{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:21:05Z","timestamp":1783297265008,"version":"3.54.6"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.neurobiolaging.2019.08.011","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T10:00:53Z","timestamp":1565863253000},"page":"54-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers"],"prefix":"10.1016","volume":"83","author":[{"given":"Qin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirubol","family":"Tosakulwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Lesnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Bove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brannelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Brushaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Dheel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford C.","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley","family":"Faber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Fields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Foroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralitza H.","family":"Gavrilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Gearhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nupur","family":"Ghoshal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graff-Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill R.","family":"Graff-Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Haley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary W.","family":"Heuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ging-Yuek R.","family":"Hsiung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Huey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Karydas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kornak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Kremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Kukull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lapid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Lucente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codrin","family":"Lungu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.A.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masood","family":"Manoochehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McGinnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Pearlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Petrucelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana M.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine P.","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Rascovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pheth","family":"Sengdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Syrjanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Tatton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howie","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Wszolek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejal","family":"Kantarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2018.03.033","article-title":"Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport","volume":"68","author":"Adalbert","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib2","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A\u00a0reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib3","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib4","doi-asserted-by":"crossref","first-page":"e37720","DOI":"10.1371\/journal.pone.0037720","article-title":"CSF T-Tau\/Abeta42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease","volume":"7","author":"Bendlin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1001\/jamaneurol.2017.4266","article-title":"Early cognitive, structural, and microstructural changes in presymptomatic C9orf72 carriers younger than 40 years","volume":"75","author":"Bertrand","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib6","doi-asserted-by":"crossref","first-page":"11856","DOI":"10.1074\/jbc.M509420200","article-title":"FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells","volume":"281","author":"Bunker","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neurobiolaging.2017.10.008","article-title":"Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study","volume":"62","author":"Cash","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrn1788","article-title":"Axon degeneration mechanisms: commonality amid diversity","volume":"6","author":"Coleman","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/ajmg.b.32443","article-title":"Unusually long duration and delayed penetrance in a family with FTD and mutation in MAPT (V337M)","volume":"174","author":"Domoto-Reilly","year":"2017","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib10","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1212\/WNL.0000000000000583","article-title":"Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia","volume":"83","author":"Dopper","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.nicl.2017.09.007","article-title":"Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease","volume":"16","author":"Elahi","year":"2017","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib12","doi-asserted-by":"crossref","first-page":"e90814","DOI":"10.1371\/journal.pone.0090814","article-title":"Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease","volume":"9","author":"Frings","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13195-018-0376-9","article-title":"Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales","volume":"10","author":"Fumagalli","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fninf.2014.00008","article-title":"Dipy, a library for the analysis of diffusion MRI data","volume":"8","author":"Garyfallidis","year":"2014","journal-title":"Front Neuroinform."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1074\/jbc.M006531200","article-title":"Tau filament formation in transgenic mice expressing P301L tau","volume":"276","author":"Gotz","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib17","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1471-4914(02)02440-1","article-title":"Tau gene mutations: dissecting the pathogenesis of FTDP-17","volume":"8","author":"Ingram","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/glia.23286","article-title":"White matter tauopathy: transient functional loss and novel myelin remodeling","volume":"66","author":"Jackson","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib19","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/hbm.22099","article-title":"Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging","volume":"34","author":"Jeurissen","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.neuroimage.2014.07.061","article-title":"Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data","volume":"103","author":"Jeurissen","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/acn3.601","article-title":"Presymptomatic