{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:27:40Z","timestamp":1786994860087,"version":"build-2736575974"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National\u00a0Institutes of Health","doi-asserted-by":"crossref","award":["P50AG005681"],"award-info":[{"award-number":["P50AG005681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National\u00a0Institutes of Health","doi-asserted-by":"crossref","award":["P01AG026276"],"award-info":[{"award-number":["P01AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National\u00a0Institutes of Health","doi-asserted-by":"crossref","award":["P01AG003991"],"award-info":[{"award-number":["P01AG003991"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National\u00a0Institutes of Health","doi-asserted-by":"crossref","award":["R01AG043434"],"award-info":[{"award-number":["R01AG043434"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National\u00a0Institutes of Health","doi-asserted-by":"crossref","award":["UL1TR000448"],"award-info":[{"award-number":["UL1TR000448"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National\u00a0Institutes of Health","doi-asserted-by":"crossref","award":["R01EB009352"],"award-info":[{"award-number":["R01EB009352"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National\u00a0Institutes of Health","doi-asserted-by":"crossref","award":["1P30NS098577"],"award-info":[{"award-number":["1P30NS098577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National\u00a0Institutes of Health","doi-asserted-by":"crossref","award":["K01AG053474-01A1"],"award-info":[{"award-number":["K01AG053474-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.neurobiolaging.2018.08.022","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T12:25:01Z","timestamp":1535804701000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Widespread distribution of tauopathy in preclinical Alzheimer's disease"],"prefix":"10.1016","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-4415","authenticated-orcid":false,"given":"Stephanie A.","family":"Schultz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-2955","authenticated-orcid":false,"given":"Brian A.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Perrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel J.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau M.","family":"Ances","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8114-0552","authenticated-orcid":false,"given":"Tammie L.S.","family":"Benzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/h0093567","article-title":"An analysis of certain psychological tests used for the evaluation of brain injury","volume":"60","author":"Armitage","year":"1946","journal-title":"Psychol. Monogr."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib2","doi-asserted-by":"crossref","first-page":"e859","DOI":"10.1212\/WNL.0000000000006075","article-title":"Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease","volume":"91","author":"Aschenbrenner","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib4","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/acn3.339","article-title":"Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease","volume":"3","author":"Bischof","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib7","doi-asserted-by":"crossref","first-page":"338ra66","DOI":"10.1126\/scitranslmed.aaf2362","article-title":"Tau and Abeta imaging, CSF measures, and cognition in Alzheimer's disease","volume":"8","author":"Brier","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib8","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/WNL.0000000000003050","article-title":"Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly","volume":"87","author":"Chhatwal","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3233\/JAD-122059","article-title":"Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807","volume":"34","author":"Chien","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ana.24711","article-title":"In\u00a0vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum","volume":"80","author":"Cho","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/WAD.0000000000000196","article-title":"Tau-PET binding distinguishes patients with early-stage posterior cortical atrophy from amnestic Alzheimer disease dementia","volume":"31","author":"Day","year":"2017","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/archneur.64.3.noc60123","article-title":"Cerebrospinal fluid tau\/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults","volume":"64","author":"Fagan","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib14","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1212\/01.WNL.0000063313.57292.00","article-title":"Amyloid beta 1-42 and tau in cerebrospinal fluid after severe traumatic brain injury","volume":"60","author":"Franz","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib15","series-title":"Boston diagnostic aphasia examination Booklet, III: Oral Expression: Animal Naming (Fluency in Controlled Association)","author":"Goodglass","year":"1983"},{"issue":"Pt 8","key":"10.1016\/j.neurobiolaging.2018.08.022_bib16","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1093\/brain\/aww139","article-title":"The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging","volume":"139","author":"Gordon","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib17","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.nicl.2015.04.017","article-title":"The effects of white matter hyperintensities and amyloid deposition on Alzheimer dementia","volume":"8","author":"Gordon","year":"2015","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1212\/WNL.38.6.900","article-title":"Screening for dementia by memory testing","volume":"38","author":"Grober","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/ana.24910","article-title":"Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline","volume":"81","author":"Hanseeuw","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ana.22628","article-title":"An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease","volume":"71","author":"Jack","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib22","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/brain\/awy059","article-title":"Longitudinal tau PET in ageing and Alzheimer's disease","volume":"141","author":"Jack","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib23","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41593-018-0070-z","article-title":"Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals","volume":"21","author":"Jacobs","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.24546","article-title":"Tau positron emission tomographic imaging in aging and early Alzheimer disease","volume":"79","author":"Johnson","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib25","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib26","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.neuroimage.2017.05.049","article-title":"The association between tau PET and retrospective cortical thinning in clinically normal elderly","volume":"157","author":"LaPoint","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.dadm.2018.01.007","article-title":"Tau positron emission tomography imaging in tauopathies: the added hurdle of off-target binding","volume":"10","author":"Lemoine","year":"2018","journal-title":"Alzheimers Dement. (Amst)"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroimage.2017.02.051","article-title":"Amyloid and tau PET demonstrate region-specific associations in normal older