{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:31:42Z","timestamp":1790339502757,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.neurobiolaging.2019.02.020","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T11:25:49Z","timestamp":1552044349000},"page":"50-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-7933","authenticated-orcid":false,"given":"Tessa","family":"Timmers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-7477","authenticated-orcid":false,"given":"Rik","family":"Ossenkoppele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander C.J.","family":"Verfaillie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris W.J.","family":"van der Weijden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-8916","authenticated-orcid":false,"given":"Rosalinde E.R.","family":"Slot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.P.","family":"Wesselman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D.","family":"Windhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E.","family":"Wolters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maqsood","family":"Yaqub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels D.","family":"Prins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1237-2891","authenticated-orcid":false,"given":"Adriaan A.","family":"Lammertsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-6408","authenticated-orcid":false,"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N.M.","family":"van Berckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12883-014-0254-4","article-title":"The Dutch Parelsnoer Institute--Neurodegenerative diseases; methods, design and baseline results","volume":"14","author":"Aalten","year":"2014","journal-title":"BMC. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3233\/JAD-160915","article-title":"Impact of recruitment methods in subjective cognitive decline","volume":"57","author":"Abdelnour","year":"2017","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib3","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1016\/j.neuropsychologia.2012.08.011","article-title":"Subjective cognitive complaints and amyloid burden in cognitively normal older individuals","volume":"50","author":"Amariglio","year":"2012","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.trci.2018.08.005","article-title":"Amyloid-associated increases in longitudinal report of subjective cognitive complaints","volume":"4","author":"Amariglio","year":"2018","journal-title":"Alzheimers Dement. (N Y)"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1212\/WNL.0000000000001712","article-title":"Subjective cognitive concerns, amyloid-beta, and neurodegeneration in clinically normal elderly","volume":"85","author":"Amariglio","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.dadm.2016.09.002","article-title":"Cognitive impairment and decline in cognitively normal older adults with high amyloid-beta: a meta-analysis","volume":"6","author":"Baker","year":"2017","journal-title":"Alzheimers Dement. (Amst)"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-3999(01)00296-3","article-title":"The validity of the Hospital Anxiety and Depression Scale. An updated literature review","volume":"52","author":"Bjelland","year":"2002","journal-title":"J.\u00a0Psychosom. Res."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib8","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jamaneurol.2017.2216","article-title":"Region-specific association of subjective cognitive decline with tauopathy independent of global beta-amyloid burden","volume":"74","author":"Buckley","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib9","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jalz.2015.12.013","article-title":"Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease","volume":"12","author":"Buckley","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib10","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1001\/jama.2017.6669","article-title":"Association between elevated brain amyloid and subsequent cognitive decline among cognitively normal persons","volume":"317","author":"Donohue","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib11","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/mp.2014.9","article-title":"Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study","volume":"19","author":"Doraiswamy","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1474-4422(18)30029-2","article-title":"Cognitive and neuroimaging features and brain beta-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study","volume":"17","author":"Dubois","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","article-title":"Sex differences in Alzheimer disease - the gateway to precision medicine","volume":"14","author":"Ferretti","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/0271678X18783628","article-title":"Quantification of [18F]florbetapir: a test-retest tracer kinetic modelling study","author":"Golla","year":"2018","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib15","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1212\/WNL.0000000000004802","article-title":"Differential effects of cognitive reserve and brain reserve on cognition in Alzheimer disease","volume":"90","author":"Groot","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/nimg.1997.0303","article-title":"Parametric imaging of ligand-receptor binding in PET using a simplified reference region model","volume":"6","author":"Gunn","year":"1997","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hbm.10123","article-title":"Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe","volume":"19","author":"Hammers","year":"2003","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jalz.2015.05.017","article-title":"Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment","volume":"12","author":"Ismail","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"issue":"Pt 1","key":"10.1016\/j.neurobiolaging.2019.02.020_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/brain\/awv326","article-title":"Is amyloid-beta harmful to the brain? Insights from human imaging studies","volume":"139","author":"Jagust","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib22","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/jamapsychiatry.2017.3391","article-title":"Association of cerebral amyloid-beta aggregation with cognitive functioning in persons without dementia","volume":"75","author":"Jansen","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib24","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jalz.2014.01.001","article-title":"A\u00a0conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease","volume":"10","author":"Jessen","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1001\/archgenpsychiatry.2010.30","article-title":"Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment","volume":"67","author":"Jessen","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.dadm.2016.12.005","article-title":"Qualitative and quantitative assessment of self-reported cognitive difficulties in nondemented elders: association with medical help seeking, cognitive deficits, and beta-amyloid imaging","volume":"5","author":"La Joie","year":"2016","journal-title":"Alzheimers Dement (Amst)."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib27","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.2967\/jnumed.116.188029","article-title":"Forward to the past: the case for quantitative PET imaging","volume":"58","author":"Lammertsma","year":"2017","journal-title":"J.\u00a0Nucl. Med."},{"issue":"Pt 12","key":"10.1016\/j.neurobiolaging.2019.02.020_bib28","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1093\/brain\/awu271","article-title":"Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects","volume":"137","author":"Lim","year":"2014","journal-title":"Brain"},{"issue":"Pt 1","key":"10.1016\/j.neurobiolaging.2019.02.020_bib29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/brain\/awt286","article-title":"Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease","volume":"137","author":"Lim","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/JAD-142322","article-title":"Cortical thinning in individuals with subjective memory impairment","volume":"45","author":"Meiberth","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jalz.2015.09.010","article-title":"Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort","volume":"12","author":"Mielke","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/acps.12336","article-title":"Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis","volume":"130","author":"Mitchell","year":"2014","journal-title":"Acta. Psychiatr. Scand."