{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:52:11Z","timestamp":1793850731946,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011898","name":"Marianne and Marcus Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Aging"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.neurobiolaging.2019.10.008","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T11:06:12Z","timestamp":1571483172000},"page":"74-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":174,"special_numbering":"C","title":["Apathy and anxiety are early markers of Alzheimer's disease"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6398-0163","authenticated-orcid":false,"given":"Maurits","family":"Johansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Stomrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Westman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per M\u00e5rten","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-9874","authenticated-orcid":false,"given":"Danielle","family":"van Westen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-7724","authenticated-orcid":false,"given":"Niklas","family":"Mattsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-7286","authenticated-orcid":false,"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-5","year":"2013"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3233\/JAD-150181","article-title":"Associations between neuropsychiatric symptoms and cerebral amyloid deposition in cognitively impaired elderly people","volume":"49","author":"Bensamoun","year":"2016","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/gps.2418","article-title":"Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease","volume":"25","author":"Berlow","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3233\/JAD-148007","article-title":"Brain structure and function related to depression in Alzheimer's disease: contributions from neuroimaging research","volume":"45","author":"Brommelhoff","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/0891988715606230","article-title":"Cortical amyloid beta deposition and current depressive symptoms in Alzheimer disease and mild cognitive impairment","volume":"29","author":"Chung","year":"2016","journal-title":"J.\u00a0Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12955-017-0759-9","article-title":"Is the Hospital Anxiety and Depression Scale (HADS) a valid measure in a general population 65-80 years old? A psychometric evaluation study","volume":"15","author":"Djukanovic","year":"2017","journal-title":"Health Qual. Life Outcomes"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1176\/appi.ajp.2017.17040442","article-title":"Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults","volume":"175","author":"Donovan","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0149-7634(03)00033-2","article-title":"Glucocorticoid regulation of diverse cognitive functions in normal and pathological emotional states","volume":"27","author":"Erickson","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1037\/1528-3542.7.2.336","article-title":"Anxiety and cognitive performance: attentional control theory","volume":"7","author":"Eysenck","year":"2007","journal-title":"Emotion"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/JAD-150146","article-title":"The apathy evaluation scale: a comparison of subject, informant, and clinician report in cognitively normal elderly and mild cognitive impairment","volume":"47","author":"Guercio","year":"2015","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib11","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1176\/appi.neuropsych.13060141","article-title":"Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly individuals","volume":"27","author":"Guercio","year":"2015","journal-title":"J.\u00a0Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib12","article-title":"Association of anxiety with subcortical amyloidosis in cognitively normal older adults","volume":"23","author":"Hanseeuw","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/gps.4489","article-title":"Amyloid burden and incident depressive symptoms in cognitively normal older adults","volume":"32","author":"Harrington","year":"2017","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1600-0404.2006.00540.x","article-title":"Amygdalar volume and psychiatric symptoms in Alzheimer's disease: an MRI analysis","volume":"113","author":"Horinek","year":"2006","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"issue":"Pt 12","key":"10.1016\/j.neurobiolaging.2019.10.008_bib16","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1093\/brain\/awv283","article-title":"Different definitions of neurodegeneration produce similar amyloid\/neurodegeneration biomarker group findings","volume":"138","author":"Jack","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib17","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nature14188","article-title":"From circuits to behaviour in the amygdala","volume":"517","author":"Janak","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/08039488.2017.1334820","article-title":"Psychometric testing of a Swedish version of the apathy evaluation scale","volume":"71","author":"Johansson","year":"2017","journal-title":"Nord J. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S1041610217002368","article-title":"Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging","volume":"30","author":"Krell-Roesch","year":"2018","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuropsychologia.2017.07.003","article-title":"The anatomy of apathy: a neurocognitive framework for amotivated behaviour","volume":"118","author":"Le Heron","year":"2017","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/jnnp-2018-318265","article-title":"Brain mechanisms underlying apathy","volume":"90","author":"Le Heron","year":"2019","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib22","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jagp.2014.10.005","article-title":"Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease","volume":"23","author":"Mah","year":"2015","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1176\/appi.neuropsych.12060156","article-title":"Apathy is associated with increased amyloid burden in mild cognitive impairment","volume":"25","author":"Marshall","year":"2013","journal-title":"J.\u00a0Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/jnnp-2013-306110","article-title":"Apathy correlates with prefrontal amyloid beta deposition in Alzheimer's disease","volume":"85","author":"Mori","year":"2014","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib25","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3109\/09540261.2013.838151","article-title":"Cerebral white matter hyperintensities in the prediction of cognitive decline and incident dementia","volume":"25","author":"Mortamais","year":"2013","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib26","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/gps.4406","article-title":"Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis","volume":"31","author":"Mourao","year":"2016","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib27","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/gps.2779","article-title":"Relationship between apathy and diffusion tensor imaging metrics of the brain in Alzheimer's disease","volume":"27","author":"Ota","year":"2012","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib28","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","article-title":"Earliest accumulation of beta-amyloid occurs within the default-mode network and concurrently affects brain connectivity","volume":"8","author":"Palmqvist","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib29","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1001\/jamaneurol.2014.1358","article-title":"Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid beta-amyloid 42: a cross-validation study against amyloid positron emission tomography","volume":"71","author":"Palmqvist","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib30","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/gps.1967","article-title":"Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging","volume":"23","author":"Panza","year":"2008","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jad.2017.12.101","article-title":"Amyloid burden and incident depressive symptoms in preclinical Alzheimer's disease","volume":"229","author":"Perin","year":"2018","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib32","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1001\/jamapsychiatry.2014.2476","article-title":"Amyloid-beta, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study","volume":"72","author":"Pietrzak","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/scan\/nsu055","article-title":"Are you gonna leave me? Separation anxiety is associated with increased amygdala responsiveness and volume","volume":"10","author":"Redlich","year":"2015","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.eurpsy.2018.07.008","article-title":"Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group","volume":"54","author":"Robert","year":"2018","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mam.2015.05.005","article-title":"Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?","volume":"43-44","author":"Rosenberg","year":"2015","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib36","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jagp.2012.10.019","article-title":"A\u00a0systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression","volume":"21","author":"Sexton","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S1041610213001725","article-title":"A\u00a0review of neuroimaging findings of apathy in Alzheimer's disease","volume":"26","author":"Theleritis","year":"2014","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib39","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1176\/appi.neuropsych.11120375","article-title":"Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's dementia","volume":"24","author":"Tighe","year":"2012","journal-title":"J.\u00a0Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib40","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/jamapsychiatry.2018.1877","article-title":"Association of apathy with risk of incident dementia: a systematic review and meta-analysis","volume":"75","author":"van Dalen","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neurobiolaging.2019.10.008_bib41","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.STR.32.6.1318","article-title":"A\u00a0new rating scale for age-related white matter changes applicable to MRI and CT","volume":"32","author":"Wahlund","year":"2001","journal-title":"Stroke"}],"container-title":["Neurobiology of Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019303719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197458019303719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:32:19Z","timestamp":1759318339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197458019303719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":41,"alternative-id":["S0197458019303719"],"URL":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.10.008","relation":{},"ISSN":["0197-4580"],"issn-type":[{"value":"0197-4580","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apathy and anxiety are early markers of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}