{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:23:38Z","timestamp":1790375018165,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003447","name":"State Scholarships Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.neurobiolaging.2019.07.019","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T18:42:09Z","timestamp":1569264129000},"page":"178-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections"],"prefix":"10.1016","volume":"84","author":[{"given":"Foteini","family":"Christidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7291-2231","authenticated-orcid":false,"given":"Efstratios","family":"Karavasilis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Rentzos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Velonakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Zouvelou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Xirou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Argyropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Papatriantafyllou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varvara","family":"Pantolewn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8531-5623","authenticated-orcid":false,"given":"Panagiotis","family":"Ferentinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kelekis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Seimenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Evdokimidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-4772","authenticated-orcid":false,"given":"Peter","family":"Bede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib1","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1016\/j.neurobiolaging.2014.05.035","article-title":"Hippocampal degeneration in patients with amyotrophic lateral sclerosis","volume":"35","author":"Abdulla","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"Suppl","key":"10.1016\/j.neurobiolaging.2019.07.019_bib2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0022-510X(95)00063-8","article-title":"Cognitive deficits in non-demented amyotrophic lateral sclerosis patients: a neuropsychological investigation","volume":"129","author":"Abrahams","year":"1995","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0022-510X(95)00060-F","article-title":"A\u00a0positron emission tomography study of frontal lobe function (verbal fluency) in amyotrophic lateral sclerosis","volume":"129","author":"Abrahams","year":"1995","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/21678421.2013.805784","article-title":"Screening for cognition and behaviour changes in ALS","volume":"15","author":"Abrahams","year":"2014","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib5","series-title":"Cluster Analysis in Neuropsychological Research Recent Applications","author":"Allen","year":"2013"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/mrm.25226","article-title":"Acquisition strategy to reduce cerebrospinal fluid partial volume effects for improved DTI tractography","volume":"73","author":"Baron","year":"2015","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib7","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3389\/fneur.2018.01065","article-title":"Emerging magnetic resonance imaging techniques and analysis methods in amyotrophic lateral sclerosis","volume":"9","author":"Barritt","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.nicl.2014.02.011","article-title":"Lessons of ALS imaging: pitfalls and future directions - a critical review","volume":"4","author":"Bede","year":"2014","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1080\/21678421.2017.1407795","article-title":"Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration","volume":"19","author":"Bede","year":"2018","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/jnnp-2012-302674","article-title":"Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality","volume":"84","author":"Bede","year":"2013","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib11","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1212\/01.wnl.0000437313.80913.2c","article-title":"Basal ganglia involvement in amyotrophic lateral sclerosis","volume":"81","author":"Bede","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib12","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1007\/s11682-018-9837-9","article-title":"Connectivity-based characterisation of subcortical grey matter pathology in frontotemporal dementia and ALS: a multimodal neuroimaging study","volume":"12","author":"Bede","year":"2018","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/WCO.0000000000000569","article-title":"The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools","volume":"31","author":"Bede","year":"2018","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/jnnp-2015-310734","article-title":"The cognitive profile of ALS: a systematic review and meta-analysis update","volume":"87","author":"Beeldman","year":"2016","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib15","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrneurol.2013.221","article-title":"Amyotrophic lateral sclerosis\u2014a model of corticofugal axonal spread","volume":"9","author":"Braak","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib17","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1007\/s11682-018-9825-0","article-title":"Structural and functional papez circuit integrity in amyotrophic lateral sclerosis","volume":"12","author":"Bueno","year":"2018","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/21678421.2016.1272615","article-title":"Visual encoding, consolidation, and retrieval in amyotrophic lateral sclerosis: executive function as a mediator, and predictor of performance","volume":"18","author":"Burke","year":"2017","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib19","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/acn3.407","article-title":"A\u00a0Cross-sectional population-based investigation into behavioral change in amyotrophic lateral sclerosis: subphenotypes, staging, cognitive predictors, and survival","volume":"4","author":"Burke","year":"2017","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib20","doi-asserted-by":"crossref","first-page":"e0160850","DOI":"10.1371\/journal.pone.0160850","article-title":"Measurement of social cognition in amyotrophic lateral sclerosis: a population based study","volume":"11","author":"Burke","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/21678421.2018.1497659","article-title":"The burden of apathy for caregivers of patients with amyotrophic lateral sclerosis","volume":"19","author":"Caga","year":"2018","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fneur.2019.00192","article-title":"The impact of cognitive and behavioral symptoms on ALS patients and their caregivers","volume":"10","author":"Caga","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib23","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nicl.2017.04.024","article-title":"Pathology of callosal damage in ALS: an ex-vivo, 7 T diffusion tensor MRI study","volume":"15","author":"Cardenas","year":"2017","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neurobiolaging.2018.07.018","article-title":"Re-examining age-related differences in white matter microstructure with free-water corrected diffusion tensor imaging","volume":"71","author":"Chad","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3389\/fneur.2019.00229","article-title":"Tracking a fast-moving disease: longitudinal markers, monitoring, and