},{"issue":"Pt 5","key":"10.1016\/j.neurobiolaging.2019.02.020_bib33","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/brain\/awn320","article-title":"Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects","volume":"132","author":"Mormino","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib34","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/cercor\/bhr025","article-title":"Relationships between beta-amyloid and functional connectivity in different components of the default mode network in aging","volume":"21","author":"Mormino","year":"2011","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib35","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.biopsych.2007.05.030","article-title":"Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints","volume":"63","author":"Mosconi","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib36","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jalz.2016.08.011","article-title":"Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: differential affective and imaging correlates","volume":"13","author":"Perrotin","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1001\/archneurol.2011.666","article-title":"Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals","volume":"69","author":"Perrotin","year":"2012","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/jamaneurol.2015.3098","article-title":"Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community","volume":"73","author":"Petersen","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-clinpsy-032816-045136","article-title":"Subjective cognitive decline in preclinical alzheimer's disease","volume":"13","author":"Rabin","year":"2017","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF01537606","article-title":"The use of the center for epidemiologic studies depression scale in adolescents and young adults","volume":"20","author":"Radloff","year":"1991","journal-title":"J.\u00a0Youth Adolesc."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib41","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1212\/WNL.0b013e3181d3e3e9","article-title":"Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB","volume":"74","author":"Resnick","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib42","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jalz.2014.11.006","article-title":"Subjective memory impairment in older adults predicts future dementia independent of baseline memory performance: evidence from the Betula prospective cohort study","volume":"11","author":"Ronnlund","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib43","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1212\/01.wnl.0000234032.77541.a2","article-title":"Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI","volume":"67","author":"Saykin","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib44","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1212\/WNL.0b013e31826c1a8d","article-title":"Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment","volume":"79","author":"Scheef","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib45","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer's disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib46","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13195-018-0390-y","article-title":"Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results","volume":"10","author":"Slot","year":"2018","journal-title":"Alzheimers Res. Ther."},{"issue":"Suppl.1","key":"10.1016\/j.neurobiolaging.2019.02.020_bib47","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.3233\/JAD-150113","article-title":"Amyloid-beta imaging in older adults presenting to a memory clinic with subjective cognitive decline: a pilot study","volume":"48","author":"Snitz","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib48","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jalz.2017.12.003","article-title":"Risk of progression from subjective cognitive decline to mild cognitive impairment: the role of study setting","volume":"14","author":"Snitz","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib49","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib50","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.neurobiolaging.2012.06.014","article-title":"Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals","volume":"34","author":"Sperling","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib51","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.neuroimage.2004.10.017","article-title":"MR-based automatic delineation of volumes of interest in human brain PET images using probability maps","volume":"24","author":"Svarer","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib52","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.2967\/jnumed.112.113654","article-title":"Longitudinal amyloid imaging using 11C-PiB: methodologic considerations","volume":"54","author":"van Berckel","year":"2013","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib53","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3233\/JAD-170850","article-title":"Amsterdam dementia cohort: performing research to optimize care","volume":"62","author":"van der Flier","year":"2018","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib54","first-page":"671","article-title":"Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes","volume":"251","author":"van der Flier","year":"2004","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib55","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1212\/WNL.0b013e3182a8418b","article-title":"Preclinical AD predicts decline in memory and executive functions in subjective complaints","volume":"81","author":"van Harten","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib56","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1002\/hbm.23695","article-title":"A\u00a0neuroimaging approach to capture cognitive reserve: application to Alzheimer's disease","volume":"38","author":"van Loenhoud","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib57","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bpsc.2017.11.012","article-title":"Subjective cognitive decline is associated with altered default mode network connectivity in individuals with a family history of alzheimer's disease","volume":"3","author":"Verfaillie","year":"2018","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib58","first-page":"497","article-title":"[An analysis of variance based on the groninger intelligence test scores]","volume":"19","author":"Verhage","year":"1964","journal-title":"Ned Tijdschr Psychol."},{"issue":"Pt 7","key":"10.1016\/j.neurobiolaging.2019.02.020_bib59","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/brain\/awv112","article-title":"Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation","volume":"138","author":"Villeneuve","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib60","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1212\/WNL.0000000000004627","article-title":"Subjective cognitive decline and beta-amyloid burden predict cognitive change in healthy elderly","volume":"89","author":"Vogel","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.02.020_bib61","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3233\/JAD-130080","article-title":"Altered default mode network connectivity in older adults with cognitive complaints and amnestic mild cognitive impairment","volume":"35","author":"Wang","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019300703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019300703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T17:21:04Z","timestamp":1606670464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458019300703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":61,"alternative-id":["S0197458019300703"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.02.020","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}