people","volume":"150","author":"Lockhart","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib29","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.dadm.2018.01.005","article-title":"Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants","volume":"10","author":"Lowe","year":"2018","journal-title":"Alzheimers Dement. (Amst)"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40478-016-0315-6","article-title":"An autoradiographic evaluation of AV-1451 Tau PET in dementia","volume":"4","author":"Lowe","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/brain\/awx320","article-title":"Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia","volume":"141","author":"Lowe","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib32","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.neuroimage.2017.05.058","article-title":"Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease","volume":"157","author":"Maass","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/ana.24517","article-title":"Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue","volume":"78","author":"Marquie","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00401-017-1740-8","article-title":"[F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging","volume":"134","author":"Marquie","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neuroimage.2017.07.050","article-title":"AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: defining a summary measure","volume":"161","author":"Mishra","year":"2017","journal-title":"Neuroimage"},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2018.08.022_bib36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S1041610297004870","article-title":"Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type","volume":"9","author":"Morris","year":"1997","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib37","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/archneurol.2009.269","article-title":"Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease","volume":"66","author":"Morris","year":"2009","journal-title":"Arch. Neurol."},{"issue":"Pt 5","key":"10.1016\/j.neurobiolaging.2018.08.022_bib38","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain"},{"issue":"Pt 4","key":"10.1016\/j.neurobiolaging.2018.08.022_bib39","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/brain\/aww015","article-title":"Cerebrospinal fluid analysis detects cerebral amyloid-beta accumulation earlier than positron emission tomography","volume":"139","author":"Palmqvist","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib40","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1212\/WNL.58.11.1622","article-title":"Tau and Abeta42 protein in CSF of patients with frontotemporal degeneration","volume":"58","author":"Riemenschneider","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib41","first-page":"904","article-title":"Correction for partial volume effects in PET: principle and validation","volume":"39","author":"Rousset","year":"1998","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib42","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Scholl","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib43","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1523\/JNEUROSCI.3263-16.2017","article-title":"Phases of hyperconnectivity and hypoconnectivity in the default mode and salience networks track with amyloid and tau in clinically normal individuals","volume":"37","author":"Schultz","year":"2017","journal-title":"J.\u00a0Neurosci."},{"issue":"Pt 5","key":"10.1016\/j.neurobiolaging.2018.08.022_bib44","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/brain\/aww023","article-title":"Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages","volume":"139","author":"Schwarz","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib45","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.1523\/JNEUROSCI.0639-16.2016","article-title":"In\u00a0vivo tau, amyloid, and gray matter profiles in the aging brain","volume":"36","author":"Sepulcre","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib46","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib47","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib48","doi-asserted-by":"crossref","first-page":"e0152082","DOI":"10.1371\/journal.pone.0152082","article-title":"Quantitative amyloid imaging in autosomal dominant Alzheimer's disease: results from the DIAN study group","volume":"11","author":"Su","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuroimage.2014.11.058","article-title":"Partial volume correction in quantitative amyloid imaging","volume":"107","author":"Su","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib50","doi-asserted-by":"crossref","first-page":"e73377","DOI":"10.1371\/journal.pone.0073377","article-title":"Quantitative analysis of PiB-PET with FreeSurfer ROIs","volume":"8","author":"Su","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib51","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.dadm.2016.12.010","article-title":"Tau-PET uptake: regional variation in average SUVR and impact of amyloid deposition","volume":"6","author":"Vemuri","year":"2017","journal-title":"Alzheimers Dement. (Amst)."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/j.semnuclmed.2016.09.006","article-title":"Abeta-amyloid and tau imaging in dementia","volume":"47","author":"Villemagne","year":"2017","journal-title":"Semin. Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.22248","article-title":"Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease","volume":"69","author":"Villemagne","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib54","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/ana.24719","article-title":"Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease","volume":"80","author":"Vlassenko","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib55","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ana.22608","article-title":"Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data","volume":"70","author":"Vlassenko","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib56","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S1474-4422(13)70194-7","article-title":"Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study","volume":"12","author":"Vos","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib57","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/jamaneurol.2016.2078","article-title":"Evaluation of tau imaging in staging alzheimer disease and revealing interactions between beta-amyloid and tauopathy","volume":"73","author":"Wang","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib58","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000478741","article-title":"Lessons from anti-amyloid-beta immunotherapies in alzheimer disease: aiming at a moving target","volume":"17","author":"Wang","year":"2017","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.neurobiolaging.2018.08.022_bib59","series-title":"Administration and Scoring Manual","article-title":"Wechsler memory scale","author":"Wechsler","year":"1997"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458018303130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458018303130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T12:55:26Z","timestamp":1604840126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458018303130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":59,"alternative-id":["S0197458018303130"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.08.022","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Widespread distribution of tauopathy in preclinical Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2018.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}