clinical trial endpoints in ALS","volume":"10","author":"Chipika","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib26","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s10072-012-1243-2","article-title":"Trail Making Test error analysis in classic motor neuron disease","volume":"34","author":"Christidi","year":"2012","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib27","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3389\/fneur.2018.01005","article-title":"Clinical and radiological markers of extra-motor deficits in amyotrophic lateral sclerosis","volume":"9","author":"Christidi","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3389\/fneur.2018.00523","article-title":"The clinical and radiological spectrum of hippocampal pathology in amyotrophic lateral sclerosis","volume":"9","author":"Christidi","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuroscience.2015.08.033","article-title":"Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease","volume":"309","author":"de Flores","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib30","first-page":"343","article-title":"Fornix as an imaging marker for episodic memory deficits in healthy aging and in various neurological disorders","volume":"6","author":"Douet","year":"2014","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib31","series-title":"The Human Hippocampus Functional Anatomy, Vascularization and Serial Sections with MRI","author":"Duvernoy","year":"2013"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib32","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1212\/WNL.0b013e318214359f","article-title":"Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia","volume":"76","author":"Elamin","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neuroimage.2018.05.041","article-title":"Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia","volume":"178","author":"Evans","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/17482968.2011.556744","article-title":"Prevalence of major depression in ALS: comparison of a semi-structured interview and four self-report measures","volume":"12","author":"Ferentinos","year":"2011","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib35","first-page":"2125","article-title":"Extrapyramidal deficits in ALS: a combined biomechanical and neuroimaging study","volume":"265","author":"Feron","year":"2018","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib85","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-019-09473-z","article-title":"The clinical and radiological profile of primary lateral sclerosis: a population-based study","author":"Finegan","year":"2019","journal-title":"J Neurol"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib36","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fneur.2019.00260","article-title":"Pathological crying and laughing in motor neuron disease: pathobiology, screening, intervention","volume":"10","author":"Finegan","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/21678421.2018.1550518","article-title":"Primary lateral sclerosis: a distinct entity or part of the ALS spectrum?","volume":"20","author":"Finegan","year":"2019","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib38","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/jnnp-2017-316799","article-title":"Longitudinal diffusion imaging across the C9orf72 clinical spectrum","volume":"89","author":"Floeter","year":"2018","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1017\/S0317167100029942","article-title":"Association between Alzheimer disease and amyotrophic lateral sclerosis?","volume":"17","author":"Frecker","year":"1990","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib41","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/archneur.65.5.636","article-title":"Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis","volume":"65","author":"Geser","year":"2008","journal-title":"Arch. Neurol."},{"issue":"1 Pt 1","key":"10.1016\/j.neurobiolaging.2019.07.019_bib42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A\u00a0voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-8993(86)91409-5","article-title":"Acetylcholine, aging and anatomy: differential effects in the hippocampus","volume":"362","author":"Haigler","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jad.2007.11.012","article-title":"Validity of the ALS-Depression-Inventory (ADI-12)--a new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis","volume":"109","author":"Hammer","year":"2008","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroimage.2015.04.042","article-title":"A\u00a0computational atlas of the hippocampal formation using ex\u00a0vivo, ultra-high resolution MRI: application to adaptive segmentation of in\u00a0vivo MRI","volume":"115","author":"Iglesias","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib46","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/acn3.655","article-title":"Evaluating the cerebral correlates of survival in amyotrophic lateral sclerosis","volume":"5","author":"Ishaque","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","article-title":"A\u00a0global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib48","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1212\/01.WNL.0000055861.95202.8D","article-title":"Are amyotrophic lateral sclerosis patients cognitively normal?","volume":"60","author":"Lomen-Hoerth","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/21678421.2015.1049183","article-title":"A\u00a0revision of the El Escorial criteria - 2015","volume":"16","author":"Ludolph","year":"2015","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1471-2202-15-83","article-title":"Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: a comparative neuropsychological study of amnestic mild cognitive impairment","volume":"15","author":"Machts","year":"2014","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib51","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1212\/WNL.0000000000002017","article-title":"Basal ganglia pathology in ALS is associated with neuropsychological deficits","volume":"85","author":"Machts","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib52","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3389\/fneur.2018.00565","article-title":"Global hippocampal volume reductions and local CA1 shape deformations in amyotrophic lateral sclerosis","volume":"9","author":"Machts","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib54","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.acn.2007.06.002","article-title":"Normative data and discriminant validity of Rey's Verbal Learning Test for the Greek adult population","volume":"22","author":"Messinis","year":"2007","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib55","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.neuroimage.2011.08.043","article-title":"How and how not to correct for CSF-contamination in diffusion MRI","volume":"59","author":"Metzler-Baddeley","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib56","series-title":"Rey Complex Figure\u00a0Test and Recognition Trial: Professional Manual","author":"Meyers","year":"1995"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib57","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S1474-4422(14)70129-2","article-title":"Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?","volume":"13","author":"Mitsumoto","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib58","doi-asserted-by":"crossref","first-page":"1851.e1","DOI":"10.1016\/j.neurobiolaging.2012.02.021","article-title":"High frequency of the expanded C9ORF72 hexanucleotide repeat in familial and sporadic Greek ALS patients","volume":"33","author":"Mok","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib59","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/jnnp-2013-307223","article-title":"Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy","volume":"86","author":"Montuschi","year":"2015","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/cercor\/bhx301","article-title":"Characteristic increases in EEG connectivity correlate with changes of structural MRI in amyotrophic lateral sclerosis","volume":"29","author":"Nasseroleslami","year":"2017","journal-title":"Cereb. Cortex."