{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:22:53Z","timestamp":1790169773298,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.neurobiolaging.2018.07.003","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T13:08:22Z","timestamp":1531314502000},"page":"81-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Effects of APOE \u03b54 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-7724","authenticated-orcid":false,"given":"Niklas","family":"Mattsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00f6ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Lampinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Insel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Lautner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Strandberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"van Westen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Palmqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Stomrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib1","series-title":"Non-linear Registration Aka Spatial Normalisation, FMRIB Technial Report TR07JA2","author":"Andersson","year":"2007"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/brain\/awv006","article-title":"Rapidly progressive Alzheimer\u2019s disease features distinct structures of amyloid-\u03b2","volume":"138","author":"Cohen","year":"2015","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib4","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.jalz.2017.04.011","article-title":"Incidence of cognitively defined late-onset Alzheimer\u2019s dementia subgroups from a prospective cohort study","volume":"13","author":"Crane","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib5","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib6","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1212\/WNL.0b013e3181a2e8d0","article-title":"Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease","volume":"72","author":"Drzezga","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib8","doi-asserted-by":"crossref","first-page":"e1605","DOI":"10.1212\/WNL.0000000000005415","article-title":"Dissociable influences of APOE \u03b54 and polygenic risk of AD dementia on amyloid and cognition","volume":"90","author":"Ge","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib9","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1212\/WNL.53.8.1825","article-title":"APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD","volume":"53","author":"Geroldi","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.dadm.2016.12.002","article-title":"The APOE \u03b54 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer\u2019s disease but not those of sTREM2","volume":"6","author":"Gispert","year":"2016","journal-title":"Alzheimers Dement.(Amst)."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib11","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1162\/jocn_a_00405","article-title":"A\u00a0surface-based analysis of language lateralization and cortical asymmetry","volume":"25","author":"Greve","year":"2013","journal-title":"J.\u00a0Cogn. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib12","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.neuroimage.2006.07.036","article-title":"Smoothing and cluster thresholding for cortical surface-based group analysis of fMRI data","volume":"33","author":"Hagler","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib15","doi-asserted-by":"crossref","first-page":"18227","DOI":"10.1523\/JNEUROSCI.3266-12.2012","article-title":"Apolipoprotein E, not fibrillar beta-amyloid, reduces cerebral glucose metabolism in normal aging","volume":"32","author":"Jagust","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/acn3.274","article-title":"CSF A\u03b242\/A\u03b240 and A\u03b242\/A\u03b238 ratios: better diagnostic markers of Alzheimer disease","volume":"3","author":"Janelidze","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib17","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fnagi.2016.00171","article-title":"A\u00a0systems view of the differences between APOE \u03b54 carriers and non-carriers in Alzheimer\u2019s disease","volume":"8","author":"Jiang","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib19","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1109\/TMI.2009.2035616","article-title":"Elastix: a toolbox for intensity-based medical image registration","volume":"29","author":"Klein","year":"2010","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib20","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/cercor\/bhs401","article-title":"Common variants in psychiatric risk genes predict brain structure at birth","volume":"24","author":"Knickmeyer","year":"2014","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2967\/jnumed.108.060756","article-title":"Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in\u00a0vivo brain amyloid imaging","volume":"50","author":"Koole","year":"2009","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/jnnp.61.4.352","article-title":"The apolipoprotein E allele epsilon 4 does not correlate with the number of senile plaques or neurofibrillary tangles in patients with Alzheimer\u2019s disease","volume":"61","author":"Landen","year":"1996","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/jnnp-2013-305858","article-title":"Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients","volume":"85","author":"Lehmann","year":"2014","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib24","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1093\/brain\/aww160","article-title":"Pittsburgh compound B imaging and cerebrospinal fluid amyloid-\u03b2 in a multicentre European memory clinic study","volume":"139","author":"Leuzy","year":"2016","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib25","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1001\/jamaneurol.2017.4325","article-title":"Association of \u03b2-amyloid and apolipoprotein E \u03b54 with memory decline in preclinical Alzheimer disease","volume":"75","author":"Lim","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib26","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1212\/WNL.0000000000004336","article-title":"APOE genotype and early \u03b2-amyloid accumulation in older adults without dementia","volume":"89","author":"Lim","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib27","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jalz.2016.01.006","article-title":"Alzheimer\u2019s disease risk variants modulate endophenotypes in mild cognitive impairment","volume":"12","author":"Louwersheimer","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib28","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.2967\/jnumed.112.115006","article-title":"Implementation and validation of an adaptive template registration method for 18F-flutemetamol imaging data","volume":"54","author":"Lundqvist","year":"2013","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1515\/CCLM.2011.082","article-title":"CSF biomarkers in neurodegenerative