Alzheimer\u2019s disease","volume":"28","author":"Zipser","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.06.004_bib82","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer\u2019s disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458018302082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458018302082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T05:19:21Z","timestamp":1547011161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458018302082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":77,"alternative-id":["S0197458018302082"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.06.004","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}