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2015.00001","article-title":"The fornix in mild cognitive impairment and Alzheimer\u00e2\u20ac\u2122s disease","volume":"7","author":"Nowrangi","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib62","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1212\/01.wnl.0000188759.87240.8b","article-title":"The effects of executive and behavioral dysfunction on the course of ALS","volume":"65","author":"Olney","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib63","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/21678421.2017.1332077","article-title":"Neuroimaging patterns along the ALS-FTD spectrum: a multiparametric imaging study","volume":"18","author":"Omer","year":"2017","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib64","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/jnnp-2011-300188","article-title":"The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study","volume":"83","author":"Phukan","year":"2012","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib65","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11065-018-9375-7","article-title":"The study of language in the amyotrophic lateral sclerosis - frontotemporal spectrum disorder: a systematic review of findings and new perspectives","volume":"28","author":"Pinto-Grau","year":"2018","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib66","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/17482960902756473","article-title":"Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis","volume":"11","author":"Pyra","year":"2010","journal-title":"Amyotroph. Lateral Scler."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib67","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3389\/fneur.2018.00844","article-title":"Biomarkers of spinal and bulbar muscle atrophy (SBMA): a comprehensive review","volume":"9","author":"Querin","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib68","doi-asserted-by":"crossref","first-page":"101618","DOI":"10.1016\/j.nicl.2018.101618","article-title":"The spinal and cerebral profile of adult spinal-muscular atrophy: a multimodal imaging study","volume":"21","author":"Querin","year":"2019","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib69","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neurobiolaging.2019.05.005","article-title":"Synergism between fornix microstructure and beta-amyloid accelerates memory decline in clinically normal older adults","volume":"81","author":"Rabin","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib70","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.neuroimage.2015.04.005","article-title":"Simulating disease propagation across white matter connectome reveals anatomical substrate for neuropathology staging in amyotrophic lateral sclerosis","volume":"124","author":"Schmidt","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib71","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1136\/jnnp-2014-309888","article-title":"Presymptomatic and longitudinal neuroimaging in neurodegeneration--from snapshots to motion picture: a systematic review","volume":"86","author":"Schuster","year":"2015","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib72","doi-asserted-by":"crossref","first-page":"e0167331","DOI":"10.1371\/journal.pone.0167331","article-title":"Development of an automated MRI-based diagnostic protocol for amyotrophic lateral sclerosis using disease-specific pathognomonic features: a quantitative disease-state classification study","volume":"11","author":"Schuster","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib73","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12883-017-0854-x","article-title":"Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics","volume":"17","author":"Schuster","year":"2017","journal-title":"BMC Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib74","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/WAD.0b013e31821cc65d","article-title":"Adult polyglucosan body disease masquerading as \"ALS with dementia of the Alzheimer type\": an exceptional phenotype in a rare pathology","volume":"26","author":"Segers","year":"2012","journal-title":"Alzheimer Dis. Assoc. Disord."},{"issue":"Suppl 1","key":"10.1016\/j.neurobiolaging.2019.07.019_bib75","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib76","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib77","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neuroimage.2005.01.028","article-title":"Demyelination increases radial diffusivity in corpus callosum of mouse brain","volume":"26","author":"Song","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib78","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/mrm.20774","article-title":"Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum","volume":"55","author":"Sun","year":"2006","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib79","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00401-008-0447-2","article-title":"Progression of hippocampal degeneration in amyotrophic lateral sclerosis with or without memory impairment: distinction from Alzheimer disease","volume":"117","author":"Takeda","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib80","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.neurobiolaging.2014.09.002","article-title":"Subcortical structures in amyotrophic lateral sclerosis","volume":"36","author":"Westeneng","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib81","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib82","series-title":"3rd Dual Congress on Psychiatry and Neurosciences, Athens","article-title":"Assessing Episodic Memory: Normative Data and Discriminant Properties for a Greek Version of Babcock Story Recall Test","author":"Zalonis I","year":"2008"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib83","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.neurobiolaging.2019.07.019_bib84","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3389\/fnagi.2018.00320","article-title":"The volume of hippocampal subfields in relation to decline of memory Recall across the adult lifespan","volume":"10","author":"Zheng","year":"2018","journal-title":"Front. Aging Neurosci."}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019303240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019303240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:32:37Z","timestamp":1759318357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458019303240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":85,"alternative-id":["S0197458019303240"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.07.019","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}