diseases","volume":"49","author":"Mattsson","year":"2011","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib30","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1038\/ncomms10918","article-title":"Increased amyloidogenic APP processing in APOE \u025b4-negative individuals with cerebral \u03b2-amyloidosis","volume":"7","author":"Mattsson","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib31","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.15252\/emmm.201707809","article-title":"18F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer\u2019s disease","volume":"9","author":"Mattsson","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib32","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jalz.2018.02.009","article-title":"Prevalence of the apolipoprotein E \u03b54 allele in amyloid \u03b2 positive subjects across the spectrum of Alzheimer\u2019s disease","volume":"14","author":"Mattsson","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib33","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/WAD.0b013e31826a94bd","article-title":"Dysexecutive versus amnestic Alzheimer disease subgroups: analysis of demographic, genetic, and vascular factors","volume":"27","author":"Mez","year":"2013","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13195-015-0111-8","article-title":"Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer\u2019s disease: a voxel-based lesion mapping study","volume":"7","author":"Morgen","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib35","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1212\/WNL.0000000000000431","article-title":"Amyloid and APOE \u03b54 interact to influence short-term decline in preclinical Alzheimer disease","volume":"82","author":"Mormino","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib36","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/brain\/awv191","article-title":"The behavioural\/dysexecutive variant of Alzheimer\u2019s disease: clinical, neuroimaging and pathological features","volume":"138","author":"Ossenkoppele","year":"2015","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib37","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer\u2019s disease","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1212\/WNL.0b013e31827f0889","article-title":"Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia","volume":"80","author":"Ossenkoppele","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib40","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.neuroimage.2009.01.009","article-title":"Mapping the effect of APOE epsilon4 on gray matter loss in Alzheimer\u2019s disease in\u00a0vivo","volume":"45","author":"Pievani","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib41","first-page":"83","article-title":"Multiple comorbid neuropathologies in the setting of Alzheimer\u2019s disease neuropathology and implications for drug development","volume":"3","author":"Rabinovici","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib42","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","article-title":"Apolipoprotein E in sporadic Alzheimer\u2019s disease: allelic variation and receptor interactions","volume":"11","author":"Rebeck","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib43","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.neurobiolaging.2010.04.007","article-title":"Amyloid imaging results from the Australian imaging, biomarkers and lifestyle (AIBL) study of aging","volume":"31","author":"Rowe","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib44","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jalz.2017.03.002","article-title":"Cognitive subtypes of probable Alzheimer\u2019s disease robustly identified in four cohorts","volume":"13","author":"Scheltens","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2018.01.013","article-title":"Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging","author":"Schindler","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib46","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib47","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1212\/WNL.0000000000001015","article-title":"CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival","volume":"83","author":"Skillb\u00e4ck","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neurobiolaging.2017.04.021","article-title":"ApoE influences regional white-matter axonal density loss in Alzheimer\u2019s disease","volume":"57","author":"Slattery","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib49","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib50","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.euroneuro.2015.03.014","article-title":"Early onset APOE E4-negative Alzheimer\u2019s disease patients show faster cognitive decline on non-memory domains","volume":"25","author":"Smits","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib51","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000104467","article-title":"Cognitive impairment in Alzheimer\u2019s disease is modified by APOE genotype","volume":"24","author":"van der Vlies","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib52","doi-asserted-by":"crossref","first-page":"20709","DOI":"10.1038\/srep20709","article-title":"Cerebral white matter lesions - associations with A\u03b2 isoforms and amyloid PET","volume":"6","author":"van Westen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib53","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neurobiolaging.2017.08.009","article-title":"(18)F-FDG PET hypometabolism patterns reflect clinical heterogeneity in sporadic forms of early-onset Alzheimer\u2019s disease","volume":"59","author":"Vanhoutte","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib54","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.STR.32.6.1318","article-title":"A\u00a0new rating scale for age-related white matter changes applicable to MRI and CT","volume":"32","author":"Wahlund","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib55","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-0404.2009.01160.x","article-title":"The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer\u2019s disease","volume":"121","author":"Wiig","year":"2010","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.neurobiolaging.2018.07.003_bib56","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1073\/pnas.1001412107","article-title":"Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer\u2019s disease","volume":"107","author":"Wolk","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458018302549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458018302549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:27:10Z","timestamp":1759318030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458018302549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":56,"alternative-id":["S0197458018302549"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.07.003","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of APOE \u03b54 on neuroimaging, cerebrospinal fluid biomarkers, and cognition in prodromal Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}