white matter integrity loss in familial frontotemporal dementia in the GENFI cohort: a cross-sectional diffusion tensor imaging study","volume":"5","author":"Jiskoot","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/brain\/awy288","article-title":"Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia","volume":"142","author":"Jiskoot","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib23","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1212\/WNL.0b013e3181f073c7","article-title":"MRS in presymptomatic MAPT mutation carriers: a potential biomarker for tau-mediated pathology","volume":"75","author":"Kantarci","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib24","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neurobiolaging.2017.04.024","article-title":"White-matter integrity on DTI and the pathologic staging of Alzheimer's disease","volume":"56","author":"Kantarci","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fnagi.2018.00047","article-title":"Longitudinal diffusion tensor imaging resembles patterns of pathology progression in behavioral variant frontotemporal dementia (bvFTD)","volume":"10","author":"Kassubek","year":"2018","journal-title":"Front Aging Neurosci."},{"issue":"Pt 11","key":"10.1016\/j.neurobiolaging.2019.08.011_bib26","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/brain\/awn234","article-title":"Development of methodology for conducting clinical trials in frontotemporal lobar degeneration","volume":"131","author":"Knopman","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib27","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/NEN.0b013e318187a80f","article-title":"White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration","volume":"67","author":"Kovacs","year":"2008","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib28","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0006-3223(99)00306-6","article-title":"Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer's disease: a morphometric MRI study","volume":"47","author":"Laakso","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000017225","article-title":"Magnetic resonance imaging and histopathology in dementia, clinically of frontotemporal type","volume":"11","author":"Larsson","year":"2000","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0002-9440(10)63812-6","article-title":"Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation","volume":"162","author":"Lin","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"Pt 12","key":"10.1016\/j.neurobiolaging.2019.08.011_bib31","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1093\/brain\/aww256","article-title":"Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology","volume":"139","author":"Ling","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ana.24296","article-title":"Longitudinal diffusion tensor imaging in frontotemporal dementia","volume":"77","author":"Mahoney","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib33","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/jnnp.56.6.605","article-title":"Dementia of frontal lobe type: neuropathology and immunohistochemistry","volume":"56","author":"Mann","year":"1993","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-017-1738-2","article-title":"Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease","volume":"134","author":"McAleese","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib35","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuroimage.2008.07.009","article-title":"Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter","volume":"43","author":"Oishi","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neurobiolaging.2018.12.017","article-title":"Gray and white matter changes in presymptomatic genetic frontotemporal dementia: a longitudinal MRI study","volume":"76","author":"Panman","year":"2019","journal-title":"Neurobiol. Aging"},{"issue":"5 Suppl","key":"10.1016\/j.neurobiolaging.2019.08.011_bib37","first-page":"S354","article-title":"Pattern of structural and functional brain abnormalities in asymptomatic granulin mutation carriers","volume":"10","author":"Pievani","year":"2014","journal-title":"Alzheimers Dement."},{"issue":"Pt 9","key":"10.1016\/j.neurobiolaging.2019.08.011_bib38","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib39","series-title":"Diffusion Specific Segmentation: Skull Stripping with Diffusion MRI Data Alone","first-page":"67","author":"Reid","year":"2018"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","article-title":"Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib41","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/WCO.0b013e32834cd442","article-title":"Phenotypic signatures of genetic frontotemporal dementia","volume":"24","author":"Rohrer","year":"2011","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib42","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.neurobiolaging.2013.12.009","article-title":"Age-related decline in white matter integrity in a mouse model of tauopathy: an in\u00a0vivo diffusion tensor magnetic resonance imaging study","volume":"35","author":"Sahara","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib43","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/ana.410390609","article-title":"The neuropathology of chromosome 17-linked dementia","volume":"39","author":"Sima","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib44","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1073\/pnas.95.13.7737","article-title":"Mutation in the tau gene in familial multiple system tauopathy with presenile dementia","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib45","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1212\/WNL.0b013e3181d9edde","article-title":"Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia","volume":"74","author":"Whitwell","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2012.7","article-title":"Neuroimaging in frontotemporal lobar degeneration--predicting molecular pathology","volume":"8","author":"Whitwell","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.08.011_bib47","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in\u00a0vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"Neuroimage"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019302891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019302891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:29:33Z","timestamp":1759318173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458019302891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":47,"alternative-id":["S0197458019302891"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.08.011","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736710453.793568299","asserted-by":"object